Assessment of IMPT versus VMAT plans using different uncertainty scenarios for prostate cancer by Michael P. Butkus, Nellie Brovold, Tejan Diwanji, Yihang Xu, Mariluz De Ornelas, Alan Dal Pra, Matt Abramowitz, Alan Pollack, Nesrin Dogan

“…Abstract Background To assess the impact of systematic setup and range uncertainties for robustly optimized (RO) intensity modulated proton therapy (IMPT) and volumetric modulated arc therapy (VMAT) plans in patients with localized prostate cancer. …”
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Orthovoltage X-ray Minibeam Radiation Therapy for the Treatment of Ocular Tumours—An In Silico Evaluation by Tim Schneider, Denis Malaise, Frédéric Pouzoulet, Yolanda Prezado

“…Although increased local control rates can be obtained with advanced techniques such as proton therapy and stereotactic radiosurgery, these modalities are not always accessible to patients (due to high costs or low availability) and side effects in structures such as the lens, eyelids or anterior chamber remain an issue. …”
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Incorporation of biological factors in radiation therapy treatment planning by Brooke, M

“…These advances have enabled highly conformal tumouricidal dose deposition with improved healthy tissue sparing. Proton therapy, in particular, has become an increasingly adopted modality due to its favourable depth-dose profile, allowing for much of the dose to be localised within the target region, with virtually no dose leakage to tissues beyond the target. …”

An analysis of plan robustness for oesophageal tumours: comparing volumetric modulated arctherapy plans and spot scanning proton planning by Warren, S, Partridge, M, Hawkins, M, Bolsi, A, Lomax, A, Hurt, C, Crosby, T, Hawkins, M

“…This study therefore seeks to compare volumetric modulated arc therapy (VMAT) and single-field optimisation (SFO) spot scanning proton therapy plans created using with simultaneous integrated boost (SIB) for dose escalation in mid-oesophageal cancer, and to analyse the effect of set-up and range uncertainties on these plans. …”

A biological modelling based comparison of radiotherapy plan robustness using photons vs protons for focal prostate boosting by Jesper Pedersen, Oscar Casares-Magaz, Jørgen B.B. Petersen, Jarle Rørvik, Lise Bentzen, Andreas G. Andersen, Ludvig P. Muren

“…In this study we applied dose response models for both tumour control and normal tissue complications to explore the benefit of proton therapy (PT) combined with focal tumour boosting, also when accounting for inter-fractional motion. …”
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Feasibility of Synchrotron-Based Ultra-High Dose Rate (UHDR) Proton Irradiation with Pencil Beam Scanning for FLASH Research by Lingshu Yin, Umezawa Masumi, Kan Ota, Daniel M. Sforza, Devin Miles, Mohammad Rezaee, John W. Wong, Xun Jia, Heng Li

“…Conclusions: The synchrotron-based proton therapy system has the capability to deliver pulsed proton UHDR PBS beams. …”
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Chemoradiotherapy for limited-stage small-cell lung cancer and interstitial lung abnormalities by Haruki Kobayashi, Kazushige Wakuda, Tateaki Naito, Nobuaki Mamesaya, Shota Omori, Akira Ono, Hirotsugu Kenmotsu, Haruyasu Murakami, Masahiro Endo, Hideyuki Harada, Yasuhiro Gon, Toshiaki Takahashi

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Quality assurance of four-dimensional computed tomography in a multicentre trial of stereotactic body radiotherapy of centrally located lung tumours by Marie Lambrecht, Jan-Jakob Sonke, Ursula Nestle, Heike Peulen, Damien C. Weber, Marcel Verheij, Coen W. Hurkmans

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Late Dental Toxicities After Proton Chemoradiation for Rhabdomyosarcoma: A Pediatric Case Report by Emma Foster-Thomas, BDS, Marianne Aznar, PhD, Daniel Indelicato, MD, Shermaine Pan, FRCR, Eunji Hwang,MBBS, Peter Sitch, PhD, Keith Horner, PhD, Ed Smith,BM, Simona Gaito, MD

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Comparison of therapeutic dosimetric data from passively scattered proton and photon craniospinal irradiations for medulloblastoma by Howell Rebecca M, Giebeler Annelise, Koontz-Raisig Wendi, Mahajan Anita, Etzel Carol J, D’Amelio Anthony M, Homann Kenneth L, Newhauser Wayne D

“…Recently, there is growing interest in using proton therapy for CSI in pediatric and adolescent patients to reduce this undesirable dose. …”
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Radiation‐induced tumor immunity in patients with non‐small cell lung cancer by Natalie A. Lockney, Mei Zhang, Christopher G. Morris, Romaine Charles Nichols, Paul Okunieff, Steven Swarts, Zhenhuan Zhang, Bingrong Zhang, Amy Zhang, Bradford S. Hoppe

“…Results Twenty‐one patients received proton therapy at 2 GyRBE/fraction (n = 17) or 6–12 Gy/fraction (n = 4); five received photon therapy at 2–2.5 GyRBE/fraction. …”
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“Radiotherapy for thymic epithelial tumors: What is the optimal dose? A systematic review.” by A. Angrisani, R. Houben, F. Marcuse, M. Hochstenbag, J. Maessen, D. De Ruysscher, S. Peeters

“…We aim to shed light on the optimal radiation dose for patients with TETs undergoing RT through a systematic review of the recent literature, including reports using modern RT techniques such as 3D-CRT, IMRT/VMAT, or proton-therapy. A comprehensive literature search of four databases was conducted following the PRISMA guidelines. …”
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IMPT of head and neck cancer: unsupervised machine learning treatment planning strategy for reducing radiation dermatitis by Noufal Manthala Padannayil, Dayananda Shamurailatpam Sharma, Sapna Nangia, Kartikeshwar C. Patro, Utpal Gaikwad, Nagarjuna Burela

“…Abstract Radiation dermatitis is a major concern in intensity modulated proton therapy (IMPT) for head and neck cancer (HNC) despite its demonstrated superiority over contemporary photon radiotherapy. …”
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PENELOPE/PRIMO-calculated photon and electron spectra from clinical accelerators by Lorenzo Brualla, Miguel Rodriguez, Josep Sempau, Pedro Andreo

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Analysis of pseudoprogression after proton or photon therapy of 99 patients with low grade and anaplastic glioma by Julianna K. Bronk, Nandita Guha-Thakurta, Pamela K. Allen, Anita Mahajan, David R. Grosshans, Susan L. McGovern

“…Background and purpose: Proton therapy is increasingly used to treat primary brain tumors. …”
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Flexible fully organic indirect detector for megaelectronvolts proton beams by Sabrina Calvi, Laura Basiricò, Sara M. Carturan, Ilaria Fratelli, Antonio Valletta, Alberto Aloisio, Stefania De Rosa, Felix Pino, Marcello Campajola, Andrea Ciavatti, Luca Tortora, Matteo Rapisarda, Sandra Moretto, Matteo Verdi, Stefano Bertoldo, Olivia Cesarini, Paolo Di Meo, Massimo Chiari, Francesco Tommasino, Ettore Sarnelli, Luigi Mariucci, Paolo Branchini, Alberto Quaranta, Beatrice Fraboni

“…This detector is designed to target real-time and in-situ dose monitoring during proton therapy and demonstrates mechanical flexibility and low power operation, assessing its potential employment as a personal dosimeter with high comfort and low risk for the patient. …”
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Extension of the open-source TIGRE toolbox for proton imaging by Stefanie Kaser, Thomas Bergauer, Ander Biguri, Wolfgang Birkfellner, Sepideh Hatamikia, Albert Hirtl, Christian Irmler, Benjamin Kirchmayer, Felix Ulrich-Pur

“…Usually, an X-ray computed tomography (CT) scan is used for treatment planning. Since proton therapy is based on the precise knowledge of the stopping power describing the energy loss of protons in the patient tissues, the Hounsfield units of the planning CT have to be converted. …”
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Association of fatigue and depression with circulating levels of proinflammatory cytokines and epidermal growth factor receptor ligands: a correlative study of a placebo-controlled... by Rich T, Zhao F, Cruciani RA, Cella D, Manola J, Fisch MJ

“…Tyvin Rich,1,* Fengmin Zhao,2,* Ricardo A Cruciani,3 David Cella,4 Judith Manola,2 Michael J Fisch5 1Hampton University Proton Therapy Institute, Hampton, VA, 2Dana-Farber Cancer Institute, Boston, MA, 3Beth Israel Medical Center, New York, NY, 4Northwestern University Feinberg School of Medicine, Chicago, IL, 5The University of Texas MD Anderson Cancer Center, Houston, TX, USA *These authors contributed equally to this work Context: The biology of fatigue and depression in cancer patients is poorly understood. …”
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13q deletion syndrome resulting from balanced chromosomal rearrangement in father: the significance of parental karyotyping by Sabine Dittner-Moormann, Madlen Reschke, Eva Biewald, Alma Kuechler, Barbara Klein, Beate Timmermann, Dietmar Lohmann, Petra Ketteler, Deniz Kanber

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Radiation as a Tool against Neurodegeneration—A Potential Treatment for Amyloidosis in the Central Nervous System by Carina Marques Coelho, Lia Pereira, Pamela Teubig, Pedro Santos, Filipa Mendes, Sílvia Viñals, Daniel Galaviz, Federico Herrera

“…However, new RT modalities such as low-dose RT, FLASH, proton therapy or nanoparticle-enhanced RT could increase biological effects while reducing toxicity. …”
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