Insight into the molecular recognition of human and polar bear pregnane X receptor by three organic pollutants using molecular docking and molecular dynamics simulations by Ruige Wang, Yaqi Lin, Ying Sun, Bing Zhao, Lin Chen

Subjects: “…Polar bear pregnane X receptor…”
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The Pregnane X Receptor and Indole-3-Propionic Acid Shape the Intestinal Mesenchyme to Restrain Inflammation and FibrosisSummary by Kyle L. Flannigan, Kristoff M. Nieves, Holly E. Szczepanski, Alex Serra, Joshua W. Lee, Laurie A. Alston, Hena Ramay, Sridhar Mani, Simon A. Hirota

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Activation of PXR induces hypercholesterolemia in wild-type and accelerates atherosclerosis in apoE deficient mice[S] by Changcheng Zhou, Nakesha King, Kwan Y. Chen, Jan L. Breslow

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Targeting the pregnane X receptor using microbial metabolite mimicry by Zdeněk Dvořák, Felix Kopp, Cait M Costello, Jazmin S Kemp, Hao Li, Aneta Vrzalová, Martina Štěpánková, Iveta Bartoňková, Eva Jiskrová, Karolína Poulíková, Barbora Vyhlídalová, Lars U Nordstroem, Chamini V Karunaratne, Harmit S Ranhotra, Kyu Shik Mun, Anjaparavanda P Naren, Iain A Murray, Gary H Perdew, Julius Brtko, Lucia Toporova, Arne Schön, Bret D Wallace, William G Walton, Matthew R Redinbo, Katherine Sun, Amanda Beck, Sandhya Kortagere, Michelle C Neary, Aneesh Chandran, Saraswathi Vishveshwara, Maria M Cavalluzzi, Giovanni Lentini, Julia Yue Cui, Haiwei Gu, John C March, Shirshendu Chatterjee, Adam Matson, Dennis Wright, Kyle L Flannigan, Simon A Hirota, Ryan Balfour Sartor, Sridhar Mani

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Regulation of PXR Function by Coactivator and Corepressor Proteins: Ligand Binding Is Just the Beginning by Juan Pablo Rigalli, Dirk Theile, Julie Nilles, Johanna Weiss

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Probiotics mixture reinforces barrier function to ameliorate necrotizing enterocolitis by regulating PXR-JNK pathway by Xiuhao Zhao, Jin Zhou, Wenhua Liang, Qingfeng Sheng, Li Lu, Tong Chen, Jianglong Chen, Kezhe Tan, Zhibao Lv

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Pregnane X Receptor Activation in Liver Macrophages Protects against Endotoxin‐Induced Liver Injury by Tingting Zhao, Guoping Zhong, Ying Wang, Renjie Cao, Shaofei Song, Yuan Li, Guohui Wan, Haiyan Sun, Min Huang, Huichang Bi, Yiming Jiang

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Cannabidiol promotes intestinal cholesterol uptake mediated by Pregnane X receptor by Conner Brown, Wangeci Kariuki, Haizhen A. Zhong, Audra Kippes, Yipeng Sui

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Associations between Pregnane X Receptor and Breast Cancer Growth and Progression by Bradley A. Creamer, Shelly N. B. Sloan, Jennifer F. Dennis, Robert Rogers, Sidney Spencer, Andrew McCuen, Purnadeo Persaud, Jeff L. Staudinger

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Development and Experimental Validation of Regularized Machine Learning Models Detecting New, Structurally Distinct Activators of PXR by Steffen Hirte, Oliver Burk, Ammar Tahir, Matthias Schwab, Björn Windshügel, Johannes Kirchmair

Subjects: “…pregnane X receptor…”
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Modulation of Xenobiotic Receptors by Steroids by Delira Robbins, Monimoy Banerjee, Taosheng Chen

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Pregnane X Receptor Mediates Atherosclerosis Induced by Dicyclohexyl Phthalate in LDL Receptor-Deficient Mice by Jingwei Liu, Rebecca Hernandez, Xiuchun Li, Zhaojie Meng, Hong Chen, Changcheng Zhou

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Target Hopping from Protein Kinases to PXR: Identification of Small-Molecule Protein Kinase Inhibitors as Selective Modulators of Pregnane X Receptor from TüKIC Library by Enni-Kaisa Mustonen, Tatu Pantsar, Azam Rashidian, Juliander Reiner, Matthias Schwab, Stefan Laufer, Oliver Burk

Subjects: “…pregnane X receptor…”
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The Interface between Cell Signaling Pathways and Pregnane X Receptor by Robert S. Rogers, Annemarie Parker, Phill D. Vainer, Elijah Elliott, Dakota Sudbeck, Kaushal Parimi, Venkata P. Peddada, Parker G. Howe, Nick D’Ambrosio, Gregory Ruddy, Kaitlin Stackable, Megan Carney, Lauren Martin, Thomas Osterholt, Jeff L. Staudinger

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Pregnane X receptor activation promotes hematopoiesis during liver regeneration by inducing proliferation of hematopoietic stem and progenitor cells in mice by Shuang Hu, Chenghua Wu, Dan Li, Xiaowen Jiang, Peng Wang, Guofang Bi, Hui Ouyang, Fengting Liang, Wenhong Zhou, Xiao Yang, Jian-Hong Fang, Huichang Bi

Subjects: “…Pregnane X receptor…”
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Deficiency of PXR decreases atherosclerosis in apoE-deficient mice by Yipeng Sui, Jinxian Xu, Jennifer Rios-Pilier, Changcheng Zhou

Subjects: “…pregnane X receptor…”
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Mangrove Tirucallane- and Apotirucallane-Type Triterpenoids: Structure Diversity of the C-17 Side-Chain and Natural Agonists of Human Farnesoid/Pregnane–X–Receptor by Zhong-Ping Jiang, Zhi-Lin Luan, Ruo-Xi Liu, Qun Zhang, Xiao-Chi Ma, Li Shen, Jun Wu

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The Nuclear Receptor PXR in Chronic Liver Disease by Katia Sayaf, Ilaria Zanotto, Francesco Paolo Russo, Daniela Gabbia, Sara De Martin

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Alpha-Tocopherol Metabolites (The Vitamin E Metabolome) and Their Interindividual Variability during Supplementation by Desirée Bartolini, Rita Marinelli, Danilo Giusepponi, Roberta Galarini, Carolina Barola, Anna Maria Stabile, Bartolomeo Sebastiani, Fabiola Paoletti, Michele Betti, Mario Rende, Francesco Galli

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Marine and Semi-Synthetic Hydroxysteroids as New Scaffolds for Pregnane X Receptor Modulation by Valentina Sepe, Francesco Saverio Di Leva, Claudio D'Amore, Carmen Festa, Simona De Marino, Barbara Renga, Maria Valeria D'Auria, Ettore Novellino, Vittorio Limongelli, Lisette D'Souza, Mahesh Majik, Angela Zampella, Stefano Fiorucci

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