Cation-controlled enantioselective and diastereoselective synthesis of indolines: an autoinductive phase-transfer initiated 5-endo-trig process by Sharma, K, Wolstenhulme, J, Painter, P, Yeo, D, Grande-Carmona, F, Johnston, C, Tantillo, D, Smith, M

“…This reaction proceeds with high levels of diastereoselectivity (>20:1) and high levels of enantioselectivity (up to 99.5:0.5 er) in the presence of CsOH·H2O and a quinine-derived ammonium salt. The reaction most likely proceeds via a delocalized 2-aza-pentadienyl anion that cyclizes either by a suprafacial electrocyclic mechanism, or through a kinetically controlled 5-endo-trig Mannich process. …”

Single dose artemisinin-mefloquine treatment for acute uncomplicated falciparum malaria. by Tran, T, Arnold, K, Nguyen, T, Pham, P, Nguyen, T, Bui, M, Le, M, Mach, Q, Le, H, Pham, P

“…Randomized comparative treatment schedules were: artemisinin alone for 5 d, mefloquine-sulfadoxine-pyrimethamine (MSP), or quinine plus sulfadoxine-pyrimethamine (SP). Parasite clearance times (PCT) were rapid for artemisinin treated inpatients (90%: 14.8-20.4 h) but also for patients receiving MSP (PCT 90%: 18.0 h) and quinine (PCT 90%: 22.5 h). …”

A Novel Morphine Drinking Model of Opioid Dependence in Rats by Pablo Berríos-Cárcamo, Mauricio Quezada, Daniela Santapau, Paola Morales, Belén Olivares, Carolina Ponce, Alba Ávila, Cristian De Gregorio, Marcelo Ezquer, María Elena Quintanilla, Mario Herrera-Marschitz, Yedy Israel, Fernando Ezquer

“…Then, quinine was removed, and the preference for morphine against water was evaluated. …”
Get full text

Docking Analysis of Some Bioactive Compounds from Traditional Plants against SARS-CoV-2 Target Proteins by Nourhan M. Abd El-Aziz, Ibrahim Khalifa, Amira M. G. Darwish, Ahmed N. Badr, Huda Aljumayi, El-Sayed Hafez, Mohamed G. Shehata

“…Results found that the chicoric acid, quinine, and withaferin A ligand strongly inhibited CoV-2 S -protein with a binding energy of −8.63, −7.85, and −7.85 kcal/mol, respectively. …”
Get full text

Quality of anti-malarial drugs provided by public and private healthcare providers in south-east Nigeria by Uzochukwu Benjamin, Shu Elvis, Dike Nkem, Kaur Harparkash, Onwujekwe Obinna, Hanson Kara, Okoye Viola, Okonkwo Paul

“…Anti-malarials (225 samples), which included artesunate, dihydroartemisinin, sulphadoxine-pyrimethamine (SP), quinine, and chloroquine, were either purchased or collected from randomly selected providers. …”
Get full text

Sexually dimorphic role for insular perineuronal nets in aversion-resistant alcohol consumption by Luana Martins de Carvalho, Hu Chen, Mason Sutter, Amy W. Lasek

“…One animal model of compulsive alcohol drinking involves the addition of bitter-tasting quinine to an ethanol solution and measuring the willingness of the animal to consume ethanol despite the aversive taste. …”
Get full text

The treatment of malaria. by White, N

“…Mefloquine, halofantrine, or quinine with tetracycline can be used to treat multidrug-resistant P. falciparum. …”

Efficacy of existing antimalarial drugs for uncomplicated malaria in Timika, Papua, Indonesia by Siswantaro, H, Ratcliff, A, Kenangalem, E, Wuwung, M, Maristela, R, Rumaseuw, R, Laihad, F, Ebsworth, P, Anstey, N, Price, R, Tjitra, E

“…Patients failing therapy were retreated with unsupervised quinine±doxycycline. 207 patients were enrolled in the study (88 P. falciparum, 40 P. vivax, 15 mixed infections, 50 P. malariae and 14 P. ovale). …”

Oscillator Strength and Quantum Efficiency of Fluoranthene Molecule by M. S. Mehdi

“…Fluorescence quantum efficiency of Fluoranthene was measured relative to Quinine Sulfate (QS) in 1N H2SO4. The obtained values were (0.5) in cyclohexane and (0.45) in ethanol …”
Get full text

Falciparum malaria complicated by black water fever by M S Madhuri, K Elavarasan, V P Benjamin, M S Sridhar, S Natarajan, V Chiranjeevi

“…In the treatment of falciparum malaria, apart from quinine, use of other antimalarials, either singly or in combination are associated with the syndrome of blackwater fever.…”
Get full text

Plasmodium malariae in Bangladesh. by Rahman, W, Chotivanich, K, Silamut, K, Tanomsing, N, Hossain, A, Faiz, M, Dondorp, A, Maude, R

“…The patient made a rapid recovery with intravenous quinine treatment.…”

Glycerol gelatin for 3D-printing of implants using a paste extrusion technique by Kempin Wiebke, Baden Anna, Weitschies Werner, Seidlitz Anne

“…The release of the model drug quinine from printed and crosslinked implants was fast and nearly completed within 6 hours.…”
Get full text

Pharmacokinetics of mirodenafil, a new erectogenic, and its metabolite, SK3541, in rats: involvement of CYP1A1/2, 2B1/2, 2D subfamily, and 3A1/2 for the metabolism of both mirodena... by Young Hee Choi, Young Sun Lee, Myung Gull Lee, Tae Kon Kim, Bong-Yong Lee

“…However, compared to controls, in rats pretreated with quinine and troleandomycin (main inhibitors of CYP2D subfamily and 3A1/2, respectively), the CLNRs of mirodenafil were significantly slower (by 36.1% and 33.2%, respectively). …”
Get full text

Study of Clinical Profile of Patients with Malarial Fever admitted in a Tertiary Care Centre by Gaurav Uday Ghurye, Nirmala Umesh Sawant, Vijaykumar Bhagwan Barge

“…for uncomplicated vivax malaria Tab chloroquine showed 60% sensitivity, tab artemether + lumefantrine showed 75% sensitivity, those who were not responding were added with quinine, doxycycline. In falciparum inj. artesunate76 % was more sensitive than quinine 69%. …”
Get full text

Inhibition of Erythromycin and Erythromycin-Induced Resistance among <i>Staphylococcus aureus</i> Clinical Isolates by Aya A. Mahfouz, Heba S. Said, Sherin M. Elfeky, Mona I. Shaaban

“…Doxorubicin, neomycin, omeprazole, quinine, ketoprofen, and fosfomycin could be potential inhibitors of erythromycin and inducible clindamycin resistance.…”
Get full text

In vitro susceptibility of Plasmodium falciparum Welch field isolates to infusions prepared from Artemisia annua L. cultivated in the Brazilian Amazon by Luiz Francisco Rocha e Silva, Pedro Melillo de Magalhães, Mônica Regina Farias Costa, Maria das Graças Costa Alecrim, Francisco Célio Maia Chaves, Ari de Freitas Hidalgo, Adrian Martin Pohlit, Pedro Paulo Ribeiro Vieira

“…Field P. falciparum isolates were resistant to chloroquine and sensitive to quinine and artemisinin. The average 50% inhibition concentration values for A. annua infusions against field isolates were 0.11-0.14 μL/mL (these infusions exhibited artemisinin concentrations of 4.7-5.6 ng/mL) and were active in vitro against P. falciparum due to their artemisinin concentration. …”
Get full text

Effects of nonsteroidal anti-inflammatory drugs on hearing by Oğuz Güçlü, Ramazan Sargın, Kürşat Duman, Abdullah Ayçiçek, Fevzi Sefa Dereköy, Vural Kavuncu

“…The more study about ototoxic effects of acetyl salicylic acid (ASA) and quinine has been at the literature. In this study, the effects to hearing of NSAID except ASA and quinine were evaluated.Methods: Twenty-three patients with started chronic medication for the pathology of muscle-skeleton system were included the study. …”
Get full text

Plant Alkaloids Inhibit Membrane Fusion Mediated by Calcium and Fragments of MERS-CoV and SARS-CoV/SARS-CoV-2 Fusion Peptides by Egor V. Shekunov, Svetlana S. Efimova, Natalia M. Yudintceva, Anna A. Muryleva, Vladimir V. Zarubaev, Alexander V. Slita, Olga S. Ostroumova

“…Piperine, tabersonine, hordenine, lupinine, quinine, and 3-isobutyl-1-methylxanthine demonstrated the most potent effects (inhibition index greater than 50%). …”
Get full text

Treatment of malaria from monotherapy to artemisinin-based combination therapy by health professionals in urban health facilities in Yaoundé, central province, Cameroon by Bley Daniel, Malvy Denis, Vernazza-Licht Nicole, Gausseres Mathieu, Sayang Collins, Millet Pascal

“…</p> <p>Results</p> <p>In 2005, twenty-seven trade-named drugs have been identified in drugstores; quinine tablets (300 mg) were the most affordable anti-malarial drugs. …”
Get full text

Discrimination of Isointense Bitter Stimuli in a Beer Model System by Molly J. Higgins, John E. Hayes

“…All used a commercial non-alcoholic beer spiked with Isolone (a hop extract), quinine sulfate dihydrate, and sucrose octaacetate (SOA). …”
Get full text