Phosphodiesterase 4 cAMP phosphodiesterases as targets for novel anti-inflammatory therapeutics by Simon J MacKenzie

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Alterations of Phosphodiesterases in Adrenocortical Tumors by Fady Hannah-Shmouni, Fabio Faucz, Constantine A. Stratakis

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Phosphodiesterase-4 Inhibition in Psoriasis by Milakovic M, Gooderham MJ

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Effect of phosphodiesterase inhibitors in the bladder by Bilal Chughtai, Aizaz Ali, Claire Dunphy, Steven A. Kaplan

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Phosphodiesterase Inhibitors: Present and Future by José L. Izquierdo-Alonso

“…Phosphodiesterase (PDE) inhibitors act on specific phosphodiesterase enzymes (fundamentally 3, 4 and 5), which are characterized by their expression in different organs. …”
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Two phosphodiesterases from Ustilago maydis share structural and biochemical properties with non-fungal phosphodiesterases by Charu eAgarwal, David J Schultz, Michael H Perlin

Subjects: “…cAMP phosphodiesterase…”
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An alkaloid initiates phosphodiesterase 3A–schlafen 12 dependent apoptosis without affecting the phosphodiesterase activity by Youwei Ai, Haibing He, Peihao Chen, Bo Yan, Wenbin Zhang, Zhangcheng Ding, Dianrong Li, Jie Chen, Yan Ma, Yang Cao, Jie Zhu, Jiaojiao Li, Jinjie Ou, Shan Du, Xiaodong Wang, Jianzhang Ma, Shuanhu Gao, Xiangbing Qi

“…PDE3A modulators for cancer therapy cause serious side effects as they inhibit PDE3A phosphodiesterase activity, which is essential for the maturation of oocytes and the formation of platelets. …”
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In Search of Monocot Phosphodiesterases: Identification of a Calmodulin Stimulated Phosphodiesterase from <i>Brachypodium distachyon</i> by Mateusz Kwiatkowski, Aloysius Wong, Anna Kozakiewicz-Piekarz, Christoph Gehring, Krzysztof Jaworski

Subjects: “…phosphodiesterase (PDE)…”
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Cyclic nucleotide phosphodiesterases in health and disease / by Beavo, Joe, Francis, Sharron H., Houslay, Miles D.

Subjects: “…Cyclic nucleotide phosphodiesterases…”

Phosphodiesterase-4 Inhibition in the Management of Psoriasis by Erika L. Crowley, Melinda J. Gooderham

“…Among the treatments for psoriasis, phosphodiesterase-4 (PDE4) inhibitors are emerging with expanding options. …”
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Phosphodiesterase inhibitors as adjunctive therapies for tuberculosis by Bintou Ahmadou Ahidjo, William R. Bishai

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Repurposing Phosphodiesterase-5 inhibitors as chemoadjuvants by Amit K. Tiwari, Zhe-Sheng eChen

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Is zucchini a phosphodiesterase or a ribonuclease? by Osamu Nureki

“…However, it has been ambiguous whether Zuc acts as a phosphodiesterase to produce phosphatidic acid (PA), the lipid signaling molecule, or as a nuclease. …”
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The use of phosphodiesterase inhibitors for the treatment of alopecia by Margit L. W. Juhász, Natasha Atanaskova Mesinkovska

Subjects: “…phosphodiesterase inhibitors…”
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Clinical Implication of Phosphodiesterase-4-Inhibition by Martin Alexander Schick, Nicolas Schlegel

Subjects: “…phosphodiesterase…”
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Role of Phosphodiesterase in the Biology and Pathology of Diabetes by Agnieszka Kilanowska, Agnieszka Ziółkowska

Subjects: “…phosphodiesterases…”
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New Avenues for Phosphodiesterase Inhibitors in Asthma by Matera MG, Ora J, Cavalli F, Rogliani P, Cazzola M

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Evaluation of the Therapeutic Index of a Novel Phosphodiesterase 4B– Selective Inhibitor Over Phosphodiesterase 4D in Mice by Osamu Suzuki, Kiyoshi Mizukami, Maki Etori, Yoshitaka Sogawa, Nana Takagi, Hiroshi Tsuchida, Kiyoshi Morimoto, Taiji Goto, Toshiharu Yoshino, Tsuyoshi Mikkaichi, Kazuki Hirahara, Satoshi Nakamura, Hiroaki Maeda

“…Phosphodiesterase 4 (PDE4) inhibitors have been developed for the treatment of pulmonary inflammatory diseases, but their clinical use was dose-limited by mainly gastric adverse effects. …”
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New Deoxycholic Acid Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitors Also Inhibit Tyrosyl-DNA Phosphodiesterase 2 by Oksana V. Salomatina, Nadezhda S. Dyrkheeva, Irina I. Popadyuk, Alexandra L. Zakharenko, Ekaterina S. Ilina, Nina I. Komarova, Jóhannes Reynisson, Nariman F. Salakhutdinov, Olga I. Lavrik, Konstantin P. Volcho

“…A series of deoxycholic acid (DCA) amides containing benzyl ether groups on the steroid core were tested against the tyrosyl-DNA phosphodiesterase 1 (TDP1) and 2 (TDP2) enzymes. In addition, 1,2,4- and 1,3,4-oxadiazole derivatives were synthesized to study the linker influence between a <i>para</i>-bromophenyl moiety and the steroid scaffold. …”
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Cyclic nucleotide specific phosphodiesterases of <it>Leishmania major</it> by Linder Markus, Kunz Stefan, Johner Andrea, Shakur Yasmin, Seebeck Thomas

“…In an attempt to better understand the role of cyclic nucleotide signalling in <it>Leishmania </it>differentiation and host-parasite interaction, we here present an initial study on the cyclic nucleotide-specific phosphodiesterases of <it>Leishmania major</it>.</p> <p>Results</p> <p>This paper presents the identification of three class I cyclic-nucleotide-specific phosphodiesterases (PDEs) from <it>L. major</it>, PDEs whose catalytic domains exhibit considerable sequence conservation with, among other, all eleven human PDE families. …”
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