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Molecular clock in neutral protein evolution
Published 2004-08-01“…</p> <p>Results</p> <p>Here, I study the behavior of the molecular clock in <it>in silico </it>protein evolution as a function of mutation rate and population size. …”
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The effects of network neighbours on protein evolution.
Published 2011-01-01“…The strongest known predictor of the rate of protein evolution remains expression level. We confirmed the previous observation that similar expression levels of neighbours indeed explain their similar evolution rates in protein-protein networks, and showed that the same is true for metabolic networks. …”
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Quantitative Analysis of Protein Evolution: The Phylogeny of Osteopontin
Published 2021-08-01“…We build on our prior phylogenetic analysis of the cytokine Osteopontin to validate the quantitative approach toward the study of protein evolution. Phylogenetic trees constructed from the number strings differentiate among all sequences. …”
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Correction: thermodynamic system drift in protein evolution.
Published 2015-02-01Get full text
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Aggregation is a Context-Dependent Constraint on Protein Evolution
Published 2021-06-01“…Thus, understanding the relationship between protein evolution and aggregation is an important goal. …”
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Photoconvertible Fluorescent Proteins and the Role of Dynamics in Protein Evolution
Published 2017-08-01Get full text
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Protein evolution via amino acid and codon elimination.
Published 2010-04-01“…Using GFP as the model protein, we present a strategy, termed protein evolution via amino acid and codon elimination, through which simplified, native-like polypeptides encoded by a reduced genetic code were obtained via screening of reduced-size ensembles.…”
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Rate and breadth of protein evolution are only weakly correlated
Published 2012-02-01“…</p> <p>Conclusions</p> <p>Rate and breadth are two distinct, and only weakly correlated, characteristics of protein evolution. The most likely explanation of their positive correlation is heterogeneity of selective constraint, such that less functionally important sites evolve faster and can accept more amino acids.…”
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Divergence, recombination and retention of functionality during protein evolution
Published 2005-09-01“…To address this, we have been simulating protein evolution in the context of structure and function using lattice models of proteins and ligands (or substrates). …”
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β-Propeller blades as ancestral peptides in protein evolution.
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