Role of Asymmetric Autocatalysis in the Elucidation of Origins of Homochirality of Organic Compounds by Kenso Soai, Tsuneomi Kawasaki, Arimasa Matsumoto

“…Pyrimidyl alkanol and related compounds were found to be asymmetric autocatalysts in the enantioselective addition of diisopropylzinc to pyrimidine-5-carbaldehyde and related aldehydes. In the asymmetric autocatalysis with amplification of enantiomeric excess (ee), the very low ee (ca. 0.00005%) of 2-alkynyl-5-pyrimidyl alkanol was significantly amplified to >99.5% ee with an increase in the amount. …”
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