Development and Radiation Response Assessment in A Novel Syngeneic Mouse Model of Tongue Cancer: 2D Culture, 3D Organoids and Orthotopic Allografts by Vui King Vincent-Chong, Mukund Seshadri

“…Phenotypic characterization and credentialing (STR profiling, exome sequencing) of RP-MOC1 cells was performed in vitro. Radiosensitivity was evaluated in 2D culture, 3D organoids, and in vivo using orthotopic allografts. …”
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Modulation of radiant oncological therapy through the intervention with substances of vegetable origin by Soledad Banega, Cintia Bertoncini, Mercedes Pascuccio, Alba Güerci

“…We consider the evaluation of green tea (Camellia Sinensis) opportune for its antioxidant and anti-inflammatory properties, while its composition in polyphenols would make it possible to reduce radiosensitivity and improve cell recovery. Thus, our objective was to assess the efficacy of this infusion in the management of mucositis developed during radiant treatment of patients with head and neck cancer. …”
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TLR9 and Glioma: Friends or Foes? by Emna Fehri, Emna Ennaifer, Rahima Bel Haj Rhouma, Monia Ardhaoui, Samir Boubaker

“…The TLR9 agonist CpG ODN 107 also enhances the radiosensitivity of human glioma U87 cells by blocking tumor angiogenesis. …”
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Potential Role of Natural Products to Combat Radiotherapy and Their Future Perspectives by Rokeya Akter, Agnieszka Najda, Md. Habibur Rahman, Muddaser Shah, Sylwia Wesołowska, Syed Shams ul Hassan, Sidra Mubin, Parveen Bibi, Saeeda Saeeda

“…Therefore, radiobiological research is emphasizing chemical compounds ’radiosensitization of cancer cells so that they are more reactive in the IR spectrum. …”
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Prediction of hub genes and key pathways associated with the radiation response of human hematopoietic stem/progenitor cells using integrated bioinformatics methods by Yoshiaki Sato, Hironori Yoshino, Junya Ishikawa, Satoru Monzen, Masaru Yamaguchi, Ikuo Kashiwakura

“…However, HSCs have high radiosensitivity, which is often a problem during radiation therapy and nuclear accidents. …”
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A Mathematical Model of Thyroid Disease Response to Radiotherapy by Araceli Gago-Arias, Sara Neira, Filippo Terragni, Juan Pardo-Montero

“…We found that simple individualization strategies based on the absorbed dose in the tumor and tumor radiosensitivity (which are both magnitudes that can potentially be individually determined for every patient) can lead to an important raise of tumor control probabilities.…”
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PTTG and p21 as prognostic biomarker in radiotherapy for non-functional pituitary adenomas by LI Yang-fang, HU Hui-min

“…According to the follow-up MRI, a decrease of tumor more than 20% was defined as radiosensitive; Expression of sixteen protein markers in pituitary adenomas was determined using a tissue microarray. …”
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Assessment of Oxaliplatin-Loaded Iodine Nanoparticles for Chemoradiotherapy of Human Colorectal Cancer (HT-29) Cells by Naser Rasouli, Daryoush Shahbazi-Gahrouei, Simin Hematti, Behzad Baradaran, Roya Salehi, Jaleh Varshosaz, Abbas Jafarizad

“…The interaction of INPs with mega-voltage photon energies is the cause of a major radiosensitization enhancement in comparison to radiation alone. …”
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Prospective Application of Ferroptosis in Hypoxic Cells for Tumor Radiotherapy by Jing Su, Qin Zhao, Zhuangzhuang Zheng, Huanhuan Wang, Chenbin Bian, Lingbin Meng, Ying Xin, Xin Jiang

“…It plays an important role in both hypoxia and radiotherapy and can enhance the radiosensitivity of hypoxic tumor cells by amplifying oxidative stress or inhibiting antioxidant regulation. …”
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Age dynamics of cancer incidence intensity indicates existence of some frailty subgroups by V.F. Obesnyuk

“…It is shown that some known facts of paradoxical changes in radiosensitivity indicators can be satisfactorily interpreted within the concept of a frailty subgroup by using numerical modelling on the example of modifying the dynamics of thyroid cancer incidence under influence of ionizing radiation. …”
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Prediction of Radiation Treatment Response for Locally Advanced Rectal Cancer via a Longitudinal Trend Analysis Framework on Cone-Beam CT by Zirong Li, Ann C. Raldow, Joanne B. Weidhaas, Qichao Zhou, X. Sharon Qi

“…Patients respond to the same radiation treatment course differently due to inter- and intra-patient variability in radiosensitivity. In-room volumetric cone-beam computed tomography (CBCT) is widely used to ensure proper alignment, but also allows us to assess tumor response during the treatment course. …”
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A Dosimetric Parameter Reference Look-Up Table for GRID Collimator-Based Spatially Fractionated Radiation Therapy by Hualin Zhang, Michael P. Grams, Joseph J. Foy, Nina A. Mayr

“…Three approximation equations were developed for calculating <i>EUD</i>s of different prescription doses for three radiosensitivity levels for 3-cm deep tumours. Dosimetric parameters were consistent and predictable across tumour sizes and depths. …”
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Use of the comet-FISH assay to compare DNA damage and repair in p53 and hTERT genes following ionizing radiation. by Declan J McKenna, Bernadette A Doherty, C Stephen Downes, Stephanie R McKeown, Valerie J McKelvey-Martin

“…We suggest this increases its potential for measuring radiosensitivity in cells and may therefore have value in a clinical setting.…”
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A Simpler Energy Transfer Efficiency Model to Predict Relative Biological Effect (RBE) for Protons and Heavier Ions. by Bleddyn eJones

“…The model input parameters are: Z (effective nuclear charge), and radiosensitivity parameters alphaL and betaL of the control low linear energy transfer (LET) radiation. …”
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Molecular Pathogenesis of Radiation-Induced Cell Toxicity in Stem Cells by Wonhee Hur, Seung Kew Yoon

“…In this review, we summarize the current advances in research regarding how normal SCs and CSCs respond to ionizing radiation, with a special emphasis on cell toxicity, radiosensitivity, signaling networks, DNA damage response (DDR) and DNA repair. …”
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Use of 3D Spheroid Models for the Assessment of RT Response in Head and Neck Cancer by Marilyn Wegge, Rüveyda Dok, Ludwig J. Dubois, Sandra Nuyts

“…We demonstrate that HPV-positive spheroids keep their higher intrinsic radiosensitivity when compared to HPV-negative spheroids. …”
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First application of GammaTile cesium-131 brachytherapy with maximal safe resection of a glioma in a patient with limited scleroderma by Melisa Pasli, Sara Cowles, Jasmin Jo, Mahmoud Yaqoub, Hilal A. Kanaan, Andrew W. Ju, Sean Peach

“…The purpose of this report is to present the first documented application of GammaTile to an intra-cranial tumor of a patient with a symptomatic radiosensitive connective tissue disorder, a case where there were significant concerns with standard oncologic strategies. …”
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Dual Targeting of DNA Damage Response Proteins Implicated in Cancer Radioresistance by Spyridon N. Vasilopoulos, Hüseyin Güner, Merve Uça Apaydın, Athanasia Pavlopoulou, Alexandros G. Georgakilas

“…It has been shown that administration of platinum-based drugs to cancer patients can increase tumor radiosensitivity, but despite this, it is associated with severe adverse effects. …”
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An Estimation of Radiobiological Parameters for Head-and-Neck Cancer Cells and the Clinical Implications by X. Allen Li, Steve P. Lee, Qiuhui Yang, X. Sharon Qi, Dian Wang

“…The repair halftime (Tr), the potential doubling time (T&lt;sub&gt;d&lt;/sub&gt;), a/β and radiosensitivity a, were estimated. Other radiobiological models: EUD, BED, TCP, &lt;em&gt;etc&lt;/em&gt;., were used to examine the potential treatment effectiveness of different IMRT techniques. …”
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Characterisation of deubiquitylating enzymes in the cellular response to high-LET ionizing radiation and complex DNA damage by Carter, R, Nickson, C, Thompson, J, Kacperek, A, Hill, M, Parsons, J

“…USP6 depletion caused cell cycle arrest and a deficiency in CDD repair mediated through instability of poly(ADP-ribose) polymerase-1 (PARP-1) protein. Increased radiosensitivity of cells to high-LET protons as a consequence of defective CDD repair was furthermore mimicked using the PARP inhibitor olaparib, and through PARP-1 small interfering RNA.…”