Characterization of candidate proteins involved in calreticulin-dependent invasion using breast cancer tissue biopsies by Noudehi, Zahra Yekta Moghaddam

“…The protein candidates investigated in this study are found to be implicated with a cancer invasive phenotype and potentially CRT-dependent. Hence the main objective of this study was to determine the expression and localization patterns of MUC1, TSP-1, CTTN, E-cadherin, and HER-2/neu in breast cancer tissues and corresponding non-malignant tissues. …”
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Ploidy detection, genetic diversity, and quantitative trait loci mapping in molly fish (poecilia spp.) by Keong, Remmy Bun Poh

“…Multiple genes interaction which acted nonadditively was also found to be influencing this phenotypic trait. However, such interaction effect was restricted in crosses generated between genetically related fish. …”
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Microbial Risk Assessment of Thermophilic Campylobacter SPP. in Raw Vegetables from Farm to Table by Chai, Lay Ching

“…The biosafety of Campylobacter jejuni was assessed by phenotypic (antibiotic resistance) and genotypic (presence of virulent and toxin genes) as well as RAPD-PCR characteristics of the strains isolated from vegetables. …”
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Growth Performance of Thamari Sheep in Yemen by Al-Nokhaif, Abdullah Ali Abdullah

“…Therefore, the contribution of the significant factors to the total phenotypic variation of the Thamari sheep performance should be eliminated before applying selection and estimating genetic parameters. …”
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A potential dissemination of distinct MRSEs in a student population at a public university by Pung, Hui Ping, Amin Nordin, Syafinaz, Tengku Jamaluddin, Tengku Zetty Maztura, Mohd Desa, Mohd Nasir

“…DNA fingerprint patterns in a dendrogram (GelCompar, Belgium) were analysed in relation to the previously determined phenotypic and genotypic properties of the isolates in order to trace the potential clonal dissemination of the isolates in the studied population. …”
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Polymorphisms in Estrogen Receptor-Α and -Β Genes and Their Correlations with Risk Factors in Iranian Breast Cancer Patients by Abbasi, Sakineh

“…Moreover, SNP in codon 392 of ER-β gene is more effective than those SNPs in three polymorphic sites of ER-α gene, in developing familial breast cancer and LN metastases phenotype. This was the first systematic association study in ER-α and ER-β genes polymorphisms and demographic characteristics for breast cancer risk in Iran. …”
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Characterization of Staphylococcus aureus isolated from small ruminants and farm workers in Albatinah south, the Sultanate of Oman by Almakhladi, Salim Sulaiman Rashid

“…This study is designed to investigate the prevalence of nasal carriage of S. aureus and MRSA in goat, sheep, and farm workers and subsequently the isolates were characterized using phenotypic and genotypic methods. Antibiotic susceptibility test (AST) was carried out using the minimum inhibitory concentration (MIC). …”
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Influence of plant growth-promoting rhizobacteria and arbuscular mycorrhizal fungi on growth and yield of strawberry (Fragaria x ananassa Duchesne) by Samsurrijal, Nur Laili

“…In Study 1, bacterial isolates obtained from rhizosphere of three strawberry cultivars (Camarosa, Festival and Chandler) grown in Cameron Highlands, were differentiated based on phenotypic characterization, evaluated for various beneficial traits and identified using molecular technique. …”
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Metabolic profiling of neurospheres derived from embryonic cerebral cortex Ts1Cje mouse model for down syndrome by Mohamed Seth, Eryse Amira

“…In this study, embryonic cerebral cortex of Ts1Cje and wild type (WT) mice were isolated at embryonic day 15.5 and cultured in the form of neurospheres. Biolog Phenotype MicroArray (PM) was employed to obtain metabolic profiles for the embryonic Ts1Cje and WT neurospheres. …”
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Inheritance and genetic analysis of seed weight and associated traits in bambara groundnut (Vigna subterranea L.) genotypes by Atiqullah, Khaliqi

“…Data were collected on 25 agro-morphological traits and statistical analysis was conducted using SAS version 9.4 software for the analysis of variance, while variance component, genotypic and phenotypic coefficient variation, heritability and genetic advance values were estimated. …”
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Genetic determinants of TAC chemotherapy response in triple negative breast cancer patients by Aziz, Ahmad Aizat Abdul

“…Triple negative breast cancer (TNBC), one of the breast cancer subtypes is characterised by aggresive phenotype, high rates of recurrence and poor prognosis and is an important clinical challenge due to lack of specific targeted therapy. …”
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A standardised fraction 1 (SF1) from clinacanthus nutans attenuates the stemness of cervical cancer stem-like cells via inhibition of notch1 signalling by Ismail, Faridah

“…SF1 effectively inhibited the cervosphere viability and stemness phenotypes in vitro and in vivo. SF1 was found to induce a concentration-dependent cytotoxicity in the cells, with a half-maximal inhibitory concentration (IC50) of 17.07 µg/ml. …”
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Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond by Van Voorhis, Wesley C., Adams, John H., Adelfio, Roberto, Ahyong, Vida, Akabas, Myles H., Alano, Pietro, Alday, Aintzane, Yesmalie, Alemán Resto, Alsibaee, Aishah, Alzualde, Ainhoa, Andrews, Katherine T., Avery, Simon V., Avery, Vicky M., Ayong, Lawrence, Baker, Mark, Baker, Stephen, Ben Mamoun, Choukri, Bickle, Quentin, Bounaadja, Lotfi, Bowling, Tana, Bosch, Jürgen, Boucher, Lauren E., Boyom, Fabrice F., Brea, Jose, Brennan, Marian, Burton, Audrey, Caffrey, Conor R., Camarda, Grazia, Carrasquilla, Manuela, Carter, Dee, Cassera, Maria Belen, Ken, Chih-Chien Cheng, Chindaudomsate, Worathad, Chubb, Anthony, Colon, Beatrice L., Colón-López, Daisy D., Corbett, Yolanda, Crowther, Gregory J., Cowan, Noemi, D’Alessandro, Sarah, Le Dang, Na, Delves, Michael, DeRisi, Joseph L., Du, Alan Y., Duffy, Sandra, Abd El-Salam El-Sayed, Shimaa, Ferdig, Michael T., Fernández Robledo, José A., Fidock, David A., Florent, Isabelle, Fokou, Patrick V. T., Galstian, Ani, Gamo, Francisco Javier, Gokool, Suzanne, Gold, Ben, Golub, Todd, Goldgof, Gregory M., Guha, Rajarshi, Guiguemde, W. Armand, Gural, Nil, Guy, R. Kiplin, Hansen, Michael A. E., Hanson, Kirsten K., Hemphill, Andrew, Hooft van Huijsduijnen, Rob, Horii, Takaaki, Horrocks, Paul, Hughes, Tyler B., Huston, Christopher, Igarashi, Ikuo, Ingram-Sieber, Katrin, Itoe, Maurice A., Jadhav, Ajit, Naranuntarat Jensen, Amornrat, Jensen, Laran T., Jiang, Rays H. Y., Kaiser, Annette, Keiser, Jennifer, Ketas, Thomas, Kicka, Sebastien, Kim, Sunyoung, Kirk, Kiaran, Kumar, Vidya P., Kyle, Dennis E., Lafuente, Maria Jose, Landfear, Scott, Lee, Nathan, Lee, Sukjun, Lehane, Adele M., Li, Fengwu, Little, David, Liu, Liqiong, Llinás, Manuel, Loza, Maria I., Lubar, Aristea, Lucantoni, Leonardo, Lucet, Isabelle, Maes, Louis, Mancama, Dalu, Mansour, Nuha R., March, Sandra, McGowan, Sheena, Medina Vera, Iset, Meister, Stephan, Mercer, Luke, Mestres, Jordi, Mfopa, Alvine N., Misra, Raj N., Moon, Seunghyun, Moore, John P., Morais Rodrigues da Costa, Francielly, Müller, Joachim, Muriana, Arantza, Nakazawa Hewitt, Stephen, Nare, Bakela, Nathan, Carl, Narraidoo, Nathalie, Nawaratna, Sujeevi, Ojo, Kayode K., Ortiz, Diana, Panic, Gordana, Papadatos, George, Parapini, Silvia, Patra, Kailash, Pham, Ngoc, Prats, Sarah, Plouffe, David M., Poulsen, Sally-Ann, Pradhan, Anupam, Quevedo, Celia, Quinn, Ronald J., Rice, Christopher A., Ruecker, Andrea, St. Onge, Robert, Salgado Ferreira, Rafaela, Samra, Jasmeet, Robinett, Natalie G., Schlecht, Ulrich, Schmitt, Marjorie, Silva Villela, Filipe, Silvestrini, Francesco, Sinden, Robert, Smith, Dennis A., Soldati, Thierry, Spitzmüller, Andreas, Stamm, Serge Maximilian, Sullivan, David J., Sullivan, William, Suresh, Sundari, Suzuki, Brian M., Suzuki, Yo, Swamidass, S. Joshua, Taramelli, Donatella, Tchokouaha, Lauve R. Y., Theron, Anjo, Thomas, David, Tonissen, Kathryn F., Townson, Simon, Tripathi, Abhai K., Trofimov, Valentin, Udenze, Kenneth O., Ullah, Imran, Vallieres, Cindy, Vigil, Edgar, Vinetz, Joseph M., Voong Vinh, Phat, Vu, Hoan, Watanabe, Nao-aki, Weatherby, Kate, White, Pamela M., Wilks, Andrew F., Winzeler, Elizabeth A., Wojcik, Edward, Wree, Melanie, Wu, Wesley, Yokoyama, Naoaki, Zollo, Paul H. A., Abla, Nada, Blasco, Benjamin, Burrows, Jeremy, Laleu, Benoît, Leroy, Didier, Spangenberg, Thomas, Wells, Timothy, Willis, Paul A., Bhatia, Sangeeta N

“…The Medicines for Malaria Venture Malaria Box is a collection of over 400 compounds representing families of structures identified in phenotypic screens of pharmaceutical and academic libraries against the Plasmodium falciparum malaria parasite. …”
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Allergic inflammatory memory in human respiratory epithelial progenitor cells by Ordovas-Montanes, Jose Manuel, Dwyer, Daniel F., Nyquist, Sarah Kate, Buchheit, Kathleen M., Vukovic, Marko, Deb, Chaarushena, Wadsworth, Marc Havens, Hughes, Travis K., Kazer, Samuel Weisgurt, Yoshimoto, Eri, Cahill, Katherine N., Bhattacharyya, Neil, Katz, Howard R., Berger Leighton, Bonnie, Laidlaw, Tanya M., Boyce, Joshua A., Barrett, Nora A., Shalek, Alexander K

“…We reveal marked differences between the epithelial compartments of the non-polyp and polyp cellular ecosystems, identifying and validating a global reduction in cellular diversity of polyps characterized by basal cell hyperplasia, concomitant decreases in glandular cells, and phenotypic shifts in secretory cell antimicrobial expression. …”
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Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop by Bedognetti, Davide, Ceccarelli, Michele, Galluzzi, Lorenzo, Lu, Rongze, Palucka, Karolina, Samayoa, Josue, Spranger-Zimmermann, Stefani, Warren, Sarah, Wong, Kwok-Kin, Ziv, Elad, Chowell, Diego, Coussens, Lisa M., De Carvalho, Daniel D., DeNardo, David G., Galon, Jérôme, Kaufman, Howard L., Kirchhoff, Tomas, Lotze, Michael T., Luke, Jason J., Minn, Andy J., Politi, Katerina, Shultz, Leonard D., Simon, Richard, Thórsson, Vésteinn, Weidhaas, Joanne B., Ascierto, Maria Libera, Ascierto, Paolo Antonio, Barnes, James M., Barsan, Valentin, Bommareddy, Praveen K., Bot, Adrian, Church, Sarah E., Ciliberto, Gennaro, De Maria, Andrea, Draganov, Dobrin, Ho, Winson S., McGee, Heather M., Monette, Anne, Murphy, Joseph F., Nisticò, Paola, Park, Wungki, Patel, Maulik, Quigley, Michael, Radvanyi, Laszlo, Raftopoulos, Harry, Rudqvist, Nils-Petter, Snyder, Alexandra, Sweis, Randy F., Valpione, Sara, Zappasodi, Roberta, Butterfield, Lisa H., Disis, Mary L., Fox, Bernard A., Cesano, Alessandra, Marincola, Francesco M.

“…The multifactorial determinants of CIR include the genetic makeup of the patient, the genomic instability central to cancer development, the evolutionary emergence of cancer phenotypes under the influence of immune editing, and external modifiers such as demographics, environment, treatment potency, co-morbidities and cancer-independent alterations including immune homeostasis and polymorphisms in the major and minor histocompatibility molecules, cytokines, and chemokines. …”
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High-throughput screening identifies histone deacetylase inhibitors that modulate GTF2I expression in 7q11.23 microduplication autism spectrum disorder patient-derived cortical neu... by Cavallo, Francesca, Troglio, Flavia, Fagà, Giovanni, Fancelli, Daniele, Shyti, Reinald, Trattaro, Sebastiano, Zanella, Matteo, D'Agostino, Giuseppe, Hughes, James M., Cera, Maria Rosaria, Pasi, Maurizio, Gabriele, Michele, Lazzarin, Maddalena, Mihailovich, Marija, Kooy, Frank, Rosa, Alessandro, Mercurio, Ciro, Varasi, Mario, Testa, Giuseppe

“…The lead compounds identified will now need to be advanced to further testing in additional models, including patient-derived brain organoids and mouse models recapitulating the gene imbalances of the 7q11.23 microduplication, in order to validate their efficacy in rescuing phenotypes across multiple functional layers within a translational pipeline towards clinical use. …”
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Adiposity and metabolic health in Asian populations: an epidemiological study using dual-energy x-ray absorptiometry in Singapore by Mina, Theresia, Xie, Wubin, Low, Dorrain Yanwen, Wang, Xiaoyan, Lam, Benjamin Chih Chiang, Sadhu, Nilanjana, Ng, Hong Kiat, Nur-Azizah Aziz, Tong, Terry Yoke Yin, Kerk, Swat Kim, Choo, Wee Lin, Low, Guo Liang, Halimah Ibrahim, Lim, Liming, Tai, E Shyong, Wansaicheong, Gervais, Dalan, Rinkoo, Yew, Yik Weng, Elliott, Paul, Riboli, Elio, Loh, Marie, Ngeow, Joanne, Lee, Eng Sing, Lee, Jimmy, Best, James, Chambers, John

“…In a subset of participants on no medication for type 2 diabetes, hypertension, and hypercholesterolaemia, we tested the relationship of BMI and visceral fat mass index (vFMI) with cardiometabolic phenotypes (glycaemic indices, lipid levels, and blood pressure), disease outcomes (type 2 diabetes, hypercholesterolaemia, and hypertension), and metabolic syndrome score with multivariable regression analyses. …”
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Polymorphism in Tmem132d regulates expression and anxiety-related behavior through binding of RNA polymerase II complex by Naik, Roshan R., Sotnikov, Sergey V., Diepold, Rebekka P., Iurato, Stella, Markt, Patrick O., Bultmann, Andrea, Brehm, Nadine, Mattheus, Tobias, Lutz, Beat, Erhardt, Angelika, Binder, Elisabeth B., Schmidt, Ulrike, Holsboer, Florian, Landgraf, Rainer, Czibere, Ludwig

“…Virus mediated overexpression of Tmem132d in the aCC of C57BL/6 J mice could confirm its role in mediating an anxiogenic phenotype. To model gene–environmental interactions, HAB mice exposed to enriched environment (HAB-EE) responded with decreased anxiety levels but, had enhanced Tmem132d mRNA expression as compared to standard-housed HAB (HAB-SH) mice. …”
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Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia by Anney, RJL, Ripke, S, Anttila, V, Grove, J, Holmans, P, Huang, H, Klei, L, Lee, PH, Medland, SE, Neale, B, Robinson, E, Weiss, LA, Zwaigenbaum, L, Yu, TW, Wittemeyer, K, Willsey, AJ, Wijsman, EM, Werge, T, Wassink, TH, Waltes, R, Walsh, CA, Wallace, S, Vorstman, JAS, Vieland, VJ, Vicente, AM, vanEngeland, H, Tsang, K, Thompson, AP, Szatmari, P, Svantesson, O, Steinberg, S, Stefansson, K, Stefansson, H, State, MW, Soorya, L, Silagadze, T, Scherer, SW, Schellenberg, GD, Sandin, S, Sanders, SJ, Saemundsen, E, Rouleau, GA, Roge, B, Roeder, K, Roberts, W, Reichert, J, Reichenberg, A, Rehnstrom, K, Regan, R, Poustka, F, Poultney, CS, Piven, J, Pinto, D, Pericak-Vance, MA, Pejovic-Milovancevic, M, Pedersen, MG, Pedersen, CB, Paterson, AD, Parr, JR, Pagnamenta, AT, Oliveira, G, Nurnberger, JI, Nordentoft, M, Murtha, MT, Mouga, S, Mortensen, PB, Mors, O, Morrow, EM, Moreno-De-Luca, D, Monaco, AP, Minshew, N, Merikangas, A, McMahon, WM, McGrew, SG, Mattheisen, M, Martsenkovsky, I, Martin, DM, Mane, SM, Magnusson, P, Magalhaes, T, Maestrini, E, Lowe, JK, Lord, C, Levitt, P, LeseMartin, C, Ledbetter, DH, Leboyer, M, LeCouteur, AS, Ladd-Acosta, C, Kolevzon, A, Klauck, SM, Jacob, S, Iliadou, B, Hultman, CM, Hougaard, DM, Hertz-Picciotto, I, Hendren, R, Hansen, CS, Haines, JL, Guter, SJ, Grice, DE, Green, JM, Green, A, Goldberg, AP, Gillberg, C, Gilbert, J, Gallagher, L, Freitag, CM, Fombonne, E, Folstein, SE, Fernandez, B, Fallin, MD, Ercan-Sencicek, AG, Ennis, S, Duque, F, Duketis, E, Delorme, R, DeRubeis, S, DeJonge, MV, Dawson, G, Cuccaro, ML, Correia, CT, Conroy, J, Conceicao, IC, Chiocchetti, AG, Celestino-Soper, PBS, Casey, J, Cantor, RM, Cafe, C, Bybjerg-Grauholm, J, Brennan, S, Bourgeron, T, Bolton, PF, Boelte, S, Bolshakova, N, Betancur, C, Bernier, R, Beaudet, AL, Battaglia, A, Bal, VH, Baird, G, Bailey, AJ, Baekvad-Hansen, M, Bader, JS, Bacchelli, E, Anagnostou, E, Amaral, D, Almeida, J, Borglum, AD, Buxbaum, JD, Chakravarti, A, Cook, EH, Coon, H, Geschwind, DH, Gill, M, Hakonarson, H, Hallmayer, J, Palotie, A, Santangelo, S, Sutcliffe, JS, Arking, DE, Devlin, B, Daly, MJ

“…We further combined these Psychiatric Genomics Consortium (PGC) ASD GWAS data with the recent PGC schizophrenia GWAS to identify additional regions which may be important in a common neurodevelopmental phenotype and identified 12 novel GWS loci. These include loci previously implicated in ASD such as FOXP1 at 3p13, ATP2B2 at 3p25.3, and a ‘neurodevelopmental hub’ on chromosome 8p11.23.…”

A novel high-throughput in-cell Western assay for the quantitative measurement of signaling dynamics in DNA damage signaling networks : cell decision processes in response to DNA d... by Tentner, Andrea R. (Andrea Ruth)

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