Characterization of outcomes and practices utilized in the management of internal carotid artery injury not requiring definitive endovascular management by Nyall R. London Jr, Abdulaziz AlQahtani, Siani Barbosa, Paolo Castelnuovo, Davide Locatelli, Aldo Stamm, Aaron A. Cohen‐Gadol, Hussam Elbosraty, Roy Casiano, Jacques Morcos, Ernesto Pasquini, Georgio Frank, Diego Mazzatenta, Garni Barkhoudarian, Chester Griffiths, Daniel Kelly, Christos Georgalas, Trichy N. Janakiram, Piero Nicolai, Daniel M. Prevedello, Ricardo L. Carrau

“…No cases of subsequent carotid rupture were found and none of these cases ultimately underwent endovascular stenting. Radiation or proton therapy has not been subsequently used in any of these patients. …”
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Who should receive single-fraction palliative radiotherapy for gastric cancer bleeding?: An exploratory analysis of a multicenter prospective observational study (JROSG 17-3) by Shuhei Sekii, Tetsuo Saito, Takashi Kosugi, Naoki Nakamura, Hitoshi Wada, Ayako Tonari, Hirofumi Ogawa, Norio Mitsuhashi, Kazunari Yamada, Takeo Takahashi, Kei Ito, Terufumi Kawamoto, Norio Araki, Miwako Nozaki, Joichi Heianna, Kenta Murotani, Yasuhiro Hirano, Atai Satoh, Tsuyoshi Onoe, Naoto Shikama

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Concurrent nivolumab and external beam radiation therapy for hepatocellular carcinoma with macrovascular invasion: A phase II study by Bo Hyun Kim, Hee Chul Park, Tae Hyun Kim, Young-Hwan Koh, Jung Yong Hong, Yuri Cho, Dong Hyun Sinn, Boram Park, Joong-Won Park

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In vivo efficacy assessment of the CDK4/6 inhibitor palbociclib and the PLK1 inhibitor volasertib in human chordoma xenografts by Thibault Passeri, Thibault Passeri, Thibault Passeri, Ahmed Dahmani, Julien Masliah-Planchon, Rania El Botty, Laura Courtois, Sophie Vacher, Elisabetta Marangoni, Fariba Nemati, Sergio Roman-Roman, Homa Adle-Biassette, Hamid Mammar, Sébastien Froelich, Ivan Bièche, Didier Decaudin, Didier Decaudin

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Reconstructive complications and early toxicity in breast cancer patients treated with proton-based postmastectomy radiation therapy by Mutlay Sayan, Mutlay Sayan, Lara Hathout, Sarah S. Kilic, Imraan Jan, Ambroise Gilles, Natalie Hassell, Maria Kowzun, Mridula George, Lindsay Potdevin, Shicha Kumar, Jeremy Sinkin, Richard Agag, Bruce G. Haffty, Nisha Ohri

“…While the number of breast cancer patients treated with proton-based PMRT has increased in recent years, there is limited data on the use of proton therapy in the postmastectomy with reconstruction setting. …”
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Dramatic In Vivo Efficacy of the EZH2-Inhibitor Tazemetostat in <i>PBRM1</i>-Mutated Human Chordoma Xenograft by Thibault Passeri, Ahmed Dahmani, Julien Masliah-Planchon, Adnan Naguez, Marine Michou, Rania El Botty, Sophie Vacher, Rachida Bouarich, André Nicolas, Marc Polivka, Coralie Franck, Anne Schnitzler, Fariba Némati, Sergio Roman-Roman, Franck Bourdeaut, Homa Adle-Biassette, Hamid Mammar, Sébastien Froelich, Ivan Bièche, Didier Decaudin

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Local and Systemic Therapy of Recurrent Medulloblastomas in Children and Adolescents: Results of the P-HIT-REZ 2005 Study by Christine Gaab, Jonas E. Adolph, Stephan Tippelt, Ruth Mikasch, Denise Obrecht, Martin Mynarek, Stefan Rutkowski, Stefan M. Pfister, Till Milde, Olaf Witt, Brigitte Bison, Monika Warmuth-Metz, Rolf-Dieter Kortmann, Stefan Dietzsch, Torsten Pietsch, Beate Timmermann, Ronald Sträter, Udo Bode, Andreas Faldum, Robert Kwiecien, Gudrun Fleischhack

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Activity-Based Costing of Intensity-Modulated Proton versus Photon Therapy for Oropharyngeal Cancer by Nikhil G. Thaker, MD, David Boyce-Fappiano, MD, Matthew S. Ning, MD, Dario Pasalic, MD, Alexis Guzman, MBA, Grace Smith, MD, PhD, MPH, Emma B. Holliday, MD, James Incalcaterra, PhD, Adam S. Garden, MD, Simona F. Shaitelman, MD, G. Brandon Gunn, MD, C. David Fuller, MD, PhD, Pierre Blanchard, MD, Thomas W. Feeley, MD, Robert S. Kaplan, PhD, Steven J. Frank, MD

“…Purpose: In value-based health care delivery, radiation oncologists need to compare empiric costs of care delivery with advanced technologies, such as intensity-modulated proton therapy (IMPT) and intensity-modulated radiation therapy (IMRT). …”
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Prediction of Early Response to Immune Checkpoint Inhibition Using FDG-PET/CT in Melanoma Patients by Ken Kudura, Florentia Dimitriou, Lucas Basler, Robert Förster, Daniela Mihic-Probst, Tim Kutzker, Reinhard Dummer, Joanna Mangana, Irene A. Burger, Michael C. Kreissl

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Multi-institutional Comparison of Intensity Modulated Photon Versus Proton Radiation Therapy in the Management of Squamous Cell Carcinoma of the Anus by Jahan J. Mohiuddin, MD, Krishan R. Jethwa, MD, Nikhil Grandhi, BS, William G. Breen, MD, Xingmei Wang, MS, Akbar Anvari, PhD, Hui Lin, PhD, Harigopal Sandhyavenu, MBBS, Abigail Doucette, MPH, John P. Plastaras, MD, PhD, William G. Rule, MD, James M. Metz, MD, Kenneth W. Merrell, MD, Terence T. Sio, MD, Jonathan B. Ashman, MD, PhD, Michael G. Haddock, MD, Edgar Ben-Josef, MD, Christopher L. Hallemeier, MD, Andrzej P. Wojcieszynski, MD

“…This study was undertaken to determine whether intensity modulated proton therapy (IMPT) is associated with less acute toxicity than intensity modulated radiation therapy (IMRT) using photons. …”
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Choline PET/CT in recurrent prostate cancer by Beatrice Detti, Maria Grazia Carnevale, Sara Lucidi, Luca Burchini, Saverio Caini, Carolina Orsatti, Niccolò Bertini, Manuele Roghi, Vanessa di Cataldo, Simona Fondelli, Gianluca Ingrosso, Giulio Francolini, Daniele Scartoni, Angela Sardaro, Antonio Pisani, Silvia Scoccianti, Cynthia Aristei, Lorenzo Livi

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Quantifying systematic RBE-weighted dose uncertainty arising from multiple variable RBE models in organ at risk by Koh, Calvin Wei Yang, Tan, Hong Qi, Ng, Yan Yee, Lin, Yen Hwa, Ang, Khong Wei, Lew, Wen Siang, Lee, James Cheow Lei, Park, Sung Yong

“…Purpose: Relative biological effectiveness (RBE) uncertainties have been a concern for treatment planning in proton therapy, particularly for treatment sites that are near organs at risk (OARs). …”
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The Pediatric Proton and Photon Therapy Comparison Cohort: Study Design for a Multicenter Retrospective Cohort to Investigate Subsequent Cancers After Pediatric Radiation Therapy by Amy Berrington de González, DPhil, Todd M. Gibson, PhD, Choonsik Lee, PhD, Paul S. Albert, PhD, Keith T. Griffin, MS, Cari Meinhold Kitahara, PhD, Danping Liu, PhD, Matthew M. Mille, PhD, Jungwook Shin, PhD, Benjamin V.M. Bajaj, PhD, Tristin E. Flood, MS, Sara L. Gallotto, MS, Harald Paganetti, PhD, Safia K. Ahmed, MD, Bree R. Eaton, MD, Daniel J. Indelicato, MD, Sarah A. Milgrom, MD, Joshua D. Palmer, MD, Sujith Baliga, MD, Matthew M. Poppe, MD, Derek S. Tsang, MD, Kenneth Wong, MD, Torunn I. Yock, MD

“…The primary analysis will examine subsequent cancer risk after proton therapy compared with photon therapy, adjusting for potential confounders and accounting for competing risks. …”
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Olfactory neuroblastoma in children and adolescents: The EXPeRT recommendations for diagnosis and management by Daniela Di Carlo, Giulia Fichera, Benoit Dumont, Enrico Pozzo, Beate Timmermann, Romain Luscan, Antoine Moya-Plana, Anna Synakiewicz, Ewa Bien, Nino Jorge dos Reis Farinha, Malgorzata Krawczyk, Rita Alaggio, Apostolos Pourtsidis, Brice Fresneau, Yves Reguerre, Tal Ben-Ami, Calogero Virgone, Jelena Roganovic, Jan Godzinski, Ines B Brecht, Dominik Schneider, Andrea Ferrari, Barbara Hero, Daniel Orbach, Gianni Bisogno

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Radiation therapy for de novo anorectal cancer in patients with a history of prostate radiation therapy by Lara Hilal, Abraham J. Wu, Marsha Reyngold, John J. Cuaron, John Navilio, Paul B. Romesser, Alexandra Dreyfuss, Sean Yin, Zhigang Zhang, Xing Bai, Sean L. Berry, Melissa Zinovoy, Maliha Nusrat, Emmanouil Pappou, Michael J. Zelefsky, Christopher H. Crane, Carla Hajj

“…Further studies, perhaps using proton therapy and/or rectal hydrogel spacers, are needed to further decrease toxicity and improve outcomes.…”
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Sensitization of Patient-Derived Colorectal Cancer Organoids to Photon and Proton Radiation by Targeting DNA Damage Response Mechanisms by Kristin Pape, Anna J. Lößner, Doreen William, Tabea Czempiel, Elke Beyreuther, Anna Klimova, Claudia Lehmann, Tim Schmäche, Sebastian R. Merker, Max Naumann, Anne-Marlen Ada, Franziska Baenke, Therese Seidlitz, Rebecca Bütof, Antje Dietrich, Mechthild Krause, Jürgen Weitz, Barbara Klink, Cläre von Neubeck, Daniel E. Stange

“…While response to photon and proton therapy was similar, PDOs revealed heterogeneous responses to irradiation and different chemotherapeutic drugs. …”
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Characterization of Ultra-High-Dose Rate Electron Beams with ElectronFlash Linac by Lucia Giuliano, Gaia Franciosini, Luigi Palumbo, Lilia Aggar, Marie Dutreix, Luigi Faillace, Vincent Favaudon, Giuseppe Felici, Federica Galante, Andrea Mostacci, Mauro Migliorati, Matteo Pacitti, Annalisa Patriarca, Sophie Heinrich

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Professional practice changes in radiotherapy physics during the COVID-19 pandemic by Jenny Bertholet, Marianne C. Aznar, Cristina Garibaldi, David Thwaites, Eduard Gershkevitsh, Daniela Thorwarth, Dirk Verellen, Ben Heijmen, Coen Hurkmans, Ludvig Muren, Kathrine Røe Redalen, Frank-André Siebert, Marco Schwarz, Wouter Van Elmpt, Dietmar Georg, Nuria Jornet, Catharine H. Clark

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Development of Volumetric Independent Dose Calculation System for Verification of the Treatment Plan in Image-Guided Adaptive Brachytherapy by Sang-Won Kang, Sang-Won Kang, Jin-Beom Chung, Kyeong-Hyeon Kim, Kyeong-Hyeon Kim, Ji-Yeon Park, Hae-Jin Park, Woong Cho, Sven Olberg, Sven Olberg, Tae Suk Suh, Tae Suk Suh, Justin C. Park, Justin C. Park

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Adjuvant therapy for children treated by enucleation at diagnosis of retinoblastoma by Yelena Diarra, Christina Brockmeyer, Karen Fischhuber, Isabel Hülsenbeck, Saskia Ting, Madlen Reschke, Tobias Kiefer, Anna Hannbücken, Maren Wagemanns, Leyla Jabbarli, Selma Sirin, Regina Wieland, Gudrun Fleischhack, Johannes H. Schulte, Martin Ebinger, Dietmar Lohmann, Bert Müller, Daniela Süsskind, Christoph Schwab, Ines Brecht, Angelika Eggert, Stefan Schönberger, Petra Ritter-Sovinz, Nikolaos Bechrakis, Sophia Göricke, Beate Timmermann, Eva Biewald, Petra Ketteler

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