-
1
Catalysis and regulation of cyclic dinucleotide specific phosphodiesterases
Published 2011“…We elucidated the catalytic mechanism of RocR, an EAL-domain containing c-di-GMP specific phosphodiesterase (PDE) from the opportunistic pathogen P. aeruginosa. …”
Get full text
Thesis -
2
14-3-3 interaction with phosphodiesterase 8A sustains PKA signaling and downregulates the MAPK pathway
Published 2024Subjects: Get full text
Journal Article -
3
The dual GGDEF/EAL domain enzyme PA0285 is a Pseudomonas species housekeeping phosphodiesterase regulating early attachment and biofilm architecture
Published 2024Subjects: Get full text
Journal Article -
4
Defining proteoform-specific interactions for drug targeting in a native cell signalling environment
Published 2025“…Given reports of undesirable side-effects involving vision, we characterized the off-target drug binding of two phosphodiesterase 5 inhibitors, vardenafil and sildenafil, to the retina rod phosphodiesterase 6 (PDE6). …”
Journal article -
5
Divergent acute versus prolonged pharmacological GLP-1R responses in adult β cell-specific β-arrestin 2 knockout mice
Published 2023“…The former defect was attributed to enhanced β-arrestin 1 and phosphodiesterase 4 activities, while reduced desensitization co-occurred with impaired GLP-1R recycling and lysosomal targeting, increased trans-Golgi network signaling, and reduced GLP-1R ubiquitination. …”
Get full text
Journal Article -
6
Exploring the regulation of myofilament function in the heart using experimental and computational approaches
Published 2024“…Current therapies, such as beta-blockers and phosphodiesterase (PDE) inhibitors, often lack specificity and have adverse effects. …”
Thesis -
7
The cyclic AMP-Vfr signaling pathway in Pseudomonas aeruginosa is inhibited by cyclic di-GMP
Published 2015“…Attempts to uncover the mechanism underlying the observed c-di-GMP-mediated lowering of cAMP content provided evidence that it is not caused by inhibition of adenylate cyclase production or activity and that it is not caused by activation of cAMP phosphodiesterase activity. In addition to the studies of the RSCVs, we present evidence that the deeper layers of wild-type P. aeruginosa biofilms have high c-di-GMP levels and low cAMP levels.…”
Get full text
Get full text
Journal Article -
8
Changes in gene expression in human skeletal stem cells transduced with constitutively active Gsα correlates with hallmark histopathological changes seen in fibrous dysplastic bone...
Published 2021“…In silico comparison of our data with the signature of FD craniofacial samples highlighted common traits, such as the upregulation of ADAM (A Disintegrin and Metalloprotease) proteins and other matrix-related factors, and of PDE7B (Phosphodiesterase 7B), which can be considered as a buffering process, activated to compensate for excess cAMP. …”
Get full text
Journal Article -
9
Neuronal control of cardiac excitability in pro-hypertensive states
Published 2016“…Further, it identifies that phosphodiesterase (PDE) 2A inhibition differentially affects the currents in the WKY and SHR, further supporting the notion of PDE2A dominance.…”
Thesis -
10
Cardiac-sympathetic dysfunction in hypertension
Published 2018“…The over-represented molecular function gene ontology families included ligand-gated ion channels and regulation of phosphodiesterase signalling. The expression of key genes was confirmed in human stellate ganglia for physiological context.…”
Thesis