Showing 1 - 10 results of 10 for search '"phosphodiesterase"', query time: 0.04s Refine Results
  1. 1

    Catalysis and regulation of cyclic dinucleotide specific phosphodiesterases by Rao, Feng

    Published 2011
    “…We elucidated the catalytic mechanism of RocR, an EAL-domain containing c-di-GMP specific phosphodiesterase (PDE) from the opportunistic pathogen P. aeruginosa. …”
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    Thesis
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    Defining proteoform-specific interactions for drug targeting in a native cell signalling environment by Lutomski, CA, Bennett, JL, El-Baba, TJ, Wu, D, Hinkle, JD, Burnap, SA, Liko, I, Mullen, C, Syka, JEP, Struwe, WB, Robinson, CV

    Published 2025
    “…Given reports of undesirable side-effects involving vision, we characterized the off-target drug binding of two phosphodiesterase 5 inhibitors, vardenafil and sildenafil, to the retina rod phosphodiesterase 6 (PDE6). …”
    Journal article
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    Divergent acute versus prolonged pharmacological GLP-1R responses in adult β cell-specific β-arrestin 2 knockout mice by Bitsi, Stavroula, El Eid, Liliane, Manchanda, Yusman, Oqua, Affiong I., Mohamed, Nimco, Hansen, Ben, Suba, Kinga, Rutter, Guy A., Salem, Victoria, Jones, Ben, Tomas, Alejandra

    Published 2023
    “…The former defect was attributed to enhanced β-arrestin 1 and phosphodiesterase 4 activities, while reduced desensitization co-occurred with impaired GLP-1R recycling and lysosomal targeting, increased trans-Golgi network signaling, and reduced GLP-1R ubiquitination. …”
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    Journal Article
  6. 6

    Exploring the regulation of myofilament function in the heart using experimental and computational approaches by Folkmanaite, M

    Published 2024
    “…Current therapies, such as beta-blockers and phosphodiesterase (PDE) inhibitors, often lack specificity and have adverse effects. …”
    Thesis
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    The cyclic AMP-Vfr signaling pathway in Pseudomonas aeruginosa is inhibited by cyclic di-GMP by Almblad, Henrik, Harrison, Joe J., Rybtke, Morten, Groizeleau, Julie, Givskov, Michael, Parsek, Matthew R., Tolker-Nielsen, Tim

    Published 2015
    “…Attempts to uncover the mechanism underlying the observed c-di-GMP-mediated lowering of cAMP content provided evidence that it is not caused by inhibition of adenylate cyclase production or activity and that it is not caused by activation of cAMP phosphodiesterase activity. In addition to the studies of the RSCVs, we present evidence that the deeper layers of wild-type P. aeruginosa biofilms have high c-di-GMP levels and low cAMP levels.…”
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    Journal Article
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    Changes in gene expression in human skeletal stem cells transduced with constitutively active Gsα correlates with hallmark histopathological changes seen in fibrous dysplastic bone... by Raimondo, Domenico, Remoli, Cristina, Astrologo, Letizia, Burla, Romina, La Torre, Mattia, Vernì, Fiammetta, Tagliafico, Enrico, Corsi, Alessandro, Del Giudice, Simona, Persichetti, Agnese, Giannicola, Giuseppe, Robey, Pamela G., Riminucci, Mara, Saggio, Isabella

    Published 2021
    “…In silico comparison of our data with the signature of FD craniofacial samples highlighted common traits, such as the upregulation of ADAM (A Disintegrin and Metalloprotease) proteins and other matrix-related factors, and of PDE7B (Phosphodiesterase 7B), which can be considered as a buffering process, activated to compensate for excess cAMP. …”
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    Journal Article
  9. 9

    Neuronal control of cardiac excitability in pro-hypertensive states by Larsen, H

    Published 2016
    “…Further, it identifies that phosphodiesterase (PDE) 2A inhibition differentially affects the currents in the WKY and SHR, further supporting the notion of PDE2A dominance.…”
    Thesis
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    Cardiac-sympathetic dysfunction in hypertension by Bardsley, E

    Published 2018
    “…The over-represented molecular function gene ontology families included ligand-gated ion channels and regulation of phosphodiesterase signalling. The expression of key genes was confirmed in human stellate ganglia for physiological context.…”
    Thesis