Preclinical characterization of ISB 1342, a CD38 × CD3 T-cell engager for relapsed/refractory multiple myeloma by Pouleau, B, Estoppey, C, Suere, P, Nallet, E, Laurendon, A, Monney, T, Pais Ferreira, D, Drake, A, Carretero-Iglesia, L, Macoin, J, Berret, J, Pihlgren, M, Doucey, M-A, Gudi, GS, Menon, V, Udupa, V, Maiti, A, Borthakur, G, Srivastava, A, Blein, S, Mbow, ML, Matthes, T, Kaya, Z, Edwards, C, Edwards, JR, Menoret, E, Kervoëlen, C, Pellat-Deceunynck, C, Moreau, P, Zhukovsky, E, Perro, M, Chimen, M

“…ISB 1342 is a bispecific antibody with a high-affinity Fab binding to CD38 on tumor cells on a different epitope than daratumumab and a detuned scFv domain affinity binding to CD3ε on T cells, to mitigate the risk of life-threatening cytokine release syndrome, using the Bispecific Engagement by Antibodies based on the TCR (BEAT) platform. In vitro, ISB 1342 efficiently killed cell lines with different levels of CD38, including those with a lower sensitivity to daratumumab. …”

Resolving plasmid structures in Enterobacteriaceae using the MinION nanopore sequencer: assessment of MinION and MinION/Illumina hybrid data assembly approaches by George, S, Pankhurst, L, Hubbard, A, Votintseva, A, Stoesser, N, Sheppard, A, Mathers, A, Norris, R, Navickaite, I, Eaton, C, Iqbal, Z, Crook, D, Phan, H

“…Isolates were sequenced using Illumina (short-read) and ONT’s MinION (long-read) platforms, and compared with fully resolved PacBio (long-read) sequence assemblies for the same isolates. …”

Expert review on global real-world vaccine effectiveness against SARS-CoV-2 by Chuenkitmongkol, S, Solante, R, Burhan, E, Chariyalertsak, S, Chiu, N-C, Do-Van, D, Husin, M, Hwang, K-P, Kiertiburanakul, S, Kulkarni, PS, Lee, P-I, Lobo, RC, Nghia, CH, Ong-Lim, A, Sivasampu, S, Suah, JL, Tok, PSK, Thwaites, G

“…<br><strong> Areas covered<br></strong> We reviewed 79 studies in the International Vaccine Access Center (IVAC) VIEW-hub platform on vaccine effectiveness (VE) after primary immunizations with two-dose schedules. …”

Conducting public involvement in dementia research: the contribution of the European Working Group of People with Dementia to the ROADMAP project by Diaz, A, Gove, D, Nelson, M, Smith, M, Tochel, C, Bintener, C, Ly, A, Bexelius, C, Gustavsson, A, Georges, J, Gallacher, J, Sudlow, C

“…<br><strong> Objective<br></strong> One of the goals of the ‘Real world Outcomes across the Alzheimer's Disease spectrum for better care: Multi‐modal data Access Platform’ (ROADMAP) project was to identify important outcomes from the perspective of people with dementia and their caregivers. …”

Retrievals of atmospheric variables on the gas giants from ground-based mid-infrared imaging by Fletcher, L, Orton, G, Yanamandra-Fisher, P, Fisher, B, Parrish, P, Irwin, P

“…This paper demonstrates that mid-IR imaging instruments operating at ground-based observatories have access to several dynamical and chemical diagnostics of the atmospheric state of the gas giants, offering the prospect for quantitative studies over much longer baselines and often covering much wider areas than is possible from spaceborne platforms. © 2008 Elsevier Inc.…”

Regulation of arousal and performance of a healthy non-human primate using closed-loop central thalamic deep brain stimulation by Baker, JL, Toth, R, Deli, A, Zamora, M, Fleming, JE, Benjaber, M, Goerzen, D, Ryou, J-W, Purpura, KP, Schiff, ND, Denison, T

“…The initial computer based approach was then experimentally validated using a customized clinicalgrade DBS device, the DyNeuMo-X, a bi-directional research platform used for rapidly testing closed-loop DBS. …”

TrueColours: real time data collection in patients with ulcerative colitis by Walsh, A

“…<p>This thesis details the adaptation and evaluation of an e-health software platform known as TrueColours (originally developed by the Oxford Department of Psychiatry for treating bipolar disorder) for use in ulcerative colitis (UC). …”

BIGSdb: Scalable analysis of bacterial genome variation at the population level by Jolley, K, Maiden, M

“… <p style="text-align:justify;"> <b>Background:</b> The opportunities for bacterial population genomics that are being realised by the application of parallel nucleotide sequencing require novel bioinformatics platforms. These must be capable of the storage, retrieval, and analysis of linked phenotypic and genotypic information in an accessible, scalable and computationally efficient manner.…”

Prevalence of sustainable and unsustainable use of wild species inferred from the IUCN Red List of Threatened Species by Marsh, SME, Hoffmann, M, Burgess, ND, Brooks, TM, Challender, DWS, Cremona, PJ, Hilton-Taylor, C, de Micheaux, FL, Lichtenstein, G, Roe, D, Böhm, M

“…Our findings on the prevalence of sustainable and unsustainable use, and variation across taxa, can inform international policy making, including the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services, the Convention on Biological Diversity, and the Convention on International Trade in Endangered Species.…”

A high-throughput pharmaceutical screen identifies compounds with specific toxicity against BRCA2-deficient tumors. by Evers, B, Schut, E, van der Burg, E, Braumuller, T, Egan, D, Holstege, H, Edser, P, Adams, D, Wade-Martins, R, Bouwman, P, Jonkers, J

“…CONCLUSIONS: We generated and validated a platform for identification of compounds with specific activity against BRCA2-deficient cells that translates well to the preclinical setting. …”

Comparative environmental and human health evaluations of thermolysis and solvolysis recycling technologies of carbon fiber reinforced polymer waste by Khalil, Y

“…Two Gate-to-Gate recycling models are developed using GaBi LCA platform. The selected functional unit (FU) is 1 kg CFRP waste and the geographical boundary of this comparative LCIA is defined to be within the U.S. …”

Novel protein editing technologies to probe cellular damage by Poh, AWJ

“…In Chapter 4, we demonstrate, to the best of our knowledge, the first real-time, dynamic tracking of neurofilament light chain (NfL) – an intrinsically disordered and aggregation-prone protein that is a putative blood-based marker for neurodegeneration – in the circulatory system of a living organism. This platform therefore now sets the stage for the unambiguous mapping of the behaviour of NfL (and its radio-metabolites) without perturbing the native assembly of this structurally dynamic protein.…”

Being white by Draper, J

“…I discuss the development of platforms that have contributed to the shifting of such classificatory trends without dissolving them completely, namely the first and second Johannesburg Biennales, <em>Africus</em> (1995) and <em>Trade Routes</em> (1997). …”

Integrating imaging and omics with machine learning approaches to infer antimicrobial susceptibility in gram-negative bacteria by Tran, TA

“…Alternatively, I utilised a high-content imaging platform to observe the cytological adaptation of Salmonella enterica serovar Typhimurium upon 24-hour of ciprofloxacin i exposure. …”

The acute management of trauma hemorrhage: a systematic review of randomized controlled trials. by Curry, N, Hopewell, S, Dorée, C, Hyde, C, Brohi, K, Stanworth, S

“…METHODS: Comprehensive searches were performed of MEDLINE, EMBASE, CENTRAL (The Cochrane Library Issue 7, 2010), Current Controlled Trials, ClinicalTrials.gov, the World Health Organization International Clinical Trials Registry Platform (ICTRP) and the National Health Service Blood and Transplant Systematic Review Initiative (NHSBT SRI) RCT Handsearch Database. …”

Prostate biopsy techniques and pre-biopsy prophylactic measures: variation in current practice patterns in the Netherlands by Tops, SCM, Koldewijn, EL, Somford, DM, Huis, AMP, Kolwijck, E, Wertheim, HFL, Hulscher, MEJL, Sedelaar, JPM

“…Methods An online questionnaire was prepared using SurveyMonkey® platform and distributed to all 420 members of the Dutch Association of Urology, who work in 81 Dutch hospitals. …”

Recombinant BCG expressing HTI prime and recombinant ChAdOx1 boost is safe and elicits HIV-1-specific T-cell responses in BALB/c mice by Kilpeläinen, A, Saubi, N, Guitart, N, Olvera, A, Hanke, T, Brander, C, Joseph, J

“…This vaccine candidate may be a useful tool in the development of an effective vaccine platform for priming protective responses against HIV-1/TB and other prevalent pediatric pathogens</p> …”

A humanized mouse model of HPV-associated pathology driven by E7 expression by Buitrago-Pérez, Á, Hachimi, M, Dueñas, M, Lloveras, B, Santos, A, Holguín, A, Duarte, B, Santiago, J, Akgül, B, Rodríguez-Peralto, J, Storey, A, Ribas, C, Larcher, F, Del Rio, M, Paramio, J, García-Escudero, R

“…Our model seems to be a valuable platform for basic research into HPV oncogenesis and preclinical testing of HPV-associated antitumor therapies.…”

Definition, management, and training in impacted fetal head at cesarean birth: a national survey of maternity professionals by Cornthwaite, K, Hewitt, P, van der Scheer, JW, Brown, IAF, Burt, J, Dufresne, E, Dixon-Woods, M, Draycott, T, Bahl, R

“…Thiscovery, an online research and development platform, was used to ask closed-ended and free-text questions. …”

Recombinant viral-vectored vaccines expressing Plasmodium chabaudi AS apical membrane antigen 1: mechanisms of vaccine-induced blood-stage protection. by Biswas, S, Spencer, A, Forbes, E, Gilbert, S, Holder, A, Hill, A, Draper, S

“…Unlike previous studies, these results confirm that Ag-specific CD4(+) T cells, induced by a clinically relevant vaccine-delivery platform, can make a significant contribution to vaccine blood-stage efficacy in the P. chabaudi model. …”