Functionalized bis(thiosemicarbazonato) complexes of zinc and copper: Synthetic platforms toward site-specific radiopharmaceuticals gan Holland, J, Aigbirhio, F, Betts, H, Bonnitcha, P, Burke, P, Christlieb, M, Churchill, G, Cowley, A, Dilworth, JR, Donnelly, P, Green, J, Peach, J, Vasudevan, SR, Warren, J

Performance evaluation of Gallium-68 radiopharmaceuticals production using liquid target PETtrace 800 cyclotron gan Ashhar, Zarif, Ahmad Fadzil, Muhammad Fakhrurazi, Md Safee, Zaitulhusna, Aziz, Firdaus, Ibarhim, Ummi Habibah, Nik Afinde, Nik Muhammad Fitri, Mat Ail, Noratikah, Jamal Harizan, Muhammad Ali Hazizi, Halib, Dzulieza, Alek Amran, Arieffuddin, Adawiyah, Rabiatul, Abd Hamid, Mohd Hamdi Noor, Mahamood, Mazurin, Razali, Nor Idayu, Said, Mohamad Aminudin

“...Due to increased demand, cyclotron has an expanding role in producing Gallium-68 (68Ga) radiopharmaceuticals using solid and liquid targets. Though the liquid target produces lower end-of-bombardment activity compared to the solid target, our study presents the performance of 68Ga radiopharmaceuticals production using the liquid target by evaluating the end-of-bombardment activity and the end-of-purification activity of 68GaGaCl3. ...”

Pengembangan formulasi radiofarmaka siprofloksasin dalam wadah tunggal = Development of ciprofloxacin radiopharmaceutical formulation in single vial gan Perpustakaan UGM, i-lib

Synthesis of 99mTc-HYNIC-interleukin-12, a new specific radiopharmaceutical for imaging T lymphocytes. gan Annovazzi, A, D'Alessandria, C, Bonanno, E, Mather, S, Cornelissen, B, van de Wiele, C, Dierckx, R, Mattei, M, Palmieri, G, Scopinaro, F, Signore, A

“... PURPOSE: Few radiopharmaceuticals have been described for the study of lymphocyte trafficking despite its high clinical relevance. ...”

Fundamentals of nuclear pharmacy / gan 245373 Saha, Gopal B.

Pynciau: “...Radiopharmaceuticals...”

Preparation and characterization of [68Ga]NODAGA-Pamidronic acid for pet bone cancer imaging gan Mohd Ashhar, Zarif Naim

Pynciau: Cael y testun llawn

Synthesis of Tc-99m-Hynic-interleukin-12, a new radiopharmaceutical for imaging Th-1-lymphocytes gan Annovazzi, A, Mather, S, Cornelissen, B, Slegers, G, D'Alessandria, C, Bonanno, E, Mattei, M, Scopinaro, F, Signore, A

Understanding the anti-tumour immune response to radionuclide therapy using PSMA targeting radiopharmaceuticals in a prostate cancer model gan Anderson, R

“...This enabled evaluation of the immune response to the clinically relevant radiopharmaceutical [177Lu]-PSMA-I&T. Using this model, I was able to show for the first time that [177Lu]PSMA-I&T is capable of inducing changes to the TIME, with a notable reduction in immune cells 72 hours post treatment followed by a return to no-treatment levels by day 12 with a trend towards an increase. ...”

Cyclotron production of Gallium-68 Radiopharmaceuticals using the 68Zn(p,n)68Ga reaction and their regulatory aspects gan Ashhar, Zarif, Ahmad Fadzil, Muhammad Fakhrurazi, Othman, Muhamad Faiz, Yusof, Nor Azah, Abdul Onny, Muhammad Adib, Mat Ail, Noratikah, Abd Rahman, Siti Fatimah

“...The use of medical cyclotrons for radiometal production can increase the availability of gallium-68 (68Ga) radiopharmaceuticals. Although generators have greatly influenced the demand for 68Ga radiopharmaceuticals, the use of medical cyclotrons is currently being explored. ...”

Assessing the influence of neglected GC-FID variables on the multiple responses using multivariate optimization for the determination of ethanol and acetonitrile in radiopharmaceuticals gan Hassan, Hishar, Othman, Muhammad Faiz, Zakaria, Zainul Amiruddin, Ahmad Saad, Fathinul Fikri, Abdul Razak, Hairil Rashmizal

“...Therefore, the proposed method is relevant for routine quality control analysis of all 18F-radiopharmaceutical derivatives for the direct determination of ethanol and acetonitrile....”

I-123-labelled interleukin-12, a new radiopharmaceutical for imaging Th1-mediated chronic inflammation: In vitro and animal studies gan Annovazzi, A, Cornelissen, B, Slegers, G, D'Alessandria, C, Bonanno, E, Van de Wiele, C, Scopinaro, F, Signore, A

Studies of the chemistry of technetium(V) gan DePamphilis, Bruno Vincent

Pynciau: Cael y testun llawn

Epidermal growth factor receptor inhibition modulates the nuclear localization and cytotoxicity of the Auger electron emitting radiopharmaceutical 111In-DTPA human epidermal growth factor. gan Bailey, K, Costantini, D, Cai, Z, Scollard, D, Chen, Z, Reilly, R, Vallis, K

“...UNLABELLED: (111)In-DTPA-human epidermal growth factor ((111)In-DTPA-hEGF [DTPA is diethylenetriaminepentaacetic acid]) is an Auger electron-emitting radiopharmaceutical that targets EGF receptor (EGFR)-positive cancer. ...”

The anti-tumor effect of the auger electron-emitting radiopharmaceutical, In-111-hEGF against MDA-MB-468 human breast cancer xenografts is tumor-size dependent. gan Chen, P, Cameron, R, Wang, J, Vallis, K, Sandhu, J, Hendler, A, Reilly, R

Antitumor effects and normal tissue toxicity of 111In-labeled epidermal growth factor administered to athymic mice bearing epidermal growth factor receptor-positive human breast ca... gan Chen, P, Cameron, R, Wang, J, Vallis, K, Reilly, R

“...A strong inverse relationship was observed between radiopharmaceutical uptake and tumor size, with small tumors (<5 mm(3)) accumulating >30% of the injected dose (%ID) per gram, compared with 5 %ID/g for tumors measuring 6-30 mm(3). ...”

Ocular metastases secondary to carcinoid tumors: the utility of imaging with [(123)I]meta-iodobenzylguanidine and [(111)In]DTPA pentetreotide. gan Isidori, A, Kaltsas, G, Frajese, V, Kola, B, Whitelocke, R, Plowman, P, Britton, K, Monson, J, Grossman, AB, Besser, G

“...The orbit and its contents appear to be a common site for carcinoid metastasis, and radiopharmaceutical imaging with labeled octreotide is useful in identifying many of these lesions....”

Pituitary imaging using a labelled somatostatin analogue in acromegaly. gan Ur, E, Mather, S, Bomanji, J, Ellison, D, Britton, K, Grossman, AB, Wass, J, Besser, G

“...RESULTS: Twelve of the acromegalic subjects showed significant uptake of the radiopharmaceutical in the pituitary fossa. Of the eight patients in whom we assessed acute GH responses, five demonstrated a significant fall in GH in response to octreotide. ...”

Osseous abnormalities associated with collateral desmopathy of the distal interphalangeal joint: part 1. gan Dakin, S, Dyson, S, Murray, R, Tranquille, C

“...CONCLUSIONS: A variety of osseous lesions of differing severity are associated with CL injury. Normal radiopharmaceutical uptake does not preclude significant osseous pathology associated with CL injury. ...”

Indium-111 labelling of liposomal HEGF for radionuclide delivery via ultrasound-induced cavitation gan Owen, J, Thomas, E, Menon, J, Gray, M, Skaripa-Koukelli, I, Gill, MR, Wallington, S, Miller, RL, Vallis, KA, Carlisle, R

“...By combining acoustic-cavitation-sensitive liposomes with radiopharmaceuticals this research represents a new concept in achieving targeted delivery of radiopharmaceuticals....”

A STUDY OF CORE ELECTRON-BINDING ENERGIES IN TC-99M COMPLEXES BY INTERNAL-CONVERSION ELECTRON-SPECTROSCOPY gan Burke, J, Archer, C, Chiu, K, Latham, I, Egdell, R

“...The role of ICES in characterizing radiopharmaceutical agents is illustrated with studies of some novel 99mTcphosphine complexes that have been developed for myocardial perfusion imaging. © 1991....”