Burrowing into prion disease. by Deacon, R, Raley, J, Perry, V, Rawlins, J

“…Burrowing is a simple, sensitive, objective, ethological measure, sensitive to preclinical prion disease. Other potential applications are in transgenic and knockout mice, models of ageing and Alzheimer's disease, and pharmacology, particularly neuroleptics.…”

Glycosylation and prion protein. by Rudd, P, Merry, A, Wormald, M, Dwek, R

“…Recent advances have elucidated the detailed glycosylation of the prion protein and highlighted the size of the sugars, which shield large areas of the protein and confer some conformational stability on the normal cellular form. …”

There is no safe dose of prions. by Fryer, H, Mclean, A

“…These data are compared to results from a within-host model in which prions accumulate according to a stochastic birth-death process. …”

Thermodynamic Stabilization of the Folded Domain of Prion Protein Inhibits Prion Infection in Vivo by Qingzhong Kong, Jeffrey L. Mills, Bishwajit Kundu, Xinyi Li, Liuting Qing, Krystyna Surewicz, Ignazio Cali, Shenghai Huang, Mengjie Zheng, Wieslaw Swietnicki, Frank D. Sönnichsen, Pierluigi Gambetti, Witold K. Surewicz

“…Prion diseases, or transmissible spongiform encephalopathies (TSEs), are associated with the conformational conversion of the cellular prion protein, PrPC, into a protease-resistant form, PrPSc. …”
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Membrane Domain Localization and Interaction of the Prion-Family Proteins, Prion and Shadoo with Calnexin by Divya Teja Dondapati, Pradeep Reddy Cingaram, Ferhan Ayaydin, Antal Nyeste, Andor Kanyó, Ervin Welker, Elfrieda Fodor

“…The cellular prion protein (PrP^C) is renowned for its infectious conformational isoform PrP^Sc, capable of templating subsequent conversions of healthy PrP^Cs and thus triggering the group of incurable diseases known as transmissible spongiform encephalopathies. …”
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Accelerated high fidelity prion amplification within and across prion species barriers. by Kristi M Green, Joaquín Castilla, Tanya S Seward, Dana L Napier, Jean E Jewell, Claudio Soto, Glenn C Telling

“…Experimental obstacles have impeded our ability to study prion transmission within and, more particularly, between species. …”
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Prion and Prion-Like Protein Strains: Deciphering the Molecular Basis of Heterogeneity in Neurodegeneration by Carlo Scialò, Elena De Cecco, Paolo Manganotti, Giuseppe Legname

Subjects: “…prion…”
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Failure To Detect Prion Infectivity in Ticks following Prion-Infected Blood Meal by Ronald A. Shikiya, Anthony E. Kincaid, Jason C. Bartz, Travis J. Bourret

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Radotinib Decreases Prion Propagation and Prolongs Survival Times in Models of Prion Disease by Yeong-Gon Choi, Byungki Jang, Jeong-Ho Park, Min-Woo Choi, Gong Yeal Lee, Dae Jin Cho, Hong Youp Kim, Hae Kyoung Lim, Won Jae Lee, Eun-Kyoung Choi, Yong-Sun Kim

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Correction: Glycoform-Selective Prion Formation in Sporadic and Familial Forms of Prion Disease. by Xiangzhu Xiao, Jue Yuan, Stéphane Haïk, Ignazio Cali, Yian Zhan, Mohammed Moudjou, Baiya Li, Jean-Louis Laplanche, Hubert Laude, Jan Langeveld, Pierluigi Gambetti, Tetsuyuki Kitamoto, Qingzhong Kong, Jean-Philippe Brandel, Brian A. Cobb, Robert B. Petersen, Wen-Quan Zou

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Contrasting Effects of Two Lipid Cofactors of Prion Replication on the Conformation of the Prion Protein. by Saurabh Srivastava, Ilia V Baskakov

“…Recent studies introduced two experimental protocols for converting full-length recombinant prion protein (rPrP) purified from E.coli into the infectious prion state (PrPSc) with high infectivity titers. …”
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Correction: Glycoform-Selective Prion Formation in Sporadic and Familial Forms of Prion Disease

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Evidence for preexisting prion substrain diversity in a biologically cloned prion strain. by Tess Gunnels, Ronald A Shikiya, Taylor C York, Alyssa J Block, Jason C Bartz

“…Prions are composed of PrPSc, the disease specific conformation of the host encoded prion protein. …”
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The Way forward for the Origin of Life: Prions and Prion-Like Molecules First Hypothesis by Sohan Jheeta, Elias Chatzitheodoridis, Kevin Devine, Janice Block

Subjects: “…prions…”
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Ex vivomammalian prions are formed of paired double helical prion protein fibrils by Terry, Cassandra, Wenborn, Adam, Gros, Nathalie, Sells, Jessica, Joiner, Susan, Hosszu, Laszlo L. P., Tattum, M. Howard, Panico, Silvia, Clare, Daniel K., Collinge, John, Saibil, Helen R., Wadsworth, Jonathan D. F.

“…Mammalian prions are hypothesized to be fibrillar or amyloid forms of prion protein (PrP), but structures observed to date have not been definitively correlated with infectivity and the three-dimensional structure of infectious prions has remained obscure. …”
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The way forward for the origin of life: prions and prion-like molecules first hypothesis by Jheeta, Sohan, Chatzitheodoridis, Elias, Devine, Kevin G., Block, Janice

“…In this paper the hypothesis that prions and prion-like molecules could have initiated the chemical evolutionary process which led to the eventual emergence of life is reappraised. …”
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Bank vole prion protein extends the use of RT-QuIC assays to detect prions in a range of inherited prion diseases by Tze How Mok, Akin Nihat, Connie Luk, Danielle Sequeira, Mark Batchelor, Simon Mead, John Collinge, Graham S. Jackson

“…Abstract The cerebrospinal fluid (CSF) real-time quaking-induced conversion assay (RT-QuIC) is an ultrasensitive prion amyloid seeding assay for diagnosis of sporadic Creutzfeldt–Jakob disease (CJD) but several prion strains remain unexplored or resistant to conversion with commonly used recombinant prion protein (rPrP) substrates. …”
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Inherited prion disease A117V is not simply a proteinopathy but produces prions transmissible to transgenic mice expressing homologous prion protein. by Emmanuel A Asante, Jacqueline M Linehan, Michelle Smidak, Andrew Tomlinson, Andrew Grimshaw, Asif Jeelani, Tatiana Jakubcova, Shyma Hamdan, Caroline Powell, Sebastian Brandner, Jonathan D F Wadsworth, John Collinge

“…Prions are infectious agents causing fatal neurodegenerative diseases of humans and animals. …”
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<i>C. elegans</i> Models to Study the Propagation of Prions and Prion-Like Proteins by Carl Alexander Sandhof, Simon Oliver Hoppe, Jessica Tittelmeier, Carmen Nussbaum-Krammer

Subjects: “…prions…”
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A unifying model for the propagation of prion proteins in yeast brings insight into the [PSI+] prion. by Paul Lemarre, Laurent Pujo-Menjouet, Suzanne S Sindi

“…The use of yeast systems to study the propagation of prions and amyloids has emerged as a crucial aspect of the global endeavor to understand those mechanisms. …”
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