Bioorthogonal chemistry: implications for pretargeted nuclear (PET/SPECT) imaging and therapy. by Knight, J, Cornelissen, B

“…Due to their rapid and highly selective nature, bioorthogonal chemistry reactions are attracting a significant amount of recent interest in the radiopharmaceutical community. Over the last few years, reactions of this type have found tremendous utility in the construction of new radiopharmaceuticals and as a method of bioconjugation. …”

Preparation, characterization, and radiolabeling of [68Ga]Nodaga-pamidronic acid: a potential PET bone imaging agent by Ashhar, Zarif, Yusof, Nor Azah, Ahmad Saad, Fathinul Fikri, Mohd Nor, Siti Mariam, Mohammad, Faruq, Wan Kamal, Wan Hamirul Bahrin, Hassan, Muhammad Hishar, Ahmad Hassali, Hazlina, Al-Lohedan, Hamad A.

“…Hence, in the present work, we tested the efficacy of a gallium-68 (68Ga)-based compound as a radiopharmaceutical agent towards the bone imaging in positron emitting tomography (PET). …”
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A method for accurate spatial registration of PET images and histopathology slices by Puri, T, Chalkidou, A, Roy, A, Henley-Smith, R, Barber, P, Oakley, R, Simo, R, Jeannon, J, McGurk, M, Marsden, P

“…Positron emission tomography (PET) is an imaging technique used for the assessment of tissue of interest via administration of radiopharmaceutical commonly known as tracer. A newly developed tracer for PET imaging should be validated by comparison with the gold standard of histopathology imaging before it can add value for clinical purposes, for example, diagnosis, prognosis and response to treatment. …”

Nuclear magnetic resonance imaging and single photon emission tomography with radio-iodine labelled compounds in the diagnosis of dementia. by Ebmeier, K, Besson, J, Crawford, JR, Palin, A, Gemmel, H, Sharp, P, Cherryman, G, Smith, F

“…All DAT and MID patients were also imaged with a gamma camera using 123Iodo-n-isopropyl-amphetamine, a radiopharmaceutical whose uptake in the brain follows the regional blood flow. …”

Surface functional polymer library by post-polymerisation modification using diarylmethylenes: metal ligand catch and release by Aphaiwong, A, Moloney, M, Christlieb, M

“…Evaluation of the binding of zinc complexes followed by ligand transfer and release of copper complexes indicated that a pyridyl modified system offered considerable potential for application in the rapid generation of ligand systems of relevance for radiopharmaceutical synthesis. © The Royal Society of Chemistry 2012.…”

SPECT imaging and biodistribution studies of 111In-EGF-Au-PEG nanoparticles in vivo by Song, L, Able, S, Falzone, N, Kersemans, V, Vallis, K

“…We have developed PEGylated epidermal growth factor (EGF)-gold nanoparticles (NP) with a high indium-111 (¹¹¹In) payload (¹¹¹In-EGF-Au-PEG NPs) as a prototypic NP-based theranostic radiopharmaceutical.…”

Phase I trial to evaluate the tumor and normal tissue uptake, radiation dosimetry and safety of (111)In-DTPA-human epidermal growth factor in patients with metastatic EGFR-positive... by Vallis, K, Reilly, R, Scollard, D, Merante, P, Brade, A, Velauthapillai, S, Caldwell, C, Chan, I, Freeman, M, Lockwood, G, Miller, N, Cornelissen, B, Petronis, J, Sabate, K

“…The safety, pharmacokinetics, biodistribution and radiation dosimetry of (111)In-DTPA-hEGF, an Auger electron-emitting radiopharmaceutical, were evaluated in a first-in-human trial. …”

Use of [123I]-2-iodo-L-phenylalanine as a tumor imaging agent in two dogs with synovial cell sarcoma. by Peremans, K, Kersemans, V, Liuti, T, Vandermeulen, E, Cornelissen, B, Gielen, I, De Spiegeleer, B, Mertens, J, Burvenich, C, Slegers, G

“…Rapid [123I]-2-iodo-L-phenylalanine tumor accumulation was observed with good tumor to background contrast and rapid clearance in these two dogs. This radiopharmaceutical is a promising alternative tumor tracer to overcome the known limitations of 18F-fluorodeoxyglucose and, when labelled with radioiodine-131, has the potential to be used for therapeutic purposes.…”

Requirements for the detection of atherosclerosis lesions in carotid arteries with SPECT by Bélanger, Marie-José, 1967-

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Trastuzumab-resistant breast cancer cells remain sensitive to the auger electron-emitting radiotherapeutic agent 111In-NLS-trastuzumab and are radiosensitized by methotrexate. by Costantini, D, Bateman, K, McLarty, K, Vallis, K, Reilly, R

“…CONCLUSION: Targeted Auger electron radioimmunotherapy with (111)In-NLS-trastuzumab can overcome resistance to trastuzumab, and MTX can potently enhance the sensitivity of HER2-overexpressing breast cancer cells to the lethal Auger electrons emitted by this radiopharmaceutical.…”

What is the potential impact of the IsoDAR cyclotron on radioisotope production: a review by Waites, Loyd H, Alonso, Jose R, Barlow, Roger, Conrad, Janet M

“…Designed to deliver 10 mA of 60 MeV protons, the current and power of this cyclotron far exceed those of existing accelerators, opening new possibilities for the production of radiopharmaceutical isotopes, producing very high-activity samples in very short times. …”
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Ion-beam studies and isotope production using dense plasma focus by S. V. Springham

“…The half-lives of these isotopes are short – ranging from 2 to 110 minutes - hence the production of isotopes must be local to the PET facility, The principle underlying PET is that each emitted positron annihilates with an electron creating two gamma-rays travelling in diametrically opposite directions from the point of origin (where the radiopharmaceutical s is localized). From the positions of these detected gamma-ray pairs the three dimensional image of the radio-pharmaceutical distribution in the patient is reconstructed.…”
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A benzimidazole functionalised DO3A chelator showing pH switchable coordination modes with lanthanide ions. by Fisher, C, Fuller, E, Burke, B, Mogilireddy, V, Pope, S, Sparke, A, Déchamps-Olivier, I, Cadiou, C, Chuburu, F, Faulkner, S, Archibald, S

“…Lanthanide complexes with macrocyclic chelators based on 1,4,7,10-tetra(carboxymethyl)-1,4,7,10-tetraazacyclododecane (DOTA) and 1,4,7-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecane (DO3A) are of interest in luminescent, radiopharmaceutical and magnetic resonance (MR) biomedical imaging applications. …”

Optimal 18F-fluorination conditions for the high radiochemical yield of [18F]AlF-NOTA-NHS complexes by Hassan, Hishar, Othman, Muhammad Faiz, Abdul Razak, Hairil Rashmizal

“…Therefore, the work described here outlines the optimum 18F-fluorination condition for the formation of [18F]AlF2+ and [18F]AlF-NOTA-NHS complex with the radiochemical yield (RCY) and purity (RCP) of more than 90% as a prerequisite step before proceeding with the radiopharmaceutical preparation using the [18F]AlF-bifunctional chelator technique. …”

Preservation of ligand functionality by click chemistry by Cornelissen, B, Knight, JC

“…Click chemistry reactions have had a considerable impact in the effort to develop efficient synthetic strategies towards new radiopharmaceutical agents. This is largely due to the ability of these reactions to proceed rapidly under ambient conditions, resulting in an easily isolated product. …”

Potential of 3'-fluoro-3' deoxythymidine as a cellular proliferation marker in PET oncology examination by Hassan, Hishar, Price, Roger, Ahmad Saad, Fathinul Fikri, Lau, Eddie Wing Fai, Carpinelli, Assunta, Nordin, Abdul Jalil

“…Development of the positron emission tomography (PET) diagnostic radiopharmaceutical (18F) fluoro-2-deoxy-D-glucose (18F-FDG) subsequently facilitated the discovery and clinical evaluation of several new tracers as imaging markers for cancer. …”
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Potential of 3’-fluoro-3’ deoxythymidine as a cellular proliferation marker in PET oncology examination by Hassan, Hishar, Price, Roger, Ahmad Saad, Fathinul Fikri, Lau, Eddie Wing Fai, Carpinelli, Assunta, Nordin, Abdul Jalil

“…Development of the positron emission tomography (PET) diagnostic radiopharmaceutical (18F) fluoro-2-deoxy-D-glucose (18F-FDG) subsequently facilitated the discovery and clinical evaluation of several new tracers as imaging markers for cancer. …”
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Choosing transportation alternatives for highly perishable goods by Bourassa, P. Louis (Pierre Louis)

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Positron emission tomographic imaging in drug discovery by Ghosh, Krishna Kanta, Padmanabhan, Parasuraman, Yang, Chang-Tong, Palanivel, Mathangi, Mishra, Sachin, Halldin, Christer, Gulyás, Balázs

“…In this review, we discuss the usage of PET imaging in radiopharmaceutical development; drug development approaches with PET imaging; and PET developments in oncological and cardiac drug discovery.…”
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Synthesis of fluorine-18-labelled choline (18F-fluorocholine): towards an early and accurate management of prostate cancer in Malaysia by Hassan, Muhammad Hishar, Abu Bakar, Suharzelim, Che A. Halim, Khairul Najah, Idris, Jaleezah, Ahmad Saad, Fathinul Fikri, Nordin, Abdul Jalil

“…In addition, the aim of this research work is to assist local Good Manufacturing Practice (GMP) radiopharmaceutical laboratories that routinely produce 18F-fluorodeoxyglucose (18F-FDG), to start producing 18F-fluorocholine as a tracer for prostate cancer imaging.…”
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