Improved Tumor Control Following Radiosensitization with Ultrasound-Sensitive Oxygen Microbubbles and Tumor Mitochondrial Respiration Inhibitors in a Preclinical Model of Head and Neck Cancer by Quezia Lacerda, Hebah Falatah, Ji-Bin Liu, Corinne E. Wessner, Brian Oeffinger, Ankit Rochani, Dennis B. Leeper, Flemming Forsberg, Joseph M. Curry, Gagan Kaushal, Scott W. Keith, Patrick O’Kane, Margaret A. Wheatley, John R. Eisenbrey

Get full text

ROS production in response to high-power microwave pulses induces p53 activation and DNA damage in brain cells: Radiosensitivity and biological dosimetry evaluation by Juie Nahushkumar Rana, Juie Nahushkumar Rana, Sohail Mumtaz, Sohail Mumtaz, Eun Ha Choi, Eun Ha Choi, Eun Ha Choi, Ihn Han, Ihn Han

Get full text

Functionalized Hybrid Iron Oxide–Gold Nanoparticles Targeting Membrane Hsp70 Radiosensitize Triple-Negative Breast Cancer Cells by ROS-Mediated Apoptosis by Zhiyuan Wu, Stefan Stangl, Alicia Hernandez-Schnelzer, Fei Wang, Morteza Hasanzadeh Kafshgari, Ali Bashiri Dezfouli, Gabriele Multhoff

“…The Fe₃O₄ core of the NPs can serve as a contrast agent enabling magnetic resonance imaging (MRI) of the tumor, and the nanogold shell radiosensitizes tumor cells by the release of secondary electrons (Auger electrons) upon X-ray irradiation. …”
Get full text

miR‐122‐5p modulates the radiosensitivity of cervical cancer cells by regulating cell division cycle 25A (CDC25A) by Feng‐Na Ding, Bao‐Hong Gao, Xia Wu, Chun‐Wu Gong, Wei‐Qing Wang, Shu‐Mao Zhang

Subjects: Get full text

Concurrent Activation of Both Survival-Promoting and Death-Inducing Signaling by Chloroquine in Glioblastoma Stem Cells: Implications for Potential Risks and Benefits of Using Chloroquine as Radiosensitizer by Andreas Müller, Patrick Weyerhäuser, Nancy Berte, Fitriasari Jonin, Bogdan Lyubarskyy, Bettina Sprang, Sven Rainer Kantelhardt, Gabriela Salinas, Lennart Opitz, Walter Schulz-Schaeffer, Alf Giese, Ella L. Kim

Subjects: Get full text

FOXK1 regulates malignant progression and radiosensitivity through direct transcriptional activation of CDC25A and CDK4 in esophageal squamous cell carcinoma by Xiaoxu Li, Juntao Lu, Lei Liu, Fei Li, Tongxin Xu, Liying Chen, Zhaoyang Yan, Yan Li, Wei Guo

“…Furthermore, silencing FOXK1 resulted in heightened radiosensitivity by impeding DNA damage repair, inducing G1 arrest, and promoting apoptosis. …”
Get full text

ALKBH5/YTHDF2‐mediated m6A modification of circAFF2 enhances radiosensitivity of colorectal cancer by inhibiting Cullin neddylation by Yingjie Shao, Zhenhua Liu, Xing Song, Rui Sun, You Zhou, Dachuan Zhang, Huihui Sun, Junchao Huang, Chenxi Wu, Wendong Gu, Xiao Zheng, Jingting Jiang

Subjects: Get full text

Radiosensitization and a Less Aggressive Phenotype of Human Malignant Glioma Cells Expressing Isocitrate Dehydrogenase 1 (IDH1) Mutant Protein: Dissecting the Mechanisms by Jacqueline Kessler, Tim Hohmann, Antje Güttler, Marina Petrenko, Christian Ostheimer, Urszula Hohmann, Matthias Bache, Faramarz Dehghani, Dirk Vordermark

“…Hence, detection of the genetic status of IDH1 before therapy massively expands the utility of immunohistochemistry to accurately distinguish patients with a less aggressive and radiosensitive IDH1-mutant diffuse glioma suitable for radiotherapy from those with a more aggressive IDH1-wildtype diffuse glioma who might benefit from an individually intensified therapy comprising radiotherapy and alternative medical treatments.…”
Get full text

SFN Enhanced the Radiosensitivity of Cervical Cancer Cells via Activating LATS2 and Blocking Rad51/MDC1 Recruitment to DNA Damage Site by Shiyu Wang, Yanan Wang, Xiangnan Liu, Yongbin Yang, Sufang Wu, Yuan Liu

“…Methods: We treated established cervical cancer cells line (SiHa, HeLa, C33A) with SFN followed by irradiation, and explored its survival, apoptosis, and DNA damage repair in vitro and validated the radiosensitivity of SFN treatment in vivo. We conducted mRNA sequencing to identify differentially expressed mRNAs after SFN treatment. …”
Get full text

Coralyne Radiosensitizes A549 Cells by Upregulation of CDKN1A Expression to Attenuate Radiation Induced G2/M Block of the Cell Cycle by Aneta Węgierek-Ciuk, Michał Arabski, Karol Ciepluch, Kamil Brzóska, Halina Lisowska, Malwina Czerwińska, Tomasz Stępkowski, Krzysztof Lis, Anna Lankoff

“…These results indicate that coralyne is a potent radiosensitizing agent that may find an application in medicine.…”
Get full text

ALKBH5‐mediated m6A demethylation of TIRAP mRNA promotes radiation‐induced liver fibrosis and decreases radiosensitivity of hepatocellular carcinoma by Yuhan Chen, Peitao Zhou, Yixun Deng, Xinni Cai, Mingrui Sun, Yining Sun, Dehua Wu

“…Notably, polarised monocytes secreted CCL20 to up‐regulate ALKBH5 expression in HSC, and reduce HCC radiosensitivity by activating ALKBH5/TIRAP axis in HCC cells. …”
Get full text

Impaired DNA double-strand break repair and effective radiosensitization of HPV-negative HNSCC cell lines through combined inhibition of PARP and Wee1 by Agnes Oetting, Sabrina Christiansen, Fruzsina Gatzemeier, Sabrina Köcher, Lara Bußmann, Arne Böttcher, Katharina Stölzel, Anna Sophie Hoffmann, Nina Struve, Malte Kriegs, Cordula Petersen, Christian Betz, Kai Rothkamm, Henrike Barbara Zech, Thorsten Rieckmann

Subjects: Get full text

The radiosensitizer 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide induces DNA damage in EMT-6 mammary carcinoma cells by Smith Colin A, Haddadin Makhluf J, Geara Fady, Haykal Joelle, Gali-Muhtasib Hala

“…Contributing factors to DCQ radiosensitization appear to be the induction of ROS and DSBs.…”
Get full text

Targeting DNA Double-Strand Break Repair Enhances Radiosensitivity of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinoma to Photons and Protons by Eirini Terpsi Vitti, Andrzej Kacperek, Jason L. Parsons

“…We observed that inhibition of ATM, ATR, and particularly DNA-Pkcs, caused a significant reduction in HNSCC cell survival post-irradiation with both photons and protons, with less of an impact on the most radiosensitive HPV-positive cell line. The inhibition of DNA-Pkcs and, to a lesser extent ATM, in combination with radiation was also more effective at inhibiting the growth of 3D spheroids derived from relatively radioresistant HPV-negative HNSCC. …”
Get full text

Heavy Ion-Responsive lncRNA EBLN3P Functions in the Radiosensitization of Non-Small Cell Lung Cancer Cells Mediated by TNPO1 by Haoyi Tang, Hao Huang, Zi Guo, Haitong Huang, Zihe Niu, Yi Ji, Yuyang Zhang, Huahui Bian, Wentao Hu

Get full text

Improve the cytotoxic effects of megavoltage radiation treatment by Fe3O4@Cus–PEG nanoparticles as a novel radiosensitizer in colorectal cancer cells by Mahshid Mohammadian, Soraya Emamgholizadeh Minaei, Amin Shiralizadeh Dezfuli

Subjects: Get full text

MicroRNA-320 Enhances Radiosensitivity of Glioma Through Down-Regulation of Sirtuin Type 1 by Directly Targeting Forkhead Box Protein M1 by Tengfei Li, Ji Ma, Xinwei Han, Yongxu Jia, Huifeng Yuan, Shaofeng Shui, Dong Guo

“…In conclusion, miR-320 enhanced radiosensitivity of glioma cells through down-regulation of Sirt1 by directly targeting FoxM1.…”
Get full text

NVP-BEZ235 and NVP-BGT226, dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitors, enhance tumor and endothelial cell radiosensitivity. by Fokas, E, Yoshimura, M, Prevo, R, Higgins, G, Hackl, W, Maira, S, Bernhard, E, Mckenna, W, Muschel, R

Methotrexate, paclitaxel, and doxorubicin radiosensitize HER2-amplified human breast cancer cells to the Auger electron-emitting radiotherapeutic agent (111)In-NLS-trastuzumab. by Costantini, D, Villani, D, Vallis, K, Reilly, R

“…Effects of coexposure of these cells to (111)In-NLS-trastuzumab and low-dose, radiosensitizing methotrexate, paclitaxel, or doxorubicin were assessed by clonogenic cell-survival assay. …”

Are signatures of radiosensitivity ready for routine clinical use? A pragmatic comparison of clinical, pathological and gene signature predictors of outcome in oropharynx head and neck cancers by Dhawan, A, Scott, JG, Sundaresan, P, Veness, M, Porceddu, S, Hau, E, Ahern, V, Harris, A, Buffa, F, Gee, HE