Regulation of Drosophila eye development by the transcription factors : eyes absent and Spenito by Jemc, Jennifer Colleen

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Characterization and modification of porosity in electrospun polymeric materials for tissue engineering applications by Lowery, Joseph Lenning

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Attenuation of corneal myofibroblast development through nanoparticle-mediated soluble transforming growth factor-β type II receptor (sTGFβRII) gene transfer by Sharma, Ajay, Rodier, Jason T., Tandon, Ashish, Klibanov, Alexander M., Mohan, Rajiv R.

“…Furthermore, PEI- or Lipofectamine-mediated sTGFβRII delivery into HCF did not alter cellular proliferation or phenotype at 12 and 24 h post-treatment. Nanoparticles treated with HCF showed more than 90% cellular viability and very low cell death (2–6 TUNEL+ cells), suggesting that the tested doses of PEI-nanoparticles do not induce significant cell death. …”
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Modulation of adaptive and innate immune responses by myeloid cells during malaria by Lai, Si Min

“…Depletion of Clec9A+ DCs resulted in a striking phenotype in the Plasmodium chabaudi chabaudi AS model of chronic malaria, characterized by higher acute blood parasitemia, multiple severe recrudescent episodes and some associated mortality. …”
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Role of N-WASP in cell proliferation : implication for organ development and cancer by Verma, Apoorva

“…While N-WASP deletion alone in the adult stage did not result in any hyper-proliferation phenotype but in KRasG12D induced lung cancer model, N-WASP deletion (N-WASPLKO/KRasG12D) resulted in significantly increased number of tumors in the lung. …”
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Effectiveness and usability of the system for assessment and intervention of frailty for community-dwelling pre-frail older adults: a pilot study by Tan, Ren Siang, Goh, Eileen Fabia, Wang, Di, Chan, Robin Chung Leung, Zeng, Zhiwei, Yeo, Audrey, Pek, Kalene, Kua, Joanne, Wong, Wei Chin, Shen, Zhiqi, Lim, Wee Shiong

“…For outcomes, we assessed frailty status using the modified Fried Frailty Phenotype (FFP) and CFS; physical performance using Short Physical Performance Battery (SPPB); and Hand Grip Strength (HGS) at baseline and 8-week. …”
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3D printed scaffolds incorporating red blood cells-derived extracellular vesicles for microRNA delivery to treat spinal cord injuries by Huang, Chongquan, Jayasinghe, Migara Kavishka, Lau, Kieran, Thi Nguyet Minh Le, Chew, Sing Yian

“…Two weeks post-implantation, the efficacy of the scaffold in promoting injury recovery and remyelination was evaluated by immunohistochemical analysis, employing specific cell phenotypic markers to identify and characterize various neural cell types that were present at and near the site of injury. …”
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Characterization of SMAD3 function in skeletal muscle growth by Ge, Xiaojia

“…Altered gene expression changes may help to explain the muscle phenotype seen in Smad3-null mice. Up-regulated expression of genes encoding two inflammatory cytokines (S100a8 and S100a9), may help to explain the systemic inflammation observed in Smad3-null mice. …”
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Dynamic drug combination methods for suppressing bacterial antibiotics resistance adaptation by Bhone, Myint Kyaw

“…The duration it took to get phenotypic mutant strains for a particular drug/phytochemical concentration was compared individually or in combination. …”
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The application of electrospun biofunctional scaffolds for stem cell differentiation and nerve regeneration by Jiang, Xu

“…Accordingly, the aim of this thesis is to develop biomimetic scaffolds capable of delivering topographical and biochemical signals to enhance tissue regeneration via electrospinning; and to understand the phenotypic changes of cells interacting with such biofunctional scaffolds. …”
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Structural studies on the interaction of nucleosomes with metal-based anticancer compounds and the high mobility group A2 protein and X-ray crystallographic investigation of bacter... by Ma, Zhujun

“…The “central dogma” of molecular biology proposes that cells utilize intricate molecular machinery to express genetic information as a phenotype by converting archival molecules into functional molecules. …”
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Computational prediction of cell fates by systems modelling of cellular signalling pathways by Zhang, Fan

“…Through a cascade of biochemical reactions, the signals are transmitted downward to the nucleus or other cellular organelles to regulate physiological functions and finally control the cellular phenotypes (e.g., apoptosis, proliferation and cell cycle). …”
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Machine learning methods for predicting cancer drug effects from signaling and cell fate data by Mishra Shital Kumar

“…As the cellular development progresses, a cell goes through several phenotypes (e.g. Apoptosis, Proliferation, G1, S, G2 and M). …”
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Mathematical modeling and simulation of stem cell differentiation and reprogramming by Waddington's epigenetic landscape by Guo, Jing

“…It de- scribes the outcome of the percolation of genetic lineages by linking the cell phenotypes with the genotypes, through the coordination of gene regulatory networks. …”
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An assessment of the impact of South Asian ethnicity on body composition, dimensions and proportions in children and adolescents, and their potential for risk of metabolic syndrome by Shah, Mahjabeen

“…South Asians (SA) are a high-risk group for cardiometabolic disease, which is partly attributed, to their ‘thin-fat’ body composition (BC) phenotype. Generally, SAs have a higher % fat mass (FM) and less skeletal muscle mass (SMM), together with a more abdominal distribution of body fat, compared with white Europeans (WE) at equivalent body mass index (BMI) values. …”
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Investigating the effect of hypoxia on the JmjC histone lysine demethylase KDM4A by Hancock, R

“…In a collaboration with Dr Tim McKinsey (University of Colorado, Denver), the KDM4 inhibitor CCT1 was tested in a phenotypic screen of cardiomyocyte hypertrophy, the results of which further support a role for KDM4A in this disease, and suggest that the use of small-molecule inhibitors of KDM4A may be a viable therapeutic strategy in CH.…”

Sleep, circadian and behavioural characterisation of two schizophrenia-relevant transgenic mouse models by Pritchett, D

“…Although the basis of this phenotype is unclear, these data speak to the debate about the suitability of running-wheels as a circadian assay for psychiatrically-relevant mouse models.…”

Molecular and cellular features of anteromedial gonarthrosis by Rout, R

“…<p>Anteromedial Gonarthrosis (AMG) is a distinct phenotype of knee osteoarthritis (OA), with a specific pattern of disease on the tibia. …”

Rare and low-frequency variants and predisposition to complex disease by Albers, P

“…Thus, this method may prove useful in the analysis of large cohorts when linked to biomedical phenotype data.</p>…”

Radiation response and tolerance in planarian stem cells by Yap, ZC

“…Multiple members of the FHL gene family were amongst the single knockdowns causing this delay phenotype. To account for potential redundancies, we knocked down the FHL family members in all possible combinatorial pairs, revealing distinct RNAi pairs that rendered planarians sensitive to gamma radiation.…”