Showing 221 - 240 results of 1,522 for search '"radiosensitivity"', query time: 0.09s Refine Results
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    DNMT3A and DNMT3B Targeting as an Effective Radiosensitizing Strategy in Embryonal Rhabdomyosarcoma by Simona Camero, Giulia Vitali, Paola Pontecorvi, Simona Ceccarelli, Eleni Anastasiadou, Francesca Cicchetti, Elisabetta Flex, Silvia Pomella, Matteo Cassandri, Rossella Rota, Francesco Marampon, Cinzia Marchese, Amalia Schiavetti, Francesca Megiorni

    Published 2021-10-01
    “…Our findings demonstrate for the first time that DNMT3A and DNMT3B overexpression may contribute to radiotherapy failure, and their inhibition might be a promising radiosensitizing strategy, mainly in the treatment of patients with metastatic or recurrent RMS tumours.…”
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    Statins Alleviate Tumor Hypoxia in Prostate Cancer Models by Decreasing Oxygen Consumption: An Opportunity for Radiosensitization? by Donatienne d’Hose, Lionel Mignion, Loïc Hamelin, Pierre Sonveaux, Bénédicte F. Jordan, Bernard Gallez

    Published 2022-10-01
    “…Background: Because statins were found to decrease the oxygen consumption rate (OCR) of a variety of normal cells, our hypothesis was that statins may also decrease the OCR of cancer cells, alleviate tumor hypoxia and radiosensitize tumors. Methods: OCR was assessed using the Seahorse XF96 technology and EPR respirometry in PC-3 prostate cancer cells. …”
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    Nimotuzumab enhances the radiosensitivity of cancer cells in vitro by inhibiting radiation-induced DNA damage repair. by Yuan-yuan Qu, Song-liu Hu, Xiang-ying Xu, Rui-zhi Wang, Hong-yang Yu, Jian-yu Xu, Lin Chen, Guang-lu Dong

    Published 2013-01-01
    “…CONCLUSIONS:Our results revealed that the possible mechanism of nimotuzumab enhancing the cancer radiosensitivity is that nimotuzumab inhibited the radiation-induced activation of DNA-PKcs through blocking the PI3K/AKT pathway, which ultimately affected the DNA DSBs repair.…”
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