Reirradiation for Locoregional Recurrent Breast Cancer by Sayeh Fattahi, BS, Safia K. Ahmed, MD, Sean S. Park, MD, PhD, Ivy A. Petersen, MD, Dean A. Shumway, MD, Bradley J. Stish, MD, Elizabeth S. Yan, MD, Nicholas B. Remmes, PhD, Robert W. Mutter, MD, Kimberly S. Corbin, MD

“…Time between RT courses and reirradiation fields was significantly associated with the development of grade 3 toxicity at any point. Proton therapy conferred a dosimetric advantage without difference in toxicity. …”
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Serum testosterone changes in patients treated with radiation therapy alone for prostate cancer on NRG oncology RTOG 9408 by R. Charles Nichols, MD, Chen Hu, PhD, Jean-Paul Bahary, MD, Kenneth L. Zeitzer, MD, Luis Souhami, MD, Mark H. Leibenhaut, MD, Marvin Rotman, MD, Elizabeth M. Gore, MD, Alexander G. Balogh, MD, David McGowan, MD, Jeff Michalski, MD, Adam Raben, MD, Shari Rudoler, MD, Christopher U. Jones, MD, Howard Sandler, MD

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Inter-Observer Variability in MR-Based Target Volume Delineation of Uveal Melanoma by Myriam G. Jaarsma-Coes, Lisa Klaassen, Berit M. Verbist, T.H. Khanh Vu, Yvonne L.B. Klaver, Myra F. Rodrigues, Claire Nabarro, Gregorius P.M. Luyten, Coen R.N. Rasch, Marcel van Herk, Jan-Willem M. Beenakker

“…Purpose: Several efforts are being undertaken toward MRI-based treatment planning for ocular proton therapy for uveal melanoma (UM). The interobserver variability of the gross target volume (GTV) on magnetic resonance imaging (MRI) is one of the important parameters to design safety margins for a reliable treatment. …”
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MRI Radiomics for Predicting Survival in Patients with Locally Advanced Hypopharyngeal Cancer Treated with Concurrent Chemoradiotherapy by Tiing Yee Siow, Chih-Hua Yeh, Gigin Lin, Chien-Yu Lin, Hung-Ming Wang, Chun-Ta Liao, Cheng-Hong Toh, Sheng-Chieh Chan, Ching-Po Lin, Shu-Hang Ng

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From Alpha to Omicron: A Radiation Oncology Network's Biocontainment-Based COVID-19 Experience by Yilin Cao, MD, Valeria Fabre, MD, Roberta Anderson, DNP, Gregory Bova, Annette N. Souranis, RT(T), Valerie Briner, RT(T), Lawrence R. Kleinberg, MD, Sarah Han-Oh, PhD, Jean L. Wright, MD, Akila N. Viswanathan, MD, MPH

“…Results: Negative air-flow environments were created across a regional network, including a multi-gantry proton therapy unit. In total, 6525 patients were treated from June 2020 through January 2022 across 5 separate centers. …”
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Impact of radiation doses on clinical relapse of biochemically recurrent prostate cancer after prostatectomy by Seiya Takano, Natsuo Tomita, Masanari Niwa, Akira Torii, Taiki Takaoka, Nozomi Kita, Kaoru Uchiyama, Mikiko Nakanishi-Imai, Shiho Ayakawa, Masato Iida, Yusuke Tsuzuki, Shinya Otsuka, Yoshihiko Manabe, Kento Nomura, Yasutaka Ogawa, Akifumi Miyakawa, Akihiko Miyamoto, Shinya Takemoto, Takahiro Yasui, Akio Hiwatashi

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Phase II study of multidisciplinary therapy combined with pembrolizumab for patients with synchronous oligometastatic non-small cell lung cancer TRAP OLIGO study (WJOG11118L) by Taichi Miyawaki, Hirotsugu Kenmotsu, Hideyuki Harada, Yasuhisa Ohde, Yasutaka Chiba, Koji Haratani, Tamio Okimoto, Tomohiro Sakamoto, Kazushige Wakuda, Kentaro Ito, Takehiro Uemura, Shinya Sakata, Yoshihito Kogure, Yasumasa Nishimura, Kazuhiko Nakagawa, Nobuyuki Yamamoto

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Proton Bragg Peak FLASH Enables Organ Sparing and Ultra-High Dose-Rate Delivery: Proof of Principle in Recurrent Head and Neck Cancer by Michael Pennock, Shouyi Wei, Chingyun Cheng, Haibo Lin, Shaakir Hasan, Arpit M. Chhabra, J. Isabelle Choi, Richard L. Bakst, Rafi Kabarriti, Charles B. Simone II, Nancy Y. Lee, Minglei Kang, Robert H. Press

“…The 6 GyE/fraction and 10 GyE/fraction plans were also created using conventional-rate intensity-modulated proton therapy techniques. PBS Bragg peak FLASH, PBS transmission FLASH, and conventional plans were compared for OAR sparing, FLASH dose rate coverage, and target coverage. …”
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Light flashes during proton and photon radiotherapy: A multicenter prospective observational study by Masashi Mizumoto, Yoshiko Oshiro, Toshio Miyamoto, Taisuke Sumiya, Motohiro Murakami, Keiichiro Baba, Shosei Shimizu, Takashi Iizumi, Haruko Numajiri, Kei Nakai, Toshiyuki Okumura, Kazushi Maruo, Takeji Sakae, Hideyuki Sakurai

“…Methods and Materials: A prospective observational study was performed in all adult patients (≥20 years old) who received photon and proton therapy at two centers between January 2019 and August 2020, except for patients who could not communicate and those with visual abnormality. …”
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Clinical impact of tumour burden on the efficacy of PD‐1/PD‐L1 inhibitors plus chemotherapy in non‐small‐cell lung cancer by Taichi Miyawaki, Hirotsugu Kenmotsu, Kosei Doshita, Hiroaki Kodama, Naoya Nishioka, Yuko Iida, Eriko Miyawaki, Nobuaki Mamesaya, Haruki Kobayashi, Shota Omori, Ryo Ko, Kazushige Wakuda, Akira Ono, Tateaki Naito, Haruyasu Murakami, Keita Mori, Hideyuki Harada, Masahiro Endo, Kazuhisa Takahashi, Toshiaki Takahashi

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Validation of a deep-learning segmentation model for adult and pediatric head and neck radiotherapy in different patient positions by Linda Chen, Patricia Platzer, Christian Reschl, Mansure Schafasand, Ankita Nachankar, Christoph Lukas Hajdusich, Peter Kuess, Markus Stock, Steven Habraken, Antonio Carlino

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Dysfunctional TLR1 reduces the therapeutic efficacy of chemotherapy by attenuating HMGB1-mediated antitumor immunity in locally advanced colorectal cancer by Kevin Chih-Yang Huang, Tao-Wei Ke, Jia-Yi Chen, Wei-Ze Hong, Shu-Fen Chiang, Chia-Ying Lai, Tsung-Wei Chen, Pei-Chen Yang, Liang-Chi Chen, Ji-An Liang, William Tzu-Liang Chen, K. S. Clifford Chao

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Clinical Study of Using Biometrics to Identify Patient and Procedure by Jason W. Sohn, Haksoo Kim, Samuel B. Park, Soyoung Lee, James I. Monroe, Thomas B. Malone, Timothy Kinsella, Min Yao, Charles Kunos, Simon S. Lo, Robert Shenk, Mitchell Machtay, Mitchell Machtay

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The significance of margins in pediatric Non‐Rhabdomyosarcoma soft tissue sarcomas: Consensus on surgical margin definition harmonization from the INternational Soft Tissue SaRcoma... by Monika Sparber‐Sauer, Andrea Ferrari, Sheri L. Spunt, Christian Vokuhl, Dana Casey, Timothy B. Lautz, William H. Meyer, David O. Walterhouse, Kristian W. Pajtler, Rita Alaggio, Andreas Schmidt, Akmal Safwat, Beate Timmermann, Patrizia Dall'Igna, Sonja Chen, Aaron R. Weiss, Daniel Orbach

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Vinorelbine Augments Radiotherapy in Hepatocellular Carcinoma by Kheng Wei Yeoh, Aldo Prawira, Muhammad Zafrie Bin Saad, Kok Ming Lee, Eric Ming Hon Lee, Gee Keng Low, Mohamed Hakim Bin Mohd Nasir, Jun Hao Phua, Wendy Wan Li Chow, Iris Jiu Hia Lim, Yusnita Binte Omar, Rebecca Zhi Wen Ho, Thi Bich Uyen Le, Thanh Chung Vu, Khee Chee Soo, Hung Huynh

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Organic–inorganic hybrid perovskite scintillators for mixed field radiation detection by Mengling Xia, Guangda Niu, Linyue Liu, Runlong Gao, Tong Jin, Pengying Wan, Weicheng Pan, Xianpeng Zhang, Zuoxiang Xie, Sam Teale, Zenghua Cai, Jiajun Luo, Shan Zhao, Haodi Wu, Shiyou Chen, Zhiping Zheng, Qingguo Xie, Xiaoping Ouyang, Edward H. Sargent, Jiang Tang

“…Abstract Sensitive and fast detection of neutrons and gamma rays is vital for homeland security, high‐energy physics, and proton therapy. Fast‐neutron detectors rely on light organic scintillators, and γ‐ray detectors use heavy inorganic scintillators and semiconductors. …”
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The Risk of Immune-Related Thyroid Dysfunction Induced by PD-1/PD-L1 Inhibitors in Cancer Patients: An Updated Systematic Review and Meta-Analysis by Yuan Tian, Yuan Tian, Ran Li, Yan Liu, Meng Li, Yuxiao Song, Yan Zheng, Yan Zheng, Aiqin Gao, Qing Wen, Guohai Su, Yuping Sun, Yuping Sun

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Dosimetric analysis and biological evaluation between proton radiotherapy and photon radiotherapy for the long target of total esophageal squamous cell carcinoma by Yongbin Cui, Yuteng Pan, Zhenjiang Li, Qiang Wu, Jingmin Zou, Dali Han, Yong Yin, Changsheng Ma

“…ObjectiveThe purpose of this study is to compare the dosimetric and biological evaluation differences between photon and proton radiation therapy.MethodsThirty esophageal squamous cell carcinoma (ESCC) patients were generated for volumetric modulated arc therapy (VMAT) planning and intensity-modulated proton therapy (IMPT) planning to compare with intensity-modulated radiation therapy (IMRT) planning. …”
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Rare solid and cystic presentation of hemangiopericytoma/ solitary fibrous tumor: A case report by Heather N. Hayenga, Chunyu Cai, David Fetzer, Sarah White, Joshua Kuban, Zabi Wardak, Robert S. Benjamin, Edward Pan, James Strauss, Boning Gao, John Minna, Javier Martin-Broto, J Louis Hinshaw

“…In 2017, she had recurrent intracranial, vertebral, and intraspinal intradural extramedullary HPC/SFTs followed by surgery, proton therapy, and SRS radiotherapy. In 2019, after an uneventful pregnancy and birth, routine surveillance revealed metastases in the liver requiring an extended right hepatectomy. …”
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Relapsed Medulloblastoma in Pre-Irradiated Patients: Current Practice for Diagnostics and Treatment by Rebecca M. Hill, Sabine L. A. Plasschaert, Beate Timmermann, Christelle Dufour, Kristian Aquilina, Shivaram Avula, Laura Donovan, Maarten Lequin, Torsten Pietsch, Ulrich Thomale, Stephan Tippelt, Pieter Wesseling, Stefan Rutkowski, Steven C. Clifford, Stefan M. Pfister, Simon Bailey, Gudrun Fleischhack

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