Correction to: Effects of phosphodiesterase 4 inhibition on bleomycin-induced pulmonary fibrosis in mice by Sergey Udalov, Rio Dumitrascu, Soni Savai Pullamsetti, Hamza M. Al-tamari, Norbert Weissmann, Hossein Ardeschir Ghofrani, Andreas Guenther, Robert Voswinckel, Werner Seeger, Friedrich Grimminger, Ralph T. Schermuly

Get full text

It takes two transducins to activate the cGMP-phosphodiesterase 6 in retinal rods by Bilal M. Qureshi, Elmar Behrmann, Johannes Schöneberg, Justus Loerke, Jörg Bürger, Thorsten Mielke, Jan Giesebrecht, Frank Noé, Trevor D. Lamb, Klaus Peter Hofmann, Christian M. T. Spahn, Martin Heck

“…Among cyclic nucleotide phosphodiesterases (PDEs), PDE6 is unique in serving as an effector enzyme in G protein-coupled signal transduction. …”
Get full text

Phosphodiesterases Inhibition by Bacilli Calmette-Guérin Contributes to Decrease Asthma in Allergic Rats by Yajuan Wang, Yali Jiang, Huifang Tang, Xuefeng Wang, Chunzhen Zhao, Jiqiang Chen

Subjects: Get full text

Phosphodiesterase Activities in the Eye of Old and Young Rats in Normoxic, Hypoxic and Hyperoxic Atmospheres by G. Spoto, A. Contento, M. Di Nicola, G. Bianchi, C. Di Giulio, L. Lobefalo, S. Forcella

“…The activities of the two enzymes, cAMP phosphodiesterase (cAMP-PDE) and cGMP phosphodiesterase (cGMP-PDE), were tested. …”
Get full text

Heart Failure with Preserved Ejection Fraction and Pulmonary Hypertension: Focus on Phosphodiesterase Inhibitors by Artem Ovchinnikov, Alexandra Potekhina, Evgeny Belyavskiy, Fail Ageev

Subjects: “…phosphodiesterase…”
Get full text

Erectile dysfunction in patients taking psychotropic drugs and treated with phosphodiesterase-5 inhibitors by Rossella Mazzilli, Gloria Angeletti, Soraya Olana, Michele Delfino, Virginia Zamponi, Chiara Rapinesi, Antonio Del Casale, Georgios D. Kotzalidis, Jlenia Elia, Gemma Callovini, Paolo Girardi, Fernando Mazzilli

Subjects: Get full text

Human Tyrosyl-DNA Phosphodiesterase 1 Possesses Transphosphooligonucleotidation Activity With Primary Alcohols by Nadezhda Dyrkheeva, Rashid Anarbaev, Rashid Anarbaev, Natalia Lebedeva, Maxim Kuprushkin, Alexandra Kuznetsova, Nikita Kuznetsov, Nadejda Rechkunova, Olga Lavrik, Olga Lavrik

Subjects: “…tyrosyl-DNA phosphodiesterase 1…”
Get full text

A Non-Systemic Phosphodiesterase-5 Inhibitor Suppresses Colon Proliferation in Mice by Avelina Lee, Iryna Lebedyeva, Wenbo Zhi, Vani Senthil, Herjot Cheema, Michael W. Brands, Weston Bush, Nevin A. Lambert, Madeline Snipes, Darren D. Browning

Subjects: “…phosphodiesterase inhibitor…”
Get full text

Cardiorenal Effects of Long‐Term Phosphodiesterase V Inhibition in Pre–Heart Failure by Scott A. Hubers, Siu‐Hin Wan, Fadi W. Adel, Sherry L. Benike, John C. Burnett, Christopher Scott, Horng H. Chen

Subjects: Get full text

Impaired cAMP processivity by phosphodiesterase-protein kinase A complexes in acrodysostosis by Varun Venkatakrishnan, Abhijeet Ghode, Nikhil K. Tulsian, Ganesh S. Anand, Ganesh S. Anand

Subjects: Get full text

Phosphodiesterase Type 5 Inhibitors and Visual Side Effects: A Narrative Review by Francisco Barroso, João Crispim Ribeiro, Eduardo P. Miranda

“…Phosphodiesterase type 5 inhibitors such as sildenafil citrate and tadalafil are well known for the treatment of erectile dysfunction. …”
Get full text

Distinct patterns of constitutive phosphodiesterase activity in mouse sinoatrial node and atrial myocardium. by Rui Hua, Andrew Adamczyk, Courtney Robbins, Gibanananda Ray, Robert A Rose

“…Phosphodiesterases (PDEs) are critical regulators of cyclic nucleotides in the heart. …”
Get full text

Once upon a Testis: The Tale of Cyclic Nucleotide Phosphodiesterase in Testicular Cancers by Federica Campolo, Maria Rita Assenza, Mary Anna Venneri, Federica Barbagallo

Subjects: “…phosphodiesterases (PDEs)…”
Get full text

Characterization of magnesium requirement of human 5'-tyrosyl DNA phosphodiesterase mediated reaction by Adhikari Sanjay, Karmahapatra Soumendra K, Karve Tejaswita M, Bandyopadhyay Sanjona, Woodrick Jordan, Manthena Praveen V, Glasgow Eric, Byers Stephen, Saha Tapas, Uren Aykut

“…<p>Abstract</p> <p>Background</p> <p>Topo-poisons can produce an enzyme-DNA complex linked by a 3'- or 5'-phosphotyrosyl covalent bond. 3'-phosphotyrosyl bonds can be repaired by tyrosyl DNA phosphodiesterase-1 (TDP1), an enzyme known for years, but a complementary human enzyme 5'-tyrosyl DNA phosphodiesterase (hTDP2) that cleaves 5'-phosphotyrosyl bonds has been reported only recently. …”
Get full text

Use of Phosphodiesterase Inhibitors in the Postoperative Period of Skin Flaps: A Systematic Review by Oona Tomiê Daronch, MD, Renata Fernanda Ramos Marcante, MD, Aristides Augusto Palhares Neto, PhD, Fausto Viterbo, PhD

“…It was observed that phosphodiesterase inhibitors, mainly types III and V, have shown promising results in terms of vascularization of the postoperative skin flap, especially when started on the first postoperative day and maintained for 7 days. …”
Get full text

The phosphodiesterase 4 inhibitor AA6216 suppresses activity of fibrosis-specific macrophages by Takashi Matsuhira, Osamu Nishiyama, Yuji Tabata, Shinji Kurashimo, Hiroyuki Sano, Takashi Iwanaga, Yuji Tohda

Subjects: Get full text

A cAMP phosphodiesterase is essential for sclerotia formation and virulence in Sclerotinia sclerotiorum by Yan Xu, Yan Xu, Yilan Qiu, Yuelin Zhang, Xin Li, Xin Li

Subjects: Get full text

Novel insights in phosphodiesterase 4 subtype inhibition to target neuroinflammation and stimulate remyelination by Melissa Schepers, Tim Vanmierlo

Get full text

Surface Binding Energy Landscapes Affect Phosphodiesterase Isoform-Specific Inhibitor Selectivity by Qing Liu, Andreas Herrmann, Qiang Huang

“…As human phosphodiesterase (PDE) proteins are attractive drug targets, a large number of selective PDE inhibitors have been developed. …”
Get full text

Phosphodiesterase 2 Inhibitors Promote Axonal Outgrowth in Organotypic Slice Co-Cultures by C. Heine, K. Sygnecka, N. Scherf, A. Berndt, U. Egerland, T. Hage, H. Franke

Subjects: Get full text