Tyro3 Targeting as a Radiosensitizing Strategy in Bladder Cancer through Cell Cycle Dysregulation by Linda Silina, Florent Dufour, Audrey Rapinat, Cécile Reyes, David Gentien, Fatlinda Maksut, François Radvanyi, Pierre Verrelle, Isabelle Bernard-Pierrot, Frédérique Mégnin-Chanet

Subjects: Get full text

Assessment of Normal Tissue Radiosensitivity by Evaluating DNA Damage and Repair Kinetics in Human Brain Organoids by Jovana Bojcevski, Changwen Wang, Haikun Liu, Amir Abdollahi, Ivana Dokic

Subjects: Get full text

Genome-scale CRISPR-Cas9 knockout screening in nasopharyngeal carcinoma for radiosensitive and radioresistant genes by Ziyan Zhou, Gang Chen, Mingjun Shen, Jixi Li, Kang Liu, Ming Liu, Shuo Shi, Dong Yang, Wei Chen, Sixia Chen, Yuanxiu Yin, Yating Qin, Xuejin Su, Weimin Chen, Min Kang

Subjects: Get full text

Thymoquinone Radiosensitizes Human Colorectal Cancer Cells in 2D and 3D Culture Models by Samar Al Bitar, Farah Ballout, Alissar Monzer, Mariam Kanso, Nour Saheb, Deborah Mukherji, Walid Faraj, Ayman Tawil, Samer Doughan, Maher Hussein, Wassim Abou-Kheir, Hala Gali-Muhtasib

Subjects: Get full text

Flow cytometric assessment of DNA double-strand break and repair kinetics in prediction of intrinsic radiosensitivity by Mohammad-Taghi Bahreyni-Toossi, Mahdieh Dayyani, Mahmoud Mahmoudi, Hosein Azimian

Subjects: Get full text

Effect of Gold Nanoparticle Radiosensitization on DNA Damage Using a Quartz Tuning Fork Sensor by Nadyah Alanazi, Reem Alanazi, Mahmoud Algawati, Khaled Alzahrani, Abdullah N. Alodhayb

Subjects: Get full text

Effect and mechanism of CyPA in radiosensitization of lung adenocarcinoma using CRISPR/Cas9 technology by Jinkun Ma, Lin Xu, Jinchang Huang, Qiaoli Zhang, Yuqin Qiu, Xuewei Qi, Lina Wang, Yuchan Cao, Zeyu Liu, Shiyun Liu

“…Keywords: CyPA, Fuzhengzengxiao decoction, Gene knockout, Lung adenocarcinoma, Radiosensitization…”
Get full text

Hypoxia-Induced Cancer Cell Responses Driving Radioresistance of Hypoxic Tumors: Approaches to Targeting and Radiosensitizing by Alexander E. Kabakov, Anna O. Yakimova

“…Molecular targets for and various approaches to radiosensitizing hypoxic tumors are considered in the present review. …”
Get full text

Tyrosine Kinase c-MET as Therapeutic Target for Radiosensitization of Head and Neck Squamous Cell Carcinomas by Lina Lüttich, María José Besso, Stephan Heiden, Lydia Koi, Michael Baumann, Mechthild Krause, Anna Dubrovska, Annett Linge, Ina Kurth, Claudia Peitzsch

“…Amongst them, crizotinib, foretinib, and Pha665752 exhibited the strongest radiosensitizing effect. Kinase activity profiling showed an association of crizotinib resistance with compensatory PI3K/AKT and MAP kinase signaling. …”
Get full text

Nafamostat Mesilate Enhances the Radiosensitivity and Reduces the Radiation-Induced Invasive Ability of Colorectal Cancer Cells by Hiroshi Sugano, Yoshihiro Shirai, Takashi Horiuchi, Nobuhiro Saito, Yohta Shimada, Ken Eto, Tadashi Uwagawa, Toya Ohashi, Katsuhiko Yanaga

Get full text

Genotyping and Characterization of HPV Status, Hypoxia, and Radiosensitivity in 22 Head and Neck Cancer Cell Lines by Eva-Leonne Göttgens, Marleen Ansems, William P. J. Leenders, Johan Bussink, Paul N. Span

Subjects: Get full text

Radiosensitization Effect of Gold Nanoparticles on Plasmid DNA Damage Induced by Therapeutic MV X-rays by Katsunori Yogo, Masaki Misawa, Hidetoshi Shimizu, Tomoki Kitagawa, Ryoichi Hirayama, Hiromichi Ishiyama, Hiroshi Yasuda, Satoshi Kametaka, Seiichi Takami

Subjects: Get full text

Telomere Length Dynamics and Chromosomal Instability for Predicting Individual Radiosensitivity and Risk via Machine Learning by Jared J. Luxton, Miles J. McKenna, Aidan M. Lewis, Lynn E. Taylor, Sameer G. Jhavar, Gregory P. Swanson, Susan M. Bailey

“…Telomeres represent a compelling biomarker of individual radiosensitivity and risk, as exposure can result in dysfunctional telomere pathologies that coincidentally overlap with many radiation-induced late effects, ranging from degenerative conditions like fibrosis and cardiovascular disease to proliferative pathologies like cancer. …”
Get full text

HIV protease inhibitors block Akt signaling and radiosensitize tumor cells both in vitro and in vivo. by Gupta, A, Cerniglia, G, Mick, R, Mckenna, W, Muschel, R

Small-molecule Polθ inhibitors provide safe and effective tumor radiosensitization in preclinical models by Rodriguez-Berriguete, G, Ranzani, M, Prevo, R, Puliyadi, R, Machado, N, Bolland, HR, Millar, V, Ebner, D, Boursier, M, Cerutti, A, Cicconi, A, Galbiati, A, Grande, D, Grinkevich, V, Majithiya, J, Piscitello, D, Rajendra, E, Stockley, M, Boulton, SJ, Heald, R, Hammond, EM, Smith, GCM, Robinson, H, Higgins, GS

“…Importantly, noncancerous cells were not radiosensitized by Polθ inhibition. Mechanistically, we show that the radiosensitization caused by Polθ inhibition is most effective in replicating cells and is due to impaired DNA damage repair. …”

Molecular targets for altering radiosensitivity: lessons from Ras as a pre-clinical and clinical model. by Cengel, K, Mckenna, W

“…Therefore, inhibiting Ras activation represents a promising molecular approach for radiosensitization in cancer therapy.…”

Region-Specific Effects of Fractionated Low-Dose Versus Single-Dose Radiation on Hippocampal Neurogenesis and Neuroinflammation by Zoé Schmal, Claudia E. Rübe

Subjects: Get full text

Radiation on Earth or in Space: What Does It Change? by Juliette Restier-Verlet, Laura El-Nachef, Mélanie L. Ferlazzo, Joëlle Al-Choboq, Adeline Granzotto, Audrey Bouchet, Nicolas Foray

Subjects: Get full text

Induction sintilimab and chemotherapy followed by concurrent chemoradiotherapy for locally advanced esophageal cancer: a proof-of-concept, single-arm, multicenter, phase 2 trialRes... by Dashan Ai, Shengnan Hao, Wenbin Shen, Qibing Wu, Shengjian Zhang, Yun Chen, Qi Liu, Jiaying Deng, Hongcheng Zhu, Ke Chen, Miao Mo, Dayong Gu, Yatian Liu, Zhi Zhang, Guoren Zhou, Jingwen Hu, Zhen Zhang, Jinjun Ye, Kuaile Zhao

Subjects: Get full text

SPOP Deregulation Improves the Radiation Response of Prostate Cancer Models by Impairing DNA Damage Repair by Rihan El Bezawy, Martina Tripari, Stefano Percio, Alessandro Cicchetti, Monica Tortoreto, Claudio Stucchi, Stella Tinelli, Valentina Zuco, Valentina Doldi, Paolo Gandellini, Riccardo Valdagni, Nadia Zaffaroni

Subjects: Get full text