Predicting the clinical outcome of severe falciparum malaria in african children: findings from a large randomized trial. by von Seidlein, L, Olaosebikan, R, Hendriksen, I, Lee, S, Adedoyin, O, Agbenyega, T, Nguah, S, Bojang, K, Deen, J, Evans, J, Fanello, C, Gomes, E, Pedro, A, Kahabuka, C, Karema, C, Kivaya, E, Maitland, K, Mokuolu, O, Mtove, G, Mwanga-Amumpaire, J, Nadjm, B, Nansumba, M, Ngum, W, Onyamboko, M, Reyburn, H

“…METHODS: African children (<15 years) with severe malaria participated in a randomized comparison of parenteral artesunate and parenteral quinine in 9 African countries. Detailed clinical assessment was performed on admission. …”

Randomized controlled trial of levamisole hydrochloride as adjunctive therapy in severe falciparum malaria with high parasitemia. by Maude, R, Silamut, K, Plewes, K, Charunwatthana, P, Ho, M, Abul Faiz, M, Rahman, R, Hossain, M, Hassan, M, Bin Yunus, E, Hoque, G, Islam, F, Ghose, A, Hanson, J, Schlatter, J, Lacey, R, Eastaugh, A, Tarning, J, Lee, S, White, N, Chotivanich, K, Day, N, Dondorp, A

“…The oral anthelminthic drug levamisole inhibits cytoadherence in vitro and reduces sequestration of late-stage parasites in uncomplicated falciparum malaria treated with quinine. METHODS: Fifty-six adult patients with severe malaria and high parasitemia admitted to a referral hospital in Bangladesh were randomized to receive a single dose of levamisole hydrochloride (150 mg) or no adjuvant to antimalarial treatment with intravenous artesunate. …”

Glucose-6-phosphate dehydrogenase (G6PD) mutations and haemoglobinuria syndrome in the Vietnamese population. by Hue, N, Charlieu, J, Chau, T, Day, N, Farrar, J, Hien, T, Dunstan, S

“… BACKGROUND: In Vietnam the blackwater fever syndrome (BWF) has been associated with malaria infection, quinine ingestion and G6PD deficiency. The G6PD variants within the Vietnamese Kinh contributing to the disease risk in this population, and more generally to haemoglobinuria, are currently unknown. …”

Pharmacokinetics, efficacy and toxicity of parenteral halofantrine in uncomplicated malaria. by Krishna, S, ter Kuile, F, Supanaranond, W, Pukrittayakamee, S, Teja-Isavadharm, P, Kyle, D, White, N

“…In the single treatment failure who received oral quinine, there was a large rise in plasma halofantrine concentration but this did not result in detectable toxicity. 5 These data provide the basis for the design of improved dosing regimens for the use of parenteral halofantrine in malaria.…”

Malaria in a cohort of Javanese migrants to Indonesian Papua. by Krisin, Basri, H, Fryauff, D, Barcus, M, Bangs, M, Ayomi, E, Marwoto, H, Elyazar, I, Richie, T, Baird, J

“…Only one of the nine subjects who developed severe malaria (requiring intravenous quinine therapy) was a child, giving an odds ratio for a case of severe malaria being in an adult of 6.1 (P=0.08).…”

Natural Alkaloids as Potential Anti-Coronavirus Compounds by Gülaçtı TOPÇU, Halil ŞENOL, Gülbahar Özge ALİM TORAMAN, Vecdi Melih ALTAN

“…The first isolated secondary metabolites have been converted into important drugs since 1800’s such as morphine, codeine, cocaine, and quinine have alkaloid skeleton as well as some of the recent anticancer drugs vinblastine, vincristine, taxol, etc. …”
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Malaria: The Past and the Present by Jasminka Talapko, Ivana Škrlec, Tamara Alebić, Melita Jukić, Aleksandar Včev

“…The sweet sagewort plant was used as early as the second century BC to treat malaria fever in China. Much later, quinine started being used as an antimalaria drug. …”
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A Simple Taste Test for Clinical Assessment of Taste and Oral Somatosensory Function—The “Seven-iTT” by Mariano Mastinu, Michał Pieniak, Anne Wolf, Tomer Green, Antje Hähner, Masha Y. Niv, Thomas Hummel

“…They underwent a whole-mouth identification test of 12 filter-paper strips impregnated with low and high concentrations of sweet, sour, salty, bitter (sucrose, citric acid, NaCl, quinine), astringency (tannin), and spiciness (capsaicin). …”
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Age-related Smell and Taste Impairments and Vitamin D Associations in the U.S. Adults National Health and Nutrition Examination Survey by Galya Bigman

“…Taste impairment was defined as failing to correctly identify quinine or sodium chloride. VD was measured as serum 25-hydroxyvitamin. …”
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Inhibition of Radiation and Temozolomide-Induced Glioblastoma Invadopodia Activity Using Ion Channel Drugs by Marija Dinevska, Natalia Gazibegovic, Andrew P. Morokoff, Andrew H. Kaye, Katharine J. Drummond, Theo Mantamadiotis, Stanley S. Stylli

“…GBM cell cytotoxicity screening of several ion channel drugs identified three drugs with potent cell killing efficacy: flunarizine dihydrochloride, econazole nitrate, and quinine hydrochloride dihydrate. These drugs demonstrated a reduction in GBM cell invadopodia activity and matrix metalloproteinase-2 (MMP-2) secretion. …”
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The Impacts of Precipitation on Fluorescent Dissolved Organic Matter (FDOM) in an Urban River System by Jiashuai Yang, Chan Gao, Xuantong Zhang

“…Overall, the total fluorescence intensities in dry and wet seasons ranged from 6.59 to 35.7 quinine sulfate units (QSU) and 3.42 to 69.3 QSU, respectively. …”
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Desymmetrization of Prochiral <i>N</i>-Pyrazolyl Maleimides via Organocatalyzed Asymmetric Michael Addition with Pyrazolones: Construction of Tri-<i>N</i>-Heterocyclic Scaffolds Be... by Jianqi Geng, Xingfu Wei, Biru He, Yuting Hao, Jingping Qu, Baomin Wang

“…The desymmetrization of <i>N</i>-pyrazolyl maleimides was realized through an asymmetric Michael addition by using pyrazolones under mild conditions, leading to the formation of a tri-<i>N</i>-heterocyclic pyrazole–succinimide–pyrazolone assembly in high yields with excellent enantioselectivities (up to 99% yield, up to 99% ee). The use of a quinine-derived thiourea catalyst was essential for achieving stereocontrol of the vicinal quaternary–tertiary stereocenters together with the C–N chiral axis. …”
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Resistance to Antimalarial Monotherapy Is Cyclic by Rachel Weitzman, Ortal Calfon-Peretz, Trishna Saha, Naamah Bloch, Karin Ben Zaken, Avi Rosenfeld, Moshe Amitay, Abraham O. Samson

“…The antimalarial drugs that exhibit cyclic resistance are quinine, chloroquine, mefloquine, amodiaquine, artesunate, artemether, sulfadoxine, doxycycline, halofantrine, piperaquine, pyrimethamine, atovaquone, artemisinin, and dihydroartemisinin. …”
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Phytochemical Screening, Antioxidant, Antidiabetic and Anticancer Activities of Elaeocarpus variabilis Fruit by Venkatachalam Balamurugan, Manikandan Sridhivya, Ramachandran Dharani, Subramaniam Selvakumar, Krishnan Vasanth

“…The most relevant contents in total phenolics (Gallic Acid Equivalent mg/g), tannin (Gallic Acid Equivalent mg/g), total flavonoids (Rutin equivalent mg/g), total alkaloids (Quinine equivalent mg/g), and total saponin (Diosgenin equivalent mg/g) were observed. …”
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Identifikasi Infraspesifik Fusarium oxysporum asal Subtrat Nonpisang dan Kemampuan Pindah Inangnya ke Tanaman Pisang by Gayuh Rahayu, Widodo Widodo, Ni Putu Winda Mahasari

“…The pathogenicity test of Foc IPBCC 88,012, 07,328, 08,561, 10,674 and 14.1236 derived from cucumbers, soil, agarwood sapwood, insect nests and quinine tree endophytes showed that these strains were able to move to banana plant. …”
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Monitoring the drug-sensitivity of Plasmodium falciparum in coastal towns in Madagascar by use of in vitro chemosensitivity and mutation detection tests by Rason M.A., Ariey F., Rafidimanantsoa L., Andrianantenaina B.H., Sahondra Harisoa J.L., Randrianarivelojosia M.

“…All of the isolates from both sites were sensitive to amodiaquine, quinine, pyrimethamine and cycloguanil. All of the isolates from Mahajanga were sensitive to chloroquine (n = 25; mean IC50 = 22.6 nM, 95 % confidence interval: 16.8-28.7 nM), whereas three of the isolates from Toamasina were resistant to chloroquine (n = 18; mean IC50 = 66.3 nM; 95 % confidence interval : 42.6-90 nM), The frequency of the Pfcrt Thr-76 and the dhfr Asn- 108 mutations was estimated by PCR/RFLP. …”
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Pathophysiology and Diagnosis of Drug-Induced Immune Thrombocytopenia by Caroline Vayne, Eve-Anne Guéry, Jérôme Rollin, Tatiana Baglo, Rachel Petermann, Yves Gruel

“…Many drugs can cause immune-mediated thrombocytopenia, but the most commonly implicated are abciximab, carbamazepine, ceftriaxone, eptifibatide, heparin, ibuprofen, mirtazapine, oxaliplatin, penicillin, quinine, quinidine, rifampicin, suramin, tirofiban, trimethoprim-sulfamethoxazole, and vancomycin. …”
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Ketamine ameliorates oxidative stress-induced apoptosis in experimental traumatic brain injury via the Nrf2 pathway by Liang J, Wu S, Xie W, He H

“…Furthermore, administration of ketamine also induced the expression of Nrf2 pathway-related downstream factors, including hemeoxygenase-1 and quinine oxidoreductase-1, at the pre- and post-transcriptional levels.Conclusion: Ketamine exhibits neuroprotective effects by attenuating oxidative stress and apoptosis after TBI. …”
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Inbred mouse strains C57BL/6J and DBA/2J vary in sensitivity to a subset of bitter stimuli by Nelson Theodore M, Raghow Sandeep, Boughter John D, Munger Steven D

“…</p> <p>Results</p> <p>B6 mice were more sensitive than D2 mice to a subset of bitter stimuli, including quinine hydrochloride (QHCl), 6-n-propylthiouracil (PROP), and MgCl₂. …”
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Catalytic atroposelective synthesis of heterobiaryls with vicinal C−C and N−N diaxes via dynamic kinetic resolution by Tian-Jiao Han, Chun-Yan Guan, Na Li, Rui Dong, Li-Ping Xu, Xiao Xiao, Min-Can Wang, Guang-Jian Mei

“…For their atroposelective synthesis, the dynamic kinetic resolution enabled by either quinine-catalyzed allylation or isothiourea-catalyzed acylation has been developed, allowing the preparation of a wide range of vicinal-axis heterobiaryls in good yields with excellent enantioselectivities. …”
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