Differential regulation of TNF-α and IL-1β production from endotoxin stimulated human monocytes by phosphodiesterase inhibitors by K. L. Molnar-Kimber, L. Yonno, R. J. Heaslip, B. M. Weichman

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The Effects of Some Phosphodiesterase 5 Inhibitors on Oxidative Stress, VEGF, BMP 2 and 9 in the Liver Tissue of Ovariectomized Rats by Hamit Hakan Alp, Zübeyir Huyut, murat Cihan, Mehmet Ramazan Şekeroğlu, Gülşah Alyar, Serkan Yildirim, Bünyamin Uçar, Halil İbrahim Akbay

“…INTRODUCTION: Osteoporosis is an important health problem and there is no effective treatment yet. phosphodiesterase 5 inhibitors are promising agents for the treatment of osteoporosis. …”
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A phosphodiesterase 4 (PDE4) inhibitor, amlexanox, reduces neuroinflammation and neuronal death after pilocarpine-induced seizure by Hyun Wook Yang, A Ra Kho, Song Hee Lee, Beom Seok Kang, Min Kyu Park, Chang Jun Lee, Se Wan Park, Seo Young Woo, Dong Yeon Kim, Hyun Ho Jung, Bo Young Choi, Won Il Yang, Hong Ki Song, Hui Chul Choi, Jin Kyu Park, Sang Won Suh

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A Promising Biomolecule Able to Degrade Neutrophil Extracellular Traps: <i>Cdc</i>PDE, a Rattlesnake Phosphodiesterase by Isadora Oliveira, Victor Costa, Flávio Veras, Isabela Ferreira, Fernando Cunha, Thiago Cunha, Wuelton Monteiro, Eliane Arantes, Manuela Pucca

Subjects: “…phosphodiesterase…”
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Influence of personality disorders on sexual behaviours and response to treatment of psychogenic erectile dysfunction in phosphodiesterase 5 inhibitor non-responders by Marina Cabello-García, Marina Cabello-García, Yolanda Sánchez-Sandoval, Yolanda Sánchez-Sandoval, Antonio Daniel García-Rojas

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Safety Profile and Tolerability of Topical Phosphodiesterase 4 Inhibitors for the Treatment of Atopic Dermatitis: A Systematic Review and Meta-Analysis by Ana Martín-Santiago, MD, Susana Puig, MD PhD, Daniel Arumi, MD PhD, Francisco Jose Rebollo Laserna, MD

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Successful shortening of tuberculosis treatment using adjuvant host-directed therapy with FDA-approved phosphodiesterase inhibitors in the mouse model. by Mamoudou Maiga, Nisheeth Agarwal, Nicole C Ammerman, Radhika Gupta, Haidan Guo, Marama C Maiga, Shichun Lun, William R Bishai

“…Here, we report that addition of the United Stated Food and Drug Administration-approved phosphodiesterase inhibitors (PDE-Is) cilostazol and sildenafil to the standard TB treatment regimen reduces tissue pathology, leads to faster bacterial clearance and shortens the time to lung sterilization by one month, compared to standard treatment alone, in a murine model of TB. …”
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Defects in AMPAR trafficking and microglia activation underlie socio-cognitive deficits associated to decreased expression of phosphodiesterase 2 a by Sébastien Delhaye, Marielle Jarjat, Asma Boulksibat, Clara Sanchez, Alessandra Tempio, Andrei Turtoi, Mauro Giorgi, Sandra Lacas-Gervais, Gabriele Baj, Carole Rovere, Viviana Trezza, Manuela Pellegrini, Thomas Maurin, Enzo Lalli, Barbara Bardoni

“…Phosphodiesterase 2 A (PDE2A) is an enzyme involved in the homeostasis of cAMP and cGMP and is the most highly expressed PDE in human brain regions critical for socio-cognitive behavior. …”
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Phosphodiesterases 4B and 4D Differentially Regulate cAMP Signaling in Calcium Handling Microdomains of Mouse Hearts by Axel E. Kraft, Nadja I. Bork, Hariharan Subramanian, Nikoleta Pavlaki, Antonio V. Failla, Bernd Zobiak, Marco Conti, Viacheslav O. Nikolaev

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RESOLUTION OF THE COUNCIL OF EXPERTS ON «THE PLACE OF PHOSPHODIESTERASE-4 INHIBITOR IN THE COMBINATION TREATMENT OF MODERATE TO SEVERE PSORIASIS AND ACTIVE PSORIATIC ARTHRITIS»

“…Resolution of the Council of Experts on «The place of phosphodiesterase-4 inhibitor in the combination treatment of moderate to severe psoriasis and active psoriatic arthritis».…”
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Single-cell transcriptomic analysis identifies downregulated phosphodiesterase 8B as a novel oncogene in IDH-mutant glioma by Zongze He, Yu Peng, Duo Wang, Chen Yang, Chengzhi Zhou, Bo Gong, Bo Gong, Siyuan Song, Yi Wang, Yi Wang

“…The comprehensive analysis identified the most altered metabolic pathways (MCPs) and genes across all cell types, which were further validated against TCGA and CGGA datasets for clinical relevance.DiscussionCrucially, the metabolic enzyme phosphodiesterase 8B (PDE8B) was found to be exclusively expressed and progressively downregulated in astrocytes and OPCs in higher-grade gliomas. …”
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Neuroprotective effects of vinpocetine, as a phosphodiesterase 1 inhibitor, on long-term potentiation in a rat model of Alzheimer’s disease by Meysam Shekarian, Iraj Salehi, Safoura Raoufi, Masoumeh Asadbegi, Masoumeh Kourosh-Arami, Alireza Komaki

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In silico exploration of antinociceptive activity of 1,4-benzodiazepines: Molecular docking on α1 A-adrenoceptor, and phosphodiesterase 4 by A. S. Akisheva, V. B. Larionov, M. Y. Golovenko, O. A. Makarenko, I. P. Valivodz, I. Y. Borysiuk, Y. O. Molodan

“…Among other ligands, propoxazepam demonstrates the lowest MMGBSA value with PDE4A (phosphodiesterase 4A). The best predicted binding scores of interaction with phosphodiesterase 4 is observed for propoxazepam with PDE4B (phosphodiesterase 4B) -10.3 kcal/mol, according to AutoDock Vina. …”
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Carney complex presenting as subclinical Cushing syndrome in a child due to a novel Phosphodiesterase 11A mutation by Qian Sun, Jie Song, Wenjing Feng, Chengqin Wang, Xuecheng Yang, Mingxin Zhang, Caixia Cao

“…Background: Several disease-causing genes have been implicated in Carney complex (CNC), including PRKAR1A, PDE8B(Phosphodiesterase 8B),and PDE11A (Phosphodiesterase 11A). …”
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Rapid Screening and Quantitative Determination of Illegal Phosphodiesterase Type 5 Inhibitors (PDE-5i) in Herbal Dietary Supplements by Thi Oanh Nguyen, Cao-Son Tran, Thi Thu Hang Do, Thi Minh Hoa Nguyen, Quang-Dong Bui, Cao-Tien Bui, Hong-Ngoc Nguyen, Thu-Hien Dang, Viet-Chien Dinh, Thi Anh Huong Nguyen, Thi Hong Hao Le

“…Phosphodiesterase type 5 inhibitors (PDE-5i) are the first-line medication for oral erectile dysfunction, which are used according to the prescription of doctors. …”
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Natural Phosphodiesterase-4 Inhibitors with Potential <i>Anti</i>-Inflammatory Activities from <i>Millettia dielsiana</i> by Vu Thi Thu Le, Hoang Van Hung, Nguyen Xuan Ha, Cao Hong Le, Pham Thi Hong Minh, Do Tien Lam

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A synthetic mimic of phosphodiesterase type 5 based on corona phase molecular recognition of single-walled carbon nanotubes by Dong, Juyao, Lee, Michael A, Rajan, Ananth Govind, Rahaman, Imon, Sun, Jessica H, Park, Minkyung, Salem, Daniel P, Strano, Michael S

“…When complexed to a single-walled carbon nanotube, some of the resulting corona phases demonstrate binding specificity remarkably similar to that of phosphodiesterase type 5 (PDE5), an enzyme that catalyzes the hydrolysis of secondary messenger. …”
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Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart. by Miller, C, Cai, Y, Oikawa, M, Thomas, T, Dostmann, W, Zaccolo, M, Fujiwara, K, Yan, C

“…Dysregulation of cyclic nucleotide phosphodiesterase (PDE) activity/expression is also associated with various diseases and several PDE inhibitors are currently available or in development for treating these pathological conditions. …”

The inhibition of antigen-induced eosinophilia and bronchoconstriction by CDP840, a novel stereo-selective inhibitor of phosphodiesterase type 4. by Hughes, B, Howat, D, Lisle, H, Holbrook, M, James, T, Gozzard, N, Blease, K, Hughes, P, Kingaby, R, Warrellow, G, Alexander, R, Head, J, Boyd, E, Eaton, M, Perry, M, Wales, M, Smith, B, Owens, R, Catterall, C, Lumb, S, Russell, A, Allen, R, Merriman, M, Bloxham, D, Higgs, G

“…The novel tri-aryl ethane CDP840, is a potent and selective inhibitor of cyclic AMP phosphodiesterase type 4 (PDE 4) extracted from tissues or recombinant PDE 4 isoforms expressed in yeast (IC50S: 4-45 nM). …”

Cancer cell cycle modulation by metabolic gene expression and role of photoreceptor phosphodiesterase 6H in cancer cell growth by Yalaz, C

“…Among the genes whose knockdown caused G1, cone phosphodiesterase 6H (PDE6H) of the retina was selected for further study as a novel controller of cancer cell cycle and metabolism, recognised for a role in controlling retinal metabolism.…”