Spiramycin does not potentiate quinine treatment of falciparum malaria in pregnancy. by Nosten, F, ter Kuile, F, Thwai, K, Maelankirri, L, White, N

A study of the factors affecting the metabolic clearance of quinine in malaria. by Pukrittayakamee, S, Looareesuwan, S, Keeratithakul, D, Davis, T, Teja-Isavadharm, P, Nagachinta, B, Weber, A, Smith, A, Kyle, D, White, N

“…RESULTS: During acute malaria infection, the systemic clearance of quinine, antipyrine and ICG and the biotransformation of quinine to 3-hydroxyquinine were all reduced significantly when compared with values during convalescence. …”

Quinine in severe falciparum malaria: evidence of declining efficacy in Thailand. by Pukrittayakamee, S, Supanaranond, W, Looareesuwan, S, Vanijanonta, S, White, N

“…Between 1981 and 1992, 196 Thai adults with severe falciparum malaria were treated with a quinine loading dose regimen. Nineteen patients died (10%) and 6 developed late hypoglycaemia. …”

Fever in uncomplicated Plasmodium falciparum infection: effects of quinine and paracetamol. by Krishna, S, Supanaranond, W, Pukrittayakamee, S, ter Kuile, F, Supputamangkol, Y, Attatamsoonthorn, K, Ruprah, M, White, N

“…Quinine alone (n = 7) had no significant effect on fever, whereas paracetamol given 2 h after quinine (n = 7) or 2 h before quinine (n = 7) reduced temperature by a mean of 2.1 degrees C (standard deviation [SD] 0.95) and 2.1 degrees C (SD 0.79) respectively. …”

The effects of quinine and chloroquine antimalarial treatments in the first trimester of pregnancy. by Mcgready, R, Thwai, K, Cho, T, Samuel, Looareesuwan, S, White, N, Nosten, F

“…Parasites were still present on day 6 or 7 in 4.7% (11/234) of episodes treated with quinine. The overall 28 day parasite reappearance rate following quinine was 28.7% (60/209) for primary treatments and 44% (11/25) for re-treatments. …”

Quinine sensitivity of isolates of Plasmodium falciparum from the coast of Kenya. by Haruki, K, Winstanley, P, Watkins, WM, Marsh, K

Intramuscular loading dose of quinine for falciparum malaria: pharmacokinetics and toxicity. by Wattanagoon, Y, Phillips, R, Warrell, D, Silamut, K, Looareesuwan, S, Nagachinta, B, Back, D

“…In a study of intramuscular injection of quinine eight adults with moderately severe falciparum malaria resistant to chloroquine were treated with quinine dihydrochloride, being given a loading dose of 20 mg salt (16.7 mg base)/kg followed by three or four eight hourly maintenance doses of 10 mg salt (8.3 mg base)/kg injected into the anterior thigh. …”

Quinine pharmacokinetics and toxicity in pregnant and lactating women with falciparum malaria. by Phillips, R, Looareesuwan, S, White, N, Silamut, K, Kietinun, S, Warrell, D

“…There was no relationship between arterial blood pressure and plasma quinine concentrations. Eight women delivered of live infants while taking quinine, had placental cord plasma quinine concentrations from 1.0 to 4.6 mg l-1 (mean 2.4) which correlated significantly with maternal plasma quinine concentrations (r = 0.78, t = 3.06, P less than 0.05). …”

Comparative effects of quinine and quinidine on glucose metabolism in healthy volunteers. by Davis, T, Karbwang, J, Looareesuwan, S, Turner, R, White, N

“…To investigate the relative effects of quinine and quinidine on glucose metabolism, 11 healthy males aged 17-32 years were given three separate 1 h intravenous infusions; normal saline alone, quinine dihydrochloride 10 mg base kg-1 body weight (BW) in normal saline, and quinidine dihydrochloride 10 mg base kg-1 BW in normal saline. …”

Glucose metabolism in quinine-treated patients with uncomplicated falciparum malaria. by Davis, T, Pukrittayakamee, S, Supanaranond, W, Looareesuwan, S, Krishna, S, Nagachinta, B, Turner, R, White, N

“…To investigate host and drug effects on glucose metabolism in acute falciparum malaria, 10 previously untreated, fasting Thai males with uncomplicated infections were given a 2-h intravenous glucose infusion (5 mg/kg ideal body weight min) with an infusion of quinine dihydrochloride (10 mg/kg body weight) during the second hour. …”

Randomized comparison of artesunate and quinine in the treatment of severe falciparum malaria. by Newton, P, Angus, B, Chierakul, W, Dondorp, A, Ruangveerayuth, R, Silamut, K, Teerapong, P, Suputtamongkol, Y, Looareesuwan, S, White, N

“…A randomized, open-label comparison of artesunate and quinine was conducted in 113 adults with clinically severe falciparum malaria in western Thailand. …”

The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine by Giovanny Garavito, Stéphane Bertani, Miguel Quiliano, Alexis Valentin, Ignacio Aldana, Eric Deharo

“…The effectiveness of methylene blue (MB) combined with pyrimethamine (PYR), chloroquine (CQ) or quinine (Q) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, Plasmodium berghei. …”
Get full text

A case of transient organic brain syndrome during quinine treatment by Peter G. Kremsner, Gertraud M. Zotter, Michael Bach, Wolfgang Graninger

Get full text

Intrarectal quinine for treating <it>Plasmodium falciparum </it>malaria: a systematic review by Omari Aika, Eisenhut Michael, MacLehose Harriet G

“…<p>Abstract</p> <p>Background</p> <p>In children with malaria caused by <it>Plasmodium falciparum</it>, quinine administered rectally may be easier to use and less painful than intramuscular or intravenous administration. …”
Get full text

Correlation of amodiaquine sensitivity to chloroquine and quinine against Plasmodium falciparum in vitro by Perpustakaan UGM, i-lib

A simple method for assessing quinine pre-treatment in acute malaria. by Silamut, K, Hough, R, Eggelte, T, Pukrittayakamee, S, Angus, B, White, N

“…Admission plasma concentrations of quinine were measured by high performance liquid chromatography (HPLC), and compared with the patients' history of previous quinine treatment. …”

Quinine and mefloquine in the treatment of multidrug-resistant Plasmodium falciparum malaria in pregnancy. by Mcgready, R, Cho, T, Hkirijaroen, L, Simpson, J, Chongsuphajaisiddhi, T, White, N, Nosten, F

“…The corresponding figures for quinine were 4% and 23%, respectively. The failure rates in the 117 women treated for recrudescent infections were higher, the increase being significant for quinine (38%; P = 0.03) but not for mefloquine (37%). …”

The pharmacokinetic properties of intramuscular quinine in Gambian children with severe falciparum malaria. by Waller, D, Krishna, S, Craddock, C, Brewster, D, Jammeh, A, Kwiatkowski, D, Karbwang, J, Molunto, P, White, N

“…Plasma quinine concentrations were measured in 21 Gambian children with severe falciparum malaria after intramuscular administration of a 20 mg (salt) per kg loading dose of quinine dihydrochloride followed by 10 mg/kg at 12 h intervals. …”

Quinine and quinidine: a comparison of EKG effects during the treatment of malaria. by White, N, Looareesuwan, S, Warrell, D

“…Despite plasma quinine concentrations of up to 20 mg/L, there was no evidence of cardiotoxicity. …”

Fatal Plasmodium falciparum malaria after an inadequate response to quinine treatment. by Looareesuwan, S, Charoenpan, P, Ho, M, White, N, Karbwang, J, Bunnag, D, Harinasuta, T

“…A 24-year-old man with severe Plasmodium falciparum malaria died after 77 h of treatment with full parenteral doses of quinine. His peripheral parasitemia at death exceeded the level on admission. …”