Are signatures of radiosensitivity ready for routine clinical use? A pragmatic comparison of clinical, pathological, and gene signature predictors of outcome in oropharynx head and neck cancers. by Dhawan, A, Scott, JG, Sundaresan, P, Veness, M, Porceddu, S, Hau, E, Ahern, V, Harris, AL, Buffa, FM, Gee, HE

Therapeutic Potential of (−)-Agelamide D, a Diterpene Alkaloid from the Marine Sponge <i>Agelas</i> sp., as a Natural Radiosensitizer in Hepatocellular Carcinoma Models by Changhoon Choi, Yeonwoo Cho, Arang Son, Sung-Won Shin, Yeon-Ju Lee, Hee Chul Park

“…Previously, we reported that extracts of the marine sponge <i>Agelas</i> sp. may contain a natural radiosensitizer for HCC treatment. In this study, we isolated (−)-agelamide D from <i>Agelas</i> extract and investigated the mechanism underlying its radiosensitization. (−)-Agelamide D enhanced radiation sensitivity of Hep3B cells with decreased clonogenic survival and increased apoptotic cell death. …”
Get full text

Evaluation of Sinensetin Derived From Flavonoids-Rich Orthosiphon Stamineus as a New Radiosensitizer in MDA-MB-231 and T47D as Breast Cancer Cell Lines by Nakisa Rezakhani, Bahram Goliaei, Fereshte Mahdizade, Alireza Nikoofar, Hoda Keshmiri Neghab, -Mohammad Hasan Soheilifar, Seyedeh Sara Azadeh, Bahareh Bigdeli

“…More ever, expression level of, Bcl-2, STAT3, and increased P53 via treated cells with Sinensetin (SIN) and X-ray.Conclusion: Due to the results, Sinensetin (SIN) can be mentioned as a novel radiosensitizer and its effects may considered increasing apoptosis following DNA damage induced by irradiation.…”
Get full text

Non-Surgical Breast-Conserving Treatment (KORTUC-BCT) Using a New Radiosensitization Method (KORTUC II) for Patients with Stage I or II Breast Cancer by Yasuhiro Ogawa, Kei Kubota, Nobutaka Aoyama, Tomoaki Yamanishi, Shinji Kariya, Norihiko Hamada, Munenobu Nogami, Akihito Nishioka, Masahide Onogawa, Mitsuhiko Miyamura

Subjects: Get full text

5-(<i>N</i>-Trifluoromethylcarboxy)aminouracil as a Potential DNA Radiosensitizer and Its Radiochemical Conversion into <i>N</i>-Uracil-5-yloxamic Acid by Paulina Spisz, Witold Kozak, Lidia Chomicz-Mańka, Samanta Makurat, Karina Falkiewicz, Artur Sikorski, Anna Czaja, Janusz Rak, Magdalena Zdrowowicz

Subjects: “…radiosensitizer…”
Get full text

OncomiR miR-182-5p Enhances Radiosensitivity by Inhibiting the Radiation-Induced Antioxidant Effect through SESN2 in Head and Neck Cancer by Min-Ying Lin, Yu-Chan Chang, Shan-Ying Wang, Muh-Hwa Yang, Chih-Hsien Chang, Michael Hsiao, Richard N. Kitsis, Yi-Jang Lee

“…Overexpression of miR-182-5p enhanced the radiosensitivity of HNSCC cells by increasing intracellular reactive oxygen species (ROS) levels, suggesting that expression of the miR-182 family is beneficial for radiotherapy. …”
Get full text

MicroRNA‐372 enhances radiosensitivity while inhibiting cell invasion and metastasis in nasopharyngeal carcinoma through activating the PBK‐dependent p53 signaling pathway by Zhe Wang, Ji‐Wei Mao, Guang‐Yan Liu, Fu‐Guang Wang, Zai‐Shuang Ju, Dong Zhou, Ruo‐Yu Wang

“…In conclusion, the study shows that up‐regulated miR‐372 promotes radiosensitivity by activating the p53 signaling pathway via inhibition of PBK.…”
Get full text

A Comprehensive Analysis of Radiosensitization Properties of Metallic Nanoparticles in Brachytherapy of Gastric Adenocarcinoma by I-125 Seed: A Simulation Study by MCNPX and MCNP6 Codes by Elham Mansouri, Asghar Mesbahi, Mohammad Saeid Hejazi, Vahideh Tarhriz, Hamed Hamishehkar, Farshad Seyednejad

Subjects: Get full text

The PI3K/mTOR dual inhibitor BEZ235 nanoparticles improve radiosensitization of hepatoma cells through apoptosis and regulation DNA repair pathway by Xiaolong Tang, Amin Li, Chunmei Xie, Yinci Zhang, Xueke Liu, Yinghai Xie, Binquan Wu, Shuping Zhou, Xudong Huang, Yongfang Ma, Weiya Cao, Ruyue Xu, Jing Shen, Zhen Huo, Shuyu Cai, Yong Liang, Dong Ma

Subjects: Get full text

Intratumoral Gene Electrotransfer of Plasmid DNA Encoding shRNA against Melanoma Cell Adhesion Molecule Radiosensitizes Tumors by Antivascular Effects and Activation of an Immune Response by Simona Kranjc Brezar, Valter Mrak, Masa Bosnjak, Monika Savarin, Gregor Sersa, Maja Cemazar

Get full text

A three-in-one-bullet for oesophageal cancer: replication fork collapse, spindle attachment failure and enhanced radiosensitivity generated by a ruthenium(II) metallo-intercalator by Gill, MR, Jarman, PJ, Halder, S, Walker, MG, Saeed, HK, Thomas, JA, Smythe, C, Ramadan, K, Vallis, KA

“…In addition to these single-agent effects, [Ru(phen) 2 (tpphz)] 2+ functions as a radiosensitizer with efficiency comparable to cisplatin, which occurs through a synergistic enhancement of DNA damage. …”

An Alternative Pipeline for Glioblastoma Therapeutics: A Systematic Review of Drug Repurposing in Glioblastoma by Seán B. Lyne, Bakhtiar Yamini

Subjects: Get full text

Hypoxic Radioresistance: Can ROS Be the Key to Overcome It? by Hui Wang, Heng Jiang, Melissa Van De Gucht, Mark De Ridder

Subjects: Get full text

Optimization of Size of Nanosensitizers for Antitumor Radiotherapy Using Mathematical Modeling by Maxim Kuznetsov, Andrey Kolobov

Subjects: Get full text

EGFR-antagonistic affibody-functionalized Pt-based nanozyme for enhanced tumor radiotherapy by Haijun Wang, Xichen Zhao, Heng Zhang, Xianwen Zou, Dianlong Jia, Wenjian Liu, Baoqing Tian, Dandan Yuan, Yihui Li, Yao Zhu, Fan Zhang, Yongsi Dai, Yu Fan, Yuchun Wei, Xiao Sun, Qing Fan, Jian Dong

Subjects: Get full text

Complete ablation of tumors using synchronous chemoradiation with bimetallic theranostic nanoparticles by Hamed Nosrati, Elahe Attari, Fatemeh Abhari, Murat Barsbay, Mohammadreza Ghaffarlou, Navid Mousazadeh, Rasoul Vaezi, Taras Kavetskyy, Hamed Rezaeejam, Thomas J. Webster, Behrooz Johari, Hossein Danafar

Subjects: Get full text

Hyaluronic Acid-Functionalized Gadolinium Oxide Nanoparticles for Magnetic Resonance Imaging-Guided Radiotherapy of Tumors by Chaoyang Wu, Rong Cai, Tian Zhao, Lin Wu, Lirong Zhang, Jie Jin, Lixia Xu, Pengfei Li, Tao Li, Miaomiao Zhang, Fengyi Du

Subjects: Get full text

Advances of Nanomedicine in Radiotherapy by Wei Liu, Bo Chen, Haocheng Zheng, Yun Xing, Guiyuan Chen, Peijie Zhou, Liting Qian, Yuanzeng Min

Subjects: Get full text

Curcumin Nanodiscs Improve Solubility and Serve as Radiological Protectants against Ionizing Radiation Exposures in a Cell-Cycle Dependent Manner by Angela C. Evans, Kelly A. Martin, Manoj Saxena, Sandra Bicher, Elizabeth Wheeler, Emilio J. Cordova, Christopher D. Porada, Graça Almeida-Porada, Takamitsu A. Kato, Paul F. Wilson, Matthew A. Coleman

Subjects: Get full text

Quantifying the Effects of Combination Trastuzumab and Radiation Therapy in Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer by Meghan J. Bloom, Patrick N. Song, John Virostko, Thomas E. Yankeelov, Anna G. Sorace

Subjects: Get full text