IDH1R132H mutation increases radiotherapy efficacy and a 4-gene radiotherapy-related signature of WHO grade 4 gliomas by Xuetao Han, Huandi Zhou, Wei Sun, Liubing Hou, Yanqiang Wang, Hong Wang, Zhongqiang Lv, Xiaoying Xue

“…First, we conducted experimental study on the effect of IDH1R132H mutation on glioma cells in vitro. Radiosensitivity of glioma cells was detected by γ-H2AX after 5 Gy radiation. …”
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Optimising radiotherapy of liver tumours: radiobiology of yttrium-90 microsphere treatment by Abbott, EM

“…</p> <p><strong>Materials and Methods:</strong> Clonogenic assays of cancer cell lines were used to assess radiosensitivity from exposure to 90Y SIRT and EBRT (LINAC and 137Cs). …”

Analisis E. Coli Pada Air Minum Dalam Kemasan Yang Beredar Di Kota Tasikmalaya by Vita Meylani, Rinaldi Rizal Putra

“…This study uses the Most Probable Number (MPN) method to test its bacterial content and gamma ray radiation to test its radiosensitivity. The sample in this study was bottled drinking water of various brands circulating in the City of Tasikmalaya. …”
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Radioimmunotherapy in HPV-Associated Head and Neck Squamous Cell Carcinoma by Xin Zhou, Xiaoshen Wang

“…Owing to its intrinsic radiosensitivity and distinct tumor microenvironment, HPV-associated HNSCC may represent a good candidate for radioimmunotherapy. …”
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Age-Dependent Small-Animal Internal Radiation Dosimetry by Tianwu Xie, Habib Zaidi

“…Rats at various ages were observed to present with different radiosensitivity and bioavailability for radiotracers commonly used in preclinical research. …”
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COMPARATIVE DOSIMETRIC STUDY IN CHEST COMPUTED TOMOGRAPHY USING PHANTOMS by Wadia Aburjaile, Mauricio Gomez, Arnaldo Prata Mourão

“…The risks of stochastic effects are greater for children due to tissue radiosensitivity coupled with longer life expectancy. In this work, a cylindrical phantom made of polymethylmethacrylate was used representing an adult chest, and a second phantom made of the same material was designed in an oblong shape, including axillary region, based on the dimensions of an eight year old pediatric patient. …”
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Study the Quality of Nasopharyngeal plans Using Evaluation Indexes of IMRT and VMAT Treatment planning Techniques by Ayat Methaq Khalaf, Basim Khalaf Rejah

“… Radiation treatment has long been the conventional approach for treating nasopharyngeal cancer (NPC) tumors due to its anatomic features, biological characteristics, and radiosensitivity. The most common treatment for nasopharyngeal carcinoma is radiotherapy. …”
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Differentially Expressed mRNAs and Potential Mechanisms of Radiation-Induced TUT4 Esophageal Cell Injury by Zhiqiang Sun, Jiaqi Zhang, Fanye Zeng, Shuyu Zhang, Zhifang Chai, Judong Luo, Jianping Cao

“…Esophageal epithelial cells are extremely sensitive to irradiation, nevertheless, factors involved in the radiosensitivity of esophageal epithelial cells are still unknown. …”
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Correlation between radiation dose and p53 protein expression levels in human lymphocytes by MARIANA B. CAVALCANTI, THIAGO S. FERNANDES, EDVANE B. SILVA, ADEMIR AMARAL

“…In conclusion, our findings indicate possible applications of this approach in evaluating individual radiosensitivity prior to radiotherapeutical procedures as well as in medical surveillance of occupationally exposed workers. …”
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Interaction between Fibroblasts and Immune Cells Following DNA Damage Induced by Ionizing Radiation by Kalaiyarasi Ragunathan, Nikki Lyn Esnardo Upfold, Valentyn Oksenych

“…However, following radiation, CAFs become senescent and produce a distinct combination of immunoregulatory molecules. Radiosensitivity of immune cells varies depending on the cell type due to inefficient DNA repair in, for example, monocytes and granulocytes. …”
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The characteristic of stem-related genes with pancreatic carcinoma cell after irradiation by Yunxiu Luo

“…Conclusions: MIAPaCa-2 cells exposed to x-rays and protons repeatedly displayed heterogeneous expression of stem-related DEGs involved in complex radiosensitivity, radio-resistance, and radio-induced mortality pathways. …”
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Relative sensitivities of repair-deficient mammalian cells for clonogenic survival after alpha-particle irradiation. by Hill, M, Herdman, M, Stevens, D, Jones, N, Thacker, J, Goodhead, D

“…Measurements of nuclear area were made to calculate the probability of surviving a single alpha-particle traversal, the average number of lethal lesions per track and per unit dose, along with the "intrinsic radiosensitivity" of these cells, allowing for the potential of multiple lethal lesions per traversal. …”

Characterisation of the histone acetyltransferase KAT7 as a novel target for radiosensitisation by Bittner, M

“…It is therefore desirable to develop tumour-specific radiosensitising agents, which can increase tumour cell kill without increasing the radiosensitivity of the surrounding normal tissue.</p> <p>This project aimed at validating the radiosensitising potential of depletion of the histone acetyltransferase KAT7, and elucidating the underlying mechanism of action. …”

Impaired lymphocyte development and antibody class switching and increased malignancy in a murine model of DNA ligase IV syndrome. by Nijnik, A, Dawson, S, Crockford, T, Woodbine, L, Visetnoi, S, Bennett, S, Jones, M, Turner, G, Jeggo, P, Goodnow, C, Cornall, R

“…Hypomorphic mutations in DNA ligase IV (LIG4) cause a human syndrome of immunodeficiency, radiosensitivity, and growth retardation due to defective DNA repair by the nonhomologous end-joining (NHEJ) pathway. …”

Farnesyltransferase inhibitors as radiation sensitizers. by Brunner, T, Gupta, A, Shi, Y, Hahn, S, Muschel, R, Mckenna, W, Bernhard, E

“…PURPOSE: The inhibition of activated Ras combined with radiotherapy was identified as a potential method for radiosensitization. MATERIALS AND METHODS: Immunoblotting was used to control for prenylation inhibition of the respective Ras isoforms and for changes in activity of downstream proteins. …”

MDC1 interacts with TOPBP1 to maintain chromosomal stability during Mitosis by Leimbacher, P-A, Jones, SE, Shorrocks, A-MK, De Marco Zompit, M, Day, M, Blaauwendraad, J, Bundschuh, D, Bonham, S, Fischer, R, Fink, D, Kessler, BM, Oliver, AW, Pearl, LH, Blackford, AN, Stucki, M

“…Disruption of MDC1-TOPBP1 binding causes a specific loss of TOPBP1 recruitment to DSBs in mitotic but not interphase cells, accompanied by mitotic radiosensitivity, increased micronuclei, and chromosomal instability. …”

The imidazoacridinone C-1311 induces p53-dependent senescence or p53-independent apoptosis and sensitizes cancer cells to radiation by Skwarska, A, Ramachandran, S, Dobrynin, G, Leszczynska, K, Hammond, E

“…Most importantly, we show that C-1311 can be effectively combined with radiation to improve the radiosensitivity of a panel of cancer cell lines. Together, our data suggest that C-1311 warrants further clinical testing in combination with radiotherapy for the treatment of solid tumors.…”

Identification of novel strategies to radiosensitise tumour cells by Anbalagan, S

“…Therefore, we selectively screened candidate aminopeptidase inhibitors and identified some promising effects on radiosensitivity.</p>…”

A theoretical framework for prescribing radiotherapy dose distributions using patient-specific biological information. by South, C, Partridge, M, Evans, P

“…The effect on local prescribed dose of variations in effective radiosensitivity, tumor burden, and proliferation rate was investigated, with results suggesting that dose variations would be significant but clinically achievable. …”

Radiation response and tolerance in planarian stem cells by Yap, ZC

“…However, the efficacy of radiotherapy is impeded by two co-existing challenges: the presence of radiotolerant cancer stem cells capable of withstanding treatment and subsequently driving cancer recurrence; coupled with collateral damage to normal stem cells, which are typically radiosensitive. Despite the pressing demand for radiotherapy, the underlying mechanisms governing radiosensitivity in normal stem cells and radiotolerance in cancer stem cells remain enigmatic, particularly within an in vivo setting. …”