J. de Morainville y el primer dibujo universal de la quina o cascarilla by Germán Rodas Chaves

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Inhibition of Potassium Channels Affects the Ability of Pig Spermatozoa to Elicit Capacitation and Trigger the Acrosome Exocytosis Induced by Progesterone by Federico Noto, Sandra Recuero, Julián Valencia, Beatrice Saporito, Domenico Robbe, Sergi Bonet, Augusto Carluccio, Marc Yeste

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Need for optimized dosages in the design of comparative clinical trials of anti-malarial drugs by Sanjeev Krishna, Peter G. Kremsner

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Comparison of Bitterness Intensity between Prednisolone and Quinine in a Human Sensory Test Indicated Individual Differences in Bitter-Taste Perception by Mengyan Deng, Noriko Hida, Taigi Yamazaki, Ryo Morishima, Yuka Kato, Yoshiaki Fujita, Akihiro Nakamura, Tsutomu Harada

“…Thus, in this study, 50 adults evaluated the bitterness of prednisolone using the generalized Labeled Magnitude Scale (gLMS), in comparison with quinine, a standard bitter substance. Overall, prednisolone-saturated solution demonstrated the same extent (mean gLMS score: 46.8) of bitterness as 1 mM quinine solution (mean gLMS score: 40.1). …”
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Quinine pharmacokinetics in cerebral malaria: predicted plasma concentrations after rapid intravenous loading using a two-compartment model. by Davis, T, White, N, Looareesuwan, S, Silamut, K, Warrell, D

“…Plasma quinine concentrations closely followed a bi-exponential decline. …”

Piperaquine concentration and malaria treatment outcomes in Ugandan children treated for severe malaria with intravenous Artesunate or quinine plus Dihydroartemisinin-Piperaquine by Byakika-Kibwika, P, Ssenyonga, R, Lamorde, M, Blessborn, D, Tarning, J

“…We evaluated piperaquine concentration and malaria treatment outcomes among Ugandan children treated for severe malaria with intravenous artesunate (AS) or quinine (QN) plus dihydroartemisininpiperaquine (DP), in Tororo District Hospital in Eastern Uganda. …”

Artemether-lumefantrine to treat malaria in pregnancy is associated with reduced placental haemozoin deposition compared to quinine in a randomized controlled trial. by Muehlenbachs, A, Nabasumba, C, McGready, R, Turyakira, E, Tumwebaze, B, Dhorda, M, Nyehangane, D, Nalusaji, A, Nosten, F, Guerin, P, Piola, P

“…A recent open label, randomized controlled trial in Mbarara, Uganda demonstrated that artemether-lumefantrine (AL) is not inferior to quinine to treat uncomplicated malaria in pregnancy. …”

Excited-State Dynamics of Quinine Sulfate and Its Di-Cation Doped in Polyvinyl Alcohol Thin Films Near Silver Nanostructure Islands by Swatantra Kumar Yadav, Gopal Rawat, Sandeep Pokharia, Satyabrata Jit, Hirdyesh Mishra

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First-trimester artemisinin derivatives and quinine treatments and the risk of adverse pregnancy outcomes in Africa and Asia: A meta-analysis of observational studies. by Stephanie Dellicour, Esperança Sevene, Rose McGready, Halidou Tinto, Halidou Tinto, Dominic Mosha, Christine Manyando, Stephen Rulisa, Meghna Desai, Peter Ouma, Martina Oneko, Anifa Vala, Maria Rupérez, Eusébio Macete, Clara Menéndez, Seydou Nakanabo-Diallo, Adama Kazienga, Innocent Valéa, Gregory Calip, Orvalho Augusto, Blaise Genton, Eric M Njunju, Kerryn A Moore, Umberto d'Alessandro, Francois Nosten, Feiko Ter Kuile, Andy Stergachis

“…<h4>Conclusions</h4>Compared to quinine, artemisinin treatment in the first trimester was not associated with an increased risk of miscarriage or stillbirth. …”
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Using Quinine as a Fluorescent Tracer to Estimate Overland Flow Velocities on Bare Soil: Proof of Concept under Controlled Laboratory Conditions by João L. M. P. de Lima, Soheil Zehsaz, M. Isabel P. de Lima, Jorge M. G. P. Isidoro, Romeu Gerardo Jorge, Ricardo Martins

Subjects: “…quinine…”
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In-silico Investigations of quinine and quinidine as potential Inhibitors of AKR1B1 and AKR1B10: Functional and structural characterization. by Syeda Abida Ejaz, Amna Saeed, Pervez Rashid Birmani, Khadijah Mohammedsalaeh Katubi, Zainab Mufarreh Elqahtani, M S Al-Buriahi, Rabail Ujan, Farhan Siddique, Samia Ben Ahmed, Z A Alrowaili

“…Currently, the study is focused on the exploration of two quinolone compounds i.e., (S)-(6-Methoxyquinolin-4-yl)[(1S,2R,4S,5R)-5-vinylquinuclidin-2-yl]methanol (Quinidine) and (R)-(6-Methoxyquinolin-4-yl)[(1S,2S,4S,5R)-5-vinylquinuclidin-2-yl]methanol (Quinine) as the potential inhibitors of AKR1B1 and AKR1B10 via detailed in-silico approach. …”
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Randomized comparison of intramuscular artemether and intravenous quinine in adult, Melanesian patients with severe or complicated, Plasmodium falciparum malaria in Papua New Guinea. by Seaton, R, Trevett, A, Wembri, J, Nwokolo, N, Naraqi, S, Black, J, Laurenson, I, Kevau, I, Saweri, A, Lalloo, D, Warrell, D

“…An open-label, randomized, controlled trial was used to compare the safety and efficacy of intramuscular artemether (a loading dose of 3.2 mg/kg, followed by 1.6 mg/kg daily for 4 days) and intravenous quinine (a loading dose of 20 mg quinine dihydrochloride/kg, followed first by 10 mg/kg every 8 h, each injection taking 4 h, for at least 48 h, and then oral quinine for a total of 7 days) in the management of strictly defined severe/complicated malaria in Melanesian adults. …”

Systematic literature review and meta-analysis of the efficacy of artemisinin-based and quinine-based treatments for uncomplicated falciparum malaria in pregnancy: methodological challenges by Saito, M, Gilder, M, Nosten, F, McGready, R, Guérin, P

“…The aim of this review is to present the currently available evidence from both observational and interventional cohort studies on anti-malarial efficacy in pregnancy and summarize the variability of assessment and reporting found in the review process.Efficacy methodology and assessment of artemisinin-based treatments (ABT) and quinine-based treatments (QBT) were reviewed systematically using seven databases and two clinical trial registries (protocol registration-PROSPERO: CRD42017054808). …”

First-trimester artemisinin derivatives and quinine treatments and the risk of adverse pregnancy outcomes in Africa and Asia: A meta-analysis of observational studies by Dellicour, S, Sevene, E, McGready, R, Tinto, H, Mosha, D, Manyando, C, Rulisa, S, Desai, M, Ouma, P, Oneko, M, Vala, A, Rupérez, M, Macete, E, Menéndez, C, Nakanabo-Diallo, S, Kazienga, A, Valéa, I, Calip, G, Augusto, O, Genton, B, Njunju, E, Moore, K, d'Alessandro, U, Nosten, F, Ter Kuile, F, Stergachis, A

“…<br/><br/>CONCLUSIONS: Compared to quinine, artemisinin treatment in the first trimester was not associated with an increased risk of miscarriage or stillbirth. …”

Improved Durability and Sensitivity of Bitterness-Sensing Membrane for Medicines by Xiao Wu, Hideya Onitake, Zhiqin Huang, Takeshi Shiino, Yusuke Tahara, Rui Yatabe, Hidekazu Ikezaki, Kiyoshi Toko

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Prescribing patterns and compliance with World Health Organization recommendations for the management of severe malaria: a modified cohort event monitoring study in public health f... by H. Hilda Ampadu, Kwaku Poku Asante, Samuel Bosomprah, Samantha Akakpo, Pierre Hugo, Helga Gardarsdottir, Hubert G. M. Leufkens, Dan Kajungu, Alexander N. O. Dodoo

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Drug-induced immune thrombocytopenia: Mapping of the drug binding site to the membrane-proximal region of platelet GPIX by Zohra Ahmadi, Jose Perdomo, Rose Wong, Beng H Chong

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Pilot feasibility study of an emergency paediatric kit for intra-rectal quinine administration used by the personnel of community-based health care units in Senegal by Gaye Oumar, Lameyre Valérie, Diack Pape, Dieye El Hadj, Faye Babacar, Tine Roger C, Ndiaye Jean, Sow Husseyn

“…<p>Abstract</p> <p>Background</p> <p>Quinine injection is the reference treatment for malaria when oral administration is impossible. …”
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Fluorescent quinine-based tracking techniques for measurement of open-channel surface flow velocities under low luminosity conditions using a UAS by Soheil Zehsaz, João L. M. P. de Lima, Jorge M. G. P. Isidoro, M. Isabel P. de Lima, Ricardo Martins

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Efficacy and safety of artemether-lumefantrine compared with quinine in pregnant women with uncomplicated Plasmodium falciparum malaria: an open-label, randomised, non-inferiority trial. by Piola, P, Nabasumba, C, Turyakira, E, Dhorda, M, Lindegardh, N, Nyehangane, D, Snounou, G, Ashley, E, Mcgready, R, Nosten, F, Guerin, P

“…We aimed to assess whether artemether-lumefantrine was at least as efficacious as oral quinine for the treatment of uncomplicated falciparum malaria during the second and third trimesters of pregnancy in Mbarara, Uganda.…”