Exploring barriers and enablers of self-management behaviours in patients with diabetic foot ulcers: A qualitative study from the perceptions of patients, caregivers, and healthcar... by Zhu, Xiaoli, Lee, Eng Sing, Lim, Phoebe X. H., Chen, Yee Chui, Chan, Frederick H. F., Griva, Konstadina

“…Diabetes mellitus (DM) is a serious threat to global health and diabetic foot ulcers (DFU) remains one of the most common complications of DM1 affecting around 20 million people annually.2 DFUs are complex to treat, take months or years to heal, and the recurrence rates remain high up to 40% within 1 year of healing.3 People with DFUs are at risk of prolonged healing times and hospitalisation, reduced quality of life4, 5 and higher five-year mortality rates.3 Moreover, DFU is a causal factor for up to 85% of patients with diabetes who subsequently undergo lower extremity amputation3, 6 and is a leading cause of global disability.2 Singapore has the highest rate of diabetic lower extremity amputation (DLEA) in the world7 because of DFU and the trend is increasing.8 Additionally, DFU is a substantial clinical and economic burden to health systems in Singapore with escalating healthcare costs corresponding to more proximal amputation levels and high re-admission rates.9 Thus, understanding barriers to managing DFU is vital for improving patient care.…”
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Stigma-making and narrative ethics in Singaporean cultural representations of HIV and AIDS by Hyder, Sophia

“…Since the start of the AIDS epidemic in the 1980s, significant medical strides have improved the quality of life and life expectancy for people living with HIV. …”
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An experimental design of a robotic delivery company by Foo, Melvin Maw Qing

“…The startup aims to reduce cost for users, increase profitability for businesses and improve quality of life for logistics workers. This report details technical and business details of the startup. …”
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A novel human stem cell platform for probing adrenoceptor signaling in iPSC derived cardiomyocytes including those with an adult atrial phenotype by Ahmad, F

“…<p>Scientific research is propelled by two objectives: Understanding and recognizing the essential biology of life, and deciphering this to uncover possible therapeutics in order to improve quality of life as well as relieve pain from disease. …”

Study protocol for a pragmatic randomised controlled trial of comparing enhanced acceptance and commitment therapy plus (+) added to usual aftercare versus usual aftercare only, in... by Khan, I, Taylor, SJC, Robinson, C, Moschopoulou, E, McCrone, P, Bourke, L, Thaha, M, Bhui, K, Rosario, D, Ridge, D, Donovan, S, Korszun, A, Little, P, Morgan, A, Quentin, O, Roylance, R, White, P, Chalder, T

“…: Background: Two million people in the UK are living with or beyond cancer and a third of them report poor quality of life (QoL) due to problems such as fatigue, fear of cancer recurrence, and concerns about returning to work. …”

Evaluating the cost-effectiveness of antenatal screening for major structural anomalies during the first trimester of pregnancy: a decision model by Campbell, H, Karim, J, Papageorgiou, AT, Wilson, E, Rivero-Arias, O

“…</p> <br> <p><strong>Main outcomes measures:</strong> Expected numbers of pregnancy outcomes, healthcare costs, and maternal quality adjusted life years (QALYs). Estimation of the incremental costeffectiveness ratio (ICER), likelihood of cost-effectiveness, and a value of information (VoI) analysis assessing if further research is needed before making a decision about screening.…”

Citizenship and the politics of poverty definition during the segregation, apartheid and democratic eras in South Africa: 1910-2010 by Magasela, W

“…</p> <p>In the post-apartheid era with a Constitution that enshrines a Bill of Rights with explicit and specific social and economic rights, and human dignity, social justice and the commitment to improve the quality of life of all citizens as foundational values aimed at addressing extensive multi-dimensional poverty, apartheid era concepts and definitions of poverty (mainly the HSL and MLL) continue. …”

Gender differences in perceptions of psoriatic arthritis disease impact, management, and physician interactions: results from a global patient survey by Eder, L, Richette, P, Coates, LC, Azevedo, VF, Cappelleri, JC, Johnson, EP, Hoang, M, Moser, J, Kessouri, M

“…<p><strong>Introduction:</strong> We evaluated the impact of gender on disease severity, health-related quality of life (HRQoL), treatment management, and patient–healthcare professional (HCP) interactions from the perspectives of patients with psoriatic arthritis (PsA).…”

Cost-utility analysis of molnupiravir plus usual care versus usual care alone as early treatment for community-based adults with COVID-19 and increased risk of adverse outcomes in... by Png, ME, Harris, V, Grabey, J, Hart, ND, Jani, BD, Butler, D, Carson-Stevens, A, Coates, M, Cureton, L, Dobson, M, Dorward, J, Evans, P, Francis, N, Gbinigie, OA, Hayward, G, Holmes, J, Hood, K, Khoo, S, Ahmed, H, Lown, M, McKenna, M, Mort, S, Nguyen-Van-Tam, J, Rahman, N, Richards, DB, Thomas, N, van Hecke, O, Hobbs, FR, Little, P, Yu, L-M, Butler, CC, Petrou, S

“…Cost-effectiveness was expressed in terms of incremental cost per quality-adjusted life year (QALY) gained. Sensitivity and subgroup analyses assessed the impacts of uncertainty and heterogeneity. …”

Using QALYs as an outcome for assessing global prediction accuracy in diabetes simulation models by Dakin, H, Gao, N, Leal, J, Holman, RR, Tran-Duy, A, Clarke, P

“…<p><strong>Objectives:</strong> (1) To demonstrate the use of quality-adjusted life-years (QALYs) as an outcome&nbsp;measure for comparing performance between simulation models and identifying the most&nbsp;accurate model for economic evaluation and health technology assessment. …”

Newborn screening for severe combined immunodeficiency in Malaysia: current status, challenges and progress by Chang, Wai Leng, Mohd Noh, Lokman, Abdul Latiff, Amir Hamzah, Woo, Kent Chee Keen, Ismail, Intan Hakimah, Abd Hamid, Intan Juliana, Siniah, Sangeetha, Zainal Abidin, Mohd Azri, Sham, Marina, Mat Ripen, Adiratna, Baharin, Mohd Farid, Abdul Wahab, Asrul, Zainudeen, Zarina Thasneem, Hashim, Ilie Fadzilah, Wong, Yee Ming, Ahmad Shawaludin, Mohamad Qazreen, Ali, Adli

“…Introduction: Early diagnosis of Severe Combined Immunodeficiency (SCID) increases survival outcomes and quality of life while significantly minimizing healthcare burden and costs. …”
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Unveiling potential therapeutic targets for breast cancer recurrence: differentially expressed genes and pathways in post-surgery patients by Hamad, Hamad Ali, Saeed, Hammad Khalaf, Hussein, Talib Hammad, Hussain, Abdalwahab Bdewi, Md Hashim, Nur Fariesha

“…The findings have uncovered key therapeutic targets associated with tumor recurrence through potential ECM-related genes whose overexpression may significantly contribute to tumorigenesis in breast cancer survivors by epithelial-to-mesenchymal transition and targeting them may improve the chances of better survival breast cancer patients and increase the quality of life by reducing the chances of recurrence. …”
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Synthesis and characterization of calcium carbonate obtained from green mussel and crab shells as a biomaterials candidate by Ismail, Rifky, Cionita, Tezara, Wong, Ling Shing, Fitriyana, Deni Fajar, Siregar, Januar Parlaungan, Bayuseno, Athanasius Priharyoto, Nugraha, Fariz Wisda, Muhamadin, Rilo Chandra, Ramli, Junid, Nor Azam, Endot

“…The improper disposal of green mussel and crab shells can cause environmental pollution, reducing the quality of life in the community. Many studies have reported the preparation of CaCO3 from green mussels and crab shells. …”
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Multi-Keel Passive Prosthetic Foot Design Optimization Using the Lower Leg Trajectory Error Framework by Prost, Victor, Peterson, Heidi V, Winter, Amos G

“…People with lower-limb amputation in low- and middle-income countries (LMICs) lack access to adequate prosthetic devices that would restore their mobility and increase their quality of life. This is largely due to the cost and durability of existing devices. …”
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Cost-effectiveness of a group psychological intervention for postnatal depression in British South Asian mothers: an economic evaluation from the ROSHNI-2 trial by Ullah, A, Lunat, F, Brugha, T, Pierce, M, Morriss, R, Sharma, D, Rahman, A, Bhui, K, Bower, P, Husain, N

“…</p> <br> <p><strong>Outcomes:</strong> The base-case intention-to-treat analysis showed PHP significantly increased costs (£912, 95% CI £420–£1405) and quality-adjusted life years (QALYs) (0.037, CI 0.006–0.068), with an incremental cost-effectiveness ratio (ICER) of £24,739 (CI £15,539–£39,692). …”

Cytotoxic effect of Bajong LN rice methanol extract on human squamous cell Carcinoma, ORL-48 by Vivi Noryati Ahmad, Nur Aliana Hidayah Mohamed, Zulkhairi Amom, Khor, Goot Heah, Nurhayati Mohamad Zain, Indah Mohd Amin

“…Oral squamous cell carcinoma (OSCC), a major oral cancer, significantly challenges treatments and impacts patient quality of life; current therapies often cause severe side effects, highlighting the urgent need for gentler alternatives. …”
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Learning a closed-loop policy for scooping task by Lau, Wei Quan

“…Assistive feeding technologies can play a crucial role in improving the quality of life for individuals with disabilities or age-related limitations who struggle with self-feeding. …”
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Development, validation and the effects of culturally specific guided imagery and progressive muscle relaxation audio for patients with functional abdominal bloating by Shen, Vincent Tee Wei

“…Significant differences were observed in terms of time effect among the Severity General, Severity in 24 hours, Quality of Life, Health-Promoting Behaviour, and anxiety variables. …”
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Foot care behaviours and associated factors among patients with type 2 diabetes: a cross-sectional study by Ang, Chin-Siang, Goh, Kelley Fann Ing, Lodh, Nandika, Qin, Vicky Mengqi, Liew, Huiling, Sidhu, Harvinder Raj Singh, Ng, Jun Jie, Subramaniam, Tavintharan, Tan, Elaine, Koh, Gerald Choon Huat, Best, James, Wong, Julian, Car, Josip, Ho, Andy Hau Yan, Venkataraman, Kavita

“…Furthermore, we identified eight influencing factors on FC behaviours, including smoking status, the availability of a caregiver, the presence of diabetic foot ulcers, amputation history, FC knowledge, subjective norms in diabetes selfcare behaviour, diabetes-related stress, and quality of life index values. The logistic regression analysis showed that current smokers were 60% less likely to practice good FC compared to non-smokers (odds ratio (OR) = 0.40; 95%; confidence interval (CI)= 0.22–0.73). …”
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Fiona Patrick - Thesis submitted in partial fulfilment of the degree of Doctor of Clinical Psychology (DClinPsych) by Patrick, F

“…<p><strong>SRL</strong> </p><p>Chronic abdominal-pelvic pain (CAPP) is debilitating and associated with distress, functional disability and reduced quality of life. CAPP is additionally associated with delays in diagnosis and treatment. …”