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Prion switching in response to environmental stress.
Published 2008-11-01“…Capacitor systems, which allow the accumulation of cryptic genetic variation and release it under stressful conditions, might provide such a mechanism. In yeast, the prion [PSI(+)] exposes a large array of previously hidden genetic variation, and the phenotypes it thereby produces are advantageous roughly 25% of the time. …”
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182
Oligomeropathies, inflammation and prion protein binding
Published 2022-08-01“…In these experimental conditions the proposed mediatory role of cellular prion protein in oligomer activities was not confirmed. …”
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Biochemical Principles in Prion-Based Inheritance
Published 2022-01-01Subjects: “…prion…”
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Prion proliferation with unbounded polymerization rates
Published 2007-02-01Subjects: Get full text
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Direct detection of soil-bound prions.
Published 2007-01-01“…Scrapie and chronic wasting disease are contagious prion diseases affecting sheep and cervids, respectively. …”
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Genetic aspects of human prion diseases
Published 2022-10-01Subjects: “…prion disease…”
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192
Involvement of Endogenous Retroviruses in Prion Diseases
Published 2013-08-01Subjects: “…prion diseases…”
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193
Human prion diseases in the United States.
Published 2010-01-01“…<h4>Background</h4>Prion diseases are a family of rare, progressive, neurodegenerative disorders that affect humans and animals. …”
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194
Prions and animal transmissible spongiform encephalopathies
Published 2017-01-01“…We still have incomplete knowledge of prions and prion diseases. Scrapie has been present for a very long time and controlled with varied success. …”
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Prion therapeutics: Lessons from the past
Published 2022-12-01Subjects: “…Prions disease…”
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196
The Prion Basis of Progressive Neurodegenerative Disorders
Published 2023-01-01“…In contrast, the proteinaceous agents of disease, called prion proteins (PrP), lacked nucleic acids and propagated by binding to the functional, endogenous form of cellular prion protein (referred to as PrPC) and altering its conformation to produce the infectious disease-causing misfolded protein (referred to as PrPSc). …”
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Biochemical insight into the prion protein family
Published 2015-02-01Subjects: Get full text
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Prion propagation in vitro: are we there yet?
Published 2008-01-01“…<p>Prion diseases are caused by proteinaceous pathogens termed prions. …”
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Differential Toxicity of Antibodies to the Prion Protein.
Published 2016-01-01“…Antibodies against the prion protein PrPC can antagonize prion replication and neuroinvasion, and therefore hold promise as possible therapeutics against prion diseases. …”
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