New physical and biological evidence of lateral transport affecting dinoflagellate cyst distribution in the benthic nepheloid layer along a land-sea transect off Figueira da Foz (A... by Iria García-Moreiras, Melissa Hatherly, Melissa Hatherly, Karin Zonneveld, Karin Zonneveld, Jesus Dubert, Jesus Dubert, Rita Nolasco, Rita Nolasco, Ana Isabel Santos, Anabela Oliveira, Anabela Oliveira, Teresa Moita, Paulo B. Oliveira, Jorge M. Magalhães, Jorge M. Magalhães, Ana Amorim, Ana Amorim

“…However, little is known about the role of suspended cysts in the benthic nepheloid layer (BNL) in the initiation and decline of planktonic populations.MethodsIn September 2019, sampling of the dinoflagellate cyst community at different water depths in the water column and in the bottom sediments, and studies of spatio-temporal changes in physical properties (temperature, salinity, density and suspended sediment concentration), were carried out along a land-sea transect off Figueira da Foz (NW Portugal) to investigate the dinoflagellate cyst distribution and the factors (physical and biological) affecting it. …”
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Exposure to green spaces, cardiovascular risk biomarkers and incident cardiovascular disease in older adults: The Seniors-Enrica II cohort by Cara Scheer, Elena Plans-Beriso, Roberto Pastor-Barriuso, Rosario Ortolá, Mercedes Sotos-Prieto, Verónica Cabañas-Sánchez, Pedro Gullón, Carlos Ojeda Sánchez, Rebeca Ramis, Pablo Fernández-Navarro, Fernando Rodríguez-Artalejo, Esther García-Esquinas

“…Conclusion: Increased exposure to residential green space was associated with a moderate reduction in CVD risk in older adults residing in densely populated areas.…”
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Long-term outcomes of moderately hypofractionated radiotherapy (67.5 Gy in 25 fractions) for prostate cancer confined to the pelvis: a single center retrospective analysis by Lihong Yao, Jianzhong Shou, Shulian Wang, Yongwen Song, Hui Fang, Ningning Lu, Yuan Tang, Bo Chen, Shunan Qi, Yong Yang, Hao Jing, Jing Jin, Zihao Yu, Yexiong Li, Yueping Liu

“…This fractionation schedule deserves further evaluation in similar populations.…”
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Neighborhood socioeconomic deprivation and individual-level socioeconomic status are associated with dopamine-mediated changes to monocyte subset CCR2 expression via a cAMP-depende... by Yvonne Baumer, Mario A. Pita, Briana S. Turner, Andrew S. Baez, Lola R. Ortiz-Whittingham, Cristhian A. Gutierrez-Huerta, Sam J. Neally, Nicole Farmer, Valerie M. Mitchell, Billy S. Collins, Tiffany M. Powell-Wiley

“…Future studies should investigate the importance of DA in CVD development and progression in populations disproportionately experiencing chronic stress due to SDoH.…”
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Strategic Harmonization of Training on Biosecurity for Laboratories in the ECOWAS Region by Abayomi Akinola Emmanuel, Denloye Abiodun Akinpelu, Diagne Rokhaya, Diallo Sada, Ellis Maureen, Faye Elhadji Abdourahmane, Faye Ousmane, Fofana Lorene, Kebe Khady, Kouame Clarisse Elogne, Manigart Olivier, Peyrefitte Christophe, Sakande Jean, Sall Amadou, Sarr Aicha Marceline, Sow Abdourahmane, Traore Tieble

“…<b>Background: </b>Good laboratory practices in terms of biosecurity and biosafety are essential for the protection of laboratory personnel, the populations and the environment. If not implemented, the risk of pathogen spreading from the laboratory is conceivable. …”
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Cardiopulmonary Exercise Testing after Surgical Repair of Tetralogy of Fallot—Does Modality Matter? by Benedetta Leonardi, Fabrizio Sollazzo, Federica Gentili, Massimiliano Bianco, Elettra Pomiato, Stefani Silva Kikina, Rachel Maya Wald, Vincenzo Palmieri, Aurelio Secinaro, Giulio Calcagni, Gianfranco Butera, Ugo Giordano, Giulia Cafiero, Fabrizio Drago

“…Our data suggest that CPET parameters should be interpreted according to test type; however, these findings should be validated in larger populations and in a variety of institutions.…”
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Physical function endpoints in cancer cachexia clinical trials: Systematic Review 1 of the cachexia endpoints series by James McDonald, Judith Sayers, Stefan D. Anker, Jann Arends, Trude Rakel Balstad, Vickie Baracos, Leo Brown, Asta Bye, Olav Dajani, Ross Dolan, Marie T. Fallon, Eilidh Fraser, Christine Griel, Aleksandra Grzyb, Marianne Hjermstad, Mariam Jamal‐Hanjani, Gunnhild Jakobsen, Stein Kaasa, Donald McMillan, Matthew Maddocks, Iain Philips, Inger O. Ottestad, Kieran F. Reid, Mariana S. Sousa, Melanie R. Simpson, Ola Magne Vagnildhaug, Richard J. E. Skipworth, Tora S. Solheim, Barry J. A. Laird, the Cancer Cachexia Endpoints Working Group

“…However, heterogeneity in study design, populations, intervention and endpoint selection make it difficult to comment on the optimal endpoint and how to measure this. …”
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Endemicity of Coxiella burnetii infection among people and their livestock in pastoral communities in northern Kenya by Josphat Muema, Mutono Nyamai, Nick Wheelhouse, Joseph Njuguna, Christine Jost, Julius Oyugi, Zipporah Bukania, Harriet Oboge, Brian Ogoti, Anita Makori, Maria del Pilar Fernandez, Sylvia Omulo, S.M. Thumbi

“…Longitudinal studies of Q-fever burden and risk factors simultaneously assessed in human and animal populations as well as the socioeconomic impacts of the disease and further explore the role of environmental factors in Q-fever epidemiology are required. …”
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Appetite and dietary intake endpoints in cancer cachexia clinical trials: Systematic Review 2 of the cachexia endpoints series by Ola Magne Vagnildhaug, Trude R. Balstad, Inger Ottestad, Asta Bye, Christine Greil, Jann Arends, Vickie Baracos, Leo R. Brown, Olav F. Dajani, Ross D. Dolan, Marie Fallon, Eilidh Fraser, Aleksandra Grzyb, Marianne J. Hjermstad, Gunnhild Jakobsen, Stein Kaasa, James McDonald, Iain Philips, Judith Sayers, Melanie R. Simpson, Mariana S. Sousa, Richard J.E. Skipworth, Barry J.A. Laird, Tora S. Solheim, the Cancer Cachexia Endpoints Working Group

“…Dietary intake assessments were used mainly to monitor compliance and are not validated in cachexia populations. Given the importance to cachexia studies, dietary intake endpoints must be validated before they are used as endpoints in clinical trials.…”
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Cellular Prion Protein Expression in the Brain Tissue from <i>Brucella ceti</i>-Infected Striped Dolphins (<i>Stenella coeruleoalba</i>) by Clotilde Beatrice Angelucci, Roberto Giacominelli-Stuffler, Marina Baffoni, Cristina Esmeralda Di Francesco, Gabriella Di Francesco, Ludovica Di Renzo, Manuela Tittarelli, Antonio Petrella, Carla Grattarola, Sandro Mazzariol, Eva Sierra, Antonio Fernández, Giovanni Di Guardo

“…Noteworthy, the inflammatory infiltrates seen in the brain and in the cervico-thoracic spinal cord segments from the herein investigated, <i>B. ceti</i>-infected and neurobrucellosis-affected striped dolphins were densely populated by macrophage/histiocyte cells, often harboring <i>Brucella</i> spp. antigen in their cytoplasm, similarly to what was reported in macrophages from mice experimentally challenged with <i>B. abortus</i>. …”
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Severe Breakthrough COVID-19 Cases during Six Months of Delta Variant (B.1.617.2) Domination in Poland by Piotr Rzymski, Monika Pazgan-Simon, Juliusz Kamerys, Anna Moniuszko-Malinowska, Katarzyna Sikorska, Joanna Wernik, Dorota Zarębska-Michaluk, Łukasz Supronowicz, Barbara Sobala-Szczygieł, Agata Skrzat-Klapaczyńska, Krzysztof Simon, Anna Piekarska, Piotr Czupryna, Małgorzata Pawłowska, Michał Brzdęk, Jerzy Jaroszewicz, Justyna Kowalska, Marcin Renke, Robert Flisiak

“…The objective of this study was to assess the frequency and the clinical characteristics of severe breakthrough COVID-19 cases recorded in 10 Polish healthcare units between 1 June and 31 December 2021, a period during which a rapid surge in the share of B.1.617.2 infections was seen, while a significant number of populations were already fully vaccinated. Overall, 723 individuals who completed the initial vaccination regime (fully vaccinated group) and an additional 18 who received a booster dose were identified—together, they represented 20.8% of all the COVID-19 patients hospitalized during the same period in the same healthcare institutions (0.5% in the case of a group that received a booster dose). …”
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Genetic Predictive Factors for Nonsusceptible Phenotypes and Multidrug Resistance in Expanded-Spectrum Cephalosporin-Resistant Uropathogenic Escherichia coli from a Multicenter Coh... by Nicole Jackson, Cheyenne R. Belmont, Nicole J. Tarlton, Yuan Hu Allegretti, Sheila Adams-Sapper, Yolanda Yue Huang, Clarissa A. Borges, Bradley W. Frazee, Danka Florence-Petrovic, Clarisse Hufana, Anna Parker, Claire F. Mastrangelo, Shevya Awasthi, Isha Kane, Zlatan Coralic, Steve Miller, Joycelyn Diaz, Christopher Fee, Cassiana E. Bittencourt, Omai Garner, Sukantha Chandrasekaran, Claudia Crandall, Julian C. Marcha, Mir H. Noorbakhsh, Patricia Rodrigues-Wong, Tara R. deBoer, Lee W. Riley

“…This study aims to characterize the phenotypic and genetic basis of multidrug resistance (MDR) among expanded-spectrum cephalosporin-resistant (ESCR) uropathogenic Escherichia coli (UPEC) causing UTIs in California patient populations. Between February and October 2019, 577 ESCR UPEC isolates were collected from patients at 6 clinical laboratory sites across California. …”
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Isolation of a highly virulent Metarhizium strain targeting the tea pest, Ectropis obliqua by Jie Zhao, Yuxi Chen, Nemat O. Keyhani, Cong Wang, Yichen Li, Huili Pu, Jincheng Li, Sen Liu, Pengyu Lai, Mengjia Zhu, Xueyou He, Shouping Cai, Xiayu Guan, Junzhi Qiu

“…E. obliqua is a polyphagus insect that is of increasing concern due to the development of populations resistant to certain chemical insecticides. …”
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Perspectives on snakebite envenoming care needs across different sociocultural contexts and health systems: A comparative qualitative analysis among US and Brazilian health provide... by Eleanor Strand, Felipe Murta, Anna Tupetz, Loren Barcenas, Ashley J. Phillips, Altair Seabra Farias, Alícia Cacau Santos, Gisele dos Santos Rocha, Catherine A. Staton, Flávia Regina Ramos, Vinícius Azevedo Machado, Fan Hui Wen, João R.N. Vissoci, Jacqueline Sachett, Wuelton Monteiro, Charles J. Gerardo

“…The challenge lies in implementing these evidence-based treatments and practices across different settings and populations. This study aims to compare data on provider perceptions of SBE care across health systems and cultural contexts to inform potential implementation science approaches. …”
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The impacts of physical activity on psychological and behavioral problems, and changes in physical activity, sleep and quality of life during the COVID-19 pandemic in preschoolers,... by Johnson C. Y. Pang, Eric L. S. Chan, Herman M. C. Lau, Kara K. L. Reeves, Tina H. Y. Chung, Heidi W. L. Hui, Alfred H. L. Leung, Allan C. L. Fu, Allan C. L. Fu, Allan C. L. Fu

“…Articles without data regarding PA or involving non-general populations were excluded. The PRISMA and MOOSE guidelines were followed. …”
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The Plasmodium falciparum Nuclear Protein Phosphatase NIF4 Is Required for Efficient Merozoite Invasion and Regulates Artemisinin Sensitivity by Xiaotong Zhu, Siqi Li, Chengqi Wang, Yuanchao Yu, Jingjing Wang, Lu He, Faiza Amber Siddiqui, Lumeng Chen, Liying Zhu, Dan Zhou, Junling Qin, Jun Miao, Liwang Cui, Yaming Cao

“…Consistent with the earlier finding of the association of PfNIF4 mutations with artemisinin resistance in Southeast Asian parasite populations, PfNIF4 KD significantly increased in vitro susceptibility to artemisinins. …”
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Flow Cytometry with Anti-Diffraction Light Sheet (ADLS) by Spatial Light Modulation by Yanyan Gong, Ming Zeng, Yueqiang Zhu, Shangyu Li, Wei Zhao, Ce Zhang, Tianyun Zhao, Kaige Wang, Jiangcun Yang, Jintao Bai

“…Flow cytometry is a widespread and powerful technique whose resolution is determined by its capacity to accurately distinguish fluorescently positive populations from negative ones. However, most informative results are discarded while performing the measurements of conventional flow cytometry, e.g., the cell size, shape, morphology, and distribution or location of labeled exosomes within the unpurified biological samples. …”
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Intrinsic Differences in Spatiotemporal Organization and Stromal Cell Interactions Between Isogenic Lung Cancer Cells of Epithelial and Mesenchymal Phenotypes Revealed by High-Dime... by Maria L. Lotsberg, Maria L. Lotsberg, Maria L. Lotsberg, Gro V. Røsland, Gro V. Røsland, Austin J. Rayford, Austin J. Rayford, Austin J. Rayford, Sissel E. Dyrstad, Camilla T. Ekanger, Ning Lu, Ning Lu, Kirstine Frantz, Linda E. B. Stuhr, Henrik J. Ditzel, Henrik J. Ditzel, Jean Paul Thiery, Jean Paul Thiery, Jean Paul Thiery, Lars A. Akslen, Lars A. Akslen, Lars A. Akslen, James B. Lorens, James B. Lorens, Agnete S. T. Engelsen, Agnete S. T. Engelsen

“…We observed a high level of heterogeneity in the expression of EMT markers in both the carcinoma cell populations and the fibroblasts. Our study supports further application of these models in pre-clinical drug testing combined with complementary high-dimensional single-cell analyses, which in turn can advance our understanding of the impact of cancer-stroma interactions and epithelial phenotypic plasticity on innate and acquired therapy resistance in NSCLC.…”
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Understanding high wintertime ozone pollution events in an oil- and natural gas-producing region of the western US by R. Ahmadov, S. McKeen, M. Trainer, R. Banta, A. Brewer, S. Brown, P. M. Edwards, J. A. de Gouw, G. J. Frost, J. Gilman, D. Helmig, B. Johnson, A. Karion, A. Koss, A. Langford, B. Lerner, J. Olson, S. Oltmans, J. Peischl, G. Pétron, Y. Pichugina, J. M. Roberts, T. Ryerson, R. Schnell, C. Senff, C. Sweeney, C. Thompson, P. R. Veres, C. Warneke, R. Wild, E. J. Williams, B. Yuan, R. Zamora

“…This study uses a regional-scale air quality model (WRF-Chem) to simulate high ozone (O₃) episodes during the winter of 2013 over the Uinta Basin (UB) in northeastern Utah, which is densely populated by thousands of oil and NG wells. The high-resolution meteorological simulations are able qualitatively to reproduce the wintertime cold pool conditions that occurred in 2013, allowing the model to reproduce the observed multi-day buildup of atmospheric pollutants and the accompanying rapid photochemical ozone formation in the UB. …”
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Identifying fibrogenic cells following salivary gland obstructive injury by Amber L. Altrieth, Amber L. Altrieth, Kevin J. O’Keefe, Kevin J. O’Keefe, Victoria A. Gellatly, Victoria A. Gellatly, Joey R. Tavarez, Joey R. Tavarez, Sage M. Feminella, Nicholas L. Moskwa, Nicholas L. Moskwa, Carmalena V. Cordi, Judy C. Turrieta, Deirdre A. Nelson, Melinda Larsen, Melinda Larsen

“…We used scRNA-seq to examine cell populations that expand with ligation and/or showed increased expression of matrisome genes. …”
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