Including Volume Effects in Biological Treatment Plan Optimization for Carbon Ion Therapy: Generalized Equivalent Uniform Dose-Based Objective in TRiP98 by Marco Battestini, Marco Battestini, Marco Schwarz, Marco Schwarz, Michael Krämer, Emanuele Scifoni

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Head and Neck Cancer Clinical Research on ClinicalTrials.gov: An Opportunity for Radiation Oncologists by Vinayak Muralidhar, MD, MSc, Nicholas J. Giacalone, MD, Nastaran Milani, MPH, Jonathan D. Schoenfeld, MD, DPhil, MPH, Roy B. Tishler, MD, PhD, Bhupendra Rawal, MS, Danielle N. Margalit, MD, MPH

“…Among RT trials, most early-phase studies tested novel modalities (eg, stereotactic body radiation therapy, proton therapy), whereas most later-phase studies tested dose and fractionation. …”
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Repeatability and Reproducibility of Microdosimetry With a Mini-TEPC by A. Bianchi, A. Bianchi, A. Bianchi, A. Selva, P. Colautti, G. Petringa, P. Cirrone, B. Reniers, A. Parisi, F. Vanhavere, V. Conte

“…Demonstration of reproducibility of measured microdosimetric quantities y¯F, y¯D and RBE10 in 62 MeV proton beam makes this TEPC a possible metrological tool for LET verification in proton therapy. Future characterization will be performed in higher energy proton beams.…”
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The need for consensus on delineation and dose constraints of dentofacial structures in paediatric radiotherapy: Outcomes of a SIOP Europe survey by Angela Davey, Shermaine Pan, Abigail Bryce-Atkinson, Henry Mandeville, Geert O. Janssens, Sarah M. Kelly, Marinka Hol, Vivian Tang, Lucy Siew Chen Davies, SIOP-Europe Radiation Oncology Working Group, Marianne Aznar

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Risk stratification of postoperative cardiopulmonary toxicity after trimodality therapy for esophageal cancer by Roman O. Kowalchuk, Grant M. Spears, Lindsay K. Morris, Dawn Owen, Harry H. Yoon, Krishan Jethwa, Michael D. Chuong, Matthew J. Ferris, Michael G. Haddock, Christopher L. Hallemeier, Dennis Wigle, Steven H. Lin, Kenneth W. Merrell

“…Patients were treated with 3D (37%), IMRT (44%), and proton therapy (19%). 61 patients had major CPTTB (score ≥ 70). …”
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Multimodal Therapy with Consolidating Haploidentical Stem Cell Transplantation and Dinutuximab Beta for Patients with High-Risk Neuroblastoma and Central Nervous System Relapse by Tim Flaadt, Martin Ebinger, Malin Schreiber, Ruth L. Ladenstein, Thorsten Simon, Holger N. Lode, Barbara Hero, Martin U. Schuhmann, Jürgen Schäfer, Frank Paulsen, Beate Timmermann, Angelika Eggert, Peter Lang

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Ex vivo radiation sensitivity assessment for individual head and neck cancer patients using deep learning-based automated nuclei and DNA damage foci detection by I. Lauwers, K.S. Pachler, M.E. Capala, N.D. Sijtsema, D.C. Van Gent, M. Rovituso, M.S. Hoogeman, G.M. Verduijn, S.F. Petit

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Brain Radiation Necrosis Outside the Target Volume After Proton Radiation Therapy: Analyses of Multiparametric Imaging and Proton Biologic Effectiveness by Julianna K. Bronk, MD, PhD, Ahmad Amer, Swapnil Khose, MD, David Flint, PhD, Antony Adair, PhD, Pablo Yepes, PhD, David Grosshans, MD, PhD, Jason Johnson, MD, Caroline Chung, MD, MSc

“…Purpose: We present the case of a 48-year-old patient with recurrent World Health Organization grade II meningioma in the left occipital region who underwent a subtotal resection, followed by postoperative proton therapy to residual disease and the resection cavity. …”
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Comparative study of the effects of different radiation qualities on normal human breast cells by Dajana Juerß, Monique Zwar, Ulrich Giesen, Ralf Nolte, Stephan Kriesen, Giorgio Baiocco, Monika Puchalska, Marc-Jan van Goethem, Katrin Manda, Guido Hildebrandt

“…The risk for the development of secondary malignant neoplasms might be significantly increased due to exposure of healthy tissue outside of the target field to secondary neutrons, in particular in proton therapy. Thus far, the radiobiological effects of these neutrons and a comparison with photons on normal breast cells have not been sufficiently characterised. …”
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Single-fraction 34 Gy Lung Stereotactic Body Radiation Therapy Using Proton Transmission Beams: FLASH-dose Calculations and the Influence of Different Dose-rate Methods and Dose/Do... by Patricia van Marlen, MSc, Wilko F.A.R. Verbakel, PhD, PDEng, Ben J. Slotman, MD, PhD, Max Dahele, PhD, MBChB

“…Methods and Materials: Clinical volumetric-modulated arc therapy (VMAT) plans, intensity modulated proton therapy (IMPT) plans and transmission beam (TB) plans were compared for 6 small and 1 large lung lesion. …”
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Phantosmia Among Pediatric, Adolescent, and Young Adult Patients Receiving Proton Beam Therapy by Shoshana J. Rosenzweig, BA, Stanislav Lazarev, MD, Shaakir Hasan, DO, Jana Fox, MD, J. Isabelle Choi, MD, Charles B. Simone, II, MD, Suzanne L. Wolden, MD, FACR

“…This study aimed to characterize the incidence of phantosmia in patients treated with intensity modulated proton therapy (IMPT). Methods and Materials: In this institutional review board–approved retrospective study, the electronic medical record of a pencil beam scanning-only proton center was queried for patients ≤39 years of age who received IMPT for primary intracranial, metastatic intracranial, skull base, nasopharyngeal or sinonasal neoplasms between August 2019 and December 2020. …”
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Proton Radiation Therapy After Chemotherapy in the Management of Aggressive Mediastinal Non-Hodgkin Lymphomas: A Particle Therapy Cooperative Group Lymphoma Subcommittee Collaborat... by Jonathan A. Baron, MD, Christopher M. Wright, MD, Russell Maxwell, MD, Michele M. Kim, PhD, Fantine Giap, MD, Raymond B. Mailhot Vega, MD, MPH, Bradford S. Hoppe, MD, MPH, Michael J. LaRiviere, MD, Amit Maity, MD, PhD, John P. Plastaras, MD, PhD, Ima Paydar, MD

“…Purpose: Combined modality therapy with multiagent chemotherapy and radiation therapy is a standard treatment option for aggressive mediastinal non-Hodgkin lymphomas (AMNHLs); however, concerns regarding acute and late radiation toxicities have fueled an effort to use systemic therapy alone. The use of proton therapy (PT) is a promising treatment option, but there are still limited data regarding clinical outcomes with this treatment modality. …”
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Initial Quality of Life and Toxicity Analysis of a Randomized Phase 3 Study of Moderately Hypofractionated Radiation Therapy With or Without Androgen Suppression for Intermediate-R... by Brady S. Laughlin, MD, Cameron S. Thorpe, MD, Todd A. DeWees, PhD, Molly M. Voss, BA, John H. Chang, MD, William F. Hartsell, MD, Christopher C. Sinesi, MD, Jean-Claude M. Rwigema, MD, Sameer R. Keole, MD, Vinai Gondi, MD, Carlos E. Vargas, MD

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Comparison of FLASH Proton Entrance and the Spread-Out Bragg Peak Dose Regions in the Sparing of Mouse Intestinal Crypts and in a Pancreatic Tumor Model by Michele M. Kim, Ioannis I. Verginadis, Denisa Goia, Allison Haertter, Khayrullo Shoniyozov, Wei Zou, Amit Maity, Theresa M. Busch, James M. Metz, Keith A. Cengel, Lei Dong, Costas Koumenis, Eric S. Diffenderfer

“…Ultra-high dose rate FLASH proton radiotherapy (F-PRT) has been shown to reduce normal tissue toxicity compared to standard dose rate proton radiotherapy (S-PRT) in experiments using the entrance portion of the proton depth dose profile, while proton therapy uses a spread-out Bragg peak (SOBP) with unknown effects on FLASH toxicity sparing. …”
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Efficacy and safety analysis in metastatic cancer patients treated with multiple courses of repeat radiation therapy by Maiwand Ahmadsei, Sebastian M. Christ, Tiuri E. Kroese, Anja Kühnis, Jonas Willmann, Panagiotis Balermpas, Nicolaus Andratschke, Stephanie Tanadini-Lang, Matthias Guckenberger

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Development of a Real-Time Pixel Array-Type Detector for Ultrahigh Dose-Rate Beams by Young Jae Jang, Tae Keun Yang, Jeong Hwan Kim, Hong Suk Jang, Jong Hwi Jeong, Kum Bae Kim, Geun-Beom Kim, Seong Hee Park, Sang Hyoun Choi

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Molecular Characterization of Medulloblastoma in a Patient with Neurofibromatosis Type 1: Case Report and Literature Review by Marco Ranalli, Alessandra Boni, Anna Maria Caroleo, Giada Del Baldo, Martina Rinelli, Emanuele Agolini, Sabrina Rossi, Evelina Miele, Giovanna Stefania Colafati, Luigi Boccuto, Iside Alessi, Maria Antonietta De Ioris, Antonella Cacchione, Rossella Capolino, Andrea Carai, Sabina Vennarini, Angela Mastronuzzi

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Additional chemotherapy improved local control and overall survival after stereotactic body radiation therapy for patients with oligo-recurrence by Masaki Nakamura, Naoki Hashimoto, Hiroshi Mayahara, Haruka Uezono, Aya Harada, Ryo Nishikawa, Yoshiro Matsuo, Hiroki Kawaguchi, Hideki Nishimura

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Dosimetric Analysis of Proximal Bronchial Tree Subsegments to Assess The Risk of Severe Toxicity After Stereotactic Body Radiation Therapy of Ultra-central Lung Tumors by Maiwand Ahmadsei, Vinojaa Jegarajah, Riccardo Dal Bello, Sebastian M. Christ, Michael M. Mayinger, Luisa Sabrina Stark, Jonas Willmann, Ivan R. Vogelius, Panagiotis Balermpas, Nicolaus Andratschke, Stephanie Tanadini-Lang, Matthias Guckenberger

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Clinical and molecular study of radiation-induced gliomas by Katerina Trkova, David Sumerauer, Adela Bubenikova, Lenka Krskova, Ales Vicha, Miroslav Koblizek, Josef Zamecnik, Bruno Jurasek, Martin Kyncl, Bela Malinova, Barbora Ondrova, David T. W. Jones, Martin Sill, Martina Strnadova, Lucie Stolova, Adela Misove, Vladimir Benes, Michal Zapotocky

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