20 Years of Real-World Data to Estimate the Prevalence of Heart Failure and Its Subtypes in an Unselected Population of Integrated Care Units by Cristina Gavina, Daniel Seabra Carvalho, Filipa Valente, Filipa Bernardo, Ricardo Jorge Dinis-Oliveira, Carla Santos-Araújo, Tiago Taveira-Gomes

“…Echocardiographic parameters (left ventricle ejection fraction (LVEF) and evidence of structural heart disease) and elevated levels of natriuretic peptides were used to define two HF phenotypes: (i) HF with a reduced ejection fraction (HFrEF, LVEF ≤ 40% and either NT-proBNP ≥ 400 pg/mL (≥600 pg/mL if atrial fibrillation (AF)/flutter) or BNP ≥ 100 pg/mL (≥125 pg/mL if AF/flutter)) and (ii) HF with a non-reduced ejection fraction (HFnrEF), which encompasses both HFpEF (LVEF ≥ 50% and either NT-proBNP ≥ 200 pg/mL (≥600 pg/mL if AF/flutter) or BNP ≥ 100 pg/mL (≥125 pg/mL if AF/flutter) in the presence of at least one structural cardiac abnormality) and HF with a mildly reduced fraction (HFmrEF, LVEF within 40–50% and either NT-proBNP ≥ 200 pg/mL (≥600 pg/mL if AF/flutter) or BNP ≥ 100 pg/mL (≥125 pg/mL if AF/flutter) in the presence of at least one structural cardiac abnormality). …”
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Regulatory role of PI16 in autoimmune arthritis and intestinal inflammation: implications for Treg cell differentiation and function by Yuankai Sun, Shiyu Lin, Hui Wang, Lei Wang, Yulu Qiu, Feifei Zhang, Nannan Hao, Fang Wang, Wenfeng Tan

“…The proportion and phenotypic differences of immune cells in 8-week-old mice were detected by cell counter and flow cytometry. …”
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The effectiveness of the first dose COVID-19 booster vs. full vaccination to prevent SARS-CoV-2 infection and severe COVID-19 clinical event: a meta-analysis and systematic review... by Junjie Xu, Junjie Xu, Xinquan Lan, Xinquan Lan, Liangyuan Zhang, Liangyuan Zhang, Xiangjun Zhang, Jiaqi Zhang, Jiaqi Zhang, Moxin Song, Moxin Song, Jiaye Liu

“…The seroconversion rate of antibodies to S and S subunits and antibody titers of SARS-CoV-2, frequency, phenotype of specific T and B cells, and clinical events involving confirmed infection, admission to the intensive care unit (ICU), and death were compared between the first booster dose of COVID-19 vaccination group and full vaccination group. …”
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Faster Gastrointestinal Transit, Reduced Small Intestinal Smooth Muscle Tone and Dysmotility in the <i>Nlgn3^R451C</i> Mouse Model of Autism by Suzanne Hosie, Tanya Abo-Shaban, Kevin Mou, Gayathri K. Balasuriya, Mitra Mohsenipour, Mohammed U. Alamoudi, Rhiannon T. Filippone, Gabrielle T. Belz, Ashley E. Franks, Joel C. Bornstein, Kulmira Nurgali, Elisa L. Hill-Yardin

“…Here, we show that gut dysfunction is a persistent phenotype of the <i>Nlgn3</i> R451C mutation in mice backcrossed onto a C57BL/6 background. …”
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The NF-Y Transcription Factor Family in Watermelon: Re-Characterization, Assembly of ClNF-Y Complexes, Hormone- and Pathogen-Inducible Expression and Putative Functions in Disease... by Siyu Jiang, Hui Wang, Ya Wen, Jiayu Liang, Dayong Li, Fengming Song

“…Overexpression of <i>ClNF-YB1</i>, <i>-YB8</i>, <i>-YB9</i>, <i>ClNF-YC2</i>, and <i>-YC7</i> in transgenic Arabidopsis resulted in an earlier flowering phenotype. Overexpression of <i>ClNF-YB8</i> in Arabidopsis led to enhanced resistance while overexpression of <i>ClNF-YA2</i> and <i>-YC2</i> resulted in decreased resistance against <i>Botrytis cinerea</i>. …”
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Methylation changes in association with early life stress and trauma-focused psychotherapy in treatment-resistant depression by R. Carvalho Silva, C. Hohoff, P. Martini, M. Bortolomasi, R. Bazzanella, V. Menesello, M. Gennarelli, B. T. Baune, A. Minelli

“…We tested the association between B-values for each CpG site (each probe set) and each phenotype/condition using a linear model approach (with paired values) as implemented in the Limma R package. …”
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Hepatic myofibroblasts exert immunosuppressive effects independent of the immune checkpoint regulator PD-L1 in liver metastasis of pancreatic ductal adenocarcinoma by Silje Beckinger, Tina Daunke, Leon Aldag, Sandra Krüger, Steffen Heckl, Steffen Heckl, Daniela Wesch, Heiner Schäfer, Christoph Röcken, Sascha Rahn, Susanne Sebens

“…Furthermore, HMF potently impair the effector phenotype of CD8+ T cells but the PD-L1/PD-1 axis apparently plays a minor role in this scenario suggesting that immune evasion of PDAC liver metastases relies on other immunosuppressive mechanisms.…”
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The protective effect of IL‐12/23 neutralizing antibody in sarcopenia associated with dextran sulfate sodium‐induced experimental colitis by Youn‐Kwan Jung, Sangyeob Lee, Jun‐Il Yoo, Kyung‐Wan Baek

“…Abstract Background The improvement of colitis symptoms by treatment with IL‐12/23 p40 neutralizing antibody should increase the muscle mass and the function of the sarcopenia phenotype. Methods An experimental colitis model was induced by oral administration of 2% dextran sulfate sodium (DSS) for 7 days. …”
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Comparison of the genetic characteristics of directly measured and Fourier-transform mid-infrared-predicted bovine milk fatty acids and proteins by Kathryn M. Tiplady, Thomas J. Lopdell, Richard G. Sherlock, Thomas J.J. Johnson, Richard J. Spelman, Bevin L. Harris, Stephen R. Davis, Mathew D. Littlejohn, Dorian J. Garrick

“…Our study indicates that genetic correlations between directly measured and FT-MIR predicted fatty acid and protein fractions are typically high, but that phenotypic variation in these traits may be underpinned by differing genetic architecture.…”
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CDR2 and CDR2L line blot performance in PCA-1/anti-Yo paraneoplastic autoimmunity by Nisa Vorasoot, Nisa Vorasoot, Madeleine Scharf, Ramona Miske, Smathorn Thakolwiboon, Divyanshu Dubey, Divyanshu Dubey, John R. Mills, Sean J. Pittock, Sean J. Pittock, Anastasia Zekeridou, Anastasia Zekeridou, Anthonina Ott, Andrew McKeon, Andrew McKeon

“…The two “CDR2L-only” positives were CSF samples with low titer PCA-1/Yo by IFA with serum negativity but with typical clinical phenotype. Group 2: All 51 PCA-1/Yo mimics were CDR2/CDR2L negative. …”
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Molecular test of Paget's disease of bone in families not linked to SQSTM1 gene mutations by Yang You, David Simonyan, Alexandre Bureau, Edith Gagnon, Caroline Albert, Jason R. Guertin, Jean-Eric Tarride, Jacques P. Brown, Laëtitia Michou

“…In unrelated individual non-carriers of SQSTM1 mutations, we previously developed a genetic test combining male sex with five genetic markers (rs499345, rs5742915, rs2458413, rs3018362, rs2234968), giving rise to an area under the curve (AUC) for PDB phenotype of 0.73 (0.69; 0.77). A combination of male sex with total calcium corrected for albumin and Procollagen type I N-terminal propeptide (P1NP), had an AUC of 0.82 (0.73; 0.92). …”
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Properties of Plasma Clots in Adult Patients Following Fontan Procedure: Relation to Clot Permeability and Lysis Time—Multicenter Study by Maciej Skubera, Aleksandra Gołąb, Dariusz Plicner, Joanna Natorska, Michał Ząbczyk, Olga Trojnarska, Anna Mazurek-Kula, Monika Smaś-Suska, Agnieszka Bartczak-Rutkowska, Piotr Podolec, Lidia Tomkiewicz-Pająk

“…Conclusion: our study shows that cellular liver damage and endothelial injury were associated with prothrombotic clot phenotype reflected by K_s and CLT.…”
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Colonization of rectal mucosa by microbes with antibiotic resistance markers in children with hematological malignancies by L.G. Boronina, E.V. Samatova, M.P. Kukushkina, S.A. Panova, S.S. Ustyugova, A.G. Asnovskaya

“…</i> </p> <p> <i><b>Aim</b>: to study the colonization of rectal mucosa by extended-spectrum beta-lactamase (ESBL) — producing carbapenem-resistant Enterobacterales, carbapenem-resistant Pseudomonas aeruginosa, and vancomycin-resistant Enterococci using phenotypic methods and gene tests.</i> </p> <p> <i><b>Patients and Methods:</b> this study was performed from December 10, 2019, to March 30, 2020. 150 samples (131 fecal specimens and 19 rectal swabs) collected from 66 patients who were admitted to the Hematological Center were examined. …”
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Comparative analysis of machine-planted and manual-planted wheat on crop and water productivity, and profitability under system of wheat intensification management by Anchal Dass, H. L. Kushwaha, P. K. Sahoo, Shiva Dhar, Anil K. Choudhary, Anil K. Choudhary, Tapan K. Khura, Subhash Babu, Arjun Singh, Arjun Singh, Indra Mani, Indra Mani, Mukesh Kumar, Rajeev Kumar, Devideen Yadav

“…The increase in grain yield is attributable to SWI methods that led to an increase in the harvest index, i.e., in the wheat plant phenotypes. The water productivity and production efficiency were higher under SWI compared to conventional seed drilling with or without SWI-management. …”
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Injurious Effect of Cisplatin on the Function of Hypothalamus-pituitary-adrenal/gonadal Axis in Mice and the Intervention Effect of Dehydroepiandrosterone by PAN Zhiqiang, NONG Zixin, XIE Haina, PENG Peike

“…In the DDP modeling group, the arrangement of spermatogenic cells at all levels in the testicular tissue was disordered and the testicular interstitial edema was observed, and a large number of primordial follicles in the ovarian tissue were activated, the number of atresia follicles increased, and the number of granulosa cells in the follicles decreased; while in the DHEA group, the damaged phenotype of testicles and ovaries was significantly improved. …”
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Genomics and cellulolytic, hemicellulolytic, and amylolytic potential of Iocasia fonsfrigidae strain SP3-1 for polysaccharide degradation by Sobroney Heng, Sawannee Sutheeworapong, Verawat Champreda, Ayaka Uke, Akihiko Kosugi, Patthra Pason, Rattiya Waeonukul, Ruben Michael Ceballos, Khanok Ratanakhanokchai, Chakrit Tachaapaikoon

“…In this study, we examine the halophilic and alkaliphilic nature of strain SP3-1 and the genetic substrates underlying phenotypic differences between strains SP3-1 and NS-1T with focus on sugar metabolism and CHA enzyme expression. …”
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Clinical and genetic characteristics of 36 children with Joubert syndrome by Yan Dong, Yan Dong, Ke Zhang, Ke Zhang, He Yao, He Yao, Tianming Jia, Jun Wang, Dengna Zhu, Falin Xu, Meiying Cheng, Shichao Zhao, Xiaoyi Shi

“…However, long-term follow-up data are scarce, and further research is needed to determine the abundant phenotypes and genetics of this disorder. The study aimed to summarize clinical manifestations, particular appearance on cranial imaging, genetic data, and prognostic features of patients with JBTS.MethodsA retrospective case review of 36 cases of JBTS from May 1986 to December 2021 was performed. …”
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2个品种不同成熟度油茶果实品质差异比较Comparison of fruit quality differences between two varieties of Camellia oleifera fruit at different maturity by 叶甜甜， 刘雪, 梁晓婕, 苏淑钗 YE Tiantian, LIU Xue, LIANG Xiaojie, SU Shuchai

“…In order to clarify the best harvest time of Camellia oleifera fruit, the changes of the phenotypic traits, nutrients and fatty acid composition and content of seed kernel oil of Ganshi 83-4 and Ganshi 447 were determined at different maturity, and the quality of the two varieties of Camellia oleifera fruits at different maturity were comprehensively evaluated by principal component analysis. …”
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Effects of abomasally infused rumen fluid from corn-challenged donor cows on production, metabolism, and inflammatory biomarkers in healthy recipient cows by M.A. Abeyta, B.M. Goetz, E.J. Mayorga, S. Rodriguez-Jimenez, J. Opgenorth, A.D. Freestone, J.M. Lourenco, T.R. Callaway, L.H. Baumgard

“…Abomasal infusion of rumen fluid from corn-challenged Donor cows decreased fecal pH but did not cause inflammation, nor did it create an immune-activated phenotype in recipient cows.…”
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Rare recurrent copy number variations in metabotropic glutamate receptor interacting genes in children with neurodevelopmental disorders by Joseph T. Glessner, Munir E. Khan, Xiao Chang, Yichuan Liu, F. George Otieno, Maria Lemma, Isabella Slaby, Heather Hain, Frank Mentch, Jin Li, Charlly Kao, Patrick M. A. Sleiman, Michael E. March, John Connolly, Hakon Hakonarson

“…Abstract Background Neurodevelopmental disorders (NDDs), such as attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD), are examples of complex and partially overlapping phenotypes that often lack definitive corroborating genetic information. …”
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