Phosphodiesterase 4 cAMP phosphodiesterases as targets for novel anti-inflammatory therapeutics by Simon J MacKenzie

Subjects: Get full text

Alterations of Phosphodiesterases in Adrenocortical Tumors by Fady Hannah-Shmouni, Fabio Faucz, Constantine A. Stratakis

Subjects: Get full text

Phosphodiesterase-4 Inhibition in Psoriasis by Milakovic M, Gooderham MJ

Subjects: Get full text

Effect of phosphodiesterase inhibitors in the bladder by Bilal Chughtai, Aizaz Ali, Claire Dunphy, Steven A. Kaplan

Subjects: Get full text

Phosphodiesterase Inhibitors: Present and Future by José L. Izquierdo-Alonso

“…Phosphodiesterase (PDE) inhibitors act on specific phosphodiesterase enzymes (fundamentally 3, 4 and 5), which are characterized by their expression in different organs. …”
Get full text

Two phosphodiesterases from Ustilago maydis share structural and biochemical properties with non-fungal phosphodiesterases by Charu eAgarwal, David J Schultz, Michael H Perlin

Subjects: “…cAMP phosphodiesterase…”
Get full text

An alkaloid initiates phosphodiesterase 3A–schlafen 12 dependent apoptosis without affecting the phosphodiesterase activity by Youwei Ai, Haibing He, Peihao Chen, Bo Yan, Wenbin Zhang, Zhangcheng Ding, Dianrong Li, Jie Chen, Yan Ma, Yang Cao, Jie Zhu, Jiaojiao Li, Jinjie Ou, Shan Du, Xiaodong Wang, Jianzhang Ma, Shuanhu Gao, Xiangbing Qi

“…PDE3A modulators for cancer therapy cause serious side effects as they inhibit PDE3A phosphodiesterase activity, which is essential for the maturation of oocytes and the formation of platelets. …”
Get full text

Cyclic nucleotide phosphodiesterases in health and disease / by Beavo, Joe, Francis, Sharron H., Houslay, Miles D.

Subjects: “…Cyclic nucleotide phosphodiesterases…”

Phosphodiesterase-4 Inhibition in the Management of Psoriasis by Erika L. Crowley, Melinda J. Gooderham

“…Among the treatments for psoriasis, phosphodiesterase-4 (PDE4) inhibitors are emerging with expanding options. …”
Get full text

Phosphodiesterase inhibitors as adjunctive therapies for tuberculosis by Bintou Ahmadou Ahidjo, William R. Bishai

Get full text

Phosphodiesterase-5 inhibitors: Raynaud's and beyond by Sanat Phatak, Sajal Ajmani, Vikas Agarwal, Durga Prasanna Misra

Subjects: Get full text

Is zucchini a phosphodiesterase or a ribonuclease? by Osamu Nureki

“…However, it has been ambiguous whether Zuc acts as a phosphodiesterase to produce phosphatidic acid (PA), the lipid signaling molecule, or as a nuclease. …”
Get full text

New Avenues for Phosphodiesterase Inhibitors in Asthma by Matera MG, Ora J, Cavalli F, Rogliani P, Cazzola M

Subjects: Get full text

Evaluation of the Therapeutic Index of a Novel Phosphodiesterase 4B– Selective Inhibitor Over Phosphodiesterase 4D in Mice by Osamu Suzuki, Kiyoshi Mizukami, Maki Etori, Yoshitaka Sogawa, Nana Takagi, Hiroshi Tsuchida, Kiyoshi Morimoto, Taiji Goto, Toshiharu Yoshino, Tsuyoshi Mikkaichi, Kazuki Hirahara, Satoshi Nakamura, Hiroaki Maeda

“…Phosphodiesterase 4 (PDE4) inhibitors have been developed for the treatment of pulmonary inflammatory diseases, but their clinical use was dose-limited by mainly gastric adverse effects. …”
Get full text

New Deoxycholic Acid Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitors Also Inhibit Tyrosyl-DNA Phosphodiesterase 2 by Oksana V. Salomatina, Nadezhda S. Dyrkheeva, Irina I. Popadyuk, Alexandra L. Zakharenko, Ekaterina S. Ilina, Nina I. Komarova, Jóhannes Reynisson, Nariman F. Salakhutdinov, Olga I. Lavrik, Konstantin P. Volcho

“…A series of deoxycholic acid (DCA) amides containing benzyl ether groups on the steroid core were tested against the tyrosyl-DNA phosphodiesterase 1 (TDP1) and 2 (TDP2) enzymes. In addition, 1,2,4- and 1,3,4-oxadiazole derivatives were synthesized to study the linker influence between a <i>para</i>-bromophenyl moiety and the steroid scaffold. …”
Get full text

Cyclic nucleotide specific phosphodiesterases of <it>Leishmania major</it> by Linder Markus, Kunz Stefan, Johner Andrea, Shakur Yasmin, Seebeck Thomas

“…In an attempt to better understand the role of cyclic nucleotide signalling in <it>Leishmania </it>differentiation and host-parasite interaction, we here present an initial study on the cyclic nucleotide-specific phosphodiesterases of <it>Leishmania major</it>.</p> <p>Results</p> <p>This paper presents the identification of three class I cyclic-nucleotide-specific phosphodiesterases (PDEs) from <it>L. major</it>, PDEs whose catalytic domains exhibit considerable sequence conservation with, among other, all eleven human PDE families. …”
Get full text

Phosphodiesterase-4 Inhibitors for the Treatment of Inflammatory Diseases by Heng Li, Heng Li, Jianping Zuo, Jianping Zuo, Wei Tang, Wei Tang, Wei Tang

Subjects: “…phosphodiesterase-4…”
Get full text

Role of phosphodiesterase in glucagon resistance of large adipocytes by Richard A. De Santis, Tessa Gorenstein, James N. Livingston, Dean H. Lockwood

“…The role of phosphodiesterase in glucagon resistance of large adipocytes was investigated. …”
Get full text

Phosphodiesterases and cAMP Pathway in Pituitary Diseases by Mariana Ferreira Bizzi, Graeme B. Bolger, Graeme B. Bolger, Márta Korbonits, Antonio Ribeiro-Oliveira Jr.

Subjects: “…phosphodiesterases…”
Get full text

Research progress of phosphodiesterase 5 in heart failure by YANG Yang, ZHANG Yarong, YANG Hongqin, WANG Jing, ZHAO Hongmei

Subjects: “…heart failure|phosphodiesterase 5|phosphodiesterase inhibitor|cyclic guanosine monophosphate…”
Get full text