A Review of Particle Therapy for Skull Base Tumors: Modern Considerations and Future Directions by Eugen B. Hug, MD, Maciej Pelak, MD, PhD, Steven J. Frank, MD, Piero Fossati, PhD

“…Skull base tumors constitute one of the established indications for particle therapy, specifically proton therapy. However, a number of prognostic factors, practical clinical management issues, and the emerging role of carbon ion therapy remain subjects of active clinical investigation. …”
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Technical Prevention of Radiation-induced Cardiovascular Toxicity by WANG Xuanyi, YU Xiaoli

“…Cardiac sparing techniques includes: (1) methods that reduce radiation fields and dose; (2) methods that increase the distance between heart and irradiated fields; (3) new techniques such as intensity modulated radiotherapy and proton therapy. Although researches in dosimetry have showed that cardiac sparing techniques could lower cardiovascular involvement dose and irradiated volume, further validation is needed for curative effect.…”
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Medical therapy and imaging fixed-field alternating-gradient accelerator with realistic magnets by S. Tygier, K. B. Marinov, R. B. Appleby, J. A. Clarke, J. M. Garland, H. L. Owen, B. J. A. Shepherd

“…The main result is an iterative design method to produce the first realistic design for a proton therapy accelerator that can rapidly deliver protons for both treatment and for imaging at up to 350 MeV. …”
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Role of adjuvant chemoradiotherapy and chemotherapy in patients with resected gallbladder carcinoma: a multi-institutional analysis (KROG 19-04) by Sung Uk Lee, Jinsil Seong, Tae Hyun Kim, Jung Ho Im, Woo Chul Kim, Kyubo Kim, Hae Jin Park, Tae Gyu Kim, Youngkyong Kim, Bae Kwon Jeong, Jin Hee Kim, Byoung Hyuck Kim, Taek-Keun Nam

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Quantitative Measurement of Perineural Invasion for Prognosis Analysis of Oral Cavity Cancer Treated by Radical Surgery With or Without Adjuvant Therapy by Kang-Hsing Fan MD, Chung-Jan Kang MD, PhD, Chien-Yu Lin MD, PhD, Shu-Hang Ng MD, Hung-Ming Wang MD, Chia-Hsun Hsieh MD, PhD, Chih-Hua Yeh MD, Chih-Hung Lin MD, Chung-Kan Tsao MD, Shiang-Fu Huang MD, PhD, Ku-Hao Fang MD, Yu-Chien Wang MD, Joseph Tong-Chieh Chang MD, MHA, Chun-Ta Liao MD, Li-Yu Lee MD

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Feasibility study: spot-scanning proton arc therapy (SPArc) for left-sided whole breast radiotherapy by Sheng Chang, Gang Liu, Lewei Zhao, Joshua T. Dilworth, Weili Zheng, Saada Jawad, Di Yan, Peter Chen, Craig Stevens, Peyman Kabolizadeh, Xiaoqiang Li, Xuanfeng Ding

“…Two proton treatment plans were generated for each patient: vertical intensity-modulated proton therapy used for clinical treatment (vIMPT, gantry angle 10°–30°) and SPArc for comparison purpose. …”
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A review of the clinical introduction of 4D particle therapy research concepts by Barbara Knäusl, Gabriele Belotti, Jenny Bertholet, Juliane Daartz, Stella Flampouri, Mischa Hoogeman, Antje C Knopf, Haibo Lin, Astrid Moerman, Chiara Paganelli, Antoni Rucinski, Reinhard Schulte, Shing Shimizu, Kristin Stützer, Xiaodong Zhang, Ye Zhang, Katarzyna Czerska

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A Nucleoside Anticancer Drug, 1-(3-C-Ethynyl-β-D-Ribo-Pentofuranosyl)Cytosine, Induces Depth-Dependent Enhancement of Tumor Cell Death in Spread-Out Bragg Peak (SOBP) of Proton Bea... by Kenichiro Maeda, Hironobu Yasui, Tohru Yamamori, Taeko Matsuura, Seishin Takao, Motofumi Suzuki, Akira Matsuda, Osamu Inanami, Hiroki Shirato

“…Thus, ECyd is a unique radiosensitizer for proton therapy that may be useful because it levels the biological dose within SOBP, which improves tumor control and reduces the risk of adverse effects at the distal edge of SOBP.…”
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Evolution of the Role of Radiotherapy for Anal Cancer by Edward Christopher Dee, James D. Byrne, Jennifer Y. Wo

“…Studies are also examining the role of newer treatment modalities such as proton therapy in treating anal cancer. Here we review the evolution of radiotherapy for anal cancer and describe recent advances. …”
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Field size effects on the risk and severity of treatment-induced lymphopenia in patients undergoing radiation therapy for solid tumors by Susannah G. Ellsworth, MD

“…RIL risk is correlated with field size, dose per fraction, and fraction number. SBRT and proton therapy techniques are associated with lower RIL risk. …”
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Proton-dynamic therapy following photosensitiser activation by accelerated protons demonstrated through fluorescence and singlet oxygen production by M. Grigalavicius, M. Mastrangelopoulou, K. Berg, D. Arous, M. Ménard, T. Raabe-Henriksen, E. Brondz, S. Siem, A. Görgen, N. F. J. Edin, E. Malinen, T. A. Theodossiou

“…The authors use accelerated protons on photosensitizers (PS, conventionally excited by light), to generate fluorescence and singlet oxygen which can enhance the efficacy of proton therapy. A pilot study on glioblastoma cells confirms differential cell death upon irradiation in the presence of PS.…”
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Review of Compton camera imaging technology development by WU Chuanpeng, LI Liang

“…Due to these advantages, Compton camera system is well applied in many fields, such as astronomical observation, medical imaging, environmental radiation monitoring, proton therapy and so on. With the development of emerging detector technology and electronics technology, Compton camera systems have been continuously optimized from scintillator detectors to high-performance semiconductor detectors. …”
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The Monte Carlo srna code as the engine in istar proton dose planning software for the tesla accelerator installation by Ilić Radovan D., Jokić-Spasić Vesna, Beličev Petar, Dragović Miloš

“…SRNA package was developed for 3D dose distribution calculation in proton therapy and dosimetry and it was based on the theory of multiple scattering. …”
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Clinical development of new drug-radiotherapy combinations. by Sharma, R, Plummer, R, Stock, J, Greenhalgh, T, Hawkins, M, NCRI CTRad Academia-Pharma Joint Working Group

“…In the past decade, significant technical advances, such as image-guided radiotherapy, intensity-modulated radiotherapy, stereotactic radiotherapy, and proton therapy enable higher doses of radiotherapy to be delivered to the tumour with significantly lower doses to normal surrounding tissues. …”

Improve the dosimetric outcome in bilateral head and neck cancer (HNC) treatment using spot-scanning proton arc (SPArc) therapy: a feasibility study by Gang Liu, Xiaoqiang Li, An Qin, Weili Zheng, Di Yan, Sheng Zhang, Craig Stevens, Peyman Kabolizadeh, Xuanfeng Ding

“…Both SPArc and 3-field Intensity Modulated Proton Therapy (IMPT) plans were generated for each patient using the same robust optimization parameters. …”
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Treatment-associated remodeling of the pancreatic cancer endothelium at single-cell resolution by Carina Shiau, Carina Shiau, Carina Shiau, Carina Shiau, Jennifer Su, Jennifer Su, Jennifer Su, Jennifer Su, Jimmy A. Guo, Jimmy A. Guo, Jimmy A. Guo, Jimmy A. Guo, Jimmy A. Guo, Theodore S. Hong, Jennifer Y. Wo, Karthik A. Jagadeesh, William L. Hwang, William L. Hwang, William L. Hwang, William L. Hwang

“…While losartan and proton therapy were associated with reduced lymphatic ECs, these therapies also correlated with an increase in reactive EndMT. …”
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Salvage pembrolizumab added to kinase inhibitor therapy for the treatment of anaplastic thyroid carcinoma by Priyanka C. Iyer, Ramona Dadu, Maria Gule-Monroe, Naifa L. Busaidy, Renata Ferrarotto, Mouhammed Amir Habra, Mark Zafereo, Michelle D. Williams, G. Brandon Gunn, Horiana Grosu, Heath D. Skinner, Erich M. Sturgis, Neil Gross, Maria E. Cabanillas

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Novel prognostic classification predicts overall survival of patients receiving salvage whole-brain radiotherapy for recurrent brain metastasis from breast cancer: A recursive part... by Jae Sik Kim, Kyubo Kim, Wonguen Jung, Kyung Hwan Shin, Seock-Ah Im, Yong Bae Kim, Jee Suk Chang, Doo Ho Choi, Haeyoung Kim, Yeon Hee Park, Dae Yong Kim, Tae Hyun Kim, Jeanny Kwon, Ki Mun Kang, Woong-Ki Chung, Kyung Su Kim, In Ah Kim

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A Longitudinal Metagenomic Comparative Analysis of Oral Microbiome Shifts in Patients Receiving Proton Radiation Versus Photon Radiation for Head and Neck Cancer by Timothy Meiller, Claire Fraser, Silvia Grant-Beurmann, Mike Humphrys, Luke Tallon, Lisa Sadewicz, Mary Ann Jabra-Rizk, Areej Alfaifi, Anmar Kensara, Jason Molitoris, Matthew Witek, William Mendes, William Regine, Phuoc Tran, Robert Miller, Ahmed Sultan

“…A more dysbiotic state was observed in patients receiving photon therapy as compared to proton therapy in which oral microbial homeostasis was maintained. …”
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Lung Stereotactic Body Radiotherapy (SBRT) Using Spot-Scanning Proton Arc (SPArc) Therapy: A Feasibility Study by Gang Liu, Gang Liu, Lewei Zhao, An Qin, Inga Grills, Rohan Deraniyagala, Craig Stevens, Sheng Zhang, Di Yan, Xiaoqiang Li, Xuanfeng Ding

“…This technology may make delivery of proton SBRT more technically feasible and less complex with fewer concerns over underdosing the target compared to other proton therapy techniques.…”
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