Cellular characterization of artemisinin resistance in human malaria. by Low, Kum Yong.

“…It is also observed that the strain is not cross-resistant to chloroquine, mefloquine, quinine and pyrimethamine.…”
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Enhanced choline and Rb+ transport in human erythrocytes infected with the malaria parasite Plasmodium falciparum. by Kirk, K, Wong, H, Elford, B, Newbold, C, Ellory, J

“…This component was less sensitive than the endogenous transporter to inhibition by the Cinchona bark alkaloids quinine, quinidine, cinchonine and cinchonidine, but showed a much greater sensitivity than the native system to inhibition by piperine. …”

Cardiotoxicity of antimalarial drugs. by White, N

“…The parenteral quinoline formulations (chloroquine, quinine, and quinidine) are predictably hypotensive when injected rapidly, and cardiovascular collapse can occur with self-poisoning. …”

Cloning and functional expression of the cDNA encoding a novel ATP-sensitive potassium channel subunit expressed in pancreatic beta-cells, brain, heart and skeletal muscle. by Sakura, H, Ammälä, C, Smith, P, Gribble, F, Ashcroft, F

“…They were blocked by external barium (5 mM), tolbutamide (<em>K</em>_d = 4.5 andmu;M) or quinine (20 andmu;M) and by 5 mM intracellular ATP. …”

Malaria. by White, N, Pukrittayakamee, S, Hien, T, Faiz, M, Mokuolu, O, Dondorp, A

“…In large trials, parenteral artesunate (an artemisinin derivative) reduced severe malaria mortality by 22·5% in Africa and 34·7% in Asia compared with quinine, whereas adjunctive interventions have been uniformly unsuccessful. …”

Clinical malaria in the tropics. by White, N, Pukrittayakamee, S

“…Sulfadoxine-pyrimethamine resistance is also common. Fortunately, quinine, and the newly introduced compounds, halofantrine and mefloquine, can be relied upon nearly everywhere. …”

The pharmacokinetics of artemether and lumefantrine in pregnant women with uncomplicated falciparum malaria. by Mcgready, R, Stepniewska, K, Lindegardh, N, Ashley, E, La, Y, Singhasivanon, P, White, N, Nosten, F

“…METHODS: Pregnant women who had recurrence of parasitaemia following 7 days supervised quinine treatment were treated with AL. Serial blood samples were taken over a 7-day period, and pharmacokinetic parameters were estimated. …”

Which Drug is Effective and Safe for Acute Malaria in Pregnancy? Reviewing the Evidence by Mcgready, R, Nosten, F

“…The results show that quinine plus clindamycin is the treatment of choice in the first trimester, while artemisinin treatment should be used in the second and third trimesters in the treatment of uncomplicated malaria. …”

High-performance liquid chromatographic determination of diazepam in plasma of children with severe malaria. by Muchoh, SN, Ogutu, B, Newton, C, Kokwar, G

“…There was no interference from drugs commonly administered to children with severe malaria (phenobarbitone, phenytoin, chloroquine, quinine, sulfadoxine, pyrimethamine, halofantrine, cycloguanil, chlorcycloguanil, acetaminophen and salicylate). …”

Severe and complicated falciparum malaria in Melanesian adults in Papua New Guinea. by Lalloo, D, Trevett, A, Paul, M, Korinhona, A, Laurenson, I, Mapao, J, Nwokolo, N, Danga-Christian, B, Black, J, Saweri, A, Naraqi, S, Warrell, D

“…Hypoglycemia was common following treatment with quinine. The overall case fatality rate was 18.6%; renal failure and cerebral malaria in particular were associated with a poor outcome. …”

Artemisinin-based combinations. by Ashley, E, White, N

“…RECENT FINDINGS: A large multicentre randomised trial conducted in East Asia has shown a 35% reduction in mortality from severe malaria following treatment with parenteral artesunate compared with quinine. There is increasing evidence that artemisinin-based combination treatments are safe and rapidly effective. …”

Therapeutic responses to different antimalarial drugs in vivax malaria. by Pukrittayakamee, S, Chantra, A, Simpson, J, Vanijanonta, S, Clemens, R, Looareesuwan, S, White, N

“…The activities of these drugs in descending order were artesunate, artemether, chloroquine, mefloquine, quinine, halofantrine, primaquine, and pyrimethamine-sulfadoxine (PS). …”

Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions. by Martins, R, Maier, J, Gorki, A, Huber, K, Sharif, O, Starkl, P, Saluzzo, S, Quattrone, F, Gawish, R, Lakovits, K, Aichinger, M, Radic-Sarikas, B, Lardeau, C, Hladik, A, Korosec, A, Brown, M, Vaahtomeri, K, Duggan, M, Kerjaschki, D, Esterbauer, H, Colinge, J, Eisenbarth, S, Decker, T, Bennett, K, Kubicek, S, Sixt, M, Superti-Furga, G, Knapp, S

“…A chemical screening approach revealed that quinine effectively prevented heme effects on the cytoskeleton, restored phagocytosis and improved survival in sepsis. …”

Halofantrine pharmacokinetics in Kenyan children with non-severe and severe malaria. by Watkins, WM, Winstanley, P, Mberu, E, Kokwaro, G, Murphy, SA, Newton, C, Mwangi, I, Forster, D, Marsh, K

“…Eight Kenyan children with severe (prostrate) falciparum malaria who were receiving intravenous quinine, were given the same HF regimen by nasogastric tube. …”

In vitro inhibition of Plasmodium falciparum by substances isolated from Amazonian antimalarial plants by Valter F de Andrade-Neto, Adrian M Pohlit, Ana Cristina S Pinto, Ellen Cristina C Silva, Karla L Nogueira, Márcia RS Melo, Marycleuma C Henrique, Rodrigo CN Amorim, Luis Francisco R Silva, Mônica RF Costa, Rita CS Nunomura, Sergio M Nunomura, Wilson D Alecrim, M das Graças C Alecrim, F Célio M Chaves, Pedro Paulo R Vieira

“…In the present study, a quassinoid, neosergeolide, isolated from the roots and stems of Picrolemma sprucei (Simaroubaceae), the indole alkaloids ellipticine and aspidocarpine, isolated from the bark of Aspidosperma vargasii and A. desmanthum (Apocynaceae), respectively, and 4-nerolidylcatechol, isolated from the roots of Pothomorphe peltata (Piperaceae), all presented significant in vitro inhibition (more active than quinine and chloroquine) of the multi-drug resistant K1 strain of Plasmodium falciparum. …”
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Sweat control in male by the use of alunogen and cypripedium pubescens by Lorenzo Martini

“…The formula comprises also the concrète of Cypripedium Pubescens (Lady’s slipper) which contains, inter alia, the cypripedin, a quinine-analog, endowed by anticholinergic activities, that can be reputed useful as astringent agent with regards to eccrine glands, synergically to the action upon apocrine glands performed by alunogen. …”
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Effect of ethanol on interactions of bitter and sweet tastes in aqueous solutions by Zdeňka PANOVSKÁ, Alena ŠEDIVÁ, Markéta JEDELSKÁ, Jan POKORNÝ

“…In all experiments, 0.01% quinine was used as a standard bitter substance. Sucrose increased the acceptability in the concentration range of up to 14%, remaining constant at higher concentrations, both in aqueous and 16% ethanolic solutions. …”
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Iron at the center of ferritin, metal/oxygen homeostasis and novel dietary strategies by X LIU, K HINTZE, B LONNERDAL, EC THEIL

“…Ferritin is a member of both the "oxidant stress response" gene family that includes thioredoxin reductase and quinine reductase, and a member of the iron responsive gene family that includes ferroportin and mt-aconitase ferritin DNA regulation responds preferentially to oxidant response inducers and ferritin mRNA to iron inducers; heme confers regulator synergy. …”
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Assay for screening for six antimalarial drugs and one metabolite using dried blood spot sampling, sequential extraction and ion-trap detection. by Blessborn, D, Romsing, S, Bergqvist, Y, Lindegardh, N

“…RESULTS: This assay detects quinine, mefloquine, sulfadoxine, pyrimethamine, lumefantrine, chloroquine and its metabolite desethylchloroquine in a 100-µl dried blood spot. …”

Characterization of "Yaa Chud" Medicine on the Thailand-Myanmar border: selecting for drug-resistant malaria and threatening public health. by Newton, P, Hampton, C, Alter-Hall, K, Teerwarakulpana, T, Prakongpan, S, Ruangveerayuth, R, White, N, Day, N, Tudino, M, Mancuso, N, Fernández, F

“…The most frequently detected active ingredients were acetaminophen (22%), chlorpheniramine (13.4%), chloroquine (12.6%), tetracycline/doxycycline (11.4%), and quinine (5.1%). Only seven bags contained potentially curative medicine for malaria. …”