Isolation, purification and characterization of 5'-phosphodiesterase from Aspergillus fumigatus. by Zhiting Luo, Yingying Fan, Qiuxia Li, Bing Han, Yang Liu, Shubo Li, Hua Qiu, Zongwen Pang

“…5'-Phosphodiesterase (5'-PDE) catalyzes the hydrolysis of ribonucleic acid to obtain a mixture of ribonucleotides, such as 5'-guanosine monophosphate and 5'-adenosine monophosphate. …”
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Regulation of the renin-angiotensin-aldosterone system by cyclic nucleotides and phosphodiesterases by Stepan Gambaryan, Sanika Mohagaonkar, Sanika Mohagaonkar, Viacheslav O. Nikolaev, Viacheslav O. Nikolaev

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Phosphodiesterase-5 inhibitors have distinct effects on the hemodynamics of the liver by Dunkern Torsten, Blum Hubert E, Schmidt René, Deibert Peter, Halverscheid Leonie, Pannen Benedikt HJ, Kreisel Wolfgang

“…<p>Abstract</p> <p>Background</p> <p>The NO - cGMP system plays a key role in the regulation of sinusoidal tonus and liver blood flow with phosphodiesterase-5 (PDE-5) terminating the dilatory action of cGMP. …”
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Functional modulation of phosphodiesterase-6 by calcium in mouse rod photoreceptors by Teemu Turunen, Ari Koskelainen

“…Abstract Phosphodiesterase-6 (PDE6) is a key protein in the G-protein cascade converting photon information to bioelectrical signals in vertebrate photoreceptor cells. …”
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First Characterization of Sphingomyeline Phosphodiesterase Expression in the Bumblebee, Bombus lantschouensis by lei Han, Shaoyu He, Jie Dong, Ye Wang, Jiaxing Huang, Jie Wu

“…The bumblebee (Bombus lantschouensis Vogt) is an important pollinator of wild plants. Sphingomyelin phosphodiesterase (SMPD) is a hydrolase that plays a major role in sphingolipid metabolism reactions. …”
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The role of phosphodiesterase 3 in endotoxin-induced acute kidney injury by Seo Jeong Wook, Kwon Kun Young, Choi Won-Il, Beagle John, Quinn Deborah A, Hales Charles A

“…We, therefore, hypothesized that endotoxin induced renal injury by activating phosphodiesterase 3 (PDE3) which metabolizes cAMP and that amrinone an inhibitor of PDE3 would prevent the renal injury.…”
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Phosphodiesterase 6 subunits are expressed and altered in idiopathic pulmonary fibrosis by Klepetko Walter, Eickelberg Oliver, Konigshoff Melanie, Ghofrani Hossein A, Weissmann Norbert, Savai Rajkumar, Guenther Andreas, Nikolova Sevdalina, Voswinckel Robert, Seeger Werner, Grimminger Friedrich, Schermuly Ralph T, Pullamsetti Soni S

“…<p>Abstract</p> <p>Background</p> <p>Idiopathic Pulmonary Fibrosis (IPF) is an unresolved clinical issue. Phosphodiesterases (PDEs) are known therapeutic targets for various proliferative lung diseases. …”
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Beneficial effects of certain phosphodiesterase inhibitors on diabetes mellitus in rats by Mostafa El Sayed El Sayed, Nehad Eid, Ahmed Seif El Din Kamel

“…The present study is conducted to investigate the possible antidiabetic effect of certain phosphodiesterase inhibitors. Diabetes mellitus was induced in 18 h-fasted male wistar albino rats by intraperitoneal injection of streptozotocin (STZ) in a single dose (50 mg/kg). …”
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Bacterial cyclic AMP-phosphodiesterase activity coordinates biofilm formation. by Eric J Kalivoda, Kimberly M Brothers, Nicholas A Stella, Matthew J Schmitt, Robert M Q Shanks

“…Herein we describe the characterization of a putative S. marcescens cAMP-phosphodiesterase gene (SMA3506), designated as cpdS, and demonstrated to be a functional cAMP-phosphodiesterase both in vitro and in vivo. …”
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Phosphodiesterase 10A upregulation contributes to pulmonary vascular remodeling. by Xia Tian, Christina Vroom, Hossein Ardeschir Ghofrani, Norbert Weissmann, Ewa Bieniek, Friedrich Grimminger, Werner Seeger, Ralph Theo Schermuly, Soni Savai Pullamsetti

“…Phosphodiesterases (PDEs) modulate the cellular proliferation involved in the pathophysiology of pulmonary hypertension (PH) by hydrolyzing cAMP and cGMP. …”
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The unrecognized effects of phosphodiesterase 4 on epithelial cells in pulmonary inflammation. by Franziska M Konrad, Annette Bury, Martin A Schick, Kristian-Christos Ngamsri, Jörg Reutershan

“…Recent studies showed evidence that phosphodiesterase (PDE)4-inhibitors stabilized endothelial cells. …”
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Editorial: Cyclic Nucleotide Phosphodiesterases (PDEs) in Immune Regulation and Inflammation by Stefan Brocke, Paul M. Epstein, Robert Nelson, Tim Vanmierlo, Tim Vanmierlo

Subjects: “…3′,5′-cyclic nucleotide phosphodiesterase…”
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Comparative analysis of diguanylate cyclase and phosphodiesterase genes in <it>Klebsiella pneumoniae</it> by Cruz Diana P, Huertas Mónica G, Lozano Marcela, Zárate Lina, Zambrano María

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Erratum to: Expression and function of phosphodiesterases (PDEs) in the rat urinary bladder by Xiaofei Zhu, Kui Zhai, Yue Mi, Guangju Ji

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Advancements in Phosphodiesterase 5 Inhibitors: Unveiling Present and Future Perspectives by Ahmed K. ElHady, Dalia S. El-Gamil, Mohammad Abdel-Halim, Ashraf H. Abadi

Subjects: “…phosphodiesterase 5 inhibitors…”
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Effects of a Phosphodiesterase inhibitor on the Browning of Adipose Tissue in Mice by Da Hea Seo, Eugene Shin, Yong-ho Lee, Se-Eun Park, Ki Taek Nam, Jae-woo Kim, Bong-Soo Cha

“…Cilostazol is a selective inhibitor of phosphodiesterase type 3 (PDE3) that increases intracellular cyclic adenosine monophosphate (cAMP), which plays a critical role in the development of the beige phenotype and the activation of its thermogenic program in white adipose tissue (WAT). …”
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No Causal Link between Phosphodiesterase Type 5 Inhibition and Melanoma by Jenny Z. Wang, Stephanie Le, Claire Alexanian, Sucharita Boddu, Alexander Merleev, Alina Marusina, Emanual Maverakis

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Phosphodiesterases maintain signaling fidelity via compartmentalization of cyclic nucleotides. by Lomas, O, Zaccolo, M

“…Novel technological advances have improved our understanding of how cyclic nucleotides are able to convey signals faithfully between cellular compartments. Phosphodiesterases play a crucial role in shaping these signals in health and disease. …”

Molecular cloning and expression of a human phosphodiesterase 4C. by Owens, R, Lumb, S, Rees-Milton, K, Russell, A, Baldock, D, Lang, V, Crabbe, T, Ballesteros, M, Perry, M

“…A cDNA coding for a human phosphodiesterase 4C (PDE4C2) was isolated from the mRNA prepared from the glioblastoma cell line, U87. …”

Phosphodiesterases and subcellular compartmentalized cAMP signaling in the cardiovascular system. by Stangherlin, A, Zaccolo, M

“…Phosphodiesterases are key enzymes in the cAMP signaling cascade. …”