Transcatheter patent ductus arteriosus closure with echocardiographic guidance: can radiation exposure be reduced? by İbrahim Cansaran Tanıdır, Alper Guzeltas, Yakup Ergul, Erkut Ozturk, Isa Ozyilmaz, Ender Odemis

“…Objectives: The radiation dose from interventional cardiac catheterization is particularly relevant when treating children because of their greater radiosensitivity compared to adults. The transcatheter closure of patent ductus arteriosus (PDA), as well as other more complex pediatric interventions, have raised concerns regarding radiation exposure, particularly relevant when treating children. …”
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Raman spectroscopy and convolutional neural networks for monitoring biochemical radiation response in breast tumour xenografts by Alejandra M. Fuentes, Apurva Narayan, Kirsty Milligan, Julian J. Lum, Alex G. Brolo, Jeffrey L. Andrews, Andrew Jirasek

“…We are interested in developing a CNN-based predictive model to characterize clinical tumour response to radiation therapy based on their degree of radiosensitivity or radioresistance. In this work, a CNN architecture is built for identifying post-irradiation spectral changes in Raman spectra of tumour tissue. …”
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Effects of Alpha Particle and Proton Beam Irradiation as Putative Cross-Talk between A549 Cancer Cells and the Endothelial Cells in a Co-Culture System by Hélène Riquier, Denis Abel, Anne-Catherine Wera, Anne-Catherine Heuskin, Géraldine Genard, Stéphane Lucas, Carine Michiels

“…Given that tumors are now considered as complex organs composed of multiple cell types that can influence radiosensitivity, we investigated the effects of proton and alpha particle irradiation on the possible radioprotective cross-talk between cancer and endothelial cells. …”
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PRDM15 interacts with DNA-PK-Ku complex to promote radioresistance in rectal cancer by facilitating DNA damage repair by Yue Yu, Tingting Liu, Guanyu Yu, Hang Wang, Zhipeng Du, Yuanyuan Chen, Nan Yang, Kun Cao, Chunlei Liu, Zhijie Wan, Hui Shen, Fu Gao, Yanyong Yang, Wei Zhang

“…Knockdown of PRDM15 inhibited DNA damage repair and increased radiosensitivity in colorectal cancer cells. Mechanistically, PRDM15 promoted DNA repair by interacting with DNA-PKcs and Ku70/Ku80 complex. …”
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KAT5 Inhibitor NU9056 Suppresses Anaplastic Thyroid Carcinoma Progression through c-Myc/miR-202 Pathway by Wenjing Xu, Liwei Xie, Yingying Yang, Jiayu Xu, Shang Cai, Ye Tian

“…Suppression of KAT5 by NU9056 inhibited survival, growth, migration, invasion, and tube formation, and increased radiosensitivity and chemosensitivity in ATC cells but showed no impact on normal thyroid cells. …”
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Inherent Radiation Sensitivity of Lymphocytes of Triple Negative (TN) and Luminal A: A Comparison Between Patients with Breast Cancer and Normal Individuals as Assayed by the Micro... by Hassan Nosrati, Hossein Mozdarani, Peyman Hadad, Ramesh Omranipour, Sahar Mozdarani, Mohsen Bakhshandeh, Sohail Mozdarani, Farhad Shahi

“…These patients show various degrees of mild to acute reactions during and after the completion of treatment.The aim of this study was to compare inherent radiosensitivity of gamma-irradiated G0-lymphocytes between BC patients and normal individuals using cytokinesis blocked micronucleous assay. …”
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Radiation induces IRAK1 expression to promote radioresistance by suppressing autophagic cell death via decreasing the ubiquitination of PRDX1 in glioma cells by Jing Li, Yuchen Sun, Xu Zhao, Yuan Ma, Yuchen Xie, Siqi Liu, Beina Hui, Xiaobo Shi, Xuanzi Sun, Xiaozhi Zhang

“…IRAK1 knockdown inhibits malignancy and enhances the radiosensitivity of glioma in vitro and in vivo. To explore the potential IRAK1 interacting targets mediating the radioresistance of glioma cells, IP/Co-IP, LC-MS/MS, GST pull-down, and ubiquitination analyses were conducted. …”
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Targeting OGG1 and PARG radiosensitises head and neck cancer cells to high-LET protons through complex DNA damage persistence by Maria Rita Fabbrizi, Catherine M. Nickson, Jonathan R. Hughes, Emily A. Robinson, Karthik Vaidya, Carlos P. Rubbi, Andrzej Kacperek, Helen E. Bryant, Thomas Helleday, Jason L. Parsons

“…From this, we subsequently validated that depletion of 8-oxoguanine DNA glycosylase (OGG1) and poly(ADP-ribose) glycohydrolase (PARG) in HeLa and head and neck cancer cells leads to significantly increased cellular radiosensitivity specifically following high-LET protons, whilst no effect was observed after low-LET protons and X-rays. …”
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Enhancing anti-tumour innate immunity by targeting the DNA damage response and pattern recognition receptors in combination with radiotherapy by Charleen M. L. Chan Wah Hak, Antonio Rullan, Emmanuel C. Patin, Malin Pedersen, Alan A. Melcher, Kevin J. Harrington

“…Targeting the DNA damage response (DDR) concomitantly with radiotherapy is an attractive strategy for overcoming radioresistance, both by enhancing the radiosensitivity of tumour relative to normal tissues, and tipping the scales in favour of an immunostimulatory tumour microenvironment. …”
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Biological Effect of Gamma Rays According to Exposure Time on Germination and Plant Growth in Wheat by Min Jeong Hong, Dae Yeon Kim, Yeong Deuk Jo, Hong-Il Choi, Joon-Woo Ahn, Soon-Jae Kwon, Sang Hoon Kim, Yong Weon Seo, Jin-Baek Kim

“…Long-term exposure caused higher radiosensitivity than short-term exposure. The results of this study could help plant breeders select an effective mutagenic induction dose rate in wheat.…”
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Evaluation of the effect of intensity‐modulated radiotherapy (IMRT) and volumetric‐modulated arc radiotherapy (VMAT) techniques on survival response in cell lines with a new radiob... by Serra Kamer, Sunde Yilmaz Susluer, Tugce Balci Okcanoglu, Cagla Kayabasi, Besra Ozmen Yelken, Sinan Hoca, Emin Tavlayan, Nezahat Olacak, Yavuz Anacak, Murat Olukman, Cumhur Gunduz

“…Results The segmented radiation approach used in IMRT applications enhanced radiosensitivity and cytotoxicity in the cancer models, while changes in dose rate had varying effects on cytotoxicity depending on the tumor cell type. …”
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Sarcoma cell-specific radiation sensitization by titanate scrolled nanosheets: insights from physicochemical analysis and transcriptomic profiling by Pierre Beaudier, Florent Vilotte, Marina Simon, Giovanna Muggiolu, Quentin Le Trequesser, Guillaume Devès, Laurent Plawinski, Antoine Mikael, Jérôme Caron, Guy Kantor, Denis Dupuy, Marie-Hélène Delville, Philippe Barberet, Hervé Seznec

“…Abstract This study aimed to explore the potential of metal oxides such as Titanate Scrolled Nanosheets (TNs) in improving the radiosensitivity of sarcoma cell lines. Enhancing the response of cancer cells to radiation therapy is crucial, and one promising approach involves utilizing metal oxide nanoparticles. …”
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Increased EZH2 expression in prostate cancer is associated with metastatic recurrence following external beam radiotherapy by Wu, X, Scott, H, Carlsson, S, Sjoberg, D, Cerundolo, L, Lilja, H, Prevo, R, Rieunier, G, Macaulay, V, Higgins, G, Verrill, C, Lamb, A, Cunliffe, V, Bountra, C, Hamdy, F, Bryant, R

“…LNCaP and PC3 cell radiosensitivity was investigated using colony formation and γH2AX assays following UNC1999 chemical probe-mediated EZH2 inhibition. …”

Clinically relevant MRE11 variants in bladder cancer by Jevons, S

“…The high expression of MRE11 could include detection of high levels of the variant, associated with defective DNA repair and hence increased radiosensitivity. An underlying mechanistic explanation further supports the use of MRE11 immunohistochemistry as a predictive biomarker. …”

Radioresistant laryngeal cancers upregulate type 1 IGF receptor and exhibit increased cellular dependence on IGF and EGF signalling by Qureishi, A, Rieunier, G, Shah, K, Aleksic, T, Winter, S, Møller, H, Macaulay, V

“…<em>In vitro</em>, radiosensitivity was enhanced by inhibition of EGFR but not IGF. …”

Evaluation of the ability of fatty acid metabolism signature to predict response to neoadjuvant chemoradiotherapy and prognosis of patients with locally advanced rectal cancer by Han Zhou, Yanping Chen, Yu Xiao, Qian Wu, Hui Li, Yi Li, Guangjian Su, Longfeng Ke, Junxin Wu, Jinluan Li

“…We screened 34 disease-free survival (DFS)-related, FAM-related, and radiosensitivity-related genes based on the Gene Expression Omnibus database. …”
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Down-regulation of lncRNA DNM3OS enhances radiotherapy sensitivity of human rectal cancer cell line SW-480 by targeting miR-193a-3p by LIU Ming-sheng, CHEN Wen-chao, CAI Ying-chang

“…DNM3OS targeted and regulated miR-193a-3p, and interference with miR-193a-3p expression reversed the effect of inhibiting lncRNA DNM3OS expression on the proliferation, apoptosis and radiosensitivity of rectal cancer SW-480 cells. Conclusions Down-regulation of expression of lncRNA DNM3OS can inhibit the proliferation of SW-480 cells by up-regulation of miR-193a-3p, thus to promote cell apoptosis and enhance cell radio-sensitivity.…”
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Case Report: Contribution of [18F]FET PET in differential diagnosis between radionecrosis and progression in metastasis—reproducibility and superiority of dynamic acquisitions by Aurélien Callaud, Anne-Claire Dupont, Anne-Claire Dupont, Marie-Agnes By, Ilyess Zemmoura, Ilyess Zemmoura, Maria-Joao Santiago-Ribeiro, Maria-Joao Santiago-Ribeiro

“…In addition, differences in radiosensitivity suggest a lower metastasis pre-test probability of progression, and it might be why a TAC analysis could be more effective in distinguishing true progression from treatment related changes in metastasis. …”
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Pharmacological effects and mechanisms of paeonol on antitumor and prevention of side effects of cancer therapy by Xindi Chang, Xindi Chang, Xiaoteng Feng, Xiaoteng Feng, Min Du, Min Du, Sijin Li, Sijin Li, Jiarou Wang, Jiarou Wang, Yiru Wang, Ping Liu

“…Its underlying mechanisms involve the induction of apoptosis, the inhibition of cell proliferation, invasion and migration, angiogenesis, cell cycle arrest, autophagy, regulating tumor immunity and enhanced radiosensitivity, as well as the modulation of multiple signaling pathways, such as the PI3K/AKT and NF-κB signaling pathways. …”
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<i>NEAT1</i> Confers Radioresistance to Hepatocellular Carcinoma Cells by Inducing Autophagy through GABARAP by Hiromi Sakaguchi, Hiroyuki Tsuchiya, Yutaka Kitagawa, Tomohiko Tanino, Kenji Yoshida, Nobue Uchida, Goshi Shiota

“…We found that <i>NEAT1</i> knockdown enhanced the radiosensitivity of HCC cell lines and concomitantly inhibited autophagy. …”
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