Multiple factors and features dictate the selective production of ct-siRNA in Arabidopsis by Feng Li, Wei Yan, Xianli Tang, Huihui Wu, Yajie Pan, Dongdong Lu, Qianyan Ling-hu, Yuelin Liu, Yongqi Liu, Xiehai Song, Muhammad Ali, Liang Fang, Hongwei Guo, Bosheng Li

“…In this study, we generated Arabidopsis mutants with deficiencies in RNA decay and/or post-transcriptional gene silencing (PTGS) pathways and performed comparative sRNA-seq analysis, revealing that multiple RNA decay and PTGS factors impede the ct-siRNA selective production. …”
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Overexpression of microRNA-206 in the skeletal muscle from myotonic dystrophy type 1 patients by Angelini Corrado, Loro Emanuele, Viola Antonella, Lepore Saverio M, Rinaldi Fabrizio, Gambardella Stefano, Vergani Lodovica, Novelli Giuseppe, Botta Annalisa

“…<p>Abstract</p> <p>Background</p> <p>MicroRNAs are highly conserved, noncoding RNAs involved in post-transcriptional gene silencing. They have been shown to participate in a wide range of biological processes, including myogenesis and muscle regeneration. …”
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Generation of Virus- and dsRNA-Derived siRNAs with Species-Dependent Length in Insects by Dulce Santos, Lina Mingels, Elise Vogel, Luoluo Wang, Olivier Christiaens, Kaat Cappelle, Niels Wynant, Yannick Gansemans, Filip Van Nieuwerburgh, Guy Smagghe, Luc Swevers, Jozef Vanden Broeck

“…Double-stranded RNA (dsRNA) molecules of viral origin trigger a post-transcriptional gene-silencing mechanism called RNA interference (RNAi). …”
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The Role of MicroRNAs in Dilated Cardiomyopathy: New Insights for an Old Entity by Elena Alonso-Villa, Fernando Bonet, Francisco Hernandez-Torres, Óscar Campuzano, Georgia Sarquella-Brugada, Maribel Quezada-Feijoo, Mónica Ramos, Alipio Mangas, Rocío Toro

“…MicroRNAs (miRNAs) are a group of small noncoding RNAs that play key roles in post-transcriptional gene silencing by targeting mRNAs for translational repression or, to a lesser extent, degradation. …”
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siRNA Mediate RNA Interference Concordant with Early On-Target Transient Transcriptional Interference by Zhiming Fang, Zhongming Zhao, Valsamma Eapen, Raymond A. Clarke

“…In fibroblast cell lines, <i>SMALLTALK</i> is transcribed at much higher levels in the opposite (convergent) direction to <i>TOSPEAK</i>. siRNA targeting of <i>SMALLTALK</i> resulted in post transcriptional gene silencing (PTGS/RNAi) of <i>SMALLTALK</i> that peaked at 72 h together with a rapid early increase in the level of both <i>TOSPEAK</i> and <i>GDF6</i> that peaked and waned after 24 h. …”
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Epigenetic Changes in Host Ribosomal DNA Promoter Induced by an Asymptomatic Plant Virus Infection by Miryam Pérez-Cañamás, Elizabeth Hevia, Carmen Hernández

“…The PLPV protein p37, reported as a suppressor of post-transcriptional gene silencing, did not lead to the same effects when expressed alone and, thus, it is unlikely to act as suppressor of transcriptional gene silencing. …”
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Antiviral efficacy of short-hairpin RNAs and artificial microRNAs targeting foot-and-mouth disease virus by Anabella Currá, Marco Cacciabue, María José Gravisaco, Sebastián Asurmendi, Oscar Taboga, María I. Gismondi

“…RNA interference (RNAi) is a well-conserved mechanism in eukaryotic cells that directs post-transcriptional gene silencing through small RNA molecules. …”
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GapmeR cellular internalization by macropinocytosis induces sequence-specific gene silencing in human primary T-cells by Fazil, Mobashar Hussain Urf Turabe, Ong, Seow Theng, Chalasani, Madhavi Latha Somaraju, Low, Jian Hui, Kizhakeyil, Atish, Mamidi, Akshay, Lim, Carey Fang Hui, Wright, Graham D., Lakshminarayanan, Rajamani, Kelleher, Dermot, Verma, Navin Kumar

“…Post-transcriptional gene silencing holds great promise in discovery research for addressing intricate biological questions and as therapeutics. …”
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Bioinformatical and experimental analysis of gene expression regulation through RNAi and alternative polyadenylation by Schlackow, M

“…</p> <p>microRNAs (miRNAs) are well studies in higher eukaryotes and participate on post-transcriptional gene silencing by degrading target mRNA or blocking translation. …”

Characterization of Curtovirus V2 Protein, a Functional Homolog of Begomovirus V2 by Ana P. Luna, Beatriz Romero-Rodríguez, Tábata Rosas-Díaz, Laura Cerero, Edgar A. Rodríguez-Negrete, Araceli G. Castillo, Eduardo R. Bejarano

“…V2 from Beet curly top virus (BCTV), the model species for the Curtovirus genus, as it begomoviral counterpart, suppresses post-transcriptional gene silencing (PTGS) by impairing the RDR6/SGS3 pathway and localizes in the nucleus spanning from the perinuclear region to the cell periphery. …”
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Pan-Sigma Receptor Modulator RC-106 Induces Terminal Unfolded Protein Response In <i>In Vitro</i> Pancreatic Cancer Model by Michela Cortesi, Alice Zamagni, Sara Pignatta, Michele Zanoni, Chiara Arienti, Daniela Rossi, Simona Collina, Anna Tesei

“…Cell death was studied by flow cytometry. Post-transcriptional gene silencing was performed to study the interactions between SRs and UPR key proteins. …”
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Molecular Characterizations and Functional Analyses of LmR2D2 in the <i>Locusta migratoria</i> siRNA Pathway by Lu Gao, Yanli Wang, Mureed Abbas, Tingting Zhang, Enbo Ma, Shuping Xing, Kun Yan Zhu, Jianzhen Zhang

“…The formation of siRNA is a highly conserved post-transcriptional gene-silencing mechanism mediated by key proteins, including Dicer2, Argonaute2 (Ago2) and R2D2. …”
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Lysosomal Storage Disease-Associated Neuropathy: Targeting Stable Nucleic Acid Lipid Particle (SNALP)-Formulated siRNAs to the Brain as a Therapeutic Approach by Maria Francisca Coutinho, Juliana Inês Santos, Liliana S. Mendonça, Liliana Matos, Maria João Prata, Amália S. Jurado, Maria C. Pedroso de Lima, Sandra Alves

“…This concept is known as substrate reduction therapy and may be triggered by several molecules, such as small interfering RNAs (siRNAs). siRNAs promote RNA interference, a naturally occurring sequence-specific post-transcriptional gene-silencing mechanism, and may target virtually any gene of interest, inhibiting its expression. …”
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Characterization of the roles of Xrn1p in small-RNA-mediated gene-silencing pathways by Getz, Matthew Aaron.

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Interferência por RNA: uma nova alternativa para terapia nas doenças reumáticas RNA interference: a new alternative for rheumatic diseases therapy by Natália Regine de França, Danilo Mesquita Júnior, Amanda Bandeira Lima, Fernando Vianna Cabral Pucci, Luís Eduardo Coelho Andrade, Neusa Pereira Silva

“…Por fim, vamos revisar os últimos avanços da experiência clínica da terapia com RNAi<br>RNA interference (RNAi) is a post-transcriptional gene silencing mechanism preserved during evolution. …”
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EGCG‐LYS Fibrils‐Mediated CircMAP2K2 Silencing Decreases the Proliferation and Metastasis Ability of Gastric Cancer Cells in Vitro and in Vivo by Jiaqi Dong, Zhousan Zheng, Mi Zhou, Yunfei Wang, Jiajie Chen, Junjie Cen, Tiefeng Cao, Taowei Yang, Yi Xu, Guannan Shu, Xuanxuan Lu, Yanping Liang

“…Further studies show that EGCG‐LYS carrying siRNA can successfully achieve lysosome escape, which allows it to be located in the cytoplasm to achieve post‐transcriptional gene silencing. In addition, EGCG‐LYS carrying si‐circMAP2K2 has good circulating stability, excellent biosafety and antitumor ability in vivo. …”
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Identification of natural host range of coconut cadang-cadang viroid and characterization of its small RNAs from oil palm by Mohammadi, Mohammadreza

“…In order to investigate the occurrence of Post-Transcriptional Gene Silencing (PTGS) and CCCVd small RNAs accumulation in oil palm, total small RNAs of 20-30 nt from two CCCVd infected asymptomatic and symptomatic oil palms were isolated and cloned. …”
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The P2 nucleic acid binding protein of Sugarcane bacilliform virus is a viral pathogenic factor by Xiongbiao Xu, Yinian Lou, Kaili Liang, Jingying Liu, Zhiyuan Wang, Baoshan Chen, Wenlan Li

“…The precise subcellular localization of P2 was verified in the transient infiltrated Nicotiana benthamiana epidermal mesophyll cells and protoplasts using the Laser scanning confocal microscope (LSCM). The post-transcriptional gene silencing (PTGS) and transcriptional gene silencing (TGS) RNA silencing suppressor activity of P2 was analyzed, respectively. …”
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Genetic reversal of the globin switch concurrently modulates both fetal and sickle hemoglobin and reduces red cell sickling by Daniel C. De Souza, Nicolas Hebert, Erica B. Esrick, M. Felicia Ciuculescu, Natasha M. Archer, Myriam Armant, Étienne Audureau, Christian Brendel, Giuseppe Di Caprio, Frédéric Galactéros, Donghui Liu, Amanda McCabe, Emily Morris, Ethan Schonbrun, Dillon Williams, David K. Wood, David A. Williams, Pablo Bartolucci, John M. Higgins

“…Abstract We previously reported initial clinical results of post-transcriptional gene silencing of BCL11A expression (NCT 03282656) reversing the fetal to adult hemoglobin switch. …”
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Whitefly-tolerant transgenic common bean (Phaseolus vulgaris) line by Amanda Lopes Ferreira, Josias Correa de Faria, Matheus da Costa Moura, Antônia Lopes de Mendonça Zaidem, Carolina Senhorinho Ramalho Pizetta, Elínea de Oliveira Freitas, Gesimária Ribeiro Costa Coelho, Jose Francisco Arruda e Silva, José Alexandre Freitas Barrigossi, Lucia Vieira Hoffmann, Thiago Lívio Pessoa Oliveira de Souza, Francisco José Lima Aragão, Patricia Valle Pinheiro, Patricia Valle Pinheiro

“…In the present work, two transgenic common bean lines were obtained with an intron-hairpin construct to induce post-transcriptional gene silencing against the B. tabaci vATPase (Bt-vATPase) gene, with stable expression of siRNA. …”
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