Application of Toxoplasma gondii-specific SAG1, GRA7 and BAG1 proteins in serodiagnosis of animal toxoplasmosis by Tongsheng Qi, Tongsheng Qi, Jingkai Ai, Jingkai Ai, Yali Sun, Yali Sun, Yali Sun, Hejia Ma, Hejia Ma, Ming Kang, Ming Kang, Xiaoqian You, Jixu Li, Jixu Li, Jixu Li

“…The TgSAG1, TgGRA7, and TgBAG1 proteins were used in the present study to develop the serological rSAG1-ELISA, rGRA7-ELISA and rBAG1-ELISA methods for the testing of T. gondii specific IgG and IgM antibodies and differentiating acute or chronic toxoplasmosis in 3733 animals, including Tibetan sheep, yaks, pigs, cows, cattle, horses, chickens, camels and donkeys from the Qinghai-Tibetan Plateau. …”
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Amitriptyline inhibits bronchoconstriction and directly promotes dilatation of the airways by Paulina Hempel, Virag Klein, Anna Michely, Svenja Böll, Annette D. Rieg, Jan Spillner, Till Braunschweig, Saskia von Stillfried, Norbert Wagner, Christian Martin, Klaus Tenbrock, Eva Verjans

“…Methods After stimulation of precision cut lung slices (PCLS) from mice (wildtype and ASM-knockout), rats, guinea pigs and human lungs with mediators of bronchoconstriction (endogenous and exogenous acetylcholine, methacholine, serotonin, endothelin, histamine, thromboxane-receptor agonist U46619 and leukotriene LTD4, airway area was monitored in the absence of or with rising concentrations of amitriptyline. …”
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Antibiotic-Resistant Arcobacter spp. in commercial and smallholder farm animals in Asante Akim North Municipality, Ghana and Korogwe Town Council, Tanzania: a cross-sectional study by Ellis Kobina Paintsil, Linda Aurelia Ofori, Charity Wiafe Akenten, Andreas E. Zautner, Joyce Mbwana, Neyaz Ahmed Khan, John P. A. Lusingu, Joseph Kaseka, Daniel T. R. Minja, Samwel Gesase, Anna Jaeger, Maike Lamshöft, Jürgen May, Kwasi Obiri-Danso, Ralf Krumkamp, Denise Dekker

“…For commercial farms, in Ghana, the presence of Arcobacter was more abundant in pigs (45.1%, n/N = 37/82), followed by ducks (38.5%, n/N = 10/26) and quails (35.7%, n/N = 10/28). …”
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Immune Molecules’ mRNA Expression in Porcine Alveolar Macrophages Co-Infected with Porcine Reproductive and Respiratory Syndrome Virus and Porcine Circovirus Type 2 by Zhiying Cui, Likun Zhou, Xingxing Hu, Shijie Zhao, Pengli Xu, Wen Li, Jing Chen, Yina Zhang, Pingan Xia

“…Porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus 2 (PCV2) are economically important pathogens in swine, and pigs with dual infections of PCV2 and PRRSV consistently have more severe clinical symptoms and interstitial pneumonia. …”
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Effects of Occult Hypoperfusion on Local Circulation and Inflammation - An Analysis in a Standardized Polytrauma Model by Sascha Halvachizadeh, Sascha Halvachizadeh, Yannik Kalbas, Yannik Kalbas, Michel Paul Johan Teuben, Henrik Teuber, Nikola Cesarovic, Miriam Weisskopf, Paolo Cinelli, Paolo Cinelli, Hans-Christoph Pape, Hans-Christoph Pape, Roman Pfeifer, Roman Pfeifer

“…The aim of this study was to analyze the association of occult hypoperfusion with local circulation and inflammation of injured soft tissue in a porcine polytrauma model.MethodsThis experimental study was performed with male landrace pigs who suffered a standardized polytrauma, including a femoral fracture, blunt chest trauma, liver laceration and a mean arterial pressure (MAP) controlled hemorrhagic shock. …”
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Molecular characterization of Glaesserella parasuis strains circulating in North American swine production systems by Robert Mugabi, Ana Paula S. Poeta Silva, Xiao Hu, Marcelo Gottschalk, Virginia Aragon, Nubia R. Macedo, Orhan Sahin, Perry Harms, Rodger Main, Alexander W. Tucker, Ganwu Li, Maria J. Clavijo

“…Abstract Background Glaesserella parasuis is the causative agent of Glässer’s disease in pigs. Serotyping is the most common method used to type G. parasuis isolates. …”
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Replication of Porcine Astrovirus Type 1-Infected PK-15 Cells In Vitro Affected by RIG-I and MDA5 Signaling Pathways by Qinting Dong, Xinyue Zhu, Leping Wang, Wenchao Zhang, Lifei Lu, Jun Li, Shuhong Zhong, Chunxia Ma, Kang Ouyang, Ying Chen, Zuzhang Wei, Yifeng Qin, Hao Peng, Weijian Huang

“…Porcine astroviruses produce mainly gastroenteritis and neurological diseases in pigs. However, astrovirus-host interactions are less well studied, particularly with respect to their antagonism of IFN. …”
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Chemical characteristics and anti-Escherichia coli mechanism of water-soluble extracts from yeast cell walls by Yana Liu, Baojing Dou, Fayuan Gong, Junpeng Hu, Meifang Zhou, Yuanhu Pan, Xiangyun Wu, Xin Huang, Zhiwen Xie, Haihong Hao, Guyue Cheng, Zhenli Liu, Yulian Wang

“…Infection with Escherichia coli (E. coli) is the most common cause of diarrhea in pigs, especially in weaning piglets. The objective of this study was to characterize chemical properties of water-soluble extract (WSE) obtained from yeast cell wall, and study its antibacterial activity and antimicrobial mechanisms against E. coli. …”
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Overview of Ecology and Aspects of Antibiotic Resistance in <i>Campylobacter</i> spp. Isolated from Free-Grazing Chicken Tissues in Rural Households by Argyrios Dermatas, Georgios Rozos, Konstantinos Zaralis, Aikaterini Dadamogia, Konstantina Fotou, Eugenia Bezirtzoglou, Konstantoula Akrida-Demertzi, Panagiotis Demertzis, Chrysoula (Chrysa) Voidarou

“…From the four ecological parameters studied (size of the flock, presence of small ruminants in the same household, presence of other poultry species in the same household, and feeding leftovers of the household), the size of the flock and the presence of small ruminants and/or pigs in the same household mostly affected the distribution of these strains. …”
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Survey of Zoonotic Diarrheagenic Protist and Hepatitis E Virus in Wild Boar (<i>Sus scrofa</i>) of Portugal by Sérgio Santos-Silva, Danny Franciele da Silva Dias Moraes, Pedro López-López, Josman D. Palmeira, Rita T. Torres, Maria São José Nascimento, Alejandro Dashti, David Carmena, Antonio Rivero-Juarez, João R. Mesquita

“…Hepatitis E virus (HEV) has also been reported both in domestic pigs and wild boar and is known to have an important public health significance. …”
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Extending heart preservation to 24 h with normothermic perfusion by Brianna L. Spencer, Spencer K. Wilhelm, Christopher Stephan, Kristopher A. Urrea, Daniela Pelaez Palacio, Robert H. Bartlett, Daniel H. Drake, Daniel H. Drake, Alvaro Rojas-Pena, Alvaro Rojas-Pena

“…Porcine hearts (n = 42) of different sizes (6–55 kg) were divided into five groups and studied during 24 h NEHP with various interventions in three piglets (small-size) heart groups: (1) Control NEHP without interventions (n = 15); (2) NEHP + plasma exchange (n = 5); (3) NEHP + hemofiltration (n = 10) and two adult-size (juvenile pigs) heart groups (to demonstrate the support of larger hearts); (4) NEHP + hemofiltration (n = 5); and (5) NEHP with intermittent left atrial (iLA) perfusion (n = 7). …”
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Human-umbilical cord matrix mesenchymal cells improved left ventricular contractility independently of infarct size in swine myocardial infarction with reperfusion by Luís Raposo, Luís Raposo, Luís Raposo, Rui J. Cerqueira, Rui J. Cerqueira, Sara Leite, Sara Leite, Sara Leite, Liliana Moreira-Costa, Tiago L. Laundos, Tiago L. Laundos, Tiago L. Laundos, Joana O. Miranda, Pedro Mendes-Ferreira, Pedro Mendes-Ferreira, João Almeida Coelho, Rita N. Gomes, Rita N. Gomes, Rita N. Gomes, Perpétua Pinto-do-Ó, Perpétua Pinto-do-Ó, Perpétua Pinto-do-Ó, Diana S. Nascimento, Diana S. Nascimento, Diana S. Nascimento, André P. Lourenço, André P. Lourenço, Nuno Cardim, Nuno Cardim, Adelino Leite-Moreira, Adelino Leite-Moreira

“…We investigated the efficacy of intracoronary (IC) delivery of xenogeneic hUCM-MSC as reperfusion-adjuvant therapy in a translational model of AMI in swine.MethodsIn a placebo-controlled trial, pot-belied pigs were randomly assigned to a sham-control group (vehicle-injection; n = 8), AMI + vehicle (n = 12) or AMI + IC-injection (n = 11) of 5 × 105 hUCM-MSC/Kg, within 30 min of reperfusion. …”
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Characterization of the monoclonal antibody and the immunodominant B-cell epitope of African swine fever virus pA104R by using mouse model by Qichao Chen, Lixinjie Liu, Shibang Guo, Liang Li, Yifeng Yu, Zhankui Liu, Chen Tan, Huanchun Chen, Xiangru Wang

“…Characterizing the immunodominant B-cell epitope of the ASFV critical proteins, such as pA104R, may contribute to developing sensitive diagnostic tools and vaccine candidate targets.IMPORTANCEAfrican swine fever (ASF) is a highly pathogenic, lethal, and contagious viral disease affecting domestic pigs and wild boars. As no effective vaccine or other treatments have been developed, the control of African swine fever virus (ASFV) relies heavily on virus detection and diagnosis. …”
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Autoregulation of Cerebral Blood Flow During 3-h Continuous Cardiopulmonary Resuscitation at 27°C by Sergei Valkov, Jan Harald Nilsen, Jan Harald Nilsen, Jan Harald Nilsen, Rizwan Mohyuddin, Torstein Schanche, Torstein Schanche, Timofei Kondratiev, Gary C. Sieck, Torkjel Tveita, Torkjel Tveita, Torkjel Tveita

“…The efficacy of cerebral autoregulation during hypothermic CPR is largely unknown and is aim of the present experiment.Methods: Anesthetized pigs (n = 8) were surface cooled to HCA at 27°C before 3 h continuous CPR. …”
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GRP94 Inhabits the Immortalized Porcine Hepatic Stellate Cells Apoptosis under Endoplasmic Reticulum Stress through Modulating the Expression of IGF-1 and Ubiquitin by Xiaohong Wang, Hairui Xin, Chuang Zhang, Xianhong Gu, Yue Hao

“…So far, all the studies on GRP94 have been conducted in mice or rats, and little study has been reported on pigs, which share more similarities with humans. …”
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Dietary supplementation with 0.4% L-arginine between days 14 and 30 of gestation enhances NO and polyamine syntheses and water transport in porcine placentae by Cassandra M. Herring, Fuller W. Bazer, Gregory A. Johnson, Heewon Seo, Shengdi Hu, Mohammed Elmetwally, Wenliang He, Daniel B. Long, Guoyao Wu

“…Abstract Background Most embryonic loss in pigs occurs before d 30 of gestation. Dietary supplementation with L-arginine (Arg) during early gestation can enhance the survival and development of conceptuses (embryo/fetus and its extra-embryonic membranes) in gilts. …”
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Measurement of Electrical Impedance Tomography-Based Regional Ventilation Delay for Individualized Titration of End-Expiratory Pressure by Thomas Muders, Benjamin Hentze, Stefan Kreyer, Karin Henriette Wodack, Steffen Leonhardt, Göran Hedenstierna, Hermann Wrigge, Christian Putensen

“…Methods: Decremental PEEP trials were performed in 15 lung-injured pigs. The PEEP level that minimized tidal recruitment was estimated from EIT-based RVDI measurement during slow inflations of 12, 9, 7.5, or 6 mL/kg BW. …”
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Effects of a water-soluble formulation of tylvalosin on disease caused by porcine reproductive and respiratory syndrome virus alone in sows or in combination with Mycoplasma hyopne... by Alfonso Lopez Rodriguez, Veronica L. Fowler, Michael Huether, David Reddick, Christine Tait-Burkard, Marie O’Shea, Stephanie Perkins, Nirosh Dias, Robin Buterbaugh, Hafid A. Benchaoui

“…In the lungs, tylvalosin reduced IL-8, IL-10 and IL-12 compared to untreated pigs (P < 0.001) and tended to reduce TNFα (P = 0.082). …”
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Caracterización biológica de tres aislamientos naturales del Rubulavirus porcino (México) by María del Tránsito Borraz-Argüello, Gerardo Santos-López, Verónica Vallejo-Ruiz, Irma Herrera-Camacho, Julio Reyes-Leyva

“…Porcine rubulavirus (PoRV) produces a neurological and reproductive syndrome in pigs called the blue-eye disease, known only from Mexico. …”
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Role of the Two-Component System CiaRH in the Regulation of Efflux Pump SatAB and Its Correlation with Fluoroquinolone Susceptibility by Xia Yang, Wei Peng, Ningning Wang, Beibei Dou, Fengming Yang, Huanchun Chen, Fangyan Yuan, Weicheng Bei

“…ABSTRACT Streptococcus suis is an important pathogen in both pigs and humans. Although the diseases associated with S. suis can typically be treated with antibiotics, such use has resulted in a sustained increase in drug resistance. …”
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