Targeting telomerase with radiolabeled inhibitors. by Waghorn, P, Jackson, M, Gouverneur, V, Vallis, K

“…However, telomerase inhibition has been shown to enhance cancer cell radiosensitivity. To investigate the strategy of simultaneously inhibiting telomerase while delivering targeted radionuclide therapy to cancer cells, (123)I-radiolabeled inhibitors of telomerase were synthesized and their effects on cancer cell survival studied. …”

Lipid Droplet Biosynthesis Impairment through DGAT2 Inhibition Sensitizes MCF7 Breast Cancer Cells to Radiation by Clelia Nisticò, Francesca Pagliari, Emanuela Chiarella, Joana Fernandes Guerreiro, Maria Grazia Marafioti, Ilenia Aversa, Geraldine Genard, Rachel Hanley, Daniel Garcia-Calderón, Heather Mandy Bond, Maria Mesuraca, Luca Tirinato, Maria Francesca Spadea, Joao Carlos Seco

“…These findings suggest that PF-06424439 pre-treatment coupled to X-ray exposure might potentiate breast cancer cell radiosensitivity and potentially improve the radiotherapy effectiveness.…”
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Identifying key mutations of radioresponsive genes in esophageal squamous cell carcinoma by Xin Xu, Yuming Wang, Yongrui Bai, Jun Lu, Yuntao Guo, Xiaohang Wang, Ling Rong, Jianmin Tang, Xiumei Ma, Jun Ma, Lei Zhang

“…High expression of NOTCH1 was accompanied with the low levels of some immunotherapy-related cells, including CD8(+) T cells and NK cells.ConclusionsThese results indicate the differences of the germline mutations and somatic mutations between the radiosensitive and radioresistence groups in ESCC and imply that NOTCH1 plays important roles in regulating the radiosensitivity of ESCC. …”
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The CD73/Ado System—A New Player in RT Induced Adverse Late Effects by Simone de Leve, Florian Wirsdörfer, Verena Jendrossek

“…The biology-based optimization of RT requires the identification of biological factors that are linked to differential radiosensitivity of normal or tumor tissues, and are amenable to therapeutic targeting. …”
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Targeting AKT-Dependent Regulation of Antioxidant Defense Sensitizes AKT-E17K Expressing Cancer Cells to Ionizing Radiation by Isabell Goetting, Safa Larafa, Katharina Eul, Mikhail Kunin, Burkhard Jakob, Burkhard Jakob, Johann Matschke, Verena Jendrossek

“…Our findings on the importance of glutathione de novo synthesis and glutathione regeneration for radiation resistance of TrC1 AKT-E17K cells offer novel perspectives for improving radiosensitivity in cancer cells with aberrant AKT activity by combining IR with inhibitors targeting AKT-dependent regulation of GSH provision.…”
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Inflammatory Signaling and DNA Damage Responses after Local Exposure to an Insoluble Radioactive Microparticle by Yusuke Matsuya, Nobuyuki Hamada, Yoshie Yachi, Yukihiko Satou, Masayori Ishikawa, Hiroyuki Date, Tatsuhiko Sato

“…Experiments with chemical inhibitors for NF-κB p65 and COX-2 suggested the involvement of such inflammatory responses both in the reduced radiosensitivity of the cells proximal to Cs-BMP and the enhanced radiosensitivity of the cells distal from Cs-BMP. …”
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Hypoxia-Induced Autophagy Is Involved in Radioresistance via HIF1A-Associated Beclin-1 in Glioblastoma Multiforme by Jielin Wei, Kuikui Zhu, Zhe Yang, Ying Zhou, Zihan Xia, Jinghua Ren, Yanxia Zhao, Gang Wu, Cuiwei Liu

“…HIF1A knockdown improved GBM radiosensitivity, and silencing Beclin-1 could reverse HIF1A-induced radioresistance under hypoxic conditions. …”
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Multifunctional nanocomposites DDMplusAF inhibit the proliferation and enhance the radiotherapy of breast cancer cells via modulating tumor-promoting factors and metabolic reprogra... by Noura M. Thabet, Mohamed K. Abdel-Rafei, Gharieb S. El-Sayyad, Mohamed Abd Elkodous, Adel Shaaban, Yi-Chun Du, Laila Ahmed Rashed, Mostafa A. Askar

“…A multiple-MTT assay was performed to evaluate the radiosensitivity of BCCs to DDMPlusAF at 3 Gy (single dose radiotherapy; SDR) and 6 Gy-FDR after 24, 48, and 72 h. …”
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Type 1 insulin-like growth factor receptor inhibition as treatment for urological cancer by Chitnis, M, Dr. Meenali M. Chitnis

“…AZ12253801 enhanced the radiosensitivity of prostate cancer cells, which appeared to be independent of effects of IGF-1R inhibition on cell cycle distribution and apoptosis induction. …”

Ferroptosis in lung cancer: dual role, multi-level regulation, and new therapeutic strategies by Yunbin Li, Xiaosong Li, Jian Li

“…On the other hand, it can counter drug resistance, enhance radiosensitivity, and promote immunotherapy. The article also discusses various combination treatment strategies based on the mechanism of ferroptosis. …”
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Signaling inhibition with radiation in colorectal cancer: clinical trials. by Mckenna, W, Muschel, R, Gupta, A, Hahn, S, Bernhard, E

“…Thus, upstream and downstream pathways from Ras could be targets for manipulation of radiosensitivity. Epidermal growth factor receptor (EGFR) expression and Akt phosphorylation are also associated with the response to radiation. …”

Aldehyde Dehydrogenase, a Therapeutic Target in Chordoma: Analysis in 3D Cellular Models by Marie-Anaïs Locquet, Anne-Lise Dechaume, Paul Berchard, Lhorra Abbes, Daniel Pissaloux, Franck Tirode, Inès Ramos, Julie Bedoucha, Julie Valantin, Marie Karanian, Raul Perret, Olivier Gille, Jean-Yves Blay, Aurélie Dutour

“…Then, we evaluated their radiosensitivity using colony-forming and spheroid size assays. …”
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The Benefit of Reactivating p53 under MAPK Inhibition on the Efficacy of Radiotherapy in Melanoma by Mohammad Krayem, Malak Sabbah, Ahmad Najem, An Wouters, Filip Lardon, Stephane Simon, François Sales, Fabrice Journe, Ahmad Awada, Ghanem E. Ghanem, Dirk Van Gestel

“…We found that the combination of BRAF inhibition (vemurafenib, which completely shuts down the MAPK pathway), together with p53 reactivation (PRIMA-1^Met) significantly enhanced the radiosensitivity of BRAF-mutant melanoma cells. This was accompanied by an increase in both p53 expression and activity. …”
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PERIOD 2 regulates low-dose radioprotection via PER2/pGSK3β/β-catenin/Per2 loop by Aris T. Alexandrou, Yixin Duan, Shanxiu Xu, Clifford Tepper, Ming Fan, Jason Tang, Jonathan Berg, Wassim Basheer, Tyler Valicenti, Paul F. Wilson, Matthew A. Coleman, Andrew T. Vaughan, Loning Fu, David J. Grdina, Jefferey Murley, Aijun Wang, Gayle Woloschak, Jian Jian Li

“…Summary: During evolution, humans are acclimatized to the stresses of natural radiation and circadian rhythmicity. Radiosensitivity of mammalian cells varies in the circadian period and adaptive radioprotection can be induced by pre-exposure to low-level radiation (LDR). …”
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Evaluation of Epigenetic and Radiomodifying Effects during Radiotherapy Treatments in Zebrafish by Gaia Pucci, Giusi Irma Forte, Vincenzo Cavalieri

“…Radiotherapy is still a long way from personalizing cancer treatment plans, and its effectiveness depends on the radiosensitivity of tumor cells. Indeed, therapies that are efficient and successful for some patients may be relatively ineffective for others. …”
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Direct evidence for the contribution of activated N-ras and K-ras oncogenes to increased intrinsic radiation resistance in human tumor cell lines. by Bernhard, E, Stanbridge, E, Gupta, S, Gupta, A, Soto, D, Bakanauskas, V, Cerniglia, G, Muschel, R, Mckenna, W

“…In addition, prenyltransferase inhibitors which inhibit ras proteins by blocking posttranslational modification radiosensitize cells with oncogenic ras. These findings suggest that oncogenic ras contributes to intrinsic radiation resistance. …”

The RAS signal transduction pathway and its role in radiation sensitivity. by Mckenna, W, Muschel, R, Gupta, A, Hahn, S, Bernhard, E

“…Upstream and downstream pathways from RAS could thus be targets for manipulation of radiosensitivity. EGFR expression and AKT phosphorylation are also associated with the response to radiation. …”

Investigation of radiation damage in DNA by using atomic force microscopy. by Boichot, S, Fromm, M, Cunniffe, S, O'Neill, P, Labrune, J, Chambaudet, A, Delain, E, Le Cam, E

“…The amount of each class of topology enables a quantitative response to be determined for both types of radiation (alpha, X). A value of the radiosensitivity of DNA was obtained as a function of the scavenger concentration. …”

p97/VCP inhibition causes excessive MRE11-dependent DNA end resection promoting cell killing after ionizing radiation by Kilgas, S, Singh, AN, Paillas, S, Then, C-K, Torrecilla, I, Nicholson, J, Browning, L, Vendrell, I, Konietzny, R, Kiltie, AE, Ramadan, K

“…The inhibition of p97 function results in excessive 5′-DNA end resection mediated by MRE11 that leads to defective DNA repair and radiosensitivity. In addition, p97 inhibition by the specific small-molecule inhibitor CB-5083 increases tumor cell killing following IR both in vitro and in vivo. …”

MiR-7-5p/KLF4 signaling inhibits stemness and radioresistance in colorectal cancer by Yuanyuan Shang, Zhe Zhu, Yuanyuan Zhang, Fang Ji, Lian Zhu, Mengcheng Liu, Yewei Deng, Guifen Lv, Dan Li, Zhuqing Zhou, Bing Lu, Chuan-gang Fu

“…Rescue experiments revealed that miR-7-5p/KLF4 axis could induce radiosensitivity by regulating CSCs in colorectal cancer cells. …”
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