Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination by Nina M. S. Gustafsson, Katarina Färnegårdh, Nadilly Bonagas, Anna Huguet Ninou, Petra Groth, Elisee Wiita, Mattias Jönsson, Kenth Hallberg, Jemina Lehto, Rosa Pennisi, Jessica Martinsson, Carina Norström, Jessica Hollers, Johan Schultz, Martin Andersson, Natalia Markova, Petra Marttila, Baek Kim, Martin Norin, Thomas Olin, Thomas Helleday

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Model-based assessment of combination therapies – ranking of radiosensitizing agents in oncology by Marcus Baaz, Tim Cardilin, Floriane Lignet, Astrid Zimmermann, Samer El Bawab, Johan Gabrielsson, Mats Jirstrand

“…In this paper, we present a method for ranking radiosensitizers using preclinical data. Methods We used data from three xenograft mice studies to calibrate a model that accounts for radiation treatment combined with radiosensitizers. …”
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Effect of temozolomide and methylprednisolone on the radiosensitivity in radiotherapy of human brain glioma cells by Yu LI, Xuejun YANG, Yongzhen CAO, Dafa YUAN, Wei WANG, Huamin WANG, Xuetao DONG, Shengping YU, Bin ZHANG, Haolang MING

“…Objective To investigate the effect of temozolomide (TMZ) and methylprednisolone (MP) on the radiosensitivity of human glioma cells (U251 cells), and to provide experimental evidence for optimal chemotherapy in malignant glioma. …”
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Biomimetic CuS nanoparticles for radiosensitization with mild photothermal therapy and GSH-depletion by Xiaoxiang Zhou, Xiang Li, Bo Wu, Zhiran Chen, Longyun Chen

“…PC demonstrates promise for both in vivo and in vitro radiosensitization due to its GSH-depletion, photothermal efficiency, and tumor-specific properties.…”
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Radiosensitization of orthotopic GIC-driven glioblastoma by doxycycline causes skin damage by Guido Frosina, Daniela Marubbi, Diana Marcello, Antonio Daga

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Tantalum-carbon-integrated nanozymes as a nano-radiosensitizer for radiotherapy enhancement by Rui Li, Weiheng Zhao, Tingting Wu, Aifeng Wang, Qing Li, Ying Liu, Huihua Xiong

“…In this study, we synthesised a tantalum-carbon-integrated nanozyme with excellent catalase-like (CAT-like) activity and radiosensitivity by immobilising an ultrasmall tantalum nanozyme into a metal-organic framework (MOF)-derived carbon nanozyme through in situ reduction. …”
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Zebrafish Avatars of rectal cancer patients validate the radiosensitive effect of metformin by Bruna Costa, Laura M. Fernandez, Oriol Parés, Ricardo Rio-Tinto, Inês Santiago, Mireia Castillo-Martin, Amjad Parvaiz, Rita Fior

“…Also, pre-clinical studies using cell lines provide evidence for the radiosensitive effect of metformin. However, no studies have been performed using rectal cancer patient samples to test this radiosensitive effect of metformin and compared it to the standard 5FU. …”
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PIXSIC: A Wireless Intracerebral Radiosensitive Probe in Freely Moving Rats by Laure Balasse, Julia Maerk, Frédéric Pain, Aurelie Genoux, Sylvain Fieux, Françoise Lefebvre, Christian Morel, Pascale Gisquet-Verrier, Philippe Lanièce, Luc Zimmer

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Retrospective growth kinetics and radiosensitivity analysis of various human xenograft models by Ji Young Lee, Mi-Sook Kim, Eun Ho Kim, Namhyun Chung, Youn Kyoung Jeong

“…Radiation-induced suppression of the growth rate (T/C%) of xenografts was positively related to the radiosensitivity of the cells in vitro (SF2; rp=0.8684, p=0.0284) and TCR (rp=0.7623, p=0.0780). …”
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Molecular Biomarkers for Predicting Cancer Patient Radiosensitivity and Radiotoxicity in Clinical Practice by Angeliki Gkikoudi, Spyridon A. Kalospyros, Sotiria Triantopoulou, Stella Logotheti, Vasiliki Softa, Constantin Kappas, Kiki Theodorou, Evagelia C. Laiakis, Gina Manda, Georgia I. Terzoudi, Alexandros G. Georgakilas

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Radiosensitivity enhancement by combined treatment of nimotuzumab and celecoxib on nasopharyngeal carcinoma cells by Huang JF, Yuan XP, Pang QF, Zhang HW, Yu JH, Yang B, Zhou LY, Zhang FZ, Liu FJ

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Radiosensitizing effects of Sestrin2 in PC3 prostate cancer cells by Hao Fu, Wenke Song, Yufei Wang, Wenyi Deng, Tingting Tang, Wenjing Fan, Shunlin Qu

“…Cell counting kit (CCK-8) was used to detect cellular proliferation. The radiosensitivity of PC3 cells was detected by clonogenic assay. …”
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Influence of Hypoxia on Radiosensitization of Cancer Cells by 5-Bromo-2′-deoxyuridine by Magdalena Zdrowowicz, Paulina Spisz, Aleksandra Hać, Anna Herman-Antosiewicz, Janusz Rak

Subjects: “…radiosensitizer…”
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The HSP90 Inhibitor Ganetespib Radiosensitizes Human Lung Adenocarcinoma Cells by Roberto Gomez-Casal, Chitralekha Bhattacharya, Michael W. Epperly, Per H. Basse, Hong Wang, Xinhui Wang, David A. Proia, Joel S. Greenberger, Mark A. Socinski, Vera Levina

“…Both pretreatment and post-radiation treatment with ganetespib at low nanomolar concentrations induced radiosensitization in lung AC cells in vitro. Ganetespib may impart radiosensitization through multiple mechanisms: such as down regulation of the PI3K/Akt pathway; diminished DNA repair capacity and promotion of cellular senescence. …”
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The alkylphospholipid, perifosine, radiosensitizes prostate cancer cells both <it>in vitro </it>and <it>in vivo</it> by Zhu Julie, Wang Xiaozhen, Brinkman Kathryn L, Sun Mianen, Ishiyama Hiromichi, Gao Yuanhong, Mai Weiyuan, Huang Ying, Floryk Daniel, Ittmann Michael, Thompson Timothy C, Butler E, Xu Bo, Teh Bin S

“…</p> <p>Conclusions</p> <p>Perifosine enhances prostate cancer radiosensitivity <it>in vitro </it>and <it>in vivo</it>. …”
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Genomic identification of sarcoma radiosensitivity and the clinical implications for radiation dose personalization by George Yang, Zhigang Yuan, Kamran Ahmed, Eric A. Welsh, William J. Fulp, Ricardo J. Gonzalez, John E. Mullinax, Douglas Letson, Marilyn Bui, Louis B. Harrison, Jacob G. Scott, Javier F. Torres-Roca, Arash O. Naghavi

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Microdosimetric Investigation and a Novel Model of Radiosensitization in the Presence of Metallic Nanoparticles by Huagang Yan, David J. Carlson, Ramin Abolfath, Wu Liu

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Comparison of radiosensitivity response to acute and chronic gamma irradiation in colored wheat by Min Jeong Hong, Dae Yeon Kim, Joon-Woo Ahn, Si-Yong Kang, Yong Weon Seo, Jin-Baek Kim

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Gadolinium-Based Nanoparticles for Theranostic MRI-Guided Radiosensitization in Hepatocellular Carcinoma by Pengcheng Hu, Zhequan Fu, Guobing Liu, Hui Tan, Jie Xiao, Hongcheng Shi, Hongcheng Shi, Dengfeng Cheng, Dengfeng Cheng

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Individual Radiosensitivity as a Risk Factor for the Radiation-Induced Acute Radiodermatitis by Juras Kišonas, Jonas Venius, Olga Sevriukova, Mindaugas Grybauskas, Daiva Dabkevičienė, Arvydas Burneckis, Ričardas Rotomskis

Subjects: “…individual radiosensitivity…”
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