Radiosensitization effect by HDAC inhibition improves NKG2D-dependent natural killer cytotoxicity in hepatocellular carcinoma by Yu-Fan Liu, Yu-Fan Liu, Yun Chiang, Yun Chiang, Feng-Ming Hsu, Feng-Ming Hsu, Chiao-Ling Tsai, Chiao-Ling Tsai, Jason Chia-Hsien Cheng, Jason Chia-Hsien Cheng, Jason Chia-Hsien Cheng

“…However, NKG2D receptor did not significantly change among tumors.ConclusionRadiosensitizing effect with combined RT and HDAC inhibition increased the expression of NKG2D ligands in HCC cells and enhanced their susceptibility to NK cell-mediated cytotoxicity. …”
Get full text

Image-Based Quantification of Gold Nanoparticle Uptake and Localization in 3D Tumor Models to Inform Radiosensitization Schedule by Ljubica Z. Petrovic, Michael Oumano, Justin Hanlon, Mark Arnoldussen, Igor Koruga, Sayeda Yasmin-Karim, Wilfred Ngwa, Jonathan Celli

Subjects: Get full text

Combining a noble gas with radiotherapy: glutamate receptor antagonist xenon may act as a radiosensitizer in glioblastoma by Thomas Büttner, Marielena K. E. Maerevoet, Frank A. Giordano, Marlon R. Veldwijk, Carsten Herskind, Arne Mathias Ruder

“…As a proof of concept, we have, for the first time, unveiled indications of radiosensitizing properties of xenon gas in glioblastoma.…”
Get full text

Pharmacologic Ascorbate Radiosensitizes Pancreatic Cancer but Radioprotects Normal Tissue: The Role of Oxidative Stress-Induced Lipid Peroxidation by Gloria Y. Chen, Brianne R. O’Leary, Juan Du, Rory S. Carroll, Garett J. Steers, Garry R. Buettner, Joseph J. Cullen

“…Pharmacologic ascorbate (P-AscH⁻) has been shown to radiosensitize pancreatic cancer cells while simultaneously radioprotecting normal cells. …”
Get full text

Radiosensitization of Breast Cancer Cells with a 2-Methoxyestradiol Analogue Affects DNA Damage and Repair Signaling In Vitro by Elsie Magdalena Nolte, Anna Margaretha Joubert, Laurence Lafanechère, Anne Elisabeth Mercier

Subjects: Get full text

Biomimetic radiosensitizers unlock radiogenetics for local interstitial radiotherapy to activate systematic immune responses and resist tumor metastasis by Jiajia Zhang, Mengdie Yang, Xin Fan, Mengqin Zhu, Yuzhen Yin, Hongyan Li, Jie Chen, Shanshan Qin, Han Zhang, Kun Zhang, Fei Yu

Subjects: Get full text

Significance of Nuclear Factor-Kappa B (NF-κB) and Survivin in Breast Cancer and Their Association with Radiosensitivity and Prognosis by Cao Q, Ai XQ, Mushajiang M

“…Knockdown of survivin by siRNA was used to analyze its association with radiosensitivity in breast cancer.Results: The gene expression of NFKB1 and BIRC5 are differentially expressed in a variety of tumours and their corresponding normal tissue species. …”
Get full text

The role of Bak-mediated dissipation of mitochondrial membrane potential in radiosensitivity of Bax-negative human prostate cancer cells by John A, Antonio S

“…These data indicate that, in Bax-negative tumours, Bak availability may lead to significant increases in the radiosensitivity, and can result in an enhanced therapeutic benefit.…”
Get full text

JNC-1043, a Novel Podophyllotoxin Derivative, Exerts Anticancer Drug and Radiosensitizer Effects in Colorectal Cancer Cells by Jin-Hee Kwon, Na-Gyeong Lee, A-Ram Kang, In-Ho Ahn, In-Young Choi, Jie-Young Song, Sang-Gu Hwang, Hong-Duck Um, Jong-Ryoo Choi, Joon Kim, Jong Kuk Park

Subjects: Get full text

Polarization of tumor-associated macrophages by TLR7/8 conjugated radiosensitive peptide hydrogel for overcoming tumor radioresistance by Yumin Zhang, Zujian Feng, Jinjian Liu, Hui Li, Qi Su, Jiamin Zhang, Pingsheng Huang, Weiwei Wang, Jianfeng Liu

“…Herein, the toll like receptor agonist TLR7/8a was conjugated with radiosensitive peptide hydrogel (Smac-TLR7/8 hydrogel) to regulate TAMs repolarization from M2 type into M1 type, thus modulating the ITM and overcoming the radioresistance. …”
Get full text

Selective inhibition of Ras, phosphoinositide 3 kinase, and Akt isoforms increases the radiosensitivity of human carcinoma cell lines. by Kim, I, Bae, S, Fernandes, A, Wu, J, Muschel, R, Mckenna, W, Birnbaum, M, Bernhard, E

“…Because pharmacologic inhibition of PI3 kinases and Akt radiosensitized cell lines with active Ras signaling, whereas inhibition of the MAP/extracellular signal-regulated kinase (ERK) kinase/ERK pathway did not, we examined the contribution of PI3 kinases and Akts to radiation survival. …”

UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization by Nakashima, R, Goto, Y, Koyasu, S, Kobayashi, M, Morinibu, A, Yoshimura, M, Hiraoka, M, Hammond, E, Harada, H

“…These results collectively suggest that cancer cells acquire antioxidant and radioresistant phenotypes through UCHL1-HIF-1-mediated metabolic reprogramming including the activation of PPP and provide a rational basis for targeting this gene network for radiosensitization.…”

Dual inhibition of the PI3K/mTOR pathway increases tumor radiosensitivity by normalizing tumor vasculature. by Fokas, E, Im, J, Hill, S, Yameen, S, Stratford, M, Beech, J, Hackl, W, Maira, S, Bernhard, E, Mckenna, W, Muschel, R

“…Because PI3K inhibition can radiosensitize tumor cells themselves, our experimental design explicitly distinguished effects on the blood vasculature versus tumor cells. …”

Inhibition of CD4/CDK6 enhances radiosensitivity of HPV negative head and neck squamous cell carcinomas by Göttgens, E, Bussink, J, Leszczynska, K, Peters, H, Span, P, Hammond, E

“…Expression of p16 in HPV+ve HNSCC is thought to mediate radiosensitivity via inhibition of cyclin-dependent kinase (CDK) 4/6. …”

Carbon-Ion beam radiosensitivity study and biological responses of high-yieldingrice line, MR219-PL-5 by Asrapil Waitul Fifika, Asmuni Mohd Ikmal, Ahmad Faiz, Nor’aishah Hasan, Harun Abdul Rahim, Hussein Sobri, Noraziyah Abd Aziz Shamsudin

“…In this study, seeds of a high-yielding pyramided rice line MR219-PL-5 were exposed to carbon ion beam irradiation at 10, 20, 40, 60, 80, and 100 Gy. The radiosensitivity test was conducted to determine the optimum dose of carbon ion beam irradiation based on the lethal dose 50% (LD50) using Sandwich Blotter Technique. …”
Get full text

Electron Scattering from 1-Methyl-5-Nitroimidazole: Cross-Sections for Modeling Electron Transport through Potential Radiosensitizers by Ana I. Lozano, Lidia Álvarez, Adrián García-Abenza, Carlos Guerra, Fábris Kossoski, Jaime Rosado, Francisco Blanco, Juan Carlos Oller, Mahmudul Hasan, Martin Centurion, Thorsten Weber, Daniel S. Slaughter, Deepthy M. Mootheril, Alexander Dorn, Sarvesh Kumar, Paulo Limão-Vieira, Rafael Colmenares, Gustavo García

Subjects: Get full text

Sorafenib inhibits ovarian cancer cell proliferation and mobility and induces radiosensitivity by targeting the tumor cell epithelial–mesenchymal transition by Tian Chuntao, Liu Ying, Xue Lingfei, Zhang Dong, Zhang Xiaotong, Su Jing, Chen Jiaohong, Li Xiangke, Wang Liuxing, Jiao Shunchang

Subjects: Get full text

A small molecule inhibitor of the UBE2F-CRL5 axis induces apoptosis and radiosensitization in lung cancer by Tiantian Xu, Qisheng Ma, Yanan Li, Qing Yu, Peichen Pan, Yawen Zheng, Zhijian Li, Xiufang Xiong, Tingjun Hou, Bin Yu, Hongmin Liu, Yi Sun

“…Biologically, HA-9104 effectively suppresses the growth and survival of lung cancer cells and confers radiosensitization in both in vitro cell culture and in vivo xenograft tumor models. …”
Get full text

Quantitative Correlations between Radiosensitivity Biomarkers Show That the ATM Protein Kinase Is Strongly Involved in the Radiotoxicities Observed after Radiotherapy by Eymeric Le Reun, Larry Bodgi, Adeline Granzotto, Laurène Sonzogni, Mélanie L. Ferlazzo, Joëlle Al-Choboq, Laura El-Nachef, Juliette Restier-Verlet, Elise Berthel, Clément Devic, Audrey Bouchet, Michel Bourguignon, Nicolas Foray

Subjects: “…radiosensitivity…”
Get full text

The Activation of the Tumor Suppressor Protein p53 by Acriflavine Leads to Mitochondrial Dysfunction and Improves the Radiosensitivity of Colon Cancer Cells by Caizhao Lin, Xiaohua Chen, Huayun Qiu, Benfeng Li, Min Guo

“…This suggests that ACF can promote p53 expression and affect mitochondrial function and the radiosensitivity of SW620. The luciferase reporting experiment showed that there was a binding site between ACF and p53. …”
Get full text