Optimal Androgen Deprivation Therapy Combined with Proton Beam Therapy for Prostate Cancer: Results from a Multi-Institutional Study of the Japanese Radiation Oncology Study Group by Motohiro Murakami, Hitoshi Ishikawa, Shosei Shimizu, Hiromitsu Iwata, Tomoaki Okimoto, Masaru Takagi, Shigeyuki Murayama, Tetsuo Akimoto, Hitoshi Wada, Takeshi Arimura, Yoshitaka Sato, Masahiko Gosho, Katsumasa Nakamura, Hideyuki Sakurai

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Photon Versus Proton Beam Therapy for T1–3 Squamous Cell Carcinoma of the Thoracic Esophagus Without Lymph Node Metastasis by Yang-Gun Suh, Unurjargal Bayasgalan, Heung Tae Kim, Jong Mog Lee, Moon Soo Kim, Youngjoo Lee, Doo Yeul Lee, Sung Uk Lee, Tae Hyun Kim, Sung Ho Moon

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Efficacy and Feasibility of Proton Beam Therapy in Relapsed High-Risk Neuroblastoma-Experiences from the Prospective KiProReg Registry by Danny Jazmati, Barbara Hero, Theresa M. Thole.-Kliesch, Julien Merta, Hedwig E. Deubzer, Christian Bäumer, Feline Heinzelmann, Stefanie Schulze Schleithoff, Friederike Koerber, Angelika Eggert, Rudolf Schwarz, Thorsten Simon, Beate Timmermann

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Charged particles in radiotherapy: A 5-year update of a systematic review by De Ruysscher, D, Mark Lodge, M, Jones, B, Brada, M, Munro, A, Jefferson, T, Pijls-Johannesma, M

“…Although proton therapy has been used for many decades because of their superior dose distribution over photons and reduced integral dose, their clinical implementation is still controversial. …”

Charged particles in radiotherapy: a 5-year update of a systematic review. by De Ruysscher, D, Mark Lodge, M, Jones, B, Brada, M, Munro, A, Jefferson, T, Pijls-Johannesma, M

“…Although proton therapy has been used for many decades because of their superior dose distribution over photons and reduced integral dose, their clinical implementation is still controversial. …”

Proton Irradiation Increases the Necessity for Homologous Recombination Repair Along with the Indispensability of Non-Homologous End Joining by Klaudia Szymonowicz, Adam Krysztofiak, Jansje van der Linden, Ajvar Kern, Simon Deycmar, Sebastian Oeck, Anthony Squire, Benjamin Koska, Julian Hlouschek, Melanie Vüllings, Christian Neander, Jens T. Siveke, Johann Matschke, Martin Pruschy, Beate Timmermann, Verena Jendrossek

“…Technical improvements in clinical radiotherapy for maximizing cytotoxicity to the tumor while limiting negative impact on co-irradiated healthy tissues include the increasing use of particle therapy (e.g., proton therapy) worldwide. Yet potential differences in the biology of DNA damage induction and repair between irradiation with X-ray photons and protons remain elusive. …”
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Comparison of knife-edge and multi-slit camera for proton beam range verification by Monte Carlo simulation by Jong Hoon Park, Sung Hun Kim, Youngmo Ku, Hyun Su Lee, Chan Hyeong Kim, Dong Ho Shin, Jong Hwi Jeong

“…The mechanical-collimation imaging is the most mature technology in prompt gamma (PG) imaging which is considered the most promising technology for beam range verification in proton therapy. The purpose of the present study is to compare the performances of two mechanical-collimation PG cameras, knife-edge (KE) camera and multi-slit (MS) camera. …”
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MCNPX simulations of the response of the extended-range rem meter WENDI-2 by de Smet Valerie, Gerardy Isabelle, Stichelbaut Frederic, Tolo Silvia

“…Proton therapy uses proton beams with energies typically between 50 and 230 MeV to treat cancerous tumors very efficiently, while protecting as much as possible surrounding healthy tissues from radiation damage. …”
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Proton Beam Therapy for Intrahepatic Cholangiocarcinoma: A Multicenter Prospective Registry Study in Japan by Masashi Mizumoto, Kazuki Terashima, Hirokazu Makishima, Motohisa Suzuki, Takashi Ogino, Takahiro Waki, Hiromitsu Iwata, Hiroyasu Tamamura, Yusuke Uchinami, Tetsuo Akimoto, Tomoaki Okimoto, Takashi Iizumi, Masao Murakami, Norio Katoh, Kazushi Maruo, Kei Shibuya, Hideyuki Sakurai

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Effective Organs-at-Risk Dose Sparing in Volumetric Modulated Arc Therapy Using a Half-Beam Technique in Whole Pelvic Irradiation by Hyunsoo Jang, Jiyeon Park, Jiyeon Park, Mark Artz, Mark Artz, Yawei Zhang, Yawei Zhang, Jacob C. Ricci, Soon Huh, Soon Huh, Perry B. Johnson, Perry B. Johnson, Mi-Hwa Kim, Mison Chun, Young-Taek Oh, O Kyu Noh, Hae-Jin Park

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Strategic Operational Redesign Improves Prior Authorization Access: A Validation Study by Eric D. Brooks, MD, MHS, Fantine Giap, MD, Vincent Cassidy, MD, Matthew S. Ning, MD, MPH, Bradlee Robbert, FACHE, MHA, RT(R)(T), Polly Redding, MBS, CPC, CHONC, Matthew Palmer, MBA, L. Montreal Turner, MBA, MHA, CMD, PMP, William M. Mendenhall, MD, Stuart Klein, MHA, Nancy P. Mendenhall, MD

“…Here, we describe the impact of a strategic novel operational PA redesign to shorten authorization time and to improve patient access to cancer care at a large United States academic proton therapy center. We ask whether such a redesign may be replicable and adoptable across oncology centers. …”
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Effect of Proton Radiation on DNA Damage in Human Malignant Melanoma A375 Cell by WANG Qiaojuan1,2;SUI Li1,2,*;LIU Jiancheng1,2;WANG Yue1,2;MA Liqiu1,2;ZHU Run1;GUO Gang1,2,*

“…However, to fully exploit the potential of proton therapy, it is important to understand the biological effects of proton radiation on cancer cells and normal tissues. …”

A Beam-Specific Optimization Target Volume for Stereotactic Proton Pencil Beam Scanning Therapy for Locally Advanced Pancreatic Cancer by Dong Han, PhD, Hamed Hooshangnejad, MS, Chin-Cheng Chen, PhD, Kai Ding, PhD

“…The beam-specific margin can be attractive to online adaptive stereotactic body proton therapy owing to the efficiency of the plan optimization.…”
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Photon- and Proton-Mediated Biological Effects: What Has Been Learned? by Enar Jumaniyazova, Daniil Smyk, Polina Vishnyakova, Timur Fatkhudinov, Konstantin Gordon

“…After systematic analysis of the literature, we can conclude that proton therapy has potentially favorable toxicological profiles compared to photon irradiation, explained mainly by physical but also biological properties of protons. …”
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Prostate bed irradiation with alternative radio-oncological approaches (PAROS) - a prospective, multicenter and randomized phase III trial by Stefan A. Koerber, Sonja Katayama, Anja Sander, Cornelia Jaekel, Matthias F. Haefner, Juergen Debus, Klaus Herfarth

“…Further, the role of proton therapy is still under debate. Two prospective phase II trials with both, hypofractionated photon and proton therapy, provided promising results. …”
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A novel optimization algorithm for enabling dynamically collimated proton arc therapy by Blake R. Smith, Ryan T. Flynn, Daniel E. Hyer

“…Abstract The advent of energy-specific collimation in pencil beam scanning (PBS) proton therapy has led to an improved lateral dose conformity for a variety of treatment sites, resulting in better healthy tissue sparing. …”
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Risk of second primary cancer from proton arc therapy of pediatric brain tumors by Laura Toussaint, Daniel J Indelicato, Ludvig P Muren, Camilla H Stokkevåg

“…Two brain-specific models for SPC induction were applied in five cases to compare volumetric modulated arc therapy (VMAT), intensity modulated proton therapy (IMPT) and PAT surrogate plans. The PAT integral dose was reduced by a median of 29% compared to VMAT, and 17% compared to IMPT. …”
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Validating a double Gaussian source model for small proton fields in a commercial Monte-Carlo dose calculation engine by Fabian Kugel, Jörg Wulff, Christian Bäumer, Martin Janson, Jana Kretschmer, Leonie Brodbek, Carina Behrends, Nico Verbeek, Hui Khee Looe, Björn Poppe, Beate Timmermann

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Patient-Derived Nasopharyngeal Cancer Organoids for Disease Modeling and Radiation Dose Optimization by Sasidharan Swarnalatha Lucky, Martin Law, Ming Hong Lui, Jamie Mong, Junli Shi, Sidney Yu, Do Kun Yoon, Shih Kien Djeng, Jiguang Wang, Chwee Ming Lim, Chwee Ming Lim, Chwee Ming Lim, Min Han Tan

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Systemic Investigation Identifying Salivary miR-196b as a Promising Biomarker for Early Detection of Head-Neck Cancer and Oral Precancer Lesions by Ann-Joy Cheng, Guo-Rung You, Che-Jui Lee, Ya-Ching Lu, Shang-Ju Tang, Yi-Fang Huang, Yu-Chen Huang, Li-Yu Lee, Kang-Hsing Fan, Yen-Chao Chen, Shiang-Fu Huang, Joseph Tung-Chieh Chang

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