Implementation of a stepped wedge cluster randomized trial to evaluate a hospital mobility program by Susan N. Hastings, Karen M. Stechuchak, Ashley Choate, Elizabeth P. Mahanna, Courtney Van Houtven, Kelli D. Allen, Virginia Wang, Nina Sperber, Leah Zullig, Hayden B. Bosworth, Cynthia J. Coffman

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The Trade-off between Impartiality and Freedom in the 21st Century Cures Act by David Fraile Navarro, Niccolò Tempini, David Teira

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Expanding methods to address RE-AIM metrics in hybrid effectiveness-implementation studies by Samantha M. Harden, Karla I. Galaviz, Paul A. Estabrooks

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Assessing the efficacy of a stepped-care group treatment programme for borderline personality disorder: study protocol for a pragmatic trial by Judy A. Pickard, Adam Finch, Elizabeth Huxley, Michelle L. Townsend, Stephanie Deuchar, Kate L. Lewis, Jason Pratt, Brin F. S. Grenyer

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The impact of COVID-19 restrictions on participant enrollment in the PREPARE trial by David Pogorzelski, Paula McKay, Michael J. Weaver, Todd Jaeblon, Robert A. Hymes, Greg E. Gaski, Joanne Fraifogl, James S. Ahn, Sofia Bzovsky, Gerard Slobogean, Sheila Sprague, Gerard P. Slobogean, Sheila Sprague, Jeffrey Wells, Mohit Bhandari, Robert V. O'Toole, Jean-Claude D'Alleyrand, Andrew Eglseder, Aaron Johnson, Christopher Langhammer, Christopher Lebrun, Jason Nascone, Raymond Pensy, Andrew Pollak, Marcus Sciadini, Gerard P. Slobogean, Yasmin Degani, Haley K. Demyanovich, Andrea Howe, Nathan N. O'Hara, Heather Phipps, Eric Hempen

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Defining key design elements of registry-based randomised controlled trials: a scoping review by Bill Karanatsios, Khic-Houy Prang, Ebony Verbunt, Justin M. Yeung, Margaret Kelaher, Peter Gibbs

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Translating Clinical Guidelines Into Care Delivery Innovation: The Importance of Rigorous Methods for Generating Evidence by Adam N. Berman, Jason H. Wasfy

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Building to learn: Information technology innovations to enable rapid pragmatic evaluation in a learning health system by Geetanjali Rajamani, Genevieve B. Melton, Deborah L. Pestka, Maya Peters, Iva Ninkovic, Elizabeth Lindemann, Timothy J. Beebe, Nathan Shippee, Bradley Benson, Abraham Jacob, Christopher Tignanelli, Nicholas E. Ingraham, Joseph S. Koopmeiners, Michael G. Usher

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Use of a real-time risk-prediction model to identify pediatric patients at risk for thromboembolic events: study protocol for the Children’s Likelihood Of Thrombosis (CLOT) trial by Shannon C. Walker, Benjamin French, Ryan Moore, Henry J. Domenico, Jonathan P. Wanderer, Sreenivasa Balla, C. Buddy Creech, Daniel W. Byrne, Allison P. Wheeler

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Poor reporting quality and high proportion of missing data in economic evaluations alongside pragmatic trials: a cross-sectional survey by Yu Xin, Ruomeng Song, Jun Hao, Wentan Li, Changjin Wu, Ling Zuo, Yuanyi Cai, Xiyan Zhang, Huazhang Wu, Wen Hui

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Improving practice guidelines for the treatment of denture-related erythematous stomatitis: a study protocol for a randomized controlled trial by Raphael F. de Souza, Muhammad Faheem Khiyani, Carolina A. L. Chaves, Jocelyne Feine, Jean Barbeau, Ramón Fuentes, Eduardo Borie, Luciana C. Crizostomo, Claudia H. Silva-Lovato, Pierre Rompre, Elham Emami

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Understanding implementability in clinical trials: a pragmatic review and concept map by Miranda S. Cumpston, Steven A. Webb, Philippa Middleton, Greg Sharplin, Sally Green, for the Australian Clinical Trials Alliance Reference Group on Impact and Implementation of CTN Trials

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Streamlining the institutional review board process in pragmatic randomized clinical trials: challenges and lessons learned from the Aspirin Dosing: A Patient-centric Trial Assessi... by Guillaume Marquis-Gravel, Holly Robertson, W. Schuyler Jones, Danielle Riley, Daniel E. Ford, David Crenshaw, Yvonne A. Joosten, Lindsey Rudov, Adrian F. Hernandez, Rachel Hess

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Comparison of explanatory and pragmatic design choices in a cluster-randomized hypertension trial: effects on enrollment, participant characteristics, and adherence by Karen L. Margolis, A. Lauren Crain, Beverly B. Green, Patrick J. O’Connor, Leif I. Solberg, MarySue Beran, Anna R. Bergdall, Pamala A. Pawloski, Jeanette Y. Ziegenfuss, Meghan M. JaKa, Deepika Appana, Rashmi Sharma, Amy J. Kodet, Nicole K. Trower, Daniel J. Rehrauer, Zeke McKinney, Christine K. Norton, Patricia Haugen, Jeffrey P. Anderson, Benjamin F. Crabtree, Sarah K. Norman, JoAnn M. Sperl-Hillen

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Internet Versus Noninternet Participation in a Decentralized Clinical Trial: Lessons From the ADAPTABLE Study by Rebecca Shen, Hillary Mulder, Lisa Wruck, E. Hope Weissler, Holly R. Robertson, Amber G. Sharlow, Sunil Kripalani, Daniel Muñoz, Mark B. Effron, Kamal Gupta, Saket Girotra, Jeff Whittle, Catherine P. Benziger, Jeffrey J. VanWormer, Tamar S. Polonsky, Russell L. Rothman, Robert A. Harrington, Adrian F. Hernandez, W. Schuyler Jones

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Is this study feasible? Facilitating management of pragmatic trial planning milestones under a phased award funding mechanism by Paula Darby Lipman, Leanora Dluzak, Catherine M. Stoney

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Analysis of the characteristics and the degree of pragmatism exhibited by pragmatic-labelled trials of antineoplastic treatments by Robbe Saesen, Kevin Depreytere, Karyna Krupianskaya, Joël Langeweg, Julie Verheecke, Denis Lacombe, Isabelle Huys

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Operationalizing a model to quantify implementation of a multi-component intervention in a stepped-wedge trial by Linnea Ferm, Charlotte Diana Nørregaard Rasmussen, Marie Birk Jørgensen

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Benefits and challenges of using the cohort multiple randomised controlled trial design for testing an intervention for depression by Petter Viksveen, Clare Relton, Jon Nicholl

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Register or electronic health records enriched randomized pragmatic trials: The future of clinical effectiveness and cost-effectiveness trials? by Joakim Ramsberg, Martin Neovius

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