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Prion replication environment defines the fate of prion strain adaptation.
Published 2018-06-01“…The main risk of emergence of prion diseases in humans is associated with a cross-species transmission of prions of zoonotic origin. …”
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Yeast prions: proteins templating conformation and an anti-prion system.
Published 2015-02-01Get full text
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Prion propagation and cellular dysfunction in prion disease: Disconnecting the dots
Published 2023-10-01Get full text
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Recombinant Mammalian Prions: The “Correctly” Misfolded Prion Protein Conformers
Published 2022-08-01Subjects: Get full text
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Prion propagation and cellular dysfunction in prion disease: Disconnecting the dots.
Published 2023-10-01Get full text
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Endoproteolysis of cellular prion protein by plasmin hinders propagation of prions
Published 2022-09-01Subjects: Get full text
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The elusive role of the prion protein and the mechanism of toxicity in prion disease.
Published 2015-05-01Get full text
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Early preclinical detection of prions in the skin of prion-infected animals
Published 2019-01-01“…There are currently no validated methods for the diagnosis of prion disease at the preclinical stage. Here the authors show that serial protein misfolding cyclic amplification and real-time quaking-induced conversion can be used to detect prions in the skin of prion-inoculated hamsters and humanized transgenic mice at early preclinical stages.…”
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Modulation of Neuroinflammation by the Gut Microbiota in Prion and Prion-Like Diseases
Published 2021-07-01Subjects: Get full text
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Virus Infection, Genetic Mutations, and Prion Infection in Prion Protein Conversion
Published 2021-11-01Subjects: “…prion…”
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Neurotoxic Antibodies against the Prion Protein Do Not Trigger Prion Replication.
Published 2016-01-01“…Antibodies targeting the globular domain (GD) of the cellular prion protein PrPC trigger a neurotoxic syndrome morphologically and molecularly similar to prion disease. …”
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The Role of Vesicle Trafficking Defects in the Pathogenesis of Prion and Prion-Like Disorders
Published 2020-09-01Subjects: “…prion…”
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Human prion diseases and the prion protein – what is the current state of knowledge?
Published 2023-10-01“…Prion diseases and the prion protein are only partially understood so far in many aspects. …”
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Glycoform-selective prion formation in sporadic and familial forms of prion disease.
Published 2013-01-01“…The four glycoforms of the cellular prion protein (PrP(C)) variably glycosylated at the two N-linked glycosylation sites are converted into their pathological forms (PrP(Sc)) in most cases of sporadic prion diseases. …”
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Neurotoxicity of prion peptides mimicking the central domain of the cellular prion protein.
Published 2013-01-01Get full text
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Copper coordination modulates prion conversion and infectivity in mammalian prion proteins
Published 2023-12-01Subjects: “…prion…”
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N-Terminal Regions of Prion Protein: Functions and Roles in Prion Diseases
Published 2020-08-01Subjects: “…prion protein…”
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Transmission of Atypical Bovine Prions to Mice Transgenic for Human Prion Protein
Published 2008-12-01Subjects: “…prions…”
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Susceptibility of Human Prion Protein to Conversion by Chronic Wasting Disease Prions
Published 2018-08-01Subjects: “…prion…”
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