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81
Multiple factors and features dictate the selective production of ct-siRNA in Arabidopsis
Published 2024-04-01“…In this study, we generated Arabidopsis mutants with deficiencies in RNA decay and/or post-transcriptional gene silencing (PTGS) pathways and performed comparative sRNA-seq analysis, revealing that multiple RNA decay and PTGS factors impede the ct-siRNA selective production. …”
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82
Overexpression of microRNA-206 in the skeletal muscle from myotonic dystrophy type 1 patients
Published 2010-05-01“…<p>Abstract</p> <p>Background</p> <p>MicroRNAs are highly conserved, noncoding RNAs involved in post-transcriptional gene silencing. They have been shown to participate in a wide range of biological processes, including myogenesis and muscle regeneration. …”
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83
Generation of Virus- and dsRNA-Derived siRNAs with Species-Dependent Length in Insects
Published 2019-08-01“…Double-stranded RNA (dsRNA) molecules of viral origin trigger a post-transcriptional gene-silencing mechanism called RNA interference (RNAi). …”
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84
The Role of MicroRNAs in Dilated Cardiomyopathy: New Insights for an Old Entity
Published 2022-11-01“…MicroRNAs (miRNAs) are a group of small noncoding RNAs that play key roles in post-transcriptional gene silencing by targeting mRNAs for translational repression or, to a lesser extent, degradation. …”
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85
siRNA Mediate RNA Interference Concordant with Early On-Target Transient Transcriptional Interference
Published 2021-08-01“…In fibroblast cell lines, <i>SMALLTALK</i> is transcribed at much higher levels in the opposite (convergent) direction to <i>TOSPEAK</i>. siRNA targeting of <i>SMALLTALK</i> resulted in post transcriptional gene silencing (PTGS/RNAi) of <i>SMALLTALK</i> that peaked at 72 h together with a rapid early increase in the level of both <i>TOSPEAK</i> and <i>GDF6</i> that peaked and waned after 24 h. …”
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86
Epigenetic Changes in Host Ribosomal DNA Promoter Induced by an Asymptomatic Plant Virus Infection
Published 2020-04-01“…The PLPV protein p37, reported as a suppressor of post-transcriptional gene silencing, did not lead to the same effects when expressed alone and, thus, it is unlikely to act as suppressor of transcriptional gene silencing. …”
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87
Antiviral efficacy of short-hairpin RNAs and artificial microRNAs targeting foot-and-mouth disease virus
Published 2021-06-01“…RNA interference (RNAi) is a well-conserved mechanism in eukaryotic cells that directs post-transcriptional gene silencing through small RNA molecules. …”
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88
GapmeR cellular internalization by macropinocytosis induces sequence-specific gene silencing in human primary T-cells
Published 2016“…Post-transcriptional gene silencing holds great promise in discovery research for addressing intricate biological questions and as therapeutics. …”
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89
Bioinformatical and experimental analysis of gene expression regulation through RNAi and alternative polyadenylation
Published 2014“…</p> <p>microRNAs (miRNAs) are well studies in higher eukaryotes and participate on post-transcriptional gene silencing by degrading target mRNA or blocking translation. …”
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90
Characterization of Curtovirus V2 Protein, a Functional Homolog of Begomovirus V2
Published 2020-06-01“…V2 from Beet curly top virus (BCTV), the model species for the Curtovirus genus, as it begomoviral counterpart, suppresses post-transcriptional gene silencing (PTGS) by impairing the RDR6/SGS3 pathway and localizes in the nucleus spanning from the perinuclear region to the cell periphery. …”
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91
Pan-Sigma Receptor Modulator RC-106 Induces Terminal Unfolded Protein Response In <i>In Vitro</i> Pancreatic Cancer Model
Published 2020-11-01“…Cell death was studied by flow cytometry. Post-transcriptional gene silencing was performed to study the interactions between SRs and UPR key proteins. …”
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92
Molecular Characterizations and Functional Analyses of LmR2D2 in the <i>Locusta migratoria</i> siRNA Pathway
Published 2021-09-01“…The formation of siRNA is a highly conserved post-transcriptional gene-silencing mechanism mediated by key proteins, including Dicer2, Argonaute2 (Ago2) and R2D2. …”
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93
Lysosomal Storage Disease-Associated Neuropathy: Targeting Stable Nucleic Acid Lipid Particle (SNALP)-Formulated siRNAs to the Brain as a Therapeutic Approach
Published 2020-08-01“…This concept is known as substrate reduction therapy and may be triggered by several molecules, such as small interfering RNAs (siRNAs). siRNAs promote RNA interference, a naturally occurring sequence-specific post-transcriptional gene-silencing mechanism, and may target virtually any gene of interest, inhibiting its expression. …”
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94
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95
Interferência por RNA: uma nova alternativa para terapia nas doenças reumáticas RNA interference: a new alternative for rheumatic diseases therapy
Published 2010-12-01“…Por fim, vamos revisar os últimos avanços da experiência clínica da terapia com RNAi<br>RNA interference (RNAi) is a post-transcriptional gene silencing mechanism preserved during evolution. …”
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96
EGCG‐LYS Fibrils‐Mediated CircMAP2K2 Silencing Decreases the Proliferation and Metastasis Ability of Gastric Cancer Cells in Vitro and in Vivo
Published 2023-11-01“…Further studies show that EGCG‐LYS carrying siRNA can successfully achieve lysosome escape, which allows it to be located in the cytoplasm to achieve post‐transcriptional gene silencing. In addition, EGCG‐LYS carrying si‐circMAP2K2 has good circulating stability, excellent biosafety and antitumor ability in vivo. …”
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97
Identification of natural host range of coconut cadang-cadang viroid and characterization of its small RNAs from oil palm
Published 2014“…In order to investigate the occurrence of Post-Transcriptional Gene Silencing (PTGS) and CCCVd small RNAs accumulation in oil palm, total small RNAs of 20-30 nt from two CCCVd infected asymptomatic and symptomatic oil palms were isolated and cloned. …”
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Thesis -
98
The P2 nucleic acid binding protein of Sugarcane bacilliform virus is a viral pathogenic factor
Published 2024-02-01“…The precise subcellular localization of P2 was verified in the transient infiltrated Nicotiana benthamiana epidermal mesophyll cells and protoplasts using the Laser scanning confocal microscope (LSCM). The post-transcriptional gene silencing (PTGS) and transcriptional gene silencing (TGS) RNA silencing suppressor activity of P2 was analyzed, respectively. …”
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99
Genetic reversal of the globin switch concurrently modulates both fetal and sickle hemoglobin and reduces red cell sickling
Published 2023-09-01“…Abstract We previously reported initial clinical results of post-transcriptional gene silencing of BCL11A expression (NCT 03282656) reversing the fetal to adult hemoglobin switch. …”
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100
Whitefly-tolerant transgenic common bean (Phaseolus vulgaris) line
Published 2022-08-01“…In the present work, two transgenic common bean lines were obtained with an intron-hairpin construct to induce post-transcriptional gene silencing against the B. tabaci vATPase (Bt-vATPase) gene, with stable expression of siRNA. …”
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