Some medical applications of the oxford scanning proton microprobe. by Vaux, D, Grime, G, Watt, F

“…Results from several medical investigations carried out using the Oxford scanning proton microprobe are presented, including maps of the hepatic copper-distribution in primary biliary cirrhosis and maps of the iron distribution in primary hemochromatosis. …”

The R Package JMbayes for Fitting Joint Models for Longitudinal and Time-to-Event Data Using MCMC by Dimitris Rizopoulos

“…All these features are illustrated using a real data example on patients with primary biliary cirrhosis.…”
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Primary autoimmune myelofibrosis: a report of three cases and review of the literature by Rakhee Kar, Shyamali Dutta, Seema Tyagi

“…In addition, myelofibrosis presenting as cytopenias and showing clinical response to immunosuppressant drugs, notably steroids, has been reported with a wide range of immune-mediated disorders, including Sjögren’s syndrome, polyarteritis nodosa, rheumatoid arthritis, ulcerative colitis, and primary biliary cirrhosis. Attempts have been made to define a syndrome of primary autoimmune myelofibrosis (PAIMF), as a distinct steroid-responsive clinicopathologic entity with excellent prognosis. …”
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Impact of ursodeoxycholic acid on circulating lipid concentrations: a systematic review and meta-analysis of randomized placebo-controlled trials by Luis E. Simental-Mendía, Mario Simental-Mendía, Adriana Sánchez-García, Maciej Banach, Maria-Corina Serban, Arrigo F. G. Cicero, Amirhossein Sahebkar

“…Conclusion This meta-analysis suggests that ursodeoxycholic acid therapy might be associated with significant total cholesterol lowering particularly in patients with primary biliary cirrhosis.…”
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Pernicious anemia with unusual associations by C A Mansoor

“…On further evaluation, he was found to have PA, duodenal carcinoids, and primary biliary cirrhosis. He was managed with heparin (followed by warfarin), parenteral Vitamin B12, and ursodeoxycholic acid. …”
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The Role of Gut Microbiota in Some Liver Diseases: From an Immunological Perspective by Li Wang, Zheng-Min Cao, Li-Li Zhang, Juan-mei Li, Wen-liang Lv

“…In this paper, we discuss the role of gut microbiota and its metabolites in the pathogenesis and development of autoimmune liver diseases((including autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis), metabolic liver disease such as non-alcoholic fatty liver disease, cirrhosisits and its complications, and liver cancer from the perspective of immune mechanism. …”
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Effect Over Dose of Metformin Drug in Pregnants White Mice Mus Musculus liver by Asmat Jamal Jameel, Aziz Khalid Hamid, Faeza Nasir Toama

“…The study included the effect of metformin drug over dose in the liver pregnant non – Diabetic mice with weight ranged (25±2) gm , Orally administration of ( 1.8 , 2.85) mg of drug from (6-18)th day of pregnancy in the morning and once time daily, Drug caused death in half number of animals in 1.8) ) mg concentrate and caused significant increase in liver weight in high concentration 2.85 mg and non significant in low concentration compared with control group ( non treated ) , In addition some histologically changes that included inflammatory cells around damaged blood vessels which increase with high dose caused primary biliary cirrhosis . Other changes include Degeneration , necrosis , Blood vessels damage ,Greenish, Congestion and hemorrhage and fibrosis in the liver of dead mice .…”
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Sex differences in autoimmune diseases by Voskuhl Rhonda

“…<p>Abstract</p> <p>Women are more susceptible to a variety of autoimmune diseases including systemic lupus erythematosus (SLE), multiple sclerosis (MS), primary biliary cirrhosis, rheumatoid arthritis and Hashimoto's thyroiditis. …”
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Cholangiopathy with Respect to Biliary Innate Immunity by Kenichi Harada, Yasuni Nakanuma

“…Moreover, in primary biliary cirrhosis (PBC) and biliary atresia, biliary innate immunity is closely associated with the dysregulation of the periductal cytokine milieu and the induction of biliary apoptosis and epithelial-mesenchymal transition (EMT), forming in disease-specific cholangiopathy. …”
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Dichotomizing continuous predictors in multiple regression: a bad idea. by Royston, P, Altman, D, Sauerbrei, W

“…We illustrate the impact of dichotomization of continuous predictor variables using as a detailed case study a randomized trial in primary biliary cirrhosis. Dichotomization of continuous data is unnecessary for statistical analysis and in particular should not be applied to explanatory variables in regression models.…”

Presence of human 65 kD heat shock protein (hsp) in inflamed joints and subcutaneous nodules of RA patients. by Karlsson-Parra, A, Söderström, K, Ferm, M, Ivanyi, J, Kiessling, R, Klareskog, L

“…A strong reactivity of the anti-hsp antibody was found in the cartilage-pannus junction in rheumatoid joints and in rheumatoid nodules, but not in normal joints or in normal or inflamed kidney or liver (irreversible graft rejection, chronic glomerulonephritis or primary biliary cirrhosis). The findings provide a new hypothetical explanation for a role of T cells reactive with the 65 kD hsp in the generation of both articular and extra-articular lesions in chronic rheumatoid arthritis.…”

Hypocalcaemia in a patient with chronic liver disease: a case report by Devaraj, Navin Kumar, Mohamad, Fadzilah, Abdul Rashid, Aneesa, Abdul Manap, Abdul Hadi, Sallahuddin, Nurin Amalina

“…This case looks at a 34-year-old woman with underlying chronic liver disease (primary biliary cirrhosis) and hypoalbuminemia presented with symptom of perioral and peripheral paraesthesia for three days and was then infused with slow intravenous calcium gluconate. …”
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Antineutrophil cytoplasmic antibodies in chronic liver diseases: prevalence, titre, specificity and IgG subclass. by Bansi, D, Chapman, R, Fleming, K

“…For autoimmune hepatitis, antineutrophil cytoplasmic antibodies were detected in 49% at 1:5, dropping to 11% at 1:50. Only 6% of primary biliary cirrhosis patients were antineutrophil cytoplasmic antibody-positive at 1:5, dropping to 3% at 1:50. …”

Retrospective Review of Pediatric and Adult Autoimmune Hepatitis in Two Quaternary Care Centres in British Columbia: Increased Prevalence Seen in British Columbia’S First Nations C... by Henry V Chung, Mark Riley, Jin K Ho, Benjamin Leung, Gareth P Jevon, Laura T Arbour, Colin Barker, Richard Schreiber, Eric M Yoshida

“…BACKGROUND: It has been previously reported that British Columbia’s (BC’s) First Nations (Aboriginal) community has an increased risk of autoimmune diseases, including rheumatological conditions (rheumatoid arthritis, systemic lupus) and primary biliary cirrhosis. The researchers hypothesized that this community may also be at increased risk for autoimmune hepatitis (AIH).…”
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Use of ursodeoxycholic acid in patients with hypertransaminasemia by Claudio Puoti, Maria Giuseppa Elmo

“…It may have antioxidant, immunomodulatory, antifibrotic and cytoprotective effects, therefore it has been extensively used in the treatment of cholestatic chronic liver diseases (primary biliary cirrhosis, primary sclerosing cholangitis, cholestasis of pregnancy, etc.). …”
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The Histone Modification Code in the Pathogenesis of Autoimmune Diseases by Yasuto Araki, Toshihide Mimura

“…In this paper, we discuss the significant roles of histone modifications involved in the pathogenesis of autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, primary biliary cirrhosis, and type 1 diabetes.…”
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Peripheral blood and portal tract lymphocyte populations in primary sclerosing cholangitis. by Snook, J, Chapman, R, Sachdev, G, Heryet, A, Kelly, P, Fleming, K, Jewell, D

“…The portal tract t lymphocyte count per high power field (mean +/- S.D.) was higher in pre-cirrhotic PSC (173 +/- 105) and primary biliary cirrhosis (PBC: 210 +/- 110) than in histologically normal liver (42 +/- 27). …”

Biliary expression of heat shock protein: a non-specific feature of chronic cholestatic liver diseases. by Martins, E, Chapman, R, Marron, K, Fleming, K

“…METHODS: Hepatic expression of HSP-60 in frozen liver biopsy specimens from patients with primary sclerosing cholangitis (PSC), primary biliary cirrhosis (PBC), auto-immune hepatitis (AIH), obstructive jaundice (LDO), alcoholic liver disease (ALD), and from normal controls was studied by immunohistochemistry using the APAAP technique and confocal laser scanning microscopy. …”

Essential thrombocythemia, hemolytic anemia and hepatic cirrhosis: Could there be an association? by Nata Pratama Hardjo Lugito, Andree Kurniawan, Yohanes Chandra Kurniawan, Enny Yacobus, Edwin Halim

“…Association betweeen autoimmune hemolytic anemia and primary biliary cirrhosis or hepatic cirrhosis has been discussed. …”
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Survival prediction based on compound covariate under Cox proportional hazard models. by Takeshi Emura, Yi-Hau Chen, Hsuan-Yu Chen

“…Two datasets, the primary biliary cirrhosis of the liver data and the non-small-cell lung cancer data, are used for illustration. …”
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