Soil macrofauna communities in Brazilian land-use systems by George Brown, Wilian Demetrio, Quentin Gabriac, Amarildo Pasini, Vanesca Korasaki, Lenita Oliveira, Julio dos Santos, Eleno Torres, Paulo Galerani, Dionisio Gazziero, Norton Benito, Daiane Nunes, Alessandra Santos, Talita Ferreira, Herlon Nadolny, Marie Bartz, Wagner Maschio, Rafaela Dudas, Mauricio Zagatto, Cintia Niva, Lina Clasen, Klaus Sautter, Luis Froufe, Carlos Eduardo Seoane, Aníbal de Moraes, Samuel James, Odair Alberton, Osvaldino Brandão Júnior, Odilon Saraiva, Antonio Garcia, Elma Oliveira, Raul César, Beatriz Corrêa-Ferreira, Lilianne Bruz, Elodie Silva, Gilherme Cardoso, Patrick Lavelle, Elena Velásquez, Marcus Cremonesi, Lucília Parron, Amilton Baggio, Edinelson Neves, Mariangela Hungria, Thiago Campos, Vagner da Silva, Carlos Reissmann, Ana Conrado, Jean-Pierre Bouillet, José Gonçalves, Carolina Brandani, Ricardo Viani, Ranieri Paula, Jean-Paul Laclau, Clara Peña-Venegas, Carlos Peres, Thibaud Decaëns, Benjamin Pey, Nico Eisenhauer, Miguel Cooper, Jérôme Mathieu

“…A total of 83,085 georeferenced occurrences of these taxa are presented, based on quantitative estimates performed using a standardised sampling method commonly adopted worldwide to collect soil macrofauna populations, i.e. the TSBF (Tropical Soil Biology and Fertility Programme) protocol. …”
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Significant changes in advanced lung cancer survival during the past decade in Hungary: impact of modern immunotherapy and the COVID-19 pandemic by Zoltán Kiss, Zoltán Kiss, Gabriella Gálffy, Veronika Müller, Judit Moldvay, Judit Moldvay, Veronika Sárosi, Zsolt Pápai-Székely, Edit Csada, Anna Kerpel-Fronius, Zsolt Király, Zoltán Szász, Gábor Hódi, Zoltán Polányi, Krisztina Kovács, Eugenia Karamousouli, Kata Knollmajer, Tamás G. Szabó, Andrea Berta, Zoltán Vokó, Zoltán Vokó, György Rokszin, Zsolt Abonyi-Tóth, Zsolt Abonyi-Tóth, Zsófia Barcza, Lilla Tamási, Krisztina Bogos

“…Survival improvements remained significant in both patient populations during the Covid-19 pandemic (2020–2021). …”
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The stroke transitional care intervention for older adults with stroke and multimorbidity: a multisite pragmatic randomized controlled trial by Maureen Markle-Reid, Kathryn Fisher, Kimberly M. Walker, Marla Beauchamp, Jill I. Cameron, David Dayler, Rebecca Fleck, Amiram Gafni, Rebecca Ganann, Ken Hajas, Barbara Koetsier, Robert Mahony, Chris Pollard, Jim Prescott, Tammy Rooke, Carly Whitmore

“…A larger pragmatic RCT is needed to determine intervention effectiveness in diverse geographic settings and ethno-cultural populations and examine intervention scalability. Trial registration ClinicalTrials.gov Identifier: NCT04278794 . …”
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Distinct DNA methylation signatures associated with blood lipids as exposures or outcomes among survivors of childhood cancer: a report from the St. Jude lifetime cohort by Qian Dong, Cheng Chen, Nan Song, Na Qin, Noel-Marie Plonski, Emily R. Finch, Kyla Shelton, John Easton, Heather Mulder, Emily Plyer, Geoffrey Neale, Emily Walker, Qian Li, I-Chan Huang, Jinghui Zhang, Hui Wang, Melissa M. Hudson, Leslie L. Robison, Kirsten K. Ness, Zhaoming Wang

“…Notably, 32 out of 74 lipid-associated CpGs showed substantial heterogeneity (P het  < 0.1 or I 2 > 70%) between EA and AA survivors, highlighting differences in DNAm markers of blood lipids between populations with diverse genetic ancestry. Ten lipid-associated CpGs were cis-expression quantitative trait methylation with their DNAm levels associated with the expression of corresponding genes, out of which seven were negatively associated. …”
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Targeting immunosuppressive Ly6C+ classical monocytes reverses anti-PD-1/CTLA-4 immunotherapy resistance by B. Leticia Rodriguez, Limo Chen, Yanli Li, Yanli Li, Shucheng Miao, Shucheng Miao, David H. Peng, Jared J. Fradette, Lixia Diao, Jessica M. Konen, Frank R. Rojas Alvarez, Luisa M. Solis, Xiaohui Yi, Xiaohui Yi, Aparna Padhye, Aparna Padhye, Laura A. Gibson, Joshua K. Ochieng, Xiaofei Zhou, Jing Wang, Don L. Gibbons, Don L. Gibbons

“…Upon extended treatment with anti-PD-1/CTLA-4 acquired resistance developed with an increase of the immunosuppressive populations, including T-regulatory cells, neutrophils and monocytes. …”
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The Role of the Microbiome in Gastroentero-Pancreatic Neuroendocrine Neoplasms (GEP-NENs) by Amr Mohamed, Sylvia L. Asa, Thomas McCormick, Hilmi Al-Shakhshir, Arvind Dasari, Retuerto Mauricio, Iman Salem, Lee M. Ocuin, David Bajor, Richard T. Lee, J. Eva Selfridge, Arash Kardan, Zhenghong Lee, Norbert Avril, Shelby Kopp, Jordan M. Winter, Jeffrey M. Hardacre, John B. Ammori, Mahmoud A. Ghannoum

“…Patients with GEP-NECs had significantly enriched populations of specific bacteria and fungi (such as <i>Enterobacter hormaechei</i>, <i>Bacteroides fragilis</i> and <i>Trichosporon asahii</i>) compared to those with GEP-NETs (<i>p</i> = 0.048, 0.0022 and 0.034, respectively). …”
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A2AR Expression and Immunosuppressive Environment Independent of <i>KRAS</i> and <i>GNAS</i> Mutations in Pseudomyxoma Peritonei by Shigeki Kusamura, Adele Busico, Elena Conca, Iolanda Capone, Luca Agnelli, Daniele Lorenzini, Silvia Brich, Marta Angelini, Chiara Costanza Volpi, Desirè Viola Trupia, Vincenzo Lagano, Tommaso Torelli, Annunziata Gloghini, Dario Baratti, Marcello Guaglio, Massimo Milione, Marcello Deraco, Federica Perrone

“…GM-CSF, A2AR, CD73, CD39, and PD-L1 expression was investigated by immunohistochemistry in 40 PMPs characterized for <i>GNAS</i> and <i>KRAS</i> mutational status. Immune cell populations were studied by immunohistochemistry and nanostring nCounter^®. …”
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The global transcriptome of Plasmodium falciparum mid-stage gametocytes (stages II–IV) appears largely conserved and gametocyte-specific gene expression patterns vary in clinical i... by Jonas A. Kengne-Ouafo, Saikou Y. Bah, Alison Kemp, Lindsay Stewart, Lucas Amenga-Etego, Kirk W. Deitsch, Julian C. Rayner, Oliver Billker, Fred N. Binka, Colin J. Sutherland, Gordon A. Awandare, Britta C. Urban, Bismarck Dinko

“…However, most of these investigations rely on laboratory strains (LS) that were adapted into in vitro culture many years ago, and the transcriptomes of clinical isolates (CI) circulating in human populations have not been assessed. In this study, RNA-seq was used to compare the global transcriptome of mid-stage gametocytes derived from three short-term cultured CI, with gametocytes derived from the NF54 reference laboratory strain. …”
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Single-cell profiling of response to neoadjuvant chemo-immunotherapy in surgically resectable esophageal squamous cell carcinoma by Gang Ji, Qi Yang, Song Wang, Xiaolong Yan, Qiuxiang Ou, Li Gong, Jinbo Zhao, Yongan Zhou, Feng Tian, Jie Lei, Xiaorong Mu, Jian Wang, Tao Wang, Xiaoping Wang, Jianyong Sun, Jipeng Zhang, Chenghui Jia, Tao Jiang, Ming-gao Zhao, Qiang Lu

“…Deconvolution of transcriptomes in pre-treatment tumors identified gene signatures in response to NAT contributed by specific immune cell populations. Upregulated genes associated with better pathological responses in CD8 + effector T cells primarily involved interferon-gamma (IFNγ) signaling, neutrophil degranulation, and negative regulation of the T cell apoptotic process, whereas downregulated genes were dominated by those in the immune response-activating cell surface receptor signaling pathway. …”
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RNA-sequencing based first choice of treatment and determination of risk in multiple myeloma by Martina Emde-Rajaratnam, Susanne Beck, Susanne Beck, Vladimir Benes, Hans Salwender, Uta Bertsch, Christoph Scheid, Mathias Hänel, Katja Weisel, Thomas Hielscher, Marc S. Raab, Hartmut Goldschmidt, Hartmut Goldschmidt, Anna Jauch, Ken Maes, Elke De Bruyne, Eline Menu, Kim De Veirman, Jérôme Moreaux, Karin Vanderkerken, Anja Seckinger, Dirk Hose

“…R-ISS and RNA-sequencing identify partially overlapping patient populations, with R-ISS missing, e.g., 30% (22/72) of highly proliferative myeloma.ConclusionRNA-sequencing based assessment of risk and targets for first choice treatment is possible in clinical routine.…”
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Adverse effects of vaping and electronic cigarettes by Álvaro García-Tenorio García, Jorge Jiménez Fernández, María Martínez Caparrós, Ainoa Martínez Ramos, Santiago Martos Quirós, Ramón Mengíbar Merino

“…Political institutions have a great impact on society, so they should implement restrictions on the sale and purchase of electronic cigarettes and/or vapers, thus reducing consumption by the population…”
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Phylogenetic Conservation of Soil Microbial Responses to Elevated Tropospheric Ozone and Nitrogen Fertilization by Zhengsheng Yu, Qun Gao, Xue Guo, Jinlong Peng, Qi Qi, Xunwen Chen, Mengying Gao, Cehui Mo, Zhaozhong Feng, Ming Hung Wong, Yunfeng Yang, Hui Li

“…Given that the global tropospheric ozone concentration will continue to increase in the coming decades, the decrease of specific microbial populations caused by elevated ozone would result in the extinction of certain microbial taxa. …”
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Concurrent training and interindividual response in women with a high number of metabolic syndrome risk factors by Pedro Delgado-Floody, Pedro Delgado-Floody, Luis Chirosa-Ríos, Felipe Caamaño-Navarrete, Pablo Valdés-Badilla, Pablo Valdés-Badilla, Tomás Herrera-Valenzuela, Matías Monsalves-Álvarez, Matías Monsalves-Álvarez, Cristian Núñez-Espinosa, Cristian Núñez-Espinosa, Cristian Núñez-Espinosa, Mauricio Castro-Sepulveda, Eduardo Guzmán-Muñoz, David C. Andrade, Cristian Álvarez

“…The non-responders (NRs) after exercise training have been poorly studied in populations with morbid obesity. The purpose of this study was to determine the NR prevalence after 20 weeks of concurrent training of morbidly obese women with a high or low number of metabolic syndrome (MetS) risk factors. …”
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Subclinical Changes in Cardiac Functional Parameters as Determined by Cardiovascular Magnetic Resonance (CMR) Imaging in Sleep Apnea and Snoring: Findings from UK Biobank by Adrian Curta, Holger Hetterich, Regina Schinner, Aaron M. Lee, Wieland Sommer, Nay Aung, Mihir M. Sanghvi, Kenneth Fung, Elena Lukaschuk, Jackie A. Cooper, José Miguel Paiva, Valentina Carapella, Stefan Neubauer, Stefan K. Piechnik, Steffen E. Petersen

“…Most studies to date have examined populations with manifest cardiovascular disease using echocardiography to analyze ventricular dysfunction with little or no reference to ventricular volumes or myocardial mass. …”
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Assessment of the Effects of Economic Sanctions on Iranians’ Right to Health by Using Human Rights Impact Assessment Tool: A Systematic Review by Fatemeh Kokabisaghi

“…In future, before imposition of sanctions, decisions makers should advice an international order to prevent such impacts on targeted countries’ populations…”
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Mortality Related to Nonalcoholic Fatty Liver Disease Is Increasing in the United States by James M. Paik, Linda Henry, Leyla De Avila, Elena Younossi, Andrei Racila, Zobair M. Younossi

“…Population‐level nonalcoholic fatty liver disease (NAFLD) death rate data are sparse. …”
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Pre-sleep protein supplementation does not improve performance, body composition, and recovery in British Army recruits (part 1) by Shaun Chapman, Shaun Chapman, Justin Roberts, Andrew J. Roberts, Henry Ogden, Rachel Izard, Lee Smith, Havovi Chichger, Lauren Struszczak, Alex J. Rawcliffe, Alex J. Rawcliffe

“…Dietary protein is crucial for optimising physical training adaptations such as muscular strength and mass, which are key aims for athletic populations, including British Army recruits. New recruits fail to meet the recommended protein intake during basic training (BT), with negligible amounts consumed in the evening. …”
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Autophagy in protists and their hosts: When, how and why? by Patricia Silvia Romano, Takahiko Akematsu, Sébastien Besteiro, Annina Bindschedler, Vern B. Carruthers, Zeinab Chahine, Isabelle Coppens, Albert Descoteaux, Thabata Lopes Alberto Duque, Cynthia Y. He, Volker Heussler, Karine G. Le Roch, Feng-Jun Li, Juliana Perrone Bezerra de Menezes, Rubem Figueiredo Sadok Menna-Barreto, Jeremy C. Mottram, Jacqueline Schmuckli-Maurer, Boris Turk, Patricia Sampaio Tavares Veras, Betiana Nebai Salassa, María Cristina Vanrell

“…These diseases, which affect more than one billion people globally, mainly the poorest populations, are characterized by severe chronic stages and the lack of effective antiparasitic treatment. …”
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Epigenomic response to albuterol treatment in asthma-relevant airway epithelial cells by Javier Perez-Garcia, Maria Pino-Yanes, Elizabeth G. Plender, Jamie L. Everman, Celeste Eng, Nathan D. Jackson, Camille M. Moore, Kenneth B. Beckman, Vivian Medina, Sunita Sharma, Daniel Efrain Winnica, Fernando Holguin, José Rodríguez-Santana, Jesús Villar, Elad Ziv, Max A. Seibold, Esteban G. Burchard

“…Abstract Background Albuterol is the first-line asthma medication used in diverse populations. Although DNA methylation (DNAm) is an epigenetic mechanism involved in asthma and bronchodilator drug response (BDR), no study has assessed whether albuterol could induce changes in the airway epithelial methylome. …”
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Features of the subpopulation composition of dendritic cells in patients with rheumatoid arthritis by M. A. Korolev, Yu. D. Kurochkina, N. E. Banshchikova, A. A. Akimova, V. O. Omelchenko, E. A. Letyagina, M. A. Surovtseva, A. P. Lykov, O. V. Poveshchenko

“…There are two major DC populations: myeloid and plasmacytoid DCs (mDCs and pDCs). …”
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