Paradoxical Radiosensitizing Effect of Carnosic Acid on B16F10 Metastatic Melanoma Cells: A New Treatment Strategy by Miguel Alcaraz, Amparo Olivares, Marina Andreu-Gálvez, Daniel Gyingiri Achel, Ana María Mercado, Miguel Alcaraz-Saura

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α-Ketoglutarate supplementation and NAD+ modulation enhance metabolic rewiring and radiosensitization in SLC25A1 inhibited cancer cells by Kexu Xiang, Mikhail Kunin, Safa Larafa, Maike Busch, Nicole Dünker, Verena Jendrossek, Johann Matschke

“…The mitochondrial citrate transport protein SLC25A1 is involved in metabolic reprogramming offering a strategy to induce metabolic bottlenecks relevant to radiosensitization through the accumulation of the oncometabolite D-2-hydroxyglutarate (D-2HG) upon SLC25A1 inhibition (SLC25A1i). …”
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AntiPD-L1 antibody conjugated Au-SPIOs nanoplatform for enhancing radiosensitivity and triggering anti-tumor immune response by Chengrun Du, Jianyun Jiang, Caifeng Wan, Guangsen Pan, Fangfang Kong, Ruiping Zhai, Chaosu Hu, Hongmei Ying

“…In conclusion, antiPD-L1-SPIOs@PLGA@Au could be used as a radiosensitizer and a MRI contrast targeting PD-L1, with the functions of blocking the PD-L1/PD-1 immune checkpoint pathway and reversing the immunosuppression caused by TAMs.…”
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Effects of Combined Inhibition of STAT3 and VEGFR2 Pathways on the Radiosensitivity of Non-Small-Cell Lung Cancer Cells [Retraction] by Hu C, Zhuang W, Qiao Y, Liu B, Liu L, Hui K, Jiang X

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The p21-dependent radiosensitization of human breast cancer cells by MLN4924, an investigational inhibitor of NEDD8 activating enzyme. by Dong Yang, Mingjia Tan, Gongxian Wang, Yi Sun

“…We have recently validated that SCF (SKP1, Cullins, and F-box protein) E3 ubiquitin ligase is an attractive radiosensitizing target. Here we tested our hypothesis that MLN4924, a newly discovered investigational small molecule inhibitor of NAE (NEDD8 Activating Enzyme) that inactivates SCF E3 ligase, could act as a novel radiosensitizing agent in breast cancer cells. …”
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Dual mTOR/DNA-PK Inhibitor CC-115 Induces Cell Death in Melanoma Cells and Has Radiosensitizing Potential by Felix Bürkel, Tina Jost, Markus Hecht, Lucie Heinzerling, Rainer Fietkau, Luitpold Distel

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4-Methylumebelliferone Enhances Radiosensitizing Effects of Radioresistant Oral Squamous Cell Carcinoma Cells via Hyaluronan Synthase 3 Suppression by Kazuki Hasegawa, Ryo Saga, Kentaro Ohuchi, Yoshikazu Kuwahara, Kazuo Tomita, Kazuhiko Okumura, Tomoaki Sato, Manabu Fukumoto, Eichi Tsuruga, Yoichiro Hosokawa

“…We previously reported that the administration of 4-MU with X-ray irradiation enhanced radiosensitization. However, an effective sensitizer for radioresistant (RR) cells is yet to be established, and it is unknown whether 4-MU exerts radiosensitizing effects on RR cells. …”
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The Effect of <i>Atm</i> Loss on Radiosensitivity of a Primary Mouse Model of <i>Pten</i>-Deleted Brainstem Glioma by Connor E. Stewart, María E. Guerra-García, Lixia Luo, Nerissa T. Williams, Yan Ma, Joshua A. Regal, Debosir Ghosh, Patrick Sansone, Mark Oldham, Katherine Deland, Oren J. Becher, David G. Kirsch, Zachary J. Reitman

“…Here, we sought to determine if ATM inactivation could radiosensitize a primary mouse model of brainstem glioma driven by <i>Pten</i> loss. …”
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PEGPH20, a PEGylated human hyaluronidase, induces radiosensitization by reoxygenation in pancreatic cancer xenografts. A molecular imaging study by Tomohiro Seki, Yu Saida, Shun Kishimoto, Jisook Lee, Yasunori Otowa, Kazutoshi Yamamoto, Gadisetti VR Chandramouli, Nallathamby Devasahayam, James B. Mitchell, Murali C. Krishna, Jeffery R. Brender

“…Conclusions: PEGPH20 may be useful for radiosensitization of pancreatic cancer but only in the subset of tumors with substantial hyaluronan accumulation. …”
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111In-labelled polymeric nanoparticles incorporating a ruthenium-based radiosensitizer for EGFR-targeted combination therapy in oesophageal cancer cells by Gill, M, Menon, J, Jarman, P, Owen, J, Skaripa-Koukelli, I, Able, S, Thomas, J, Carlisle, R, Vallis, K

“…This work demonstrates nanoparticle co-delivery of a therapeutic radionuclide plus a ruthenium-based radiosensitizer can achieve combinational and targeted therapeutic effects in cancer cells that overexpress EGFR.…”

EP-2324: Non-invasive PET imaging of radiosensitive tumour regions using γH2AX-targeted immunoconjugate by Yaromina, A, Knight, J, Dubois, L, Bauwens, M, Biemans, R, Lieuwes, N, Cornelissen, B, Lambin, P

A ruthenium polypyridyl intercalator stalls DNA replication forks, radiosensitizes human cancer cells and is enhanced by Chk1 inhibition by Gill, M, Harun, S, Halder, S, Boghozian, R, Ramadan, K, Ahmad, H, Vallis, K

“…Furthermore, pre-treatment of HeLa cells with [Ru(dppz)2(PIP)]2+ before external beam ionising radiation results in a supra-additive decrease in cell survival accompanied by increased γ-H2AX expression, indicating the compound functions as a radiosensitizer. Together, these results indicate ruthenium-based intercalation can block replication fork progression and demonstrate how these DNA-binding agents may be combined with DDR inhibitors or ionising radiation to achieve more efficient cancer cell killing.…”

Relationship between in vitro chromosomal radiosensitivity of peripheral blood lymphocytes and the expression of normal tissue damage following radiotherapy for breast cancer. by Barber, J, Burrill, W, Spreadborough, A, Levine, E, Warren, C, Kiltie, A, Roberts, SA, Scott, D

“…However, there were no trends towards increased chromosomal radiosensitivity with the micronucleus scores at HDR or LDR, or with G(2) chromosomal radiosensitivity. …”

E3 ligase cIAP2 mediates downregulation of MRE11 and radiosensitization in response to HDAC inhibition in bladder cancer by Nicholson, J, Jevons, S, Groselj, B, Ellermann, S, Konietzny, R, Kerr, M, Kessler, B, Kiltie, A

“…Meiotic recombination 11 homolog (MRE11) is downregulated by histone deacetylase inhibition (HDACi), resulting in reduced levels of DNA repair in bladder cancer cells and radiosensitization. In this study, we show that the mechanism of this downregulation is post-translational and identify a C-terminally truncated MRE11, which is formed after HDAC inhibition as full-length MRE11 is downregulated. …”

Phase I/II trial of bevacizumab and radiotherapy for locally advanced inoperable colorectal cancer: vasculature-independent radiosensitizing effect of bevacizumab. by Koukourakis, M, Giatromanolaki, A, Sheldon, H, Buffa, F, Kouklakis, G, Ragoussis, I, Sivridis, E, Harris, A

“…CONCLUSIONS: The combination of radiotherapy with bevacizumab is feasible and results in a high rate of durable complete responses in patients with LA/I-CRC. Radiosensitization may occur through a direct effect on tumor cells followed by a wide scale suppression of transcription factors and genes involved in DNA repair and proliferation.…”

A ruthenium polypyridyl intercalator stalls DNA replication forks, radiosensitizes human cancer cells and is enhanced by Chk1 inhibition by Gill, Martin R., Harun, Siti Norain, Halder, Swagata, Boghozian, Ramon A., Ramadan, Kristijan, Ahmad, Haslina, Vallis, Katherine A.

“…Furthermore, pre-treatment of HeLa cells with [Ru(dppz)2(PIP)](2+) before external beam ionising radiation results in a supra-additive decrease in cell survival accompanied by increased γ-H2AX expression, indicating the compound functions as a radiosensitizer. Together, these results indicate ruthenium-based intercalation can block replication fork progression and demonstrate how these DNA-binding agents may be combined with DDR inhibitors or ionising radiation to achieve more efficient cancer cell killing.…”
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Synergetic radiosensitization effects of bismuth oxide nanoparticles, cisplatin and baicalein-rich fraction from oroxylum indicum combinations for clinical radiotherapy by Sisin, Noor Nabilah Talik

“…Integration of novel nanomaterials and natural product as radiosensitizer to increase the anti-tumors efficacy are also promising to enhance the treatment performance. …”
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Cisplatin Concentrations in Long and Short Duration Infusion: Implications for the Optimal Time of Radiation Delivery by Pradeep Rajkumar, Binu Susan Mathew, Saikat Das, Rajesh Isaiah, Subashini John, Ratna Prabha, Denise Helen Fleming

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MAPK11 (p38β) is a major determinant of cellular radiosensitivity by controlling ionizing radiation-associated senescence: An in vitro study by D.M. Fernández-Aroca, N. García-Flores, S. Frost, J. Jiménez-Suárez, A. Rodríguez-González, P. Fernández-Aroca, S. Sabater, I. Andrés, C. Garnés-García, B. Belandia, F.J. Cimas, D. Villar, M.J. Ruiz-Hidalgo, R. Sánchez-Prieto

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Methylglyoxal from gut microbes boosts radiosensitivity and radioimmunotherapy in rectal cancer by triggering endoplasmic reticulum stress and cGAS-STING activation by Lei Wang, Kai Wang, Jinluan Li, Junxin Wu, Libin Liu, Da Zhang, Jianji Pan, Han Zhou, Zhiwen Lin, Chenwei Jiang, Xingte Chen, Lingdong Shao

“…Candidate gut microbiome-derived metabolites linked with radiosensitization were screened using 16s rRNA gene sequencing and ultrahigh-performance liquid chromatography-mass coupled with mass spectrometry. …”
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