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861
Cell Signaling Pathways That Promote Radioresistance of Cancer Cells
Published 2022-03-01“…Thus, targeting these prosurvival signaling pathways could potentially improve the radiosensitivity of cancer cells. In this review, we summarize the contribution of these pathways to the radioresistance of cancer cells.…”
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862
An Approach to Elucidate NBS1 Function in DNA Repair Using Frequent Nonsynonymous Polymorphism in Wild Medaka (Oryzias latipes) Populations.
Published 2017-01-01“…Nbs1 is one of the genes responsible for Nijmegen breakage syndrome, which is marked with high radiosensitivity. In human NBS1 (hNBS1), Q185E polymorphism is known as the factor to cancer risks, although its DSB repair defect has not been addressed. …”
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863
Radiotherapy plus CAR-T cell therapy to date: A note for cautions optimism?
Published 2022-11-01“…Factors such as hypoxia, the radiosensitivity of immune cells, and cancer stem cells (CSCs) all come into play in influencing the significant impact of radioresistance in the irradiated tumor microenvironment (TME). …”
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864
Parp Inhibitors and Radiotherapy: A New Combination for Prostate Cancer (Systematic Review)
Published 2023-08-01“…PARPi, in combination with ionizing radiation, has demonstrated the ability to enhance cellular radiosensitivity in different tumors. The rationale is that the exposure to radiation leads to both physical and biochemical damage to DNA, prompting cells to initiate three primary mechanisms for DNA repair. …”
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865
The Chromatin Architectural Protein CTCF Is Critical for Cell Survival upon Irradiation-Induced DNA Damage
Published 2022-03-01“…We demonstrate that the radiosensitivity of different cell lines is increased upon lowering the amount of the architectural protein. …”
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866
Brusatol modulates diverse cancer hallmarks and signaling pathways as a potential cancer therapeutic
Published 2022-07-01“…Extensive studies have indicated that brusatol exhibits anticancer effects by arresting the cell cycle; promoting apoptosis; inducing autophagy; attenuating epithelial-mesenchymal transition; inhibiting migration, invasion and angiogenesis; and increasing chemosensitivity and radiosensitivity. These effects involve various oncogenic signaling pathways, including the MAPK, NF-κB, PI3K/AKT/mTOR, JAK/STAT and Keap1/Nrf2/ARE signaling pathways. …”
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867
Radiobiological Evaluation of Combined Gamma Knife Radiosurgery and Hyperthermia for Pediatric Neuro-Oncology
Published 2021-06-01“…We explore the potential of such treatment enhancement via radiobiological modelling, specifically via the linear-quadratic (LQ) model adapted to thermoradiotherapy through modulating the radiosensitivity of temperature-dependent parameters. We extend this well-established model by incorporating oxygenation effects. …”
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868
Curcumin enhances the radio-sensitivity of prostate cancer cell line PC-3
Published 2021-12-01“…Conclusions Curcumin has a certain radiosensitizing effect in vitro, which potentially strengthen the inhibitory effect of radiotherapy on the growth of prostate cancer PC-3 cells.…”
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869
Gene expression profiling of human dermal fibroblasts exposed to bleomycin sulphate does not differentiate between radiation sensitive and control patients
Published 2011-04-01“…<p>Abstract</p> <p>Background</p> <p>Gene expression profiling of the transcriptional response of human dermal fibroblasts to <it>in vitro </it>radiation has shown promise as a predictive test of radiosensitivity. This study tested if treatment with the radiomimetic drug bleomycin sulphate could be used to differentiate radiation sensitive patients and controls in patients who had previously received radiotherapy for early breast cancer.…”
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870
Radiation sensitization by inhibition of activated Ras.
Published 2004“…Clonogenic assays with human and rodent tumor cell lines served for testing radiosensitivity. In vivo, farnesyltransferase inhibitors (FTIs) and irradiation were used to treat xenograft tumors. …”
Journal article -
871
Novel approaches to targeting ATM-deficient tumours
Published 2022“…Germline mutations in ATM give rise to ataxia-telangiectasia (A-T), a genome instability syndrome characterised by progressive neurodegeneration, profound radiosensitivity and susceptibility to cancer.</p> <p>The role of ATM in the DNA damage response (DDR) to irradiation and irinotecan treatment was evaluated using both ATM-deficient cell lines and mice, and by using pharmacological inhibition of ATM.…”
Thesis -
872
Revisiting the ultra-high dose rate effect: implications for charged particle radiotherapy using protons and light ions.
Published 2012“…RESULTS: The literature findings were that, for X-ray and electron dose rates of around 10(9) Gy s(-1), 5-10 Gy depletes cellular oxygen, significantly changing the radiosensitivity of cells already in low oxygen tension (around 3 mmHg or 0.4 kPa). …”
Journal article -
873
Hypoxia-activated tumor pathways of angiogenesis and pH regulation independent of anemia in head-and-neck cancer.
Published 2004“…Furthermore, the ability of tumors to upregulate hypoxia-regulated molecular pathways may affect radiosensitivity by mechanisms independent of the traditional concept of "oxygen effect." …”
Journal article -
874
The effects of 1-131 on different types of cancer Cell lines
Published 2015“…The findings of this study suggest that the cellular uptake of 1-131, cells viability and proliferation were highly dependent on cells metabolism, mitotic rate, occurrence of apoptosis, doubling time, cells radiosensitivity, and so on with consideration of some limitations.…”
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Monograph -
875
Circular RNA circEYA3 promotes the radiation resistance of hepatocellular carcinoma via the IGF2BP2/DTX3L axis
Published 2023-12-01“…Results CircEYA3 decreased the radiosensitivity of HCC cells both in vitro and in vivo. …”
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876
The CD44high Subpopulation of Multifraction Irradiation-Surviving NSCLC Cells Exhibits Partial EMT-Program Activation and DNA Damage Response Depending on Their p53 Status
Published 2021-02-01“…Our data indicated that autophagy is not necessarily associated with CSC-like cells’ radiosensitivity, emphasizing that careful assessment of other milestone processes (such as senescence and autophagy-p53-Zeb1 axis) of primary radiation responses may provide new potential targets modulated for therapeutic benefit through radiosensitizing cancer cells while rescuing normal tissue. …”
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877
Turfgrass varietal improvement for shade and drought tolerance using gamma ray irradiation
Published 2014“…The optimum dosage was calculated based on 50% radiosensitivity tests on survival rate and plant height. …”
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Thesis -
878
Unraveling Mitochondrial Determinants of Tumor Response to Radiation Therapy
Published 2022-09-01“…We focused on recent findings pointing to a major role of mitochondria in response to radiotherapy, along with their implication in the mechanisms underlying radioresistance and radiosensitivity, and briefly summarized some of the recently proposed mitochondria-targeting strategies to overcome the radioresistant phenotype in cancer.…”
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879
Applications of Nonlinear Programming to the Optimization of Fractionated Protocols in Cancer Radiotherapy
Published 2020-06-01“…After establishing the boundedness of the optimal number of fractions, we investigate by numerical simulation the optimal solution behavior for experimentally meaningful parameter ranges, recognizing the crucial role of some parameters, such as the radiosensitivity ratio, in determining the optimality of hypo- or equi-fractionated treatments. …”
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880
The 6th R of Radiobiology: Reactivation of Anti-Tumor Immune Response
Published 2019-06-01“…These 5Rs are: Repair, Redistribution, Reoxygenation, Repopulation and, more recently, intrinsic Radiosensitivity. Advances in radiobiology have demonstrated that RT is able to modify the tumor micro environment (TME) and to induce a local and systemic (abscopal effect) immune response. …”
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