Trastuzumab-resistant breast cancer cells remain sensitive to the auger electron-emitting radiotherapeutic agent 111In-NLS-trastuzumab and are radiosensitized by methotrexate. by Costantini, D, Bateman, K, McLarty, K, Vallis, K, Reilly, R

“…UNLABELLED: Our goals in this study were to determine whether (111)In-trastuzumab coupled to peptides harboring nuclear localizing sequences (NLSs) could kill trastuzumab-resistant breast cancer cell lines through the emission of Auger electrons and whether the combination of radiosensitization with methotrexate (MTX) would augment the cytotoxicity of this radiopharmaceutical. …”

X-rays-Induced Bystander Effect Consists in the Formation of DNA Breaks in a Calcium-Dependent Manner: Influence of the Experimental Procedure and the Individual Factor by Juliette Restier-Verlet, Aurélie Joubert, Mélanie L. Ferlazzo, Adeline Granzotto, Laurène Sonzogni, Joëlle Al-Choboq, Laura El Nachef, Eymeric Le Reun, Michel Bourguignon, Nicolas Foray

Subjects: Get full text

Influence of the Hypersensitivity to Low Dose Phenomenon on the Tumor Response to Hypofractionated Stereotactic Body Radiation Therapy by Eymeric Le Reun, Adeline Granzotto, Adeline Pêtre, Larry Bodgi, Guillaume Beldjoudi, Thomas Lacornerie, Véronique Vallet, Audrey Bouchet, Joëlle Al-Choboq, Michel Bourguignon, Juliette Thariat, Jean Bourhis, Eric Lartigau, Nicolas Foray

Subjects: Get full text

18F-FDG Micro PET/CT imaging to evaluate the effect of BRCA1 knockdown on MDA-MB231 breast cancer cell radiosensitivity by Weitao Tao, Siqi Wang, Alei Xu, Yangyang Xue, Hui Wang, Huiqin Xu

Subjects: Get full text

Low-Dose Radiation Therapy (LDRT) against Cancer and Inflammatory or Degenerative Diseases: Three Parallel Stories with a Common Molecular Mechanism Involving the Nucleoshuttling o... by Eymeric Le Reun, Nicolas Foray

Subjects: Get full text

New Insights into the Relationship between Gut Microbiota and Radiotherapy for Cancer by Zhipeng Li, Xiyang Ke, Dan Zuo, Zhicheng Wang, Fang Fang, Bo Li

Subjects: Get full text

Kinase Inhibitors of DNA-PK, ATM and ATR in Combination with Ionizing Radiation Can Increase Tumor Cell Death in HNSCC Cells While Sparing Normal Tissue Cells by Eva-Maria Faulhaber, Tina Jost, Julia Symank, Julian Scheper, Felix Bürkel, Rainer Fietkau, Markus Hecht, Luitpold V. Distel

Subjects: Get full text

Forty-six cases of nasopharyngeal carcinoma treated with 50 Gy radiotherapy plus hematoporphyrin derivative: 20 years of follow-up and outcomes from the Sun Yat-sen University Canc... by Bing-Qing Xu, Zi-Wei Tu, Ya-Lan Tao, Zhi-Gang Liu, Xiao-Hui Li, Wei Yi, Chang-Bing Jiang, Yun-Fei Xia

Subjects: Get full text

The Intermediate Filament Synemin Regulates Non-Homologous End Joining in an ATM-Dependent Manner by Sara Sofia Deville, Anne Vehlow, Sarah Förster, Ellen Dickreuter, Kerstin Borgmann, Nils Cordes

Subjects: Get full text

Ginsenoside Rg5 enhances the radiosensitivity of lung adenocarcinoma via reducing HSP90-CDC37 interaction and promoting client protein degradation by Hansong Bai, Jiahua Lyu, Xinyu Nie, Hao Kuang, Long Liang, Hongyuan Jia, Shijie Zhou, Churong Li, Tao Li

“…In conclusion, ginsenoside Rg5 may be a potential radiosensitizer for lung adenocarcinoma. It interacts with HSP90α and reduces the binding between HSP90 and CDC37, thereby increasing the ubiquitin-mediated proteasomal degradation of the HSP90-CDC37 client proteins.…”
Get full text

Correction: RRM2 silencing suppresses malignant phenotype and enhances radiosensitivity via activating cGAS/STING signaling pathway in lung adenocarcinoma by Xueping Jiang, Yangyi Li, Nannan Zhang, Yanping Gao, Linzhi Han, Shuying Li, Jiali Li, Xingyu Liu, Yan Gong, Conghua Xie

Get full text

Association of long noncoding RNA MALAT1 with the radiosensitivity of lung adenocarcinoma cells via the miR-140/PD-L1 axis by Shujie Li, Yue Xie, Wei Zhou, Qian Zhou, Dan Tao, Haonan Yang, Kaijin Mao, Shi Li, Jinyan Lei, Yongzhong Wu, Ying Wang

“…Objective: To investigate the effect of MALAT1 on the modulating the radiosensitivity of lung adenocarcinoma, through regulation of the expression of the miR-140/PD-L1 axis. …”
Get full text

Oleanolic acid combined with olaparib enhances radiosensitization in triple negative breast cancer and hypoxia imaging with 18F-FETNIM micro PET/CT by A-Lei Xu, Yang-Yang Xue, Wei-Tao Tao, Si-Qi Wang, Hui-Qin Xu

Subjects: Get full text

LINC02532 Contributes to Radiosensitivity in Clear Cell Renal Cell Carcinoma through the miR-654-5p/YY1 Axis by Xiaoguang Zhou, Bowen Zeng, Yansheng Li, Haozhou Wang, Xiaodong Zhang

“…Conclusions: Our results revealed a positive feedback loop of LINC02532/miR-654-5p/YY1 in regulating the radiosensitivity of ccRCC, suggesting that LINC02532 might be a potential target for ccRCC radiotherapy. …”
Get full text

Quantifying Radiosensitization of PSMA-Targeted Gold Nanoparticles on Prostate Cancer Cells at Megavoltage Radiation Energies by Monte Carlo Simulation and Local Effect Model by Ryder M. Schmidt, Daiki Hara, Jorge D. Vega, Marwan B. Abuhaija, Wensi Tao, Nesrin Dogan, Alan Pollack, John C. Ford, Junwei Shi

“…Active targeting gold nanoparticles (AuNPs) are a very promising avenue for cancer treatment with many publications on AuNP mediated radiosensitization at kilovoltage (kV) photon energies. …”
Get full text

Cancer-Associated Fibroblasts Exposed to High-Dose Ionizing Radiation Promote M2 Polarization of Macrophages, Which Induce Radiosensitivity in Cervical Cancer by Yuhan Sheng, Baofang Zhang, Biyuan Xing, Zhao Liu, Yu Chang, Gang Wu, Yingchao Zhao

Get full text

Downregulation of the type 1 insulin-like growth factor receptor in mouse melanoma cells is associated with enhanced radiosensitivity and impaired activation of Atm kinase. by Macaulay, V, Salisbury, A, Bohula, E, Playford, M, Smorodinsky, N, Shiloh, Y

“…Cells expressing AS-IGF1R transcripts were more radiosensitive in vitro and in vivo than controls. Also they showed reduced radiation-induced p53 accumulation and p53 serine 18 phosphorylation, and radioresistant DNA synthesis. …”

IGF-1R inhibition enhances radiosensitivity and delays double-strand break repair by both non-homologous end-joining and homologous recombination. by Chitnis, M, Lodhia, K, Aleksic, T, Gao, S, Protheroe, A, Macaulay, V

“…In contrast, IGF-1R inhibition did not influence radiosensitivity or γH2AX focus resolution in LNCaP-LN3 cells, suggesting that radiosensitization tracks with the ability of IGF-1R to influence DSB repair. …”

Melatonin as a Radio-Sensitizer in Cancer by Carolina Alonso-González, Alicia González, Javier Menéndez-Menéndez, Carlos Martínez-Campa, Samuel Cos

Subjects: Get full text

Biological Mechanisms to Reduce Radioresistance and Increase the Efficacy of Radiotherapy: State of the Art by Fabio Busato, Badr El Khouzai, Maddalena Mognato

Subjects: Get full text