Probenecid by Evan C. Klein, MD, Jack Rubinstein, MD, Jennifer L. Strande, MD, PhD

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Influence of Probenecid on the Pharmacokinetics and Pharmacodynamics of Sorafenib by Koen G. A. M. Hussaarts, Leni van Doorn, Karel Eechoute, Jeffrey Damman, Qiang Fu, Nadia van Doorn, Eric D. Eisenmann, Alice A. Gibson, Esther Oomen-de Hoop, Peter de Bruijn, Sharyn D. Baker, Stijn L. W. Koolen, Teun van Gelder, Roelof W. F. van Leeuwen, Ron H. J. Mathijssen, Alex Sparreboom, Sander Bins

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Chemosensitization of Plasmodium falciparum by probenecid in vitro. by Nzila, A, Mberu, E, Bray, P, Kokwaro, G, Winstanley, P, Marsh, K, Ward, S

“…In the present study we tested the ability of probenecid to reverse antifolate resistance in P. falciparum in vitro. …”

Probenecid Inhibits Respiratory Syncytial Virus (RSV) Replication by Jackelyn Murray, Harrison C. Bergeron, Les P. Jones, Zachary Beau Reener, David E. Martin, Fred D. Sancilio, Ralph A. Tripp

“…The studies showed that nanomolar concentrations of all probenecid regimens prevent RSV strain A and B replication in vitro and RSV strain A in vivo, representing a potential prophylactic and chemotherapeutic for RSV.…”
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Antiviral Activity of Probenecid and Oseltamivir on Influenza Virus Replication by Jackelyn Murray, David E. Martin, Fred D. Sancilio, Ralph A. Tripp

“…In this study, we evaluated the efficacy of the neuraminidase inhibitor, oseltamivir, against probenecid, which targets the host cells and is less likely to engender resistance. …”
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Effect of Probenecid on Pharmacokinetics and Tolerability of Olmesartan in Healthy Chinese Volunteers by Kun-Yan Li, PhD, Yu Qiu, MS, Yun Jiang, BS, Chen-Hui Luo, MS, Xiao-Ping Lin, BS, Jing Wang, BS, Nong Yang, MS

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Effects of probenecid and cimetidine on the pharmacokinetics of nemonoxacin in healthy Chinese volunteers by Zhang YF, Dai XJ, Yang Y, Chen XY, Wang T, Tang YB, Tsai CY, Chang LW, Chang YT, Zhong DF

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A transcriptomic study of probenecid on injured spinal cords in mice by Yu-Xin Zhang, Sai-Nan Wang, Jing Chen, Jian-Guo Hu, He-Zuo Lü

Subjects: “…Probenecid…”
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Combination of probenecid-sulphadoxine-pyrimethamine for intermittent preventive treatment in pregnancy by Gutman Julie, Kachur S, Slutsker Laurence, Nzila Alexis, Mutabingwa Theonest

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Oral Probenecid for Nonhospitalized Adults with Symptomatic Mild-to-Moderate COVID-19 by David E. Martin, Neelam Pandey, Purvi Chavda, Gurpreet Singh, Rakesh Sutariya, Frederic Sancilio, Ralph A. Tripp

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Probenecid inhibits SARS-CoV-2 replication in vivo and in vitro by Jackelyn Murray, Robert J. Hogan, David E. Martin, Kathy Blahunka, Fred D. Sancilio, Rajiv Balyan, Mark Lovern, Richard Still, Ralph A. Tripp

“…These data support the potential clinical utility of probenecid to control SARS-CoV-2 infection in humans.…”
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Probenecid treatment improves outcomes in a novel mouse model of peripartum cardiomyopathy. by Evan Onusko, Michael R McDermott, Nathan Robbins, Guansheng Liu, Evangelia G Kranias, Jack Rubinstein, Sheryl E Koch

“…This study tested the use of probenecid on a novel mouse model of peripartum cardiomyopathy (PPCM) as a potential treatment option. …”
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Influence of probenecid on endoxifen systemic exposure in breast cancer patients on adjuvant tamoxifen treatment by Stefan A. J. Buck, C. Louwrens Braal, Maaike M. Hofman, Esther Oomen-de Hoop, Peter de Bruijn, Inge M. Ghobadi Moghaddam-Helmantel, Koen G. A. M. Hussaarts, Mijntje B. Vastbinder, Quirine C. van Rossum-Schornagel, Ron H. N. van Schaik, Agnes Jager, Stijn L. W. Koolen, Ron H. J. Mathijssen

“…We hypothesized that we could increase endoxifen concentrations by induction of its formation and inhibition of its metabolism by co-administration of probenecid. Methods: We conducted a crossover study and measured endoxifen concentrations in patients on steady-state tamoxifen monotherapy and after 14 days of combination treatment with probenecid. …”
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Neuroprotective Effects of the Pannexin-1 Channel Inhibitor: Probenecid on Spinal Cord Injury in Rats by Qi Qi, Qi Qi, Xiao-Xuan Wang, Xiao-Xuan Wang, Jing-Lu Li, Jing-Lu Li, Yu-Qing Chen, Yu-Qing Chen, Jian-Rong Chang, Jin Xi, He-Zuo Lü, He-Zuo Lü, He-Zuo Lü, Yu-Xin Zhang, Yu-Xin Zhang

Subjects: “…probenecid…”
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Smilagenin Protects Dopaminergic Neurons in Chronic MPTP/Probenecid—Lesioned Parkinson’s Disease Models by Xuan He, Shuangshuang Yang, Rui Zhang, Lina Hou, Jianrong Xu, Yaer Hu, Rang Xu, Hao Wang, Yongfang Zhang

“…Recent work elucidates whether smilagenin (abbreviated SMI), a steroidal sapogenin from traditional Chinese medicinal herbs, can take neuroprotective effect on dopaminergic neurons in a chronic model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) conjuncted with probenecid mice. We reported for the first time that SMI significantly improved the locomotor ability of chronic MPTP/probenecid–lesioned mice. …”
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Probenecid, an Old Drug with Potential New Uses for Central Nervous System Disorders and Neuroinflammation by Claudia García-Rodríguez, Paula Mujica, Javiera Illanes-González, Araceli López, Camilo Vargas, Juan C. Sáez, Arlek González-Jamett, Álvaro O. Ardiles

Subjects: “…probenecid…”
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Effect of Probenecid on Endothelial Cell Growth Rate and Retinal Angiogenesis in an Oxygen-Induced Retinopathy Model by Jingbo Jiang, Weiming Ou, Xianqiong Luo, Jianwen Xiang, Guosheng Liu, Shuiqing Huang, Hongping Li, Longkai He, Jiamin Gan, Shasha Han, Chuan Nie

“…In OIR rats, probenecid was administered by intraperitoneal injection (i.p.) from postnatal day (P) 1 to P7. …”
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Probenecid slows disease progression in a murine model of autosomal dominant polycystic kidney disease by Sergey N. Arkhipov, D'Anna L. Potter, Regina F. Sultanova, Daria V. Ilatovskaya, Peter C. Harris, Tengis S. Pavlov

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Probenecid Improves Cardiac Function in Patients With Heart Failure With Reduced Ejection Fraction In Vivo and Cardiomyocyte Calcium Sensitivity In Vitro by Nathan Robbins, Mark Gilbert, Mohit Kumar, James W. McNamara, Patrick Daly, Sheryl E. Koch, Ginger Conway, Mohamed Effat, Jessica G. Woo, Sakthivel Sadayappan, Jack Rubinstein

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Two fabricated carbon paste electrodes for novel potentiometric determination of probenecid in dosage form and human plasma by Mahmoud A. Tantawy, Israa A. Wahba, Samah S. Saad, Nesrin K. Ramadan

“…The modified carbon paste electrode successfully detected up to 8.0 × 10−7 mol/L probenecid. Results of this modified carbon paste electrode were also compared to unmodified one.…”
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