Effect of gibberellic acid and kinetin on some morphological features in two lentil cultivars under salinity stress by Fariba Shohani

“…Objective: An experiment was conducted to study the effect of two plant growth regulators (gibberellic acid and quinine) on seed germination and initial seedling growth and salinity tolerance in both Kimia and Shirvan local cultivars.Materials and Methods: This experiment was performed as a factorial experiment with a completely randomized design. …”
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Development of Transcriptomic Resources for Interrogating the Biosynthesis of Monoterpene Indole Alkaloids in Medicinal Plant Species by Gongora-Castillo, Elsa, Childs, Kevin L., Fedewa, Greg, Hamilton, John P., Liscombe, David K., Magallanes-Lundback, Maria, Mandadi, Kranthi K., Nims, Ezekiel, Runguphan, Weerawat, Vaillancourt, Brieanne, Varbanova-Herde, Marina, DellaPenna, Dean, McKnight, Thomas D., O'Connor, Sarah Ellen, Buell, C. Robin

“…One group of plant-derived compounds, the monoterpene indole alkaloids (MIAs), includes well-documented therapeutic agents used in the treatment of cancer (vinblastine, vincristine, camptothecin), hypertension (reserpine, ajmalicine), malaria (quinine), and as analgesics (7-hydroxymitragynine). …”
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Identification and structural validation of purine nucleoside phosphorylase from Plasmodium falciparum as a target of MMV000848 by Chung, Zara, Lin, Jianqing, Wirjanata, Grennady, Dziekan, Jerzy Michal, El Sahili, Abbas, Preiser, Peter Rainer, Bozdech, Zbynek, Lescar, Julien

“…An isobologram analysis shows subadditivity with immucillin H and with quinine respectively, suggesting overlapping modes of action between these compounds. …”
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Changes in serological immunology measures in UK and Kenyan adults post-controlled human malaria infection by Hodgson, S, Llewellyn, D, Silk, S, Milne, K, Elias, S, Miura, K, Kamuyu, G, Juma, E, Magiri, C, Muia, A, Jin, J, Spencer, A, Longley, R, Mercier, T, Decosterd, L, Long, C, Osier, F, Hoffman, S, Ogutu, B, Hill, A, Marsh, K, Draper, S

“…A significant difference in ADRB activity was seen between KCS volunteers with minimal and definite prior exposure to malaria and significant increases were seen in ADRB activity post-CHMI in Kenyan volunteers. Quinine and atovaquone/proguanil, previously assumed to be removed by IgG purification, were identified as likely giving rise to aberrantly high in vitro GIA results. …”

Antimalarial drug toxicity: a review. by Taylor, W, White, N

“…Dose-related serious neuropsychiatric toxicity can occur; mefloquine is contraindicated in individuals with a history of epilepsy or psychiatric disease. Quinine is the mainstay for treating severe malaria in many countries. …”

Pharmacokinetics and pharmacodynamics of antimalarial drugs in pregnant women by Kloprogge, F

“…This further supports the urgent need for a study in pregnant women with a non-pregnant control group. (4) Quinine pharmacokinetics was not affected by pregnancy trimester within the study population and a study with a non-pregnant control group is needed to evaluate the absolute effects of pregnancy. (5) Finally, a data-dependent power calculation methodology using the log likelihood ratio test was successfully used for sample size calculations of mixed pharmacokinetic study designs (i.e. sparsely and densely sampled patients). …”

Malaria case-management under artemether-lumefantrine treatment policy in Uganda by Zurovac, D, Tibenderana, J, Nankabirwa, J, Ssekitooleko, J, Njogu, J, Rwakimari, J, Meek, S, Talisuna, A, Snow, R

“…Of 1,200 patients who needed treatement with AL according to guidelines, AL was prescribed for 60%, CQ+SP for 14%, quinine for 4%, CQ for 3%, other antimalarials for 3%, and 16% of patients had no antimalarial drug prescribed. …”

Human Cytochrome P450 1, 2, 3 Families as Pharmacogenes with Emphases on Their Antimalarial and Antituberculosis Drugs and Prevalent African Alleles by Chiratidzo R. Chamboko, Wayde Veldman, Rolland Bantar Tata, Birgit Schoeberl, Özlem Tastan Bishop

“…Afrocentric alleles such as CYP2A6*17, CYP2A6*23, CYP2A6*25, CYP2A6*28, CYP2B6*6, CYP2B6*18, CYP2C8*2, CYP2C9*5, CYP2C9*8, CYP2C9*9, CYP2C19*9, CYP2C19*13, CYP2C19*15, CYP2D6*2, CYP2D6*17, CYP2D6*29, and CYP3A4*15 are implicated in diverse metabolic phenotypes of different antimalarials such as artesunate, mefloquine, quinine, primaquine, and chloroquine. Moreover, CYP3A4, CYP1A1, CYP2C8, CYP2C18, CYP2C19, CYP2J2, and CYP1B1 are implicated in the metabolism of some second-line antituberculosis drugs such as bedaquiline and linezolid. …”
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H2O2-responsive polymer prodrug nanoparticles with glutathione scavenger for enhanced chemo-photodynamic synergistic cancer therapy by Guanchun Wang, Yue Su, Xinliang Chen, Yongfeng Zhou, Ping Huang, Wei Huang, Deyue Yan

“…Concurrently, PBA can be transformed into a GSH-scavenger (quinine methide, QM) under intracellular H2O2 and prevent the depletion of 1O2, which induces the cooperatively strong oxidative stress and enhanced cancer cell apoptosis. …”
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Isatin Counteracts Diethylnitrosamine/2-Acetylaminofluorene-Induced Hepatocarcinogenesis in Male Wistar Rats by Upregulating Anti-Inflammatory, Antioxidant, and Detoxification Path... by Nagwa G. Tawfik, Wafaa R. Mohamed, Hanan S. Mahmoud, Mohammed A. Alqarni, Ibrahim A. Naguib, Alzhraa M. Fahmy, Osama M. Ahmed

“…Isatin treatment also upregulated expression of the major stress-response transcription factor Nrf2 and the detoxifying enzymes NAD(P)H quinine oxidoreductase and glutathione-S-transferase alpha 2 and downregulated expression of the proliferation marker Ki67. …”
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Spasmolytic Activity of <i>Gentiana lutea</i> L. Root Extracts on the Rat Ileum: Underlying Mechanisms of Action by Nemanja Kitić, Jelena Živković, Katarina Šavikin, Milica Randjelović, Miloš Jovanović, Dušanka Kitić, Bojana Miladinović, Milica Milutinović, Nenad Stojiljković, Suzana Branković

“…The mechanism of action was monitored using the models of spontaneous contractions and acetylcholine-, histamine-, CaCl₂-, Bay K8644-, L-NAME-, ODQ-, apamin-, BaCl₂-, charybdotoxin-, glibenclamide-, TRAM-34-, and quinine-modified contractions. UAE, having the best bioactivity, was further subjected to a liquid–liquid extraction fractionation. …”
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Anti-malarial drug use, appropriateness and associated factors among children under-five with febrile illnesses presenting to a tertiary health facility: a cross sectional study by Richard Nyeko, Felix Otim, Evelyn Miriam Obiya, Catherine Abala

“…The most commonly used anti-malarials were artemether-lumefantrine 60/72 (88.3%), while a lesser proportion of quinine 7/72 (9.7%), artesunate 3/72 (4.2%) and dihydroartemisinin-piperaquine 2/72 (2.8%) were used. …”
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The Potential Applications of Real-Time Monitoring of Water Quality in a Large Shallow Lake (Lake Taihu, China) Using a Chromophoric Dissolved Organic Matter Fluorescence Sensor by Cheng Niu, Yunlin Zhang, Yongqiang Zhou, Kun Shi, Xiaohan Liu, Boqiang Qin

“…CDOM concentration expressed in quinine sulfate equivalent units, was highly correlated with the CDOM absorption coefficient (r2 = 0.80, p &lt; 0.001), fluorescence intensities (Ex.…”
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An open-source platform for head-fixed operant and consummatory behavior by Adam Gordon-Fennell, Joumana M Barbakh, MacKenzie T Utley, Shreya Singh, Paula Bazzino, Raajaram Gowrishankar, Michael R Bruchas, Mitchell F Roitman, Garret D Stuber

“…In a multi-spout brief-access consumption task, mice displayed licking as a function of concentration of sucrose, quinine, and sodium chloride, with licking modulated by homeostatic or circadian influences. …”
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Moschus exerted protective activity against H2O2-induced cell injury in PC12 cells through regulating Nrf-2/ARE signaling pathways by Danni Xie, Ting Deng, Zhenwei Zhai, Tao Qin, Caiyou Song, Ying Xu, Tao Sun

“…The cell viability loss, lactate dehydrogenase releases, MMP levels, ROS productions, and Malondialdehyde (MDA) activities decreased, and BAX, Caspase-3, and Kelch-like ECH-associated protein 1 expression also significantly down-regulated and heme oxygenase 1, nuclear factor erythroid-2-related factor 2 (Nrf-2), and quinine oxidoreductase 1 expression upregulated after pretreatment of Moschus. …”
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Alismol Purified from the Tuber of <i>Alisma orientale</i> Relieves Acute Lung Injury in Mice via Nrf2 Activation by Kyun Ha Kim, Soyeon Kim, Min Jung Kwun, Ji Yeon Lee, Sei-Ryang Oh, Jun-Yong Choi, Myungsoo Joo

“…Consequently, alismol induced the expression of prototypic genes regulated by Nrf2, including <i>Heme Oxygenase-1</i> (<i>HO-1</i>), <i>NAD(P)H: quinine oxidoreductase-1</i> (<i>NQO-1</i>), and <i>glutamyl cysteine ligase catalytic units</i> (GCLC). …”
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A highly contiguous, scaffold-level nuclear genome assembly for the fever tree (Cinchona pubescens Vahl) as a novel resource for Rubiaceae research by Nataly Allasi Canales, Oscar A. Pérez-Escobar, Robyn F. Powell, Mats Töpel, Catherine Kidner, Mark Nesbitt, Carla Maldonado, Christopher J. Barnes, Nina Rønsted, Natalia A. S. Przelomska, Ilia J. Leitch, Alexandre Antonelli

“….; Rubiaceae) is a source of bioactive quinine alkaloids used to treat malaria. C. pubescens Vahl is a valuable cash crop within its native range in northwestern South America, however, genomic resources are lacking. …”
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Application of loop-mediated isothermal amplification for malaria diagnosis during a follow-up study in São Tomé by Lee Pei-Wen, Ji Dar-Der, Liu Chia-Tai, Rampao Herodes S, do Rosario Virgilio E, Lin I-Feng, Shaio Men-Fang

“…First-line treatment with artesunate-amodiaquine was given for uncomplicated malaria and intravenous quinine was given for complicated malaria. Children with persistent positivity for malaria by microscopy, or either by nested PCR, or by LAMP on day 7 were given second-line treatment with artemether-lumefantrine. …”
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Determinants of Patients’ Adherence to Malaria Treatment in the Democratic Republic of the Congo by Nsengi Y. Ntamabyaliro, Christian Burri, Yves N. Lula, Didier B. Nzolo, Aline B. Engo, Mireille A. Ngale, Hippolyte N. Situakibanza, Eric S. Mukomena, Gauthier K. Mesia, Samuel M. Mampunza, Gaston L. Tona

“…Logistic regression was used to assess predictors. (3) Results: 1732 households participated. Quinine was the most used drug; adherence to artesunate–amodiaquine was the lowest and the main reason for treatment discontinuation was adverse reactions. …”
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Protective Effect of the Anthocyanidin Extract of Hippophae rhamnoides L. on H1299 Cell Injury Induced by Hydrogen Peroxide and Effect of Nrf2/HO-1 Pathway by Yurong ZHENG, Long CHEN, Xiao WANG, Jun LI, Baoguo LI

“…Also the expression of proteins heme oxygenase-1 (HO-1), NAD(P)H quinine oxidoreductase 1 (NQO1), Kelch-like epichlorohydrin-associated protein 1 (Keap1) and nuclear factor-erythroid 2-related factor 2 (Nrf2) were tested. …”
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